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DE916108C - Process for obtaining highly effective adrenal extracts - Google Patents

Process for obtaining highly effective adrenal extracts

Info

Publication number
DE916108C
DE916108C DEB22712A DEB0022712A DE916108C DE 916108 C DE916108 C DE 916108C DE B22712 A DEB22712 A DE B22712A DE B0022712 A DEB0022712 A DE B0022712A DE 916108 C DE916108 C DE 916108C
Authority
DE
Germany
Prior art keywords
highly effective
adrenal
obtaining highly
extracts
adrenal extracts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB22712A
Other languages
German (de)
Inventor
Dipl-Chem Dr Hansju Staudinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DEB22712A priority Critical patent/DE916108C/en
Application granted granted Critical
Publication of DE916108C publication Critical patent/DE916108C/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Description

Verfahren zur Gewinnung hochwirksamer Nebennieren-Extrakte Im Patent 879 902 ist ein Verfahren zur Steigerung der Wirksamkeit von nach üblichen Methoden hergestellten Nebennieren-Extrakten beschrieben, welches darauf beruht, daß man den Organbrei vor der Extraktion mit solchen physiologischen Stoffen behandelt, die in den natürlichen Stoffwechsel der Nebennierenrinde eingreifen, selbst aber keine corticoide Wirkung aufweisen. Dort wird in diesem Sinne u. a. Ascorbinsäure genannt.Process for obtaining highly effective adrenal extracts In the patent 879 902 is a method for increasing the effectiveness of by conventional methods produced adrenal extracts described, which is based on the fact that one treats the organ pulp with such physiological substances before extraction, which intervene in the natural metabolism of the adrenal cortex, but themselves have no corticoid effect. There is in this sense, inter alia. Ascorbic acid called.

Es wurde nun gefunden, daß man eine weitere Aktivitätssteigerung von (nach an sich üblichen Methoden gewonnenen) Nebennieren-Extrakten erreichen kann, wenn man unter Anwendung des Verfahrens des Hauptpatents die Ascorbinsäure ganz oder teilweise durch Dehydroascorbinsäure ersetzt. Beispiel Ersetzt man die im Beispiel des Patents 879 902 als Zusatz angegebene Menge von 5 g Ascorbinsäure durch die gleiche Menge Dehydroascorbinsäure, so zeigt der erhaltene Nebennieren-Extrakt eine gegenüber vergleichbaren, aus unbehandelten Drüsen hergestellten Extrakten auf das Dreifache gesteigerte Aktivität.It has now been found that a further increase in activity of Adrenal extracts (obtained by conventional methods) can achieve, if one uses the procedure of the main patent the ascorbic acid whole or partially replaced by dehydroascorbic acid. Example Replaces those in the example of the patent 879 902 specified as an additive amount of 5 g of ascorbic acid by the the same amount of dehydroascorbic acid, the adrenal extract obtained shows a compared to comparable extracts made from untreated glands on the Activity increased three times.

Claims (1)

PATENTANSPRUCH: Verfahren zur Gewinnung hochwirksamer Nebennieren-Extrakte nach Anspruch 5 des Patents 879 9o2, dadurch gekennzeichnet, daß man die Ascorbinsäure ganz oder teilweise durch Dehydroascorbinsäure ersetzt.PATENT CLAIM: Process for obtaining highly effective adrenal extracts according to claim 5 of patent 879 902, characterized in that the ascorbic acid completely or partially replaced by dehydroascorbic acid.
DEB22712A 1952-11-01 1952-11-01 Process for obtaining highly effective adrenal extracts Expired DE916108C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB22712A DE916108C (en) 1952-11-01 1952-11-01 Process for obtaining highly effective adrenal extracts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB22712A DE916108C (en) 1952-11-01 1952-11-01 Process for obtaining highly effective adrenal extracts

Publications (1)

Publication Number Publication Date
DE916108C true DE916108C (en) 1954-08-05

Family

ID=6960979

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB22712A Expired DE916108C (en) 1952-11-01 1952-11-01 Process for obtaining highly effective adrenal extracts

Country Status (1)

Country Link
DE (1) DE916108C (en)

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