DE800877C - Disinfectants and preservatives - Google Patents

Description

(WiGBl. P. 175)

ISSUED DECEMBER 11, 1950

ρ τ3038 II 'a j 30 i D

It has been found that 4,4'-dioxy-3, 3'-dimethyl diphenyl has a surprisingly strong effect as a preservative * and disinfectant. Comparative attempts to inhibit fermentation in dextrose bouillon and yeast containing Fermentation solutions resulted in z. H. compared to the often used as a preservative p-Oxybenzoic acid esters the following concentrations, at which within 14 days Inhibition occurs:

Ph 3.5 Ph 4.5 ~ 6 neutral point p-oxybenzoic acid ester 1: 5,000 1: 1000 > as 1: 1000 4,4'-dioxy-3,3'-

dimethyldiphenyl 1: 20000 1: 5000 1: 2000

Similar results were obtained from attempts to inhibit mold growth on apple juice obtain

for p-oxybenzoic acid esters 1: 2000,

at 4. 4'-dioxy-3,3'-dimethyldiphenyl 1: 10000.

Hei comparison tests with benzoic acid and salicylic acid, which with a pn of 4 only with ι: rooo up to ι: 2000, at Pij (i even inhibited below 1: τ000, became the same for 4,4'-dioxy-3, 3'-dimethyldiphenyl favorable concentrations as found above.

4. 4'-Dioxy-3,3'-diethyldiphenyl is particularly effective against pathogens Bacteria. Thus, the growth of Staphylococcus aureus strain FT in the dilution series test with surface inoculation in a dilution of ι: 50,000 to 1: 100,000 inhibited, compared to Cresol 1: 2000 and p-oxybenzoic acid ester 1: 1000 until ι: 2000.

The comparison with o-cresol showed the following inhibition limits in the fermentation test (20% dextrose bouillon with baker's yeast):

o-cresol 1: 2000,

4, 4'-I) ioxy-3, 3'-dimethyldiphenyl 1: 10,000; against mold:

o-cresol 1: 2000,

4,4'-Dioxy-3,3'-dimethyldiphenyl r: iobis2oooo; against Staphylococcus aureus:

o-cresol 1: 2000,

4, 4 '"Di ° ^x y ~ 3>3'-dimethyldiphenyl ι: 50 to
ι oo ooo.

In a comparative disinfection attempt (concentration / time method) the following values were found:

4,4'-Dioxy-3, 3'-dimethyldiphenyl 1: 1000 according to

6 minutes sterilization,
Phenol 1: 100 kill after 3 hours,
o-cresol 1: 100 after ¹ ½ hour no sterilization.

The toxicity of 4,4'-dioxy-3, 3'-dimethyldiphenyl is very cheap: the dose letalis med. is about 1.5 g per kilogram on the white mouse per os. In the long-term experiment, six mice were administered 200 mg / kg daily for 30 days. No toxic phenomena occurred. Subsequent administration of 200 mg / kg each Per os on three rabbits there was neither an influence on the hemoglobin nor a change the blood count.

4, 4'-Dioxy-3, 3'-dimethyldiphenyl as a disinfectant also has particular advantages in its resistance to cooking, its odorless and tastelessness and its good \ ^r tolerable; speed. The substance can be used as such or in the form of its salts, ζ. B. can be used in the form of their alkali salts alone or together with other substances, being added to the material to be preserved dry or in solution. However, it can also be added to emulsions, powders and pastes as a disinfectant and preservative.

example

To use the 4,4'-dioxy-3, 3'dimethyldiphenyls as a preservative, dissolve the required amount of the substance either directly in the material to be preserved, if necessary with heating, or one puts an alcoholic Solution of the substance and pour the same into the goods to be preserved. You can use 4,4'-dioxy-3, 3'-dimethyldiphenyl but also dissolve in a deficit of lye and add this solution to the one to be preserved Add material.

Claims (1)

Claim: Disinfectants and preservatives, characterized by the use of 4, 4'-Dioxy-3, 3'-dimethyldiphenyl or its salts. 2900 12.50