DE810027C - Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols - Google Patents
Process for the production of a novel Abkoemmlings des ‡ -PhenylaethylalkoholsInfo
- Publication number
- DE810027C DE810027C DEP19118D DEP0019118D DE810027C DE 810027 C DE810027 C DE 810027C DE P19118 D DEP19118 D DE P19118D DE P0019118 D DEP0019118 D DE P0019118D DE 810027 C DE810027 C DE 810027C
- Authority
- DE
- Germany
- Prior art keywords
- production
- novel
- phenylaethylalkohols
- abkoemmlings
- des
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 229940067107 phenylethyl alcohol Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 150000003900 succinic acid esters Chemical class 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 229940014800 succinic anhydride Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WAPNOHKVXSQRPX-UHFFFAOYSA-N 1-phenylethanol Chemical compound CC(O)C1=CC=CC=C1 WAPNOHKVXSQRPX-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines neuartigen Abkömmlings des a-Phenyläthylalkohols Es ist bekannt, daß man durch Umsetzung von a-Phenyläthylalkohol mit Bernsteinsäureanhydrid den sauren Bernsteinsäureester erhält, doch ist dessen Aufarbeitung und Abtrennung von mitentstandenen Nebenprcdukten umständlich und insbesondere die Isolierung und Reind irstellung seiner in Wasser leicht löslichen und schlecht kristallisierenden Alkali- und Erdalkalisalze mit Schwierigkeiten verbunden.Process for the preparation of a novel derivative of a-phenylethyl alcohol It it is known that by reacting α-phenylethyl alcohol with succinic anhydride the acid succinic acid ester is obtained, but its work-up and separation is of incidental byproducts cumbersome and especially the isolation and Purification of its easily soluble in water and poorly crystallizing Alkali and alkaline earth salts associated with difficulties.
Es wurde nun gefunden, daß man aus den wäßrigen Lösungen der Salze eine gut kristallisierende Doppelverbindung abscheiden kann, wenn man die Salzlösungen mit überschüssigem Calciumchlorid versetzt. It has now been found that the aqueous solutions of the salts a double compound that crystallizes well can be deposited if one uses the salt solutions mixed with excess calcium chloride.
Auf Grund ihrer Löslichkeitseigenschaften kann diese Doppelverbindung leicht von Begleitstoffen abgetrennt und in reiner Form in sehr guter Ausbeute erhalten werden.Due to their solubility properties, this double compound can easily separated from accompanying substances and obtained in pure form in very good yield will.
Das neue Calciumchloriddoppe lsalz besitzt wertvolle therapeutische Eigenschaften und kann als solches oder als Zwischenprodukt zur Herstellung von Heilmitteln verwendet werden. The new calcium chloride double salt has valuable therapeutic properties Properties and can be used as such or as an intermediate in the manufacture of Remedies are used.
Beispiel 6i g a-Phenyläthylalkohol werden mit 50 g Bernsteinsäureanhydrid 21/2 Stunden auf I40° erhitzt und die entstandene Estersäure nach Aufnehmen mit Benzol und Abfiltrieren von geringen Mengen Bernsteinsäure mit der berechneten Menge verdünnter Natronlauge in Lösung gebracht. Die neutrale, wäßrige Lösung des Natriumsalzes wird mit überschüssiger wäßriger Calciumchloridlösung versetzt. Hierbei fällt das Calciumchloriddoppelsalz als weißer kristalliner Niederschlag aus, der abgesaugt und nach dem Nachwaschen mit Wasser zunächst an der Luft und dann bei 50 bis 70" getrocknet wird. Example 6i g of a-phenylethyl alcohol are mixed with 50 g of succinic anhydride Heated 21/2 hours to 140 ° and the ester acid formed after absorption with Benzene and filter off small amounts of succinic acid with the calculated amount diluted sodium hydroxide solution brought into solution. The neutral, aqueous solution of the sodium salt is mixed with excess aqueous calcium chloride solution. This is where it falls Calcium chloride double salt as a white crystalline precipitate, which is sucked off and after washing with water first in the air and then at 50 to 70 " is dried.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP19118D DE810027C (en) | 1948-10-22 | 1948-10-22 | Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP19118D DE810027C (en) | 1948-10-22 | 1948-10-22 | Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE810027C true DE810027C (en) | 1951-08-06 |
Family
ID=7367328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEP19118D Expired DE810027C (en) | 1948-10-22 | 1948-10-22 | Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE810027C (en) |
-
1948
- 1948-10-22 DE DEP19118D patent/DE810027C/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE810027C (en) | Process for the production of a novel Abkoemmlings des ‡ -Phenylaethylalkohols | |
| AT140867B (en) | Process for the preparation of dihydroresorcinol. | |
| AT318813B (en) | PROCESS FOR PREPARING NEW ACYLOXY ALKYLESTERS OF 6- (ALPHA-AMINOPHENYLACETAMIDO) PENICILLANIC ACID | |
| DE927269C (en) | Process for the preparation of new derivatives of 2-mercapto-naphthimidazole | |
| DEP0019118DA (en) | Process for the production of a novel derivative of alpha; -phenylethyl alcohol. | |
| DE734957C (en) | Process for the production of p-aminobenzenesulfonamide pellets | |
| AT147483B (en) | Process for the preparation of compounds of methyl N-methyltetrahydronicotinate. | |
| DE846398C (en) | Process for the production of organic cerium compounds | |
| DE450022C (en) | Process for the preparation of allylarsic acid | |
| DE938249C (en) | Process for the preparation of dihydrocodeine hydrorhodanide | |
| DE944953C (en) | Process for the preparation of a therapeutic agent consisting of the calcium salt of Ca-ethylene diamine tetraacetic acid | |
| DE865453C (en) | Process for the preparation of non-hygroscopic choline salts | |
| DE720937C (en) | Process for the production of therapeutically valuable gold compounds from keratin breakdown products | |
| DE1593317B2 (en) | METHOD OF MANUFACTURING AN ISMUTH ALUMINUM DOUBLE PECTATE | |
| AT267750B (en) | Process for the production of a new penicillin | |
| AT340380B (en) | PROCESS FOR THE MANUFACTURING OF PURE SODIUM (DI-N-PROPYL) ACETATE | |
| AT274248B (en) | Process for the preparation of new derivatives of bufadienolide glycosides | |
| DE469554C (en) | Process for the preparation of a bismuth alkaline tartrate | |
| DE619348C (en) | Process for the production of pure diacetyl from wood vinegar or other mixtures containing diacetyl | |
| CH263037A (en) | Process for the preparation of a new derivative of 2-oxy-5-aminobenzoic acid. | |
| CH121259A (en) | Process for the preparation of an acyl compound of amino-3-chloro-4-oxybenzene-1-arsic acid. | |
| CH293814A (en) | Process for the preparation of a salt of an amino ester of penicillin. | |
| DE1004172B (en) | Process for the production of crystallizable complex compounds of 2,6-trans, trans-pentaenaldehydes with vitamin A aldehyde structure | |
| DE1018052B (en) | Process for the preparation of antimony complex compounds of ª ‡, ª ‡ '-Dimercaptosuccinic acid | |
| CH265118A (en) | Method for producing a local anesthetic. |