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DE69318854D1 - Spiroazacyclischderivate als substanz p antagonisten - Google Patents

Spiroazacyclischderivate als substanz p antagonisten

Info

Publication number
DE69318854D1
DE69318854D1 DE69318854T DE69318854T DE69318854D1 DE 69318854 D1 DE69318854 D1 DE 69318854D1 DE 69318854 T DE69318854 T DE 69318854T DE 69318854 T DE69318854 T DE 69318854T DE 69318854 D1 DE69318854 D1 DE 69318854D1
Authority
DE
Germany
Prior art keywords
pct
compounds
antagonists
substance
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69318854T
Other languages
English (en)
Other versions
DE69318854T2 (de
Inventor
Manoj Desai
Lawrence VINCENT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE69318854D1 publication Critical patent/DE69318854D1/de
Application granted granted Critical
Publication of DE69318854T2 publication Critical patent/DE69318854T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DE69318854T 1993-03-04 1993-12-10 Spiroazacyclischderivate als substanz p antagonisten Expired - Fee Related DE69318854T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2638293A 1993-03-04 1993-03-04
PCT/US1993/011793 WO1994020500A1 (en) 1993-03-04 1993-12-10 Spiroazacyclic derivatives as substance p antagonists

Publications (2)

Publication Number Publication Date
DE69318854D1 true DE69318854D1 (de) 1998-07-02
DE69318854T2 DE69318854T2 (de) 1998-10-08

Family

ID=21831515

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69318854T Expired - Fee Related DE69318854T2 (de) 1993-03-04 1993-12-10 Spiroazacyclischderivate als substanz p antagonisten

Country Status (13)

Country Link
US (1) US5688806A (de)
EP (1) EP0687268B1 (de)
JP (1) JP2832754B2 (de)
CN (1) CN1099035A (de)
AT (1) ATE166650T1 (de)
AU (1) AU6226494A (de)
CA (1) CA2157117C (de)
DE (1) DE69318854T2 (de)
DK (1) DK0687268T3 (de)
ES (1) ES2116587T3 (de)
FI (1) FI105916B (de)
IL (1) IL108769A0 (de)
WO (1) WO1994020500A1 (de)

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US5688960A (en) * 1995-05-02 1997-11-18 Schering Corporation Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
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TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
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US6103932A (en) * 1996-03-14 2000-08-15 Warner-Lambert Company Substituted cyclic amino acids as pharmaceutical agents
AU722541B2 (en) * 1996-06-21 2000-08-03 Merck Sharp & Dohme Limited Spiro-piperidine derivatives and their use as therapeutic agents
GB9613969D0 (en) * 1996-07-03 1996-09-04 Merck Sharp & Dohme Therapeutic agents
ATE320432T1 (de) * 1996-09-25 2006-04-15 Merck Sharp & Dohme Spiro-azacyclische derivate, deren herstellung und verwendung als tachykinin-antagonisten
US5929094A (en) * 1996-10-25 1999-07-27 Merck & Co., Inc. Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
GB9625843D0 (en) * 1996-12-12 1997-01-29 Merck & Co Inc Phenyl spiroethercycloalkyl tachykinn receptor antagonists
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
US5945428A (en) * 1996-11-01 1999-08-31 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
EP0942731B1 (de) * 1996-12-02 2004-11-17 MERCK SHARP & DOHME LTD. Die verwendung von nk-1 rezeptor antagonisten für die behandlung von substanz-verwendung störungen
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KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
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US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
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US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
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Also Published As

Publication number Publication date
CN1099035A (zh) 1995-02-22
FI105916B (fi) 2000-10-31
IL108769A0 (en) 1994-06-24
WO1994020500A1 (en) 1994-09-15
EP0687268A1 (de) 1995-12-20
JPH08503226A (ja) 1996-04-09
CA2157117A1 (en) 1994-09-15
FI941022L (fi) 1994-09-05
AU6226494A (en) 1994-09-26
FI941022A0 (fi) 1994-03-03
ES2116587T3 (es) 1998-07-16
US5688806A (en) 1997-11-18
DE69318854T2 (de) 1998-10-08
ATE166650T1 (de) 1998-06-15
DK0687268T3 (da) 1998-10-12
EP0687268B1 (de) 1998-05-27
JP2832754B2 (ja) 1998-12-09
CA2157117C (en) 1999-01-05

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee