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DE69223965D1 - Anticonvulsives aminosäurederivat - Google Patents

Anticonvulsives aminosäurederivat

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Publication number
DE69223965D1
DE69223965D1 DE69223965T DE69223965T DE69223965D1 DE 69223965 D1 DE69223965 D1 DE 69223965D1 DE 69223965 T DE69223965 T DE 69223965T DE 69223965 T DE69223965 T DE 69223965T DE 69223965 D1 DE69223965 D1 DE 69223965D1
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DE
Germany
Prior art keywords
anticonvulsive
amino acid
acid derivative
compounds
cns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69223965T
Other languages
English (en)
Other versions
DE69223965T2 (de
Inventor
Harold Kohn
Darrell Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application granted granted Critical
Publication of DE69223965D1 publication Critical patent/DE69223965D1/de
Publication of DE69223965T2 publication Critical patent/DE69223965T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
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    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
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DE69223965T 1991-06-04 1992-06-04 Anticonvulsives aminosäurederivat Expired - Lifetime DE69223965T2 (de)

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US07/710,610 US5378729A (en) 1985-02-15 1991-06-04 Amino acid derivative anticonvulsant
PCT/US1992/004687 WO1992021648A1 (en) 1991-06-04 1992-06-04 Amino acid derivative anticonvulsant

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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654301A (en) * 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
ATE202079T1 (de) * 1996-03-15 2001-06-15 Res Corp Technologies Inc Krampflösende, enantiomere aminosäure-derivate
WO1998013336A1 (en) * 1996-09-27 1998-04-02 Research Corporation Technologies, Inc. Propionamide derivatives and their use as anticonvulsants
JP4222632B2 (ja) 1996-12-18 2009-02-12 テバ・ファーマシューティカル・インダストリーズ・リミテッド アミノインダン誘導体
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
ES2184300T3 (es) * 1997-07-15 2003-04-01 Res Corp Technologies Inc Derivados de aminoacidos utiles para tratar el accidente vascular encefalico.
SK15602000A3 (sk) * 1998-04-16 2001-03-12 Texas Biotechnology Corporation Zlúčeniny, ktoré inhibujú viazanie integrínov na ich receptory
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
ES2190305B1 (es) * 2000-05-24 2004-07-01 Medichem S.A. Compuestos intermedios para la preparacion de mirtazapina y sus procedimientos de obtencion.
DK1695703T3 (da) * 2000-08-25 2010-10-25 Res Corp Technologies Inc Nye anvendelser for aminosyrekrampestillende midler
EP1243262B1 (de) * 2001-03-20 2006-05-31 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
EP1243263B1 (de) * 2001-03-21 2002-11-27 Schwarz Pharma Ag Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
EP1426356B1 (de) * 2001-09-14 2008-04-16 Medichem S.A. Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
EP1689378B1 (de) * 2003-12-02 2009-04-15 Schwarz Pharma Ag Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen
US20060009384A1 (en) * 2003-12-05 2006-01-12 David Rudd Novel use of peptide compounds for treating status epilepticus or related conditions
EP1579858A1 (de) * 2004-03-26 2005-09-28 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von diabetishen Neuropathie
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
EA013591B1 (ru) * 2004-04-16 2010-06-30 Шварц Фарма Аг Применение пептидных соединений для профилактики, облегчения и лечения головной боли и болезненных состояний, связанных с или вызванных распространяющейся кортикальной депрессией (csd)
EP1604654A1 (de) 2004-05-18 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von Dyskynesien
EP1604655A1 (de) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von Trigeminusneuralgie
EP1604656A1 (de) 2004-06-09 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
PL1781276T3 (pl) * 2004-08-27 2010-11-30 Ucb Pharma Gmbh Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
JP2008528532A (ja) 2005-01-28 2008-07-31 シュヴァルツ・ファーマ・アーゲー 統合失調症のアドオン治療用ｓｐｍ９２７
EP1688137A1 (de) * 2005-01-28 2006-08-09 Schwarz Pharma Ag SPM 927 zur Co-Therapie der Schizophrenie
ES2536351T3 (es) * 2005-06-13 2015-05-22 Merck Sharp & Dohme Limited Agentes terapéuticos
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (de) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamid (SPM 927) zur Behandlung von Myalgien, z.B. Fibromyalgie
US20070048372A1 (en) * 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
ES2632638T3 (es) * 2005-12-09 2017-09-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva
NZ567108A (en) * 2005-12-20 2011-10-28 Nps Pharma Inc Fluorinated compounds
US7902401B2 (en) * 2006-12-14 2011-03-08 Nps Pharmaceuticals, Inc. Fluorinated compounds
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
EP1873527A1 (de) * 2006-06-30 2008-01-02 Schwarz Pharma Ag Verfahren zur Identifizierung von CRMP-Modulatoren
EP1925314A1 (de) * 2006-11-22 2008-05-28 Schwarz Pharma Ag Pharmazeutische Zusammensetzung mit synergistischer antikonvulsiver Wirkung
AU2007260207B2 (en) 2006-06-15 2012-11-08 Ucb Pharma Gmbh Pharmaceutical composition with synergistic anticonvulsant effect
EP2099444A4 (de) 2006-12-14 2012-11-07 Nps Pharma Inc Verwendung von d-serin-derivaten zur behandlung von angststörungen
WO2009053070A1 (en) 2007-10-23 2009-04-30 Schwarz Pharma Ag Compounds for treating demyelination conditions
WO2009145816A2 (en) * 2008-04-01 2009-12-03 The University Of North Carolina At Chapel Hill Novel n-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents
EP2509939A4 (de) 2009-09-23 2013-09-18 Univ North Carolina Neuartige n-benzylamid-substituierte derivate aus 2-(acylamid-)essigsäure und 2-(acylamid-)propionsäuren: starke neurologische wirkstoffe
AU2011299551A1 (en) * 2010-09-08 2013-03-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education P53-Mdm2 antagonists
WO2012041986A1 (en) 2010-10-01 2012-04-05 Ucb Pharma Gmbh Process for the preparation of amino acid derivatives
GB201020026D0 (en) 2010-11-25 2011-01-12 Cambrex Karlskoga Ab New process
GB201219627D0 (en) 2012-11-01 2012-12-12 Cambrex Karlskoga Ab New process
AU2016381366A1 (en) 2015-12-30 2018-06-28 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of seizure-related disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2676188A (en) * 1950-12-16 1954-04-20 American Home Prod Acylated glycinamides
US2721197A (en) * 1953-01-05 1955-10-18 Bristol Lab Inc Bicyclic lactams
DE1185194B (de) * 1959-06-11 1965-01-14 Nippon Shinyaku Co Ltd Verfahren zur Herstellung von Abkoemmlingen des Salicylsaeureamides
GB1051220A (de) * 1963-03-21
US3252866A (en) * 1965-06-28 1966-05-24 Mead Johnson & Co 2-hydrocarbon substituted-amido mercaptopropionamides in hair waving compositions and processes
IE33790B1 (en) * 1968-06-04 1974-10-30 Beecham Group Ltd Derivatives of n-acylaminoacid amides
US3887543A (en) 1970-12-07 1975-06-03 Yoshitomi Pharmaceutical Thieno(2,3-E)(1,4)diazepine derivatives
US3707559A (en) * 1971-05-14 1972-12-26 Searle & Co N-acyl phenylalanine amides
US4002764A (en) 1972-11-28 1977-01-11 Ciba-Geigy Corporation Diazepine derivatives in the treatment of tension, agitation and epilepsy
US4209516A (en) 1974-01-14 1980-06-24 Ciba-Geigy Corporation Triazole derivatives
US4018826A (en) * 1974-11-04 1977-04-19 Dynapol Corporation Process for preparing polyvinylamine and salts thereof
LU75836A1 (de) 1976-09-20 1978-05-12
DE2807286A1 (de) * 1978-02-21 1979-08-23 Bayer Ag Stereoselektive spaltung von phenylglycinderivaten und 4-hydroxyphenylglycinderivaten mit enzymharzen
JPS557242A (en) * 1978-06-30 1980-01-19 Tanabe Seiyaku Co Ltd Phenethylamine derivative
DE2937698A1 (de) * 1979-09-18 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln N-propionylsarcosinanilide, deren herstellungsverfahren und arzneimittel auf deren basis
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4372974A (en) 1980-06-25 1983-02-08 New York University Anticonvulsive compositions and method of treating convulsive disorders
FR2489319A1 (fr) * 1980-08-27 1982-03-05 Clin Midy Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant
BE885303A (fr) * 1980-09-19 1981-03-19 Continental Pharma Glycinamides
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
IE58422B1 (en) * 1985-02-15 1993-09-22 Res Corp Technologies Inc Amino acid derivatives and use thereof for the preparation of an anticonvulsant
NZ222045A (en) * 1986-08-21 1989-10-27 Res Corp Technologies Inc From diamides up to tetrapeptides for use as anticanvulsants
US4873241A (en) * 1988-10-31 1989-10-10 Fisons Corporation 2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics
WO1990015069A2 (en) 1989-05-19 1990-12-13 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
DE3920618A1 (de) * 1989-06-02 1991-02-21 Grafenwald Kunststoff Flaschen und umverpackung enthaltende anordnung

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DE69223965T2 (de) 1998-04-30
EP0592490A4 (en) 1994-08-17
ATE161824T1 (de) 1998-01-15
CA2110693C (en) 2003-05-20
EP0592490B1 (de) 1998-01-07
JPH06510985A (ja) 1994-12-08
AU2162192A (en) 1993-01-08
JP3330374B2 (ja) 2002-09-30
US5378729A (en) 1995-01-03
EP0592490A1 (de) 1994-04-20
WO1992021648A1 (en) 1992-12-10
CA2110693A1 (en) 1992-12-10
JP2002241355A (ja) 2002-08-28

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