DE69230787D1 - Polymere Phosphoniumsalze, die Chemilumineszenzverstärkung von 1,2-Dioxetanen hervorrufen, und deren Verwendung. - Google Patents
Polymere Phosphoniumsalze, die Chemilumineszenzverstärkung von 1,2-Dioxetanen hervorrufen, und deren Verwendung.Info
- Publication number
- DE69230787D1 DE69230787D1 DE69230787T DE69230787T DE69230787D1 DE 69230787 D1 DE69230787 D1 DE 69230787D1 DE 69230787 T DE69230787 T DE 69230787T DE 69230787 T DE69230787 T DE 69230787T DE 69230787 D1 DE69230787 D1 DE 69230787D1
- Authority
- DE
- Germany
- Prior art keywords
- dioxetanes
- phosphonium salts
- polymeric phosphonium
- chemiluminescence enhancement
- induce chemiluminescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical class C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 title abstract 3
- 150000004714 phosphonium salts Chemical class 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000007826 nucleic acid assay Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/855,537 US5393469A (en) | 1992-03-20 | 1992-03-20 | Polymeric phosphonium salts providing enhanced chemiluminescence from 1,2-dioxetanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69230787D1 true DE69230787D1 (de) | 2000-04-20 |
| DE69230787T2 DE69230787T2 (de) | 2000-11-23 |
Family
ID=25321510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69230787T Expired - Lifetime DE69230787T2 (de) | 1992-03-20 | 1992-08-06 | Polymere Phosphoniumsalze, die Chemilumineszenzverstärkung von 1,2-Dioxetanen hervorrufen, und deren Verwendung. |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US5393469A (de) |
| EP (1) | EP0561033B1 (de) |
| JP (2) | JP2648423B2 (de) |
| AT (1) | ATE190724T1 (de) |
| DE (1) | DE69230787T2 (de) |
Families Citing this family (46)
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| US5336596A (en) * | 1991-12-23 | 1994-08-09 | Tropix, Inc. | Membrane for chemiluminescent blotting applications |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5451347A (en) * | 1993-06-24 | 1995-09-19 | Lumigen, Inc. | Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants |
| FR2710655B1 (fr) * | 1993-09-29 | 1995-12-01 | Inst Nat Rech Securite | Procédé pour effectuer un test biologique destiné à identifier et à doser des gènes, des protéines et autres molécules. |
| US5773628A (en) * | 1994-11-14 | 1998-06-30 | Tropix, Inc. | 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use |
| US5846753A (en) * | 1995-05-30 | 1998-12-08 | The United States Of America As Represented By The Secretary Of The Army | Chemiluminescence-based method for rapid and sensitive in-situ detection of organophosphorus compounds and metal ions |
| US5777135A (en) * | 1995-07-31 | 1998-07-07 | Lumigen, Inc. | Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions |
| US5721370A (en) * | 1995-07-31 | 1998-02-24 | Lumigen Inc. | Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability |
| US5631167A (en) * | 1995-07-31 | 1997-05-20 | Bayer Corporation | Capsule chemistry analytical methods employing dioxetane chemiluminescence |
| US5783381A (en) * | 1995-10-19 | 1998-07-21 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| WO1998033863A1 (en) * | 1997-02-03 | 1998-08-06 | Ciba Specialty Chemicals Holding Inc. | Process for the preparation of fluorescent compositions, fluorescent compositions and their use |
| US5772926A (en) * | 1997-05-13 | 1998-06-30 | Lumigen, Inc. | Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates |
| US6555698B1 (en) * | 1998-11-17 | 2003-04-29 | Tropix, Inc. | Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor |
| US6783948B1 (en) | 1999-07-30 | 2004-08-31 | Bayer Corporation | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes |
| JP2001249079A (ja) * | 1999-12-28 | 2001-09-14 | Fujirebio Inc | 発光量調節剤を用いた化学発光測定方法及び酵素免疫測定方法 |
| US6852503B1 (en) * | 2001-05-30 | 2005-02-08 | Pierce Biotechnology, Inc. | Compositions and methods for utilizing mixed substrate solutions of luminols and dioxetanes |
| US6774249B2 (en) * | 2001-09-27 | 2004-08-10 | Lumigen, Inc. | Uses of improved polymer-supported photosensitizers in the generation of singlet oxygen |
| US6545102B1 (en) | 2001-09-27 | 2003-04-08 | Lumigen, Inc. | Polymer-supported photosensitizers |
| US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
| WO2003099802A1 (en) * | 2002-05-23 | 2003-12-04 | Brij Pal Giri | POLYMERIC AMMONIUM AND OR PHOSPHONIUM SALTS HAVING ADDED π-ELECTRONS AND HIGHER MOLECULAR WEIGHT AS ENHANCERS FOR CHEMILUMINESCENT SYSTEMS |
| US7276343B2 (en) | 2002-06-24 | 2007-10-02 | Fujirebio Inc. | Chemiluminescence enhancer |
| US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| JP4259229B2 (ja) | 2003-08-28 | 2009-04-30 | 東ソー株式会社 | 1,2−ジオキセタンの化学発光方法および化学発光用組成物 |
| US20060033088A1 (en) * | 2004-07-27 | 2006-02-16 | Gyongtae Kim | Polymer for a photochromic compound matrix, and a matrix comprising the said polymer |
| US7645719B2 (en) * | 2004-10-13 | 2010-01-12 | Ncr Corporation | Thermal paper with security features |
| US7504044B2 (en) * | 2004-11-05 | 2009-03-17 | Cabot Microelectronics Corporation | Polishing composition and method for high silicon nitride to silicon oxide removal rate ratios |
| US7531105B2 (en) * | 2004-11-05 | 2009-05-12 | Cabot Microelectronics Corporation | Polishing composition and method for high silicon nitride to silicon oxide removal rate ratios |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| WO2006116687A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanoassays |
| WO2007142314A1 (ja) * | 2006-06-08 | 2007-12-13 | Fujirebio Inc. | 発光増幅剤 |
| US9129907B2 (en) * | 2006-09-08 | 2015-09-08 | Cabot Microelectronics Corporation | Onium-containing CMP compositions and methods of use thereof |
| CN102311731B (zh) | 2010-06-30 | 2016-08-03 | 深圳迈瑞生物医疗电子股份有限公司 | 增强化学发光的试剂、方法和化学发光液 |
| CN102311730B (zh) | 2010-06-30 | 2014-09-24 | 深圳迈瑞生物医疗电子股份有限公司 | 化学发光液,增强化学发光的试剂和方法 |
| CN102329611B (zh) | 2010-07-13 | 2015-01-07 | 深圳迈瑞生物医疗电子股份有限公司 | 化学发光增强试剂及其使用方法和化学发光液 |
| KR101934152B1 (ko) * | 2012-09-07 | 2018-12-31 | 베카에르트 빈장 스틸 코드 코., 엘티디. | 표면하 인장 잔류 응력을 갖는 성형된 소잉 와이어 |
| CN104597233B (zh) | 2014-11-05 | 2016-09-14 | 深圳市美凯特科技有限公司 | 用于增强化学发光的增强液及制备化学发光液的方法 |
| EP3433376A4 (de) * | 2016-03-25 | 2020-03-18 | Floyd, William, Clary | Lichtaktivierbare beschichtung und materialien |
| AU2017290887B2 (en) | 2016-06-30 | 2021-08-05 | Beckman Coulter, Inc. | Chemiluminescent substrates |
| US11274230B1 (en) * | 2021-04-27 | 2022-03-15 | Rohm And Haas Electronic Materials Cmp Holdings, Inc. | Polishing composition and method of polishing a substrate having enhanced defect inhibition |
| WO2022261614A1 (en) * | 2021-06-10 | 2022-12-15 | Versum Materials Us, Llc | Phosphonium based polymers and copolymers as additives for chemical mechanical planarization slurries |
| CN119654558A (zh) | 2022-07-29 | 2025-03-18 | 贝克曼库尔特有限公司 | 用于检测碱性磷酸酶的化学发光试剂 |
| WO2025155731A1 (en) | 2024-01-16 | 2025-07-24 | Beckman Coulter, Inc. | Alternative substrate pack for automated clinical analyzer and methods of use |
| WO2025155701A1 (en) | 2024-01-16 | 2025-07-24 | Beckman Coulter, Inc. | Automated clinical analyzer with alternative substrate and method of use |
| WO2025160022A1 (en) * | 2024-01-26 | 2025-07-31 | Beckman Coulter, Inc. | Detecting phosphorylated tau (p-tau) 217 using chemiluminescent dioxetane compounds |
| WO2025160030A1 (en) * | 2024-01-26 | 2025-07-31 | Beckman Coulter, Inc. | Chemiluminescent dioxetane compounds for detecting p24 antigen |
| WO2026015434A1 (en) | 2024-07-08 | 2026-01-15 | Beckman Coulter, Inc. | Alternative substrate for automated clinical analyzer and methods of use |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS502559Y1 (de) * | 1969-11-26 | 1975-01-23 | ||
| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
| US4204839A (en) * | 1978-08-09 | 1980-05-27 | Eastman Kodak Company | Fluorimetric analysis method for bilirubin |
| US4412005A (en) * | 1979-10-25 | 1983-10-25 | Eastman Kodak Company | Determination of total bilirubin |
| US4338095A (en) * | 1980-07-11 | 1982-07-06 | Eastman Kodak Company | Method for selective determination of conjugated and unconjugated bilirubin |
| US4446284A (en) * | 1982-05-28 | 1984-05-01 | The Goodyear Tire & Rubber Company | Method for preparing a polymer containing pendant unsaturation |
| GB8420053D0 (en) * | 1984-08-07 | 1984-09-12 | Secr Social Service Brit | Enhanced luminescent/luminometric assay |
| US4959182A (en) * | 1986-07-17 | 1990-09-25 | Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US5004565A (en) * | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US4857652A (en) * | 1986-07-17 | 1989-08-15 | Board Of Governors Of Wayne State University | Chemiluminescent 1,2-dioxetane compounds |
| US5013827A (en) * | 1986-07-17 | 1991-05-07 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| US4931223A (en) * | 1986-07-24 | 1990-06-05 | Tropix, Inc. | Methods of using chemiluminescent 1,2-dioxetanes |
| JP2506396B2 (ja) * | 1986-07-24 | 1996-06-12 | トロピックス・インコーポレーテッド | ジオキセタン類の酵素的に誘導される分解を使用する物質検出法 |
| US4978614A (en) * | 1988-10-26 | 1990-12-18 | Tropix, Inc. | Method of detecting a substance using enzymatically-induced decomposition of dioxetanes |
| JPS63186229A (ja) * | 1987-01-28 | 1988-08-01 | Fuji Photo Film Co Ltd | 感光材料 |
| JPH07120080B2 (ja) * | 1987-03-31 | 1995-12-20 | 藤倉化成株式会社 | 静電潜像現像トナ−用正電荷制御剤およびそれを含有するトナ− |
| US4927769A (en) * | 1987-07-08 | 1990-05-22 | Ciba Corning Diagnostics Corp. | Method for enhancement of chemiluminescence |
| JPH01170943A (ja) * | 1987-12-25 | 1989-07-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料の処理方法 |
| EP0348532B1 (de) * | 1988-01-06 | 1994-12-07 | Fuji Photo Film Co., Ltd. | Verfahren zur verarbeitung photographischen silberhalogenid- materials |
| US4952707A (en) * | 1988-06-30 | 1990-08-28 | Tropix, Inc. | Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes |
| US5032381A (en) * | 1988-12-20 | 1991-07-16 | Tropix, Inc. | Chemiluminescence-based static and flow cytometry |
| GB2233451B (en) * | 1989-06-27 | 1993-09-15 | Tropix Inc | Chemiluminescence enhancement |
| JPH04266880A (ja) * | 1991-02-22 | 1992-09-22 | Japan Tobacco Inc | 3 −dpa− ラクトンの製造方法 |
-
1992
- 1992-03-20 US US07/855,537 patent/US5393469A/en not_active Expired - Lifetime
- 1992-08-06 AT AT92113448T patent/ATE190724T1/de not_active IP Right Cessation
- 1992-08-06 EP EP92113448A patent/EP0561033B1/de not_active Expired - Lifetime
- 1992-08-06 DE DE69230787T patent/DE69230787T2/de not_active Expired - Lifetime
- 1992-10-08 JP JP4270457A patent/JP2648423B2/ja not_active Expired - Lifetime
-
1994
- 1994-02-10 US US08/194,517 patent/US5431845A/en not_active Expired - Lifetime
- 1994-02-14 US US08/195,100 patent/US5439617A/en not_active Expired - Lifetime
- 1994-02-14 US US08/195,439 patent/US5474725A/en not_active Expired - Lifetime
-
1995
- 1995-08-14 US US08/514,833 patent/US5582775A/en not_active Expired - Lifetime
-
1996
- 1996-07-31 JP JP20154196A patent/JP3471530B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3471530B2 (ja) | 2003-12-02 |
| JP2648423B2 (ja) | 1997-08-27 |
| JPH05287267A (ja) | 1993-11-02 |
| US5582775A (en) | 1996-12-10 |
| EP0561033A1 (de) | 1993-09-22 |
| US5439617A (en) | 1995-08-08 |
| ATE190724T1 (de) | 2000-04-15 |
| US5393469A (en) | 1995-02-28 |
| EP0561033B1 (de) | 2000-03-15 |
| DE69230787T2 (de) | 2000-11-23 |
| US5431845A (en) | 1995-07-11 |
| US5474725A (en) | 1995-12-12 |
| JPH09136923A (ja) | 1997-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R071 | Expiry of right |
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