DE722408C - Process for the production of a neutral complex thorium sodium tartrate - Google Patents
Process for the production of a neutral complex thorium sodium tartrateInfo
- Publication number
- DE722408C DE722408C DEC55873D DEC0055873D DE722408C DE 722408 C DE722408 C DE 722408C DE C55873 D DEC55873 D DE C55873D DE C0055873 D DEC0055873 D DE C0055873D DE 722408 C DE722408 C DE 722408C
- Authority
- DE
- Germany
- Prior art keywords
- thorium
- production
- sodium tartrate
- tartrate
- neutral complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000007935 neutral effect Effects 0.000 title claims description 5
- XLNXOLNUPAPUHB-UHFFFAOYSA-L C(=O)([O-])C(O)C(O)C(=O)[O-].[Na+].[Th+4] Chemical compound C(=O)([O-])C(O)C(O)C(=O)[O-].[Na+].[Th+4] XLNXOLNUPAPUHB-UHFFFAOYSA-L 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- FICFXYPPTMJWTI-UHFFFAOYSA-J 2,3-dihydroxybutanedioate thorium(4+) Chemical compound C(=O)([O-])C(O)C(O)C(=O)[O-].[Th+4].C(=O)([O-])C(O)C(O)C(=O)[O-] FICFXYPPTMJWTI-UHFFFAOYSA-J 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 239000001433 sodium tartrate Substances 0.000 description 2
- 229960002167 sodium tartrate Drugs 0.000 description 2
- 235000011004 sodium tartrates Nutrition 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- LISYCWMGWAORRH-UHFFFAOYSA-N [Na].[Th] Chemical compound [Na].[Th] LISYCWMGWAORRH-UHFFFAOYSA-N 0.000 description 1
- OHJVTPZAWMZDNH-UHFFFAOYSA-N [Th].[K] Chemical compound [Th].[K] OHJVTPZAWMZDNH-UHFFFAOYSA-N 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- VGBPIHVLVSGJGR-UHFFFAOYSA-N thorium(4+);tetranitrate Chemical compound [Th+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VGBPIHVLVSGJGR-UHFFFAOYSA-N 0.000 description 1
- -1 thorium-ammonium tartrates Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/418—Preparation of metal complexes containing carboxylic acid moieties
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines neutralen komplexen Thorium-Natrium-tartra,ts Es ist bekannt, daß man durch Fällen von Thoriumnitratlösung mit Weinsäure, Auflösen des Niederschlages nach Zugabe von Ätzkali bzw. Ammoniak durch Erhitzen auf dem Wasserbad und Entfernung der entstandenen Nitrate durch Eindampfen und fraktionierte Kristallisation zu komplexen Thorium-Kalium- bzw. Thorium-Ammonium-tartraten gelangt (R o s e nheim, Samter und Davidsohn, Zeitschr. f. anorgan. Chemie 35 (19o3), S. 443).Process for the preparation of a neutral complex thorium sodium tartra, ts It is known that one can dissolve by precipitating thorium nitrate solution with tartaric acid of the precipitate after adding caustic potash or ammonia by heating on the Water bath and removal of the nitrates formed by evaporation and fractionation Crystallization leads to complex thorium-potassium or thorium-ammonium tartrates (R o s e nheim, Samter and Davidsohn, Zeitschr. F. Inorganic. Chemistry 35 (19o3), p. 443).
Das entsprechende komplexe Thorium-Natrium-tartrat konnte auf diesem Wege nicht rein erhalten werden, da es nicht vom Natriumnitrat zu trennen war.The corresponding complex thorium sodium tartrate could be based on this Ways could not be kept pure because it could not be separated from the sodium nitrate.
Es wurde nun gefunden, daß man zu einem reinen komplexen Thorium-Natrium-tartrat gelangt, indem man zunächst natronalkalische Lösungen von Thoriumtartrat, wie sie beispielsweise durch Auflösen von reinem Thoriumtartrat in Natronlauge erhalten werden, kurze Zeit erhitzt, darauf mit Weinsäure neutralisiert und nach dem Einengen kristallisieren läßt, wobei im Überschuß angewandtes Natriumhydroxyd als Natriumtartrat in Lösung bleibt. Man erhält auf diese Weise ein neutrales komplexes Th orium-Natrium-tartrat, aus dessen Lösungen dasThorium weder durch Ätzalkalien noch durch kohlensaure Alkalien fällbar ist.It has now been found that a pure complex thorium sodium tartrate can be obtained obtained by first using sodium-alkaline solutions of thorium tartrate, such as them obtained for example by dissolving pure thorium tartrate in sodium hydroxide solution are heated for a short time, then neutralized with tartaric acid and after concentrating lets crystallize, with sodium hydroxide used in excess as sodium tartrate remains in solution. In this way a neutral complex th orium sodium tartrate is obtained, from its solutions the thorium neither by caustic alkalis nor by carbonic acid alkalis is precipitable.
Das nach vorliegendem Verfahren hergestellte Produkt soll als Röntgenkontrastmittel Verwendung finden. Beispiel 84 Teile Thoriumtartrat werden mit 125 Teilen Wasser und 75 Raumteilen 2o Vol. °/oiger Natronlauge verrührt und auf dem Wasserbad erhitzt, bis eine klare Lösung entstanden ist. Diese wird noch i Stunde lang unter Rückfluß gekocht, dann mit Weinsäure neutralisiert und bis zur beginnenden Kristallisation eingeengt. Nach dem Erkalten, Absaugen, Waschen mit Methanol und Trocknen erhält man Ein schweres, weißes, kristallinisches Pulver von neutraler Reaktion, das sich im Verhältnis i ; 2 in Wasser löst. Es enthält 52 °(o Th02 und 7 0;o N a.The product manufactured according to the present process is intended as an X-ray contrast medium Find use. Example 84 parts of thorium tartrate are mixed with 125 parts of water and 75 parts by volume of 2o vol.% sodium hydroxide solution and stirred on the water bath heated, until a clear solution is obtained. This is refluxed for another hour boiled, then neutralized with tartaric acid and until crystallization begins constricted. After cooling, suction, washing with methanol and drying is obtained man A heavy, white, crystalline powder of neutral reaction, which in the ratio i; 2 dissolves in water. It contains 52 ° (o Th02 and 7 0; o N a.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC55873D DE722408C (en) | 1940-06-27 | 1940-06-27 | Process for the production of a neutral complex thorium sodium tartrate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC55873D DE722408C (en) | 1940-06-27 | 1940-06-27 | Process for the production of a neutral complex thorium sodium tartrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE722408C true DE722408C (en) | 1942-07-09 |
Family
ID=7028222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEC55873D Expired DE722408C (en) | 1940-06-27 | 1940-06-27 | Process for the production of a neutral complex thorium sodium tartrate |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE722408C (en) |
-
1940
- 1940-06-27 DE DEC55873D patent/DE722408C/en not_active Expired
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