DE947827C - Process for the preservation of decomposable substances - Google Patents

Description

Process for the preservation of decomposing materials. Present invention refers to a method of preserving decomposable substances, such as food and Genoa, cosmetic, pharmaceutical, antiseptic and disinfectant preparations, but also other substances exposed to decomposition by microorganisms.

The procedure consists in removing these substances if necessary even at one stage of production, certain ethers of ethylene glycol are added. So you can optionally these ether the basis or the substrate of a disinfectant or add antiseptic preparation or a solvent.

The ethers of ethylene glycol to be used are ethers for which one of the hydroxyl groups is etherified by a purely aromatic group, z. B. the phenyl or naphthyl group. It can also be a mixture of these ethers or a mixture of one or more of these ethers with ethylene glycol monomethyl ether, Ethylene glycol monoethyl ether, ethylene glycol monopropyl ether or ethylene glycol monobutyl ether can be used, which can also be used in mixture.

The ethers have the formula where R is an aryl group. The aryl groups can be phenyl, naphthyl or similar groups. They can also contain substituents such as halogen, alkyl, aralkyl, aryl or additional hydroxyl groups or alkoxy groups.

In the patent specification 649 2o6 a method for disinfection is described, which is characterized by the use of solutions or emulsions that are unsaponifiable Compounds of the general formula R # X # R '(OH) "in which R is an organic, in particular aliphatic, cycloaliphatic and aliphatic-aromatic, at least 6 carbon atoms containing radical, R 'an organic, especially lower aliphatic radical, X is a divalent or polyvalent atom or a group of atoms and n means at least the number I.

However, this method does not apply to the use of purely aromatic Groups such as the phenyl or naphthyl group. The claimed ethers are off the ethers known from the patent, namely the aliphatic monoglycol ethers, and also largely superior to benzyne monoglycol ether in effect.

One can in this way the development of mushrooms and of many Bacteria, also ferment yeast into various materials, the carbohydrates contain, prevent. These ethers kill microorganisms in a short time. Among the ethers that can be used are ethylene glycol-o-, -m-, -p-chlorophenyl ether, ethylene glycol-I-naphthyl ether, ethylene glycol phenyl ether.

These substances can be used after their incorporation into inert Powder, e.g. B. talc, or in the form of ointments or solutions or suspensions. Further Mixtures with similar active substances are possible.

For example, an addition of 1.2% of the monophenyl ether is sufficient of ethylene glycol, as shown in Example 5, to prevent any development of microorganisms in meat broth or gelatin infusion (gel) to prevent. In an addition of o, 2 g of pressed, top-fermenting distillery yeast to 25 ccm of a 10/0 glucose solution prevented the addition of 0.3) / o ethylene glycol p-chlorophenyl ether or 0.5% ethylene glycol chlorophenyl ether each fermentation at 37 ° C for 24 hours.

The sufficient disinfecting effect of the various ethers will be clearly shown by determining the concentrations at which the development of Staphylococcus aureus, Bacterium coli, Bacterium parathyphosus, Bacterium pyocyaneum, Sahnonella typhae or similar microorganisms in a dilute aqueous or normal saline solution or a nutrient medium (suspension method) or dried on a batiste strip (carrier method) is completely suppressed.

The following concentrations have been found to be effective Phenyl ether of ethylene glycol =, o 0/0 kills B. pyocyaneum in distilled water (suspension method) within 30 minutes I, 2% - - - 5 - B. coli in distilled water (suspension method) 1.20 / 0 - - - 5 - B. coli in normal nutrient broth (suspension method) 1.20 /, - - - 5 - Sal. Typhae in serum broth (suspension method) ", 511/0 - - - 5 - B. coli in Ringer's solution (suspension method) I, 5% - - - 30 - staph. aureus in distilled water (suspension method) 1.511 / 0 - - - 5 - B. paratyphosus in distilled water (suspension method) I, 5% - - - 5 - Sal.typhae in distilled water (suspension method) 1.6 0/0 - - - 5 - staph. aureus in distilled water (suspension method) 1.6 0/0 - - - 5 - B. coli in distilled water (suspension method) I; 6 0/0 - - - 3 - staph. aureus, dried on batiste strips, in distilled water 1.6 0/0 - - - 5 - B. pyocyäneum in n-saline solution (suspension method) 2, o 0/0 - - - 5 - Staph. aureus in nutrient broth (suspension method) p-Chlorophenyl ether of, ethylene glycol 0.5% kills B. coli in distilled water within 5 minutes (suspension method) - 0; 5% - - - 5 - staph. aureus in distilled water (suspension method) 0.511 / 0 - - - 5 - B. pyocaneum in distilled water (suspension method) 0.50 / 0 - - - 5 - B. coli, dried on batiste strips, in distilled water 0.5 0/0 - - - 6o - staph. aureus in distilled water (suspension method) 0.5 0/0 - - - 5 - - B. pyocyaneum in distilled water (suspension method) A mixture of 10/0 normal butyl ether of ethylene glycol and 1.550 phenyl ether kills Staphylococcus aureus and Bacterium pyocyaneum in normal saline (suspension method) in 5 minutes. o-cresol ether of ethylene glycol 0.6% kills staph within 60 minutes. aureus in Ringer's solution (suspension method) o, 6 "/, - - - 5 - B. coli in Ringer's solution (suspension method) o, 6 0/0 - - - 5 - B. pyocyaneum in Ringer's solution (suspension method) The antiseptic effect is increased if, instead of the individual ethers of ethylene glycol, their mixtures with one another or with other glycol ethers are used. In particular, it has been found that the bactericidal effect of the mixed ethers is considerably greater than that of the individual components.

The following examples show how the invention is carried out. Example i 2.5 parts by weight of monophenyl ether of ethylene glycol are mixed with 7.5 parts by weight Glycerine or ethylene glycol mixed. 90 parts by weight of Vaseline are added to the mixture admitted. The ointment obtained can be used for disinfecting purposes. Instead of of the phenyl ether of ethylene glycol, mixtures of the same with the butyl, Propyl or benzyl ethers can be used in appropriate concentrations. example 2 2 parts by weight of monophenyl ether of ethylene glycol are in 98 parts by weight a powder introduced, which consists of talc or starch or a mixture of these consists of both and which can be used for the production of face powder. By applying small amounts of this powder in a wet culture medium that infects evenly is with Bacterium pyocyaneum, the development of these bacteria is completely prevented, and in a limited time the bacteria are killed. Example 3 A mixture of = part by weight of monophenyl ether of ethylene glycol and i part by weight of monon-butyl ether of the ethylene glycol is added to 98 parts by weight of a protein solution and protects the same against any destruction by microorganisms. Example q. A 3% glucose containing gelatin, to which x part by weight phenyl or 0.4% p-chlorophenymonoether The ethylene glycol is added, is open to the infection by mold, fermentation bacteria and other ubiquitous microorganisms. The gelatin (gel) remains free from any infection.

Example s Ordinary sterile meat broth or serum broth to which 1.20 / 0 monophenyl ether of ethylene glycol is added and which is openly exposed to infection by microorganisms, remains sterile for many weeks. Instead of phenyl ether, 0.5 % p-chlorophenyl ether can be used. Example 6 A mixture of q. Parts by weight of the monon-butyl ether and 1 part by weight of the monophenyl ether of ethylene glycol is introduced into 95 parts by weight of a starch paste. This mixture is protected against rot even if it is kept in a damp room. If such a concentrated paste is diluted with water, even the diluted substances remain preserved for a long time.

Example 7 2 parts by weight of mono-β-naphthyl ether of ethylene glycol are mixed with 98 parts by weight of lactose. The mixture kills disease-causing bacteria, such as Streptococcus pyogenes, after a few minutes. For the same purpose a mixture of ethylene glycol α-naphthyl ether and ethylene glycol β-naphthyl ether, each at 0.75 parts by weight, as well as a mixture of 0.501, of o-chlorophenyl ether of ethylene glycol and 0.5 % of p -Chlorhenyl ether of ethylene glycol. Example 8 A mixture of 3 parts by weight of the mono-butyl ether of ethylene glycol and 1 part by weight of the monophenyl ether of ethylene glycol, in which 0.5 parts by weight of the mono-p-chlorophenyl ether of ethylene glycol are dissolved and which is diluted with 97 parts by weight of water, is for disinfecting purposes usable of all kinds. Example 9 An addition of 0.5% monophenyl ether and 0.2% mono-p-chlorophenyl ether of ethylene glycol to rubber latex protects it from mold. Example 10 A solution of 2% mono-n-butyl, 2% a of monophenyl and 0.2% of the mono-p-chlorophenyl ether of ethylene glycol in sterile water is used for the sterilization and preservation of catgut. Example ii For sterile storage of instruments and apparatus, a mixture of 20%, phenyl and 2% n-butyl monoether in sterile distilled water is used.

Claims (3)

PATENT CLAIMS: i. Process for the preservation of decomposable substances using monoethers of ethylene glycol, characterized by the application those ethers whose one oxy group is replaced by a purely aromatic group, e.g. B. the Phenyl or naphthyl group, is etherified. 2. Embodiment according to claim i, characterized characterized in that these ethers are also used in a mixture with one another or individually or in a mixture with the monomethyl, monoethyl, Monopropyl or monobutyl ether of ethylene glycol or a mixture of the latter. 3. Procedure for the production of antiseptic and disinfecting preparations, characterized in that that an ether or ether of ethylene glycol, as specified in claims r and 2 are, in a suitable solvent, emulsifier, substrate or base is introduced. Considered publications: German Patent No. 6 [9 2o6; Houben, "The Methods of Organic Chemistry", Vol. 111, 1923, pp. 136/137.