DE69316217D1 - Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel - Google Patents

Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel

Info

Publication number: DE69316217D1
Authority: DE; Germany
Prior art keywords: absorption; homo; pct; conveyors; application
Prior art date: 1992-06-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69316217T

Other languages

English (en)

Other versions

DE69316217T2 (de

Inventor

Fabio Berlati

Giancarlo Ceschel

Aldo Roda

Enrico Roda

Celestino Ronchi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Monteresearch Srl

Original Assignee

Monteresearch Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1993-06-15

Publication date

1998-02-12

1993-06-15 Application filed by Monteresearch Srl filed Critical Monteresearch Srl

1998-02-12 Application granted granted Critical

1998-02-12 Publication of DE69316217D1 publication Critical patent/DE69316217D1/de

1998-08-20 Publication of DE69316217T2 publication Critical patent/DE69316217T2/de

2013-06-16 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000010521 absorption reaction Methods 0.000 title abstract 3
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
238000004770 highest occupied molecular orbital Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
239000003613 bile acid Substances 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
230000029142 excretion Effects 0.000 abstract 1
230000000968 intestinal effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69316217T 1992-06-30 1993-06-15 Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel Expired - Fee Related DE69316217T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI921601A IT1255449B (it)	1992-06-30	1992-06-30	Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
PCT/EP1993/001508 WO1994000155A1 (en)	1992-06-30	1993-06-15	The use of nor- and homo- bile acids derivatives as absorption enhancers for medicaments

Publications (2)

Publication Number	Publication Date
DE69316217D1 true DE69316217D1 (de)	1998-02-12
DE69316217T2 DE69316217T2 (de)	1998-08-20

Family

ID=11363597

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69316217T Expired - Fee Related DE69316217T2 (de)	1992-06-30	1993-06-15	Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel

Country Status (9)

Country	Link
US (1)	US5656277A (de)
EP (1)	EP0652773B1 (de)
JP (1)	JPH07508013A (de)
AT (1)	ATE161731T1 (de)
DE (1)	DE69316217T2 (de)
DK (1)	DK0652773T3 (de)
ES (1)	ES2114056T3 (de)
IT (1)	IT1255449B (de)
WO (1)	WO1994000155A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6387390B1 (en) *	1998-10-05	2002-05-14	The Penn State Research Foundation	Compositions and methods for enhancing receptor-mediated cellular internalization
EP0821970A1 (de) *	1996-08-02	1998-02-04	Edward Henri Charles Verhaeren	Träger zur Beeinflussung der Durchlässigkeit der dichten Verbindungsstellen
AU731909B2 (en) *	1997-07-01	2001-04-05	Isis Pharmaceuticals, Inc.	Compositions and methods for the delivery of oligonucleotides via the alimentary canal
US7070799B1 (en) *	1998-02-10	2006-07-04	Generex Pharmaceuticals, Inc.	Method for administering insulin to the buccal region
US6350458B1 (en)	1998-02-10	2002-02-26	Generex Pharmaceuticals Incorporated	Mixed micellar drug deliver system and method of preparation
US6375975B1 (en)	1998-12-21	2002-04-23	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary application
US6849263B2 (en) *	1998-12-21	2005-02-01	Generex Pharmaceutical Incorporated	Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) *	1998-12-21	2006-08-08	Generex Pharmaceuticals Incorporated	Methods of administering and enhancing absorption of pharmaceutical agents
US6451286B1 (en)	1998-12-21	2002-09-17	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6294192B1 (en)	1999-02-26	2001-09-25	Lipocine, Inc.	Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6267985B1 (en)	1999-06-30	2001-07-31	Lipocine Inc.	Clear oil-containing pharmaceutical compositions
US6761903B2 (en)	1999-06-30	2004-07-13	Lipocine, Inc.	Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6982281B1 (en) *	2000-11-17	2006-01-03	Lipocine Inc	Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en)	1999-08-17	2002-10-01	Lipocine, Inc.	Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6309663B1 (en)	1999-08-17	2001-10-30	Lipocine Inc.	Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
US20030118547A1 (en) *	2000-01-27	2003-06-26	Vandenberg Grant William	Composition for intestinal delivery
JP4452970B2 (ja) *	2002-03-27	2010-04-21	日本臓器製薬株式会社	ジクロフェナクナトリウム経口製剤
WO2006073458A2 (en)	2004-04-30	2006-07-13	Alnylam Pharmaceuticals, Inc.	Oligonucleotides comprising a c5-modified pyrimidine
EP2392335B1 (de)	2005-05-12	2015-06-24	Medizinische Universität Graz	Verwendung von 24-norUDCA
SI2182954T1 (sl) *	2007-07-25	2019-04-30	Medizinische Universitat Graz	Uporaba nor-žolčnih kislin pri zdravljenju arterioskleroze
US11304960B2 (en)	2009-01-08	2022-04-19	Chandrashekar Giliyar	Steroidal compositions
US20180153904A1 (en)	2010-11-30	2018-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9034858B2 (en)	2010-11-30	2015-05-19	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9358241B2 (en)	2010-11-30	2016-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20120148675A1 (en)	2010-12-10	2012-06-14	Basawaraj Chickmath	Testosterone undecanoate compositions
WO2016033549A2 (en)	2014-08-28	2016-03-03	Lipocine Inc.	(17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en)	2014-08-28	2016-03-03	Lipocine Inc.	BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
HK1243930A1 (zh)	2014-11-06	2018-07-27	英安塔制药有限公司	作爲fxr/tgr5激动剂的胆汁酸类似物和其使用方法
WO2016086115A1 (en)	2014-11-26	2016-06-02	Enanta Pharmaceuticals, Inc.	Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10519191B2 (en) *	2014-11-26	2019-12-31	Enanta Pharmaceuticals, Inc.	Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
US10208081B2 (en)	2014-11-26	2019-02-19	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
SG11201706089RA (en)	2015-02-11	2017-09-28	Enanta Pharm Inc	Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
SMT202100593T1 (it)	2015-03-31	2021-11-12	Enanta Pharm Inc	Derivati degli acidi biliari come agonisti di fxr/tgr5 e metodi per il loro uso
US20160361322A1 (en)	2015-06-15	2016-12-15	Lipocine Inc.	Composition and method for oral delivery of androgen prodrugs
WO2017147137A1 (en)	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
US10364267B2 (en)	2016-02-23	2019-07-30	Enanta Pharmaceuticals, Inc.	Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2017147174A1 (en)	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
EP3544614B1 (de)	2016-11-28	2025-12-31	Lipocine Inc.	Orale testosteron-undecanoat-therapie
KR102499441B1 (ko)	2016-11-29	2023-02-13	이난타 파마슈티칼스, 인코포레이티드	술포닐우레아 담즙산 유도체의 제조 방법
US10472386B2 (en)	2017-02-14	2019-11-12	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR agonists and methods of use thereof
AU2018249950B2 (en)	2017-04-07	2023-09-21	Enanta Pharmaceuticals, Inc.	Process for preparation of sulfonyl carbamate bile acid derivatives
CA3107214A1 (en)	2018-07-20	2020-01-23	Lipocine Inc.	Liver disease
GB201911821D0 (en)	2019-08-16	2019-10-02	Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid	Compounds for use in the treatment of liver disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4746508A (en) *	1983-06-06	1988-05-24	Beth Israel Hospital Assn.	Drug administration
IT1212835B (it) *	1983-08-18	1989-11-30	Lehner Ag	Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.

1992
- 1992-06-30 IT ITMI921601A patent/IT1255449B/it active IP Right Grant
1993
- 1993-06-15 WO PCT/EP1993/001508 patent/WO1994000155A1/en not_active Ceased
- 1993-06-15 JP JP6501998A patent/JPH07508013A/ja active Pending
- 1993-06-15 DK DK93912975T patent/DK0652773T3/da active
- 1993-06-15 DE DE69316217T patent/DE69316217T2/de not_active Expired - Fee Related
- 1993-06-15 ES ES93912975T patent/ES2114056T3/es not_active Expired - Lifetime
- 1993-06-15 AT AT93912975T patent/ATE161731T1/de not_active IP Right Cessation
- 1993-06-15 EP EP93912975A patent/EP0652773B1/de not_active Expired - Lifetime
- 1993-06-15 US US08/360,833 patent/US5656277A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1994000155A1 (en)	1994-01-06
US5656277A (en)	1997-08-12
ES2114056T3 (es)	1998-05-16
DE69316217T2 (de)	1998-08-20
ATE161731T1 (de)	1998-01-15
DK0652773T3 (da)	1998-09-07
ITMI921601A1 (it)	1993-12-30
JPH07508013A (ja)	1995-09-07
EP0652773B1 (de)	1998-01-07
ITMI921601A0 (it)	1992-06-30
IT1255449B (it)	1995-10-31
EP0652773A1 (de)	1995-05-17

Publication	Publication Date	Title
DE69316217D1 (de)	1998-02-12	Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel
AU640137B2 (en)	1993-08-19	Novel arylpyridazines, their manufacture, use and medicaments containing them
TR199902626T2 (xx)	2000-06-21	Enflamasyon tedavisi i�in ikameli benzopiran t�revleri.
FI952900A0 (fi)	1995-06-13	Polypeptidi ja siitä valmistettu anti-HIV-aine
FI113644B (fi)	2004-05-31	Menetelmä terapeuttisesti aktiivisten N-substituoitujen 3- atsabisykloalkaanijohdannaisten valmistamiseksi
IL108382A0 (en)	1994-04-12	Amino acid derivatives, their preparation and pharmaceutical compositions containing them
ATE202563T1 (de)	2001-07-15	Benzoylguanidine, ihre herstellung und ihre verwendung in arzneimitteln
BR9611175B1 (pt)	2009-01-13	compostos e composiÇÕes farmacÊuticas.
PT672041E (pt)	2002-04-29	Derivados da piridina farmacologicamente activos e processos para a sua preparacao
DK0623121T3 (da)	1998-10-07	Fremstilling af N-acetylneuraminsyrederivater
PT722319E (pt)	2002-10-31	Derivados de antraciclinona e a sua utilizacao no tratamento da amiloidose
DE59108744D1 (de)	1997-07-10	8-EN-19, 11 beta-ÜBERBRÜCKTE STEROIDE, DEREN HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE
DK0561846T3 (da)	1995-08-21	4,5-dihydroxy- og 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracencarboxylsyre-dicarbonater og -urethaner med terapeutisk virkning
ES2110258T3 (es)	1998-02-01	Derivados de 1,3,5(10)-estratrieno activos por via oral.
AU3862997A (en)	1998-02-20	Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
GEP20032975B (en)	2003-05-27	Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition
DE69323191D1 (de)	1999-03-04	Wasserlösliche retinoide
IT1273455B (it)	1997-07-08	Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
ATE144986T1 (de)	1996-11-15	Aminoacylderivate von gem- diphosphonsauren,verfahren zu deren herstellung und pharmazeutische zubereitungen,die sie enthalten
AU674909B2 (en)	1997-01-16	New triazoloquinazolines, their production and their use
DK0617731T3 (da)	1995-07-24	N-acyl-phosphatidylethanolamin som oxidationsbeskyttelsesmiddel
BR9508521A (pt)	1997-10-28	Inibição da biossintese de leucotrienos com derivados de uréia
IT1277736B1 (it)	1997-11-12	Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
ATE221068T1 (de)	2002-08-15	Anellierte beta-carboline
TH14322A (de)	1994-06-30

Legal Events

Date	Code	Title	Description
1999-02-11	8364	No opposition during term of opposition
2010-04-22	8339	Ceased/non-payment of the annual fee