DE69320367D1 - Therapeutische verbindungen für die behandlung von krankheiten, die mit einem glutathion-defizit assoziiert sind, herstellungsprozess und diese enthaltene pharmazeutische zusammensetzungen - Google Patents
Therapeutische verbindungen für die behandlung von krankheiten, die mit einem glutathion-defizit assoziiert sind, herstellungsprozess und diese enthaltene pharmazeutische zusammensetzungenInfo
- Publication number
- DE69320367D1 DE69320367D1 DE69320367T DE69320367T DE69320367D1 DE 69320367 D1 DE69320367 D1 DE 69320367D1 DE 69320367 T DE69320367 T DE 69320367T DE 69320367 T DE69320367 T DE 69320367T DE 69320367 D1 DE69320367 D1 DE 69320367D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- pharmaceutical compositions
- pct
- compositions containing
- glutathion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 229960003180 glutathione Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 230000006735 deficit Effects 0.000 title 1
- 235000003969 glutathione Nutrition 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 239000004201 L-cysteine Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI922742A IT1256178B (it) | 1992-11-30 | 1992-11-30 | Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. |
| PCT/EP1993/003354 WO1994012527A1 (en) | 1992-11-30 | 1993-11-30 | Therapeutic compounds suitable for the treatment of diseases connected with glutathione deficiency, process for their preparation, and pharmaceutical compositions containing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69320367D1 true DE69320367D1 (de) | 1998-09-17 |
| DE69320367T2 DE69320367T2 (de) | 1998-12-17 |
Family
ID=11364384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69320367T Expired - Fee Related DE69320367T2 (de) | 1992-11-30 | 1993-11-30 | Therapeutische verbindungen für die behandlung von krankheiten, die mit einem glutathion-defizit assoziiert sind, herstellungsprozess und diese enthaltene pharmazeutische zusammensetzungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5736565A (de) |
| EP (1) | EP0674653B1 (de) |
| AT (1) | ATE169635T1 (de) |
| CA (1) | CA2150548A1 (de) |
| DE (1) | DE69320367T2 (de) |
| ES (1) | ES2122221T3 (de) |
| IT (1) | IT1256178B (de) |
| WO (1) | WO1994012527A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6369106B1 (en) | 1996-12-26 | 2002-04-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment of ischemic brain injuries with brain targeted anti oxidant compounds |
| US6420429B1 (en) * | 1997-12-23 | 2002-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Brain targeted low molecular weight hydrophobic antioxidant compounds |
| AU728488B2 (en) | 1997-04-02 | 2001-01-11 | Sankyo Company Limited | Dithiolan derivatives, their preparation and their therapeutic effect |
| WO1999055894A1 (en) | 1998-04-29 | 1999-11-04 | Oklahoma Medical Research Foundation | Construction of retroviral producer cells from adenoviral and retroviral vectors |
| CA2470583C (en) * | 2001-12-18 | 2011-03-15 | Xiangqun Gao | Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes |
| JP4520089B2 (ja) * | 2002-05-31 | 2010-08-04 | サントリーホールディングス株式会社 | ルブロフサリン配糖体含有組成物 |
| EP1946750A1 (de) * | 2007-01-18 | 2008-07-23 | The Jordanian Pharmaceutical Manufacturing Co. | Kopräzipitat, Herstellungsverfahren und Anwendungen davon |
| JPWO2008117730A1 (ja) * | 2007-03-23 | 2010-07-15 | 日清ファルマ株式会社 | 肝疾患の予防または治療用組成物 |
| KR20110060940A (ko) * | 2008-09-22 | 2011-06-08 | 닛신 파마 가부시키가이샤 | 항염증성 펩티드 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT40447A (en) * | 1984-03-29 | 1986-12-28 | Sandoz Ag | Process for preparing substituted alpha-amino acids and pharmaceutical compositions containing such compounds |
| IT1216096B (it) * | 1988-03-15 | 1990-02-22 | Farmaceutica Italiana S P A S | L_piroglutamil_l_cisteina, dipeptide ad elevata attivita'anticatarattogena e composizioni farmaceutiche che lo contengono. |
| IT1244548B (it) * | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche |
| IT1249650B (it) * | 1991-05-29 | 1995-03-09 | Poli Ind Chimica Spa | N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico |
-
1992
- 1992-11-30 IT ITMI922742A patent/IT1256178B/it active IP Right Grant
-
1993
- 1993-11-30 AT AT94901919T patent/ATE169635T1/de not_active IP Right Cessation
- 1993-11-30 CA CA002150548A patent/CA2150548A1/en not_active Abandoned
- 1993-11-30 WO PCT/EP1993/003354 patent/WO1994012527A1/en not_active Ceased
- 1993-11-30 ES ES94901919T patent/ES2122221T3/es not_active Expired - Lifetime
- 1993-11-30 EP EP94901919A patent/EP0674653B1/de not_active Expired - Lifetime
- 1993-11-30 DE DE69320367T patent/DE69320367T2/de not_active Expired - Fee Related
-
1995
- 1995-05-24 US US08/449,802 patent/US5736565A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2122221T3 (es) | 1998-12-16 |
| DE69320367T2 (de) | 1998-12-17 |
| ATE169635T1 (de) | 1998-08-15 |
| EP0674653A1 (de) | 1995-10-04 |
| ITMI922742A0 (it) | 1992-11-30 |
| EP0674653B1 (de) | 1998-08-12 |
| IT1256178B (it) | 1995-11-29 |
| WO1994012527A1 (en) | 1994-06-09 |
| US5736565A (en) | 1998-04-07 |
| CA2150548A1 (en) | 1994-06-09 |
| ITMI922742A1 (it) | 1994-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |