[go: up one dir, main page]

DE69223793D1 - Nadelloser injektor - Google Patents

Nadelloser injektor

Info

Publication number
DE69223793D1
DE69223793D1 DE69223793T DE69223793T DE69223793D1 DE 69223793 D1 DE69223793 D1 DE 69223793D1 DE 69223793 T DE69223793 T DE 69223793T DE 69223793 T DE69223793 T DE 69223793T DE 69223793 D1 DE69223793 D1 DE 69223793D1
Authority
DE
Germany
Prior art keywords
injector
pct
piston
outlet orifice
cam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69223793T
Other languages
English (en)
Other versions
DE69223793T2 (de
Inventor
Terence Edward Weston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of DE69223793D1 publication Critical patent/DE69223793D1/de
Application granted granted Critical
Publication of DE69223793T2 publication Critical patent/DE69223793T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G7/00—Botany in general
    • A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Saccharide Compounds (AREA)
DE69223793T 1991-08-23 1992-08-21 Nadelloser injektor Expired - Fee Related DE69223793T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118204A GB9118204D0 (en) 1991-08-23 1991-08-23 Needle-less injector
PCT/GB1992/001539 WO1993003779A1 (en) 1991-08-23 1992-08-21 Needleless injector

Publications (2)

Publication Number Publication Date
DE69223793D1 true DE69223793D1 (de) 1998-02-05
DE69223793T2 DE69223793T2 (de) 1998-04-23

Family

ID=10700421

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223793T Expired - Fee Related DE69223793T2 (de) 1991-08-23 1992-08-21 Nadelloser injektor

Country Status (14)

Country Link
US (1) US5480381A (de)
EP (1) EP0599940B1 (de)
JP (2) JP3257794B2 (de)
KR (1) KR100233339B1 (de)
AT (1) ATE161427T1 (de)
AU (1) AU2444592A (de)
BR (1) BR9206407A (de)
CA (1) CA2116341C (de)
DE (1) DE69223793T2 (de)
ES (1) ES2110513T3 (de)
GB (1) GB9118204D0 (de)
NO (1) NO307817B1 (de)
RU (1) RU2129445C1 (de)
WO (1) WO1993003779A1 (de)

Families Citing this family (453)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
US5569190A (en) * 1987-06-08 1996-10-29 D'antonio; Nicholas F. Hypodermic fluid dispenser
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
RU2179864C2 (ru) * 1993-07-31 2002-02-27 Вестон Медикал Лимитед Безыгольный инъектор
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
DE29507987U1 (de) * 1995-05-15 1996-09-19 Ferton Holding, Delemont Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit
US6223786B1 (en) 1998-11-14 2001-05-01 Pen Jet Corporation Apparatus and method for mixing medication and filling an ampule of a needle-less injector
US5730723A (en) * 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6080130A (en) * 1998-11-14 2000-06-27 Castellano; Thomas P. Gas power source for a needle-less injector
US5800388A (en) 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5921967A (en) 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5865795A (en) 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5722953A (en) 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5697917A (en) 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5769138A (en) * 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
GB9607549D0 (en) * 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
JP3624543B2 (ja) * 1996-05-02 2005-03-02 東ソー株式会社 免疫反応試薬及びその製造方法
PL186641B1 (pl) 1996-07-01 2004-02-27 Pharmacia Ab Sposób i urządzenie do dostarczania preparatu
FR2751228B1 (fr) * 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
BR9711420A (pt) * 1996-09-26 1999-08-24 Akzo Nobel Nv Injetor sem agulha
WO1998013087A2 (en) 1996-09-27 1998-04-02 Weston Medical Limited Needleless injector accessory
US5875976A (en) 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US5911703A (en) * 1997-05-22 1999-06-15 Avant Drug Delivery Systems, Inc. Two-stage fluid medicament jet injector
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6156008A (en) * 1998-05-04 2000-12-05 Castellano; Thomas P. Device for avoiding subdermal hematomas from an injection
ES2276524T3 (es) * 1998-07-27 2007-06-16 Antares Pharma, Inc. Sonda de ayuda a la inyeccion para conjunto inyector medico.
WO2000006227A1 (en) * 1998-07-27 2000-02-10 Medi-Ject Corporation Loading mechanism for medical injector assembly
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
US6689095B1 (en) 1999-04-22 2004-02-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US6565528B1 (en) 1999-05-07 2003-05-20 Scimed Life Systems, Inc. Apparatus and method for delivering therapeutic and diagnostic agents
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
EP1187652B1 (de) 1999-06-02 2006-10-11 Boston Scientific Limited Arzneimittelabgabevorrichtungen
FR2796288B1 (fr) * 1999-07-16 2001-08-10 Cross Site Technologies Seringue sans aiguille avec injecteur a elements emboites
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
DE60144229D1 (de) * 2000-01-07 2011-04-28 Valeritas Inc Injektionsvorrichtung
US6210359B1 (en) 2000-01-21 2001-04-03 Jet Medica, L.L.C. Needleless syringe
DE10010123A1 (de) 2000-03-03 2001-09-20 Boehringer Ingelheim Int Nadelloser Injektor in Miniaturausführung
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US20020156418A1 (en) * 2000-11-30 2002-10-24 Gonnelli Robert R. Injection systems
US6758837B2 (en) * 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
JP5208347B2 (ja) 2001-02-23 2013-06-12 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 新規なワクチン
US6500239B2 (en) 2001-03-14 2002-12-31 Penjet Corporation System and method for removing dissolved gas from a solution
ZA200200808B (en) * 2001-03-22 2002-08-12 Roche Diagnostics Gmbh Needleless hypodermic injection system, application device and medication cartridge therefor.
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
EP1427463A2 (de) 2001-04-27 2004-06-16 PenJet Corporation Verfahren und vorrichtung zum befüllen und wiederbefüllen eines nadellosen injektors
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
WO2002096311A1 (en) * 2001-05-30 2002-12-05 Tomoyuki Takahashi Safe laser hair removal system with a protraction-retraction mechanism
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US8061006B2 (en) 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
US6669664B2 (en) 2001-09-07 2003-12-30 Avant Drug Delivery Systems, Inc. Vacuum control cycle for jet injector
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
US6939323B2 (en) * 2001-10-26 2005-09-06 Massachusetts Institute Of Technology Needleless injector
CA2371466C (en) * 2002-02-12 2010-02-09 Medical International Technology (Mit) Inc. Needleless injector
AU2003245919A1 (en) * 2002-06-10 2003-12-22 Akzo Nobel N.V. Needle-less injector
WO2007095318A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
CA2495238A1 (en) 2002-08-26 2004-03-04 Penjet Corporation Apparatus for needle-less injection with a degassed fluid
AU2003270355A1 (en) * 2002-09-06 2004-03-29 Massachusetts Institute Of Technology Needless drug injection device
US7018356B2 (en) 2002-10-31 2006-03-28 Wise Roger R Method and apparatus for adjusting the contents of a needle-less injector
DE10252917A1 (de) * 2002-11-12 2004-05-27 Lothar Bode Druckinjektions-Handgerät zum Einbringen von Substanzen unter Druck eines gasförmigen oder flüssigen Druckmittels in eine zu behandelnde Hautstelle
US6939319B1 (en) * 2002-11-20 2005-09-06 Conrad Anstead Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
CN100464796C (zh) * 2002-11-25 2009-03-04 特克法马许可公司 包括可复位安全释放设备的自动注射器
FR2853836B1 (fr) * 2003-04-16 2006-01-06 Crossject Seringue sans aiguille avec un injecteur-receptacle optimise
BRPI0410562B8 (pt) 2003-05-22 2021-05-25 Fralunhofer Usa Inc proteína de veículo e seu método de produção em uma planta, ácido nucleico isolado, vetor de expressão e célula hospedeira
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
WO2005051465A1 (en) * 2003-11-27 2005-06-09 Novo Nordisk A/S Impulse chamber for jet delivery device
WO2005070482A1 (en) * 2004-01-26 2005-08-04 Novo Nordisk A/S Impulse chamber for jet delivery device
AU2005253993B2 (en) * 2004-06-09 2010-05-27 Mark Anderson And Associates, Incorporated Hypodermic injection system
AU2005287532B2 (en) 2004-09-22 2011-09-01 Glaxosmithkline Biologicals S.A. Immunogenic composition
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US8221347B2 (en) * 2004-12-01 2012-07-17 Acushot, Inc. Needle-free injector
JP5364110B2 (ja) * 2005-01-07 2013-12-11 柴田科学株式会社 透過光量測定装置及び相対吸光度測定装置、並びにこれらの測定方法
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
NZ561822A (en) 2005-03-23 2010-04-30 Glaxosmithkline Biolog Sa Multivalent influenza virus vaccine
PL1866296T3 (pl) 2005-04-04 2017-05-31 University Of Florida Research Foundation, Inc. Polieterowe analogi desferritiocyny
JP2009502207A (ja) * 2005-08-03 2009-01-29 フラウンホーファー ユーエスエー， インコーポレイテッド イムノグロブリンの産生のための組成物および方法
US8591457B2 (en) * 2005-08-10 2013-11-26 Alza Corporation Method for making a needle-free jet injection drug delivery device
JP5401095B2 (ja) 2005-11-17 2014-01-29 ゾゲニクス インコーポレーティッド 無針注射による粘性製剤の送達方法
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
US9267937B2 (en) * 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
ES2707499T3 (es) 2005-12-22 2019-04-03 Glaxosmithkline Biologicals Sa Vacuna de conjugado de polisacárido neumocócico
CA2637209A1 (en) * 2006-01-17 2007-07-26 Zogenix, Inc. Single-dose needle-free administration of antithrombotic medications
US20070264130A1 (en) * 2006-01-27 2007-11-15 Phluid, Inc. Infusion Pumps and Methods for Use
JP2009526780A (ja) * 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド Ｈｐｖ抗原、ワクチン組成物、および関連する方法
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
EP1998684A4 (de) * 2006-03-10 2014-09-17 Massachusetts Inst Technology Konjugate und nanosysteme mit ausgelöstem selbstzusammenbau
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
US20100021503A1 (en) 2006-03-30 2010-01-28 Glaxosmithkline Biologicals S.A. Immunogenic composition
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
CN101426543A (zh) * 2006-04-21 2009-05-06 诺沃-诺迪斯克有限公司 两级射流注射设备
WO2007133807A2 (en) 2006-05-15 2007-11-22 Massachusetts Institute Of Technology Polymers for functional particles
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
CN104356230A (zh) 2006-06-02 2015-02-18 哈佛大学校长及研究员协会 蛋白质表面重建
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2422810B1 (de) 2006-07-17 2014-10-22 GlaxoSmithKline Biologicals s.a. Influenzaimpfstoff
US9115358B2 (en) * 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
WO2008073161A2 (en) * 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
CA2666755C (en) 2006-09-01 2014-03-25 Massachusetts Institute Of Technology Needle-free injector device with autoloading capability
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
KR101151202B1 (ko) 2006-10-12 2012-06-11 글락소스미스클라인 바이오로지칼즈 에스.에이. 수중유 에멀젼 애주번트를 포함하는 백신
EP2433648A3 (de) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Impfstoff mit einem Öl-in-wasser-emulsionshilfsstoff
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
KR20090106493A (ko) 2006-12-01 2009-10-09 안테리오스, 인코퍼레이티드 양쪽성 엔티티 나노입자
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
SG177918A1 (en) 2006-12-26 2012-02-28 Lantheus Medical Imaging Inc Ligands for imaging cardiac innervation
EP2952522B1 (de) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilisierte P53-Peptide und deren Verwendungen
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US7744563B2 (en) * 2007-02-23 2010-06-29 Bioject, Inc. Needle-free injection devices and drug delivery systems therefor
CA2680592C (en) 2007-03-15 2016-07-05 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof in treating pathological conditions
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
WO2008121767A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Stitched polypeptides
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
CN101687024A (zh) * 2007-04-28 2010-03-31 美国弗劳恩霍夫股份有限公司 锥虫抗原、疫苗组合物和相关方法
BRPI0811459A8 (pt) * 2007-06-14 2015-09-22 Berna Biotech Ag Preparação virossômica, uso de uma preparação virossômica, kit, e, métodos para vacinar um ser humano contra infecções de influenza, e para vacinar indivíduos mamíferos contra infecções da influenza
US8524444B2 (en) 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
ES2626662T3 (es) 2007-06-26 2017-07-25 Glaxosmithkline Biologicals S.A. Vacuna que comprende conjugados de polisacárido capsular de Streptococcus pneumoniae
WO2009009759A2 (en) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
EP2190472A2 (de) * 2007-08-20 2010-06-02 Fraunhofer USA, Inc. Prophylaktische und therapeutische influenza-vakzine, antigene, zusammensetzungen und verfahren
EP2205074A4 (de) * 2007-10-04 2013-07-31 Harvard College Moenomycin-analoga, syntheseverfahren und verwendung
MX350501B (es) 2007-10-12 2017-09-07 Massachusetts Inst Technology Nanotecnologia de vacuna.
KR20100111275A (ko) * 2008-01-03 2010-10-14 메사츄세츠 인스티튜트 어브 테크놀로지 유인 인플루엔자 치료제
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8986253B2 (en) * 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
TW201000107A (en) * 2008-04-09 2010-01-01 Infinity Pharmaceuticals Inc Inhibitors of fatty acid amide hydrolase
WO2009127676A1 (en) 2008-04-16 2009-10-22 Glaxosmithkline Biologicals S.A. Vaccine
EP3000462A1 (de) 2008-04-28 2016-03-30 Zogenix, Inc. Neuartige formulierungen zur behandlung von migräne
AU2009243187C1 (en) * 2008-04-28 2015-12-24 President And Fellows Of Harvard College Supercharged proteins for cell penetration
AU2009249132B2 (en) * 2008-05-19 2014-07-17 Tandem Diabetes Care Inc. Disposable pump reservoir and related methods
KR100888831B1 (ko) 2008-06-02 2009-03-19 (주)클래시스 무바늘 분출 주사장치
EP3650017A1 (de) 2008-06-26 2020-05-13 Anterios, Inc. Dermale verabreichung
DK2318832T3 (da) 2008-07-15 2014-01-20 Academia Sinica Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder
WO2010011318A2 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activatiqn of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
EP2356139A4 (de) 2008-07-23 2013-01-09 Harvard College Ligieren zusammengehefteter polypeptide
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) * 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8591905B2 (en) * 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US9974844B2 (en) 2008-11-17 2018-05-22 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
US20110008867A1 (en) * 2008-12-22 2011-01-13 Greenlight Biosciences Compositions and methods for the production of a compound
GB0900930D0 (en) * 2009-01-20 2009-03-04 Future Injection Technologies Ltd Injection device
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
CA2753214C (en) 2009-02-27 2017-07-25 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
JP2012523424A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
EP2424877A4 (de) 2009-04-28 2013-01-02 Harvard College Suprageladene proteine zur zellpenetration
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
WO2010141074A2 (en) 2009-06-01 2010-12-09 President And Fellows Of Harvard College O-glcnac transferase inhibitors and uses thereof
EP2453908B1 (de) 2009-07-13 2018-03-14 President and Fellows of Harvard College Bifunktionelle gestapelte polypeptide und verwendungen davon
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
US9265461B2 (en) 2009-09-01 2016-02-23 Massachusetts Institute Of Technology Identification techniques and device for testing the efficacy of beauty care products and cosmetics
WO2011028719A2 (en) 2009-09-01 2011-03-10 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
AU2010298338A1 (en) 2009-09-22 2012-04-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2483307A1 (de) 2009-09-29 2012-08-08 Fraunhofer USA, Inc. Influenza-hämagglutinin-antikörper, zusammensetzungen daraus und zugehörige verfahren
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US9333060B2 (en) 2009-12-15 2016-05-10 Massachusetts Institute Of Technology Plaque removal and differentiation of tooth and gum
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
CN102178990B (zh) * 2010-01-08 2013-10-09 江苏丞宇米特医疗科技有限公司 无针注射器
US8637456B2 (en) 2010-01-27 2014-01-28 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
MX361692B (es) * 2010-02-03 2018-12-13 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de ácido graso.
US9180105B2 (en) 2010-03-08 2015-11-10 Sloan-Kettering Institute For Cancer Research CDC7 kinase inhibitors and uses thereof
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
WO2011119549A1 (en) 2010-03-22 2011-09-29 President And Fellows Of Harvard College Trioxacarcins and uses thereof
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (de) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolone als fettsäuresynthasehemmer
US8956833B2 (en) 2010-05-07 2015-02-17 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
EP2569019B1 (de) 2010-05-11 2019-10-02 Lantheus Medical Imaging, Inc. Zusammensetzungen, verfahren und systeme zur synthese und verwendung von bildgebungsmitteln
ES2664872T3 (es) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd Moduladores PRPK-TPRKB y sus usos
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2016111360A (ru) 2010-08-13 2018-11-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
DK3219796T3 (da) 2010-08-31 2020-12-21 Greenlight Biosciences Inc Fremgangsmåder til kontrol af strømningen i metaboliske reaktionsveje ved hjælp af proteasemanipulation
AU2011302072B2 (en) 2010-09-15 2014-05-15 Zogenix, Inc. Needle-free injectors and design parameters thereof that optimize injection performance
EP2640405A4 (de) 2010-09-21 2015-04-15 Massachusetts Inst Technology An den menschen angepasste ha-polypeptide, impfstoffe daraus und influenza-behandlung damit
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
LT4108671T (lt) 2010-10-01 2025-01-10 Modernatx, Inc. Modifikuoti nukleozidai, nukleotidai, nukleorūgštys bei jų panaudojimas
EP2624864B1 (de) 2010-10-04 2017-12-06 Massachusetts Institute of Technology Hämagglutinin-polypeptide und -reagenzien sowie verfahren in zusammenhang damit
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
WO2012097000A1 (en) 2011-01-10 2012-07-19 Pingda Ren Processes for preparing isoquinolinones and solid forms of isoquinolinones
CA2824317C (en) 2011-01-19 2014-12-16 Terakine Therapeutics, Inc. Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia
KR20240119180A (ko) 2011-01-24 2024-08-06 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
JP5938838B2 (ja) 2011-01-24 2016-06-22 アンテリオス， インコーポレイテッド ナノ粒子組成物
KR20140003573A (ko) 2011-01-24 2014-01-09 안테리오스, 인코퍼레이티드 오일 조성물
EP3510998A1 (de) 2011-03-03 2019-07-17 Tersus Pharmaceuticals, LLC Zusammensetzungen und verfahren mit c16:1n7-palmitoleat
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
EP2691396B1 (de) 2011-03-30 2016-08-10 Brown University Enopeptine, verwendungen davon und syntheseverfahren dafür
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
AR086405A1 (es) 2011-05-17 2013-12-11 Glaxosmithkline Biolog Sa Vacuna de streptococcus pneumoniae
WO2012177997A1 (en) 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
JP6027611B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
JP6027610B2 (ja) 2011-07-19 2016-11-16 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環式化合物及びその使用
US9115053B2 (en) 2011-07-22 2015-08-25 Massachusetts Institute Of Technology Activators of class I histone deacetlyases (HDACS) and uses thereof
SG11201400310WA (en) 2011-08-29 2014-06-27 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
AU2012304359B2 (en) 2011-09-09 2016-11-17 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN104093848A (zh) 2011-09-09 2014-10-08 绿光生物科学公司 碳青霉烯(carbapenem)的无细胞制备
EP3384938A1 (de) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Manipulierte nukleinsäuren und verfahren zur verwendung davon
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
EP3682905B1 (de) 2011-10-03 2021-12-01 ModernaTX, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
AU2012352025B2 (en) 2011-12-16 2018-01-18 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
WO2013102245A1 (en) * 2012-01-06 2013-07-11 Svw Technologies Pty Ltd Method and apparatus for castration of animals
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
CN108912211A (zh) 2012-02-15 2018-11-30 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
EP2850090B1 (de) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatische verfahren zur synthetisierung von moenomycin-analoga
EP2850091A1 (de) 2012-04-06 2015-03-25 President and Fellows of Harvard College Verfahren und verbindungen zur identifizierung von glycosyltransferaseinhibitoren
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP2841128A4 (de) 2012-04-23 2015-11-25 Zogenix Inc Kolbenverschlüsse für arzneimittelabgabekapseln
HK1207970A1 (en) 2012-05-10 2016-02-19 Massachusetts Institute Of Technology Agents for influenza neutralization
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US9914956B2 (en) 2012-08-18 2018-03-13 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
SI2920197T1 (sl) 2012-09-26 2021-08-31 President And Fellows Of Harvard College Speti peptidi, spojine s prolinom, in njihova uporaba
WO2014055564A1 (en) 2012-10-01 2014-04-10 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014059383A1 (en) 2012-10-12 2014-04-17 The Broad Institute, Inc. Gsk3 inhibitors and methods of use thereof
EP2909194A1 (de) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Hemmer der cyclinabhängigen kinase 7 (cdk7)
US9758522B2 (en) 2012-10-19 2017-09-12 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
EP2917203B1 (de) 2012-11-02 2019-04-03 Dana-Farber Cancer Institute, Inc. Verfahren zur identifizierung von myc inhibitoren
MX2015006390A (es) 2012-11-21 2015-08-05 Topokine Therapeutics Inc Metodos y composiciones para incrementar localmente la grasa corporal.
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
US9775915B2 (en) 2012-11-26 2017-10-03 President And Fellows Of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
EP2935243B1 (de) 2012-12-21 2018-03-14 Epizyme, Inc. Prmt5-inhibitoren mit einem dihydro- oder tetrahydroisochinolin und verwendungen davon
US9908887B2 (en) 2012-12-21 2018-03-06 Epizyme, Inc. PRMT5 inhibitors and uses thereof
HRP20182037T1 (hr) 2012-12-21 2019-02-08 Epizyme, Inc. Inhibitori prmt5 i njihova uporaba
HK1217215A1 (zh) 2013-01-17 2016-12-30 Modernatx, Inc. 用於改变细胞表型的信号传感器多核苷酸
EP2953967B1 (de) 2013-02-07 2019-05-01 Massachusetts Institute of Technology Menschliche anpassung von h5-influenza
ES2959258T3 (es) 2013-02-07 2024-02-22 Childrens Medical Center Antígenos proteicos que proporcionan protección contra la colonización y/o la enfermedad neumocócicas
CA2903769A1 (en) 2013-03-11 2014-10-09 Durect Corporation Injectable controlled release composition comprising high viscosity liquid carrier
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CA2909620C (en) 2013-03-13 2025-07-22 Harvard College Stapled and stitched polypeptides and uses thereof
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP2981285B1 (de) 2013-04-03 2020-06-03 N-Fold Llc Neuartige nanopartikelzusammensetzungen
EP2988597B1 (de) 2013-04-04 2022-06-08 President and Fellows of Harvard College Makrolide sowie verfahren zu deren herstellung und verwendung
EP2983659B1 (de) 2013-04-09 2019-11-20 Massachusetts Institute of Technology Wirkstofffreisetzendes polymer und verwendungen davon
US10301359B2 (en) 2013-04-30 2019-05-28 Massachusetts Institute Of Technology Human adaptation of H3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (de) 2013-05-10 2018-06-16
ES2834638T3 (es) 2013-05-30 2021-06-18 Infinity Pharmaceuticals Inc Tratamiento de cánceres usando moduladores de isoforma de PI3 cinasa
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
EP3030239A4 (de) 2013-06-11 2017-03-08 Kala Pharmaceuticals, Inc. Harnstoffderivate und verwendungen davon
EP3008081B1 (de) 2013-06-14 2017-08-30 President and Fellows of Harvard College Stabilisierte polypeptid-insulinrezeptor-modulatoren
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
CN105658807A (zh) 2013-08-05 2016-06-08 绿光生物科技股份有限公司 具有蛋白酶切割位点的工程化蛋白
BR112016002354A2 (pt) 2013-08-05 2017-09-12 Glaxosmithkline Biologicals Sa composição imunogênica, métodos para proteger um bebê contra infecção ou doença e para evocar uma resposta imune, regime de vacinação, e, kit
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
BR112016007467B1 (pt) 2013-10-04 2022-09-20 Infinity Pharmaceuticals, Inc Compostos heterocíclicos e usos dos mesmos
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015057894A1 (en) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
WO2015058140A1 (en) 2013-10-18 2015-04-23 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
US20160264551A1 (en) 2013-10-18 2016-09-15 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN108530458A (zh) 2013-11-01 2018-09-14 卡拉制药公司 治疗化合物的结晶形式及其用途
JP6494631B2 (ja) 2013-12-24 2019-04-03 プレジデント アンド フェローズ オブ ハーバード カレッジ コルチスタチン類縁体並びにその合成及び使用
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015112027A1 (en) 2014-01-27 2015-07-30 Te Pari Products Limited A fluid dispenser
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
AU2015226911B2 (en) 2014-03-07 2018-03-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Non-narcotic CRMP2 peptides targeting sodium channels for chronic pain
CN113620958A (zh) 2014-03-19 2021-11-09 无限药品股份有限公司 用于治疗PI3K-γ介导的障碍的杂环化合物
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
EP3122375B1 (de) 2014-03-28 2021-03-03 University of Washington through its Center for Commercialization Impfungen gegen brust- und eierstockkrebs
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
CA2949535C (en) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
KR20170005142A (ko) 2014-05-27 2017-01-11 아카데미아 시니카 증진된 항체 효능을 위한 범용 당형태에 관한 조성물 및 방법
JP2017518989A (ja) 2014-05-27 2017-07-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 抗ｃｄ２０糖操作抗体群およびその使用
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP3154582A4 (de) 2014-05-28 2018-01-10 Academia Sinica Anti-tnf-alpha-glycoantikörper und verwendungen davon
CA2951430A1 (en) 2014-06-13 2015-12-17 Glaxosmithkline Biologicals Sa Immunogenic combinations
ME03334B (de) 2014-06-19 2019-10-20 Ariad Pharma Inc Heteroarylverbindungen zur kinasehemmung
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
EP3164379A1 (de) 2014-07-02 2017-05-10 Massachusetts Institute of Technology Lipidoide aus polyaminfettsäure und verwendungen davon
US10759836B2 (en) 2014-07-18 2020-09-01 University Of Washington Cancer vaccine compositions and methods of use thereof
WO2016025643A1 (en) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Brush-poly(glycoamidoamine)-lipids and uses thereof
CN107001404B (zh) 2014-09-08 2021-06-29 中央研究院 使用醣脂激活人类iNKT细胞
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2965169C (en) 2014-10-21 2021-11-16 Ariad Pharmaceuticals, Inc. Crystalline forms of 5-chloro-n4-[2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidine-2,4-diamine
JP2017533238A (ja) 2014-10-28 2017-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗原特異的寛容のための組成物及び方法
WO2016077125A1 (en) 2014-11-10 2016-05-19 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
HK1245274A1 (zh) 2014-12-10 2018-08-24 Kala Pharmaceuticals, Inc. 1-氨基-三唑并(1，5-a)吡啶取代的脲衍生物及其用途
CA2972239A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
EP3037119A1 (de) * 2014-12-23 2016-06-29 Hipra Scientific, S.L.U. Vorrichtung zur Verabreichung medizinischer Produkte
CN107206256A (zh) 2014-12-23 2017-09-26 索隆-基特林癌症研究协会 榴菌素b的多形体
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
WO2016118191A1 (en) 2015-01-24 2016-07-28 Academia Sinica Novel glycan conjugates and methods of use thereof
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
EP3273966B1 (de) 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
JP6843065B2 (ja) 2015-03-30 2021-03-17 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． リボ核酸の無細胞生産
AU2016255770A1 (en) 2015-04-27 2017-11-16 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
EP3307728A4 (de) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Kombinationstherapie von transkriptionshemmern und kinasehemmern
AU2016278970B2 (en) 2015-06-19 2020-10-29 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2016319125B2 (en) 2015-09-09 2021-04-08 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3347372A4 (de) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Peptidomimetische makrocyclen als modulatoren von mcl-1
WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017049275A2 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a stabilizing tail region
WO2017049245A2 (en) 2015-09-17 2017-03-23 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US9925170B2 (en) 2015-10-01 2018-03-27 Kythera Biopharmaceuticals, Inc. Methods of adipolysis and compositions useful therein
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
AU2016377681B2 (en) 2015-12-22 2021-05-13 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
CN109195996A (zh) 2016-03-08 2019-01-11 中央研究院 N-聚醣及其阵列的模组化合成方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
JP7011599B2 (ja) 2016-04-06 2022-02-10 グリーンライト バイオサイエンシーズ インコーポレーテッド リボ核酸の無細胞的生産
CA3026094A1 (en) 2016-06-03 2017-12-07 Sanofi Pasteur Inc. Modification of engineered influenza hemagglutinin polypeptides
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017218704A1 (en) 2016-06-14 2017-12-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
US11241489B2 (en) 2016-08-05 2022-02-08 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
IL264553B2 (en) 2016-08-05 2023-04-01 Sanofi Pasteur Inc A multivalent pneumococcal protein-polysaccharide conjugate preparation
AU2017316663B2 (en) 2016-08-22 2024-02-22 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
CN106345010B (zh) * 2016-08-24 2019-08-23 吉林省农业科学院 一种具有存储功能的动物用注射装置
SG10201609111WA (en) 2016-10-31 2018-05-30 Miracle Man Pte Ltd Safety-Enhanced Needle-Free Injector And System For Use Through Both Porous And Non-Porous Materials
JP6801381B2 (ja) * 2016-11-07 2020-12-16 東ソー株式会社 凍結乾燥状態の検体前処理試薬
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
DE102017102765A1 (de) 2017-02-13 2018-08-16 Rudolf Götz Kit-of-Parts
US11969506B2 (en) 2017-03-15 2024-04-30 Modernatx, Inc. Lipid nanoparticle formulation
PL3596041T3 (pl) 2017-03-15 2023-03-06 Modernatx, Inc. Związek i kompozycje do dokomórkowego dostarczania środków terapeutycznych
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
WO2018187630A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
CN107252512B (zh) * 2017-06-16 2018-03-13 南阳市中心医院 一种气动无针注射器
WO2018237221A1 (en) 2017-06-23 2018-12-27 Nosocomial Vaccine Corporation Immunogenic compositions
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
EP3675817A1 (de) 2017-08-31 2020-07-08 Modernatx, Inc. Verfahren zur herstellung von lipidnanopartikeln
AR113764A1 (es) 2017-10-11 2020-06-10 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfato y ácido ribonucleico
EP3717033B1 (de) 2017-12-01 2025-10-22 North Carolina State University Fibrinpartikel und verfahren zu ihrer herstellung
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
SG11202006387QA (en) 2018-02-05 2020-07-29 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition
DE102018107100A1 (de) 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102018107103A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102018107101A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102018107102A1 (de) * 2018-03-26 2019-09-26 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
AU2019295632B2 (en) 2018-06-25 2025-03-06 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
EP3853202A1 (de) 2018-09-19 2021-07-28 ModernaTX, Inc. Verbindungen und zusammensetzungen zur intrazellulären verabreichung von therapeutischen wirkstoffen
EP3852728B1 (de) 2018-09-20 2024-09-18 ModernaTX, Inc. Herstellung von lipidnanopartikeln und verfahren zu deren verabreichung
US10953213B2 (en) * 2018-10-22 2021-03-23 Carson B. Vester Tattoo device
WO2020140098A1 (en) 2018-12-28 2020-07-02 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 and uses thereof
WO2020150385A1 (en) 2019-01-16 2020-07-23 Curza Global, Llc Antimicrobial compounds and methods
EP3911643A1 (de) 2019-01-16 2021-11-24 Curza Global LLC Antimikrobielle verbindungen und verfahren
ES2992653T3 (en) 2019-01-31 2024-12-16 Modernatx Inc Methods of preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
WO2020205615A1 (en) * 2019-03-29 2020-10-08 Aijex Pharma International, Inc. Needleless injector and related methods
AU2020319876A1 (en) 2019-07-31 2022-02-24 Modernatx, Inc. Compositions and methods for delivery of RNA interference agents to immune cells
AU2020323498A1 (en) 2019-07-31 2022-03-03 Sk Bioscience Co., Ltd. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
DE102019123732A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123737A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123734A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123731A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123733A1 (de) * 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
DE102019123735A1 (de) 2019-09-04 2021-03-04 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CN115297930B (zh) 2019-11-13 2025-02-14 库扎环球有限责任公司 抗微生物化合物和方法
CN114867513A (zh) * 2019-12-18 2022-08-05 诺和诺德股份有限公司 固定剂量注射装置
KR102518758B1 (ko) * 2020-01-21 2023-04-06 미라클스코프(주) 무침주사기
WO2021155274A1 (en) 2020-01-31 2021-08-05 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
JP7625614B2 (ja) 2020-03-09 2025-02-03 アイデックス ラボラトリーズ インコーポレイテッド 液体サンプルの成分を除去するために使用されるマトリックスならびに関連のサンプルカップまたは混合カップ
JP7679396B2 (ja) * 2020-03-09 2025-05-19 アイデックス ラボラトリーズ インコーポレイテッド 液体サンプルの干渉成分を化学試薬検査スライドへの適用前に除去するための方法
RU200703U1 (ru) * 2020-03-20 2020-11-06 Общество с ограниченной ответственностью "АТ-ЛИРТ" Жидкостный насос для хемилюминесцентных измерений с борта летательных аппаратов
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
KR102427261B1 (ko) * 2020-06-15 2022-08-02 유수옥 주사기
DE102020119751A1 (de) 2020-07-27 2022-01-27 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CA3186827A1 (en) * 2020-07-28 2022-02-03 Grant Sinclair Plant injection apparatus and method
WO2022092294A1 (ja) 2020-10-30 2022-05-05 学校法人慶應義塾 サルコペニア関連疾患等の新規治療および予防
JPWO2022092295A1 (de) 2020-10-30 2022-05-05
AR124267A1 (es) 2020-12-09 2023-03-01 Genentech Inc Métodos de alto rendimiento para preparar nanopartículas lipídicas y sus usos
KR102669122B1 (ko) * 2020-12-22 2024-05-27 조민수 자동 무침 주사기
EP4305088A1 (de) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Verzweigte poly(aminoester) zur verabreichung von nukleinsäuren
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
TW202333778A (zh) 2021-10-08 2023-09-01 美商賽諾菲巴斯德公司 多價流感疫苗
CA3237134A1 (en) 2021-11-05 2023-05-11 Timothy ALEFANTIS Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
CN118302190A (zh) 2021-11-05 2024-07-05 赛诺菲 包含血凝素和神经氨酸酶的杂合多价流感疫苗及其使用方法
US12171779B2 (en) 2021-12-08 2024-12-24 University Of South Florida Regulated drug delivery via controlled degradable chondroitin sulfate particles
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
EP4457217A1 (de) 2021-12-30 2024-11-06 Curza Global LLC Antimikrobielle verbindungen und verfahren
US20250161255A1 (en) 2022-01-25 2025-05-22 Motoshi Hayano New therapy and prevention for suppressing aging-related disorders including sarcopenia
EP4469565A1 (de) 2022-01-27 2024-12-04 Sanofi Pasteur Modifizierte vero-zellen und verfahren zur verwendung davon zur virusherstellung
EP4494146A1 (de) 2022-03-14 2025-01-22 Sanofi Pasteur, Inc. Maschinenlernverfahren beim proteinentwurf zur impfstofferzeugung
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
EP4561546A1 (de) 2022-07-29 2025-06-04 ModernaTX, Inc. Lipidnanopartikelzusammensetzungen mit oberflächenlipidderivaten und zugehörige verwendungen
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
EP4561547A1 (de) 2022-07-29 2025-06-04 ModernaTX, Inc. Lipidnanopartikelzusammensetzungen mit phospholipidderivaten und zugehörige verwendungen
KR20250053926A (ko) 2022-09-01 2025-04-22 지카니 테라퓨틱스, 인크. 13-원 마크롤리드를 사용한 가족성 선종성 폴립증의 치료
WO2024091918A2 (en) 2022-10-25 2024-05-02 Modernatx, Inc. Methods of lipid nanoparticle production in cross-mixers
KR102783012B1 (ko) * 2022-11-08 2025-03-18 미라클스코프(주) 캠팔로워 부하 감소형 무침주사기
WO2024121380A1 (en) 2022-12-08 2024-06-13 Pierre Fabre Medicament Vaccinal composition and adjuvant
WO2024229176A1 (en) 2023-05-04 2024-11-07 Affinivax, Inc. Rhizavidin variants
WO2024246358A1 (en) 2023-06-01 2024-12-05 Sanofi Thermostable compositions comprising mrna lipid nanoparticles
WO2024259373A1 (en) 2023-06-14 2024-12-19 Modernatx, Inc. Compounds and compositions for delivery of therapeutic agents
TW202527960A (zh) 2023-09-06 2025-07-16 美商賽諾菲巴斯德公司 經修飾ｂ型流感血球凝集素多肽及核酸及其用途
WO2025160127A1 (en) 2024-01-23 2025-07-31 Modernatx, Inc. Ionizable lipids and compositions thereof for delivery of therapeutic agents
WO2025160381A1 (en) 2024-01-26 2025-07-31 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2025166202A1 (en) 2024-01-31 2025-08-07 Modernatx, Inc. Lipid nanoparticle compositions comprising sialic acid derivatives and the uses thereof
KR102859292B1 (ko) * 2024-03-11 2025-09-12 주식회사 테라시스디앤씨 이미용 약액 주입장치
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2398544A (en) * 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
FR1049564A (fr) * 1951-11-22 1953-12-30 Normeca Seringue à injection perfectionnée
US2762369A (en) * 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector with adjustable impact plunger
DK87314C (da) * 1954-10-27 1959-05-19 Astra Apotekarnes Kem Fab Injektionssprøjte.
GB805184A (en) * 1957-01-29 1958-12-03 Becton Dickinson Co Hypodermic assembly
US2928390A (en) * 1957-07-15 1960-03-15 Scherer Corp R P Multi-dose hypodermic injector
GB915262A (en) * 1957-11-01 1963-01-09 Secr Aviation Improvements in/or relating to hypodermic injection apparatus
CH393640A (de) * 1960-06-10 1965-06-15 Int Treuhand Ag Spritzampulle
GB993309A (en) * 1961-04-11 1965-05-26 Express Injector Company Ltd Improved hypodermic injector
GB971162A (en) * 1961-11-21 1964-09-30 British Oxygen Co Ltd Injection inoculation instruments
GB1052043A (en) * 1962-10-02 1966-12-21 Benger Lab Ltd Hypodermic injection device
US3330276A (en) * 1963-10-07 1967-07-11 Scherer Corp R P Hypodermic jet injector
US3526225A (en) * 1967-03-31 1970-09-01 Tokyo Sokuhan Kk Jet-type hypodermic injection device
BE755224A (fr) * 1969-08-25 1971-02-24 Philips Nv Seringue d'injection
BE795162A (fr) * 1972-02-10 1973-08-08 Philips Nv Injektie-inrichting
US3802430A (en) * 1972-06-30 1974-04-09 L Arnold Disposable pyrotechnically powered injector
US3859996A (en) * 1973-07-18 1975-01-14 Mizzy Inc Multi-dose injector
US3882863A (en) * 1973-08-01 1975-05-13 Survival Technology Hypodermic injection device having cannula covered with resilient sheath
JPS51130094A (en) 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4031893A (en) * 1976-05-14 1977-06-28 Survival Technology, Inc. Hypodermic injection device having means for varying the medicament capacity thereof
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
SU718111A1 (ru) * 1978-07-12 1980-02-29 Предприятие П/Я А-3556 Безыгольный инъектор
ATE9546T1 (de) * 1980-02-19 1984-10-15 Stephen Clark Wardlaw Hypodermatische spritzen.
US4329988A (en) * 1980-12-23 1982-05-18 Survival Technology, Inc. Plural injection assembly
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
DE3278101D1 (en) * 1981-08-10 1988-03-17 Duphar Int Res Automatic injection syringe
EP0107874B1 (de) * 1982-10-27 1986-11-26 Duphar International Research B.V Automatische Injektionsvorrichtung
FR2539302B1 (fr) * 1983-01-17 1986-03-14 Brunet Jean Louis Seringue a usage medical
DE3342407A1 (de) * 1983-11-24 1985-06-05 Erwin 6950 Mosbach Maurer Injektionsgeraet
US4578064A (en) * 1983-12-21 1986-03-25 Survival Technology Inc. Plural dosage automatic injector with improved safety
US4484910A (en) * 1983-12-21 1984-11-27 Survival Technology, Inc. Dual mode automatic injector
FR2567760A1 (fr) * 1984-07-18 1986-01-24 Hibon Joseph Appareil pour executer des series d'injections medicamenteuses
DE3427189A1 (de) * 1984-07-24 1986-02-20 Hoechst Ag, 6230 Frankfurt Verriegelung fuer die abnehmbare impfstoffpumpe eines nadellosen injektionsgeraetes
BR8404286A (pt) * 1984-08-28 1986-04-08 Sergio Landau Seringa hipodermica a pressao
ATE39325T1 (de) * 1984-11-02 1989-01-15 Duphar Int Res Automatische injektionsvorrichtung.
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
ES2017924B3 (es) * 1985-10-11 1991-03-16 Duphar Int Res B V Inyector automatico.
ES2024489B3 (es) * 1986-05-15 1992-03-01 Duphar Int Res B V Inyector automatico.
FR2609400A2 (fr) * 1986-06-16 1988-07-15 Michel Pistor Dispositif therapeutique, portable, totalement autonome, transdermique, pourvu de moyens d'introduction d'un agent a activite therapeutique dans un reservoir du dispositif a un moment quelconque
US4722728A (en) 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US4850968A (en) * 1987-07-27 1989-07-25 Ar.Ma.S.R.L. Self-blocking hypodermic syringe for once-only use, comprising a needle protection cap
JPH01198561A (ja) * 1987-11-16 1989-08-10 Medhi Tek Internatl Ltd 液体注入装置
US4874367A (en) * 1988-02-05 1989-10-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
BR8801952A (pt) * 1988-04-22 1989-11-14 Sergio Landau Capsula descartavel,nao re-utilizavel,contendo dose individual de vacina a ser injetada hipodermicamente,sem agulha,com aparelho injetor a pressao
JPH0284962A (ja) * 1988-06-14 1990-03-26 Vci Corp 負圧圧着無針注射器
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
GB8819977D0 (en) * 1988-08-23 1988-09-21 Medimech Ltd Automatic injectors
DE8813905U1 (de) * 1988-11-07 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
DE8813938U1 (de) * 1988-11-08 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart Injektionsgerät
US5102788A (en) 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
EP0405320A3 (en) * 1989-06-27 1991-04-03 Elkom - Tovarna Stikalnih Naprav Multipurpose automatic injector
US5085641A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use auto-injector with improved cap structure
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
FR2651314A1 (fr) * 1989-08-25 1991-03-01 Taddei Andre Dispositif portatif pour effectuer des dosages multiples d'un produit liquide ou pateux.
AU6550990A (en) * 1989-11-09 1991-05-16 Bioject, Inc. Needleless hypodermic injection device
WO1991012839A1 (fr) * 1990-03-02 1991-09-05 Igor Alexandrovich Khanin Injecteur a aiguille-jet destine a l'introduction de preparations medicales dans un organe interne d'un patient
DE4008068A1 (de) * 1990-03-14 1991-09-19 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
US5092843A (en) * 1990-04-12 1992-03-03 Survival Technology, Inc. Dispersion multichamber auto-injector
DE9005419U1 (de) * 1990-05-12 1990-07-19 Nothdurft, Klaus, 7000 Stuttgart Betätigungsvorrichtung für eine Einmalspritze
CA2095858A1 (en) * 1990-11-09 1992-05-10 Peter Elliott Rosenzweig Needleless hypodermic jet injector device
GB9100819D0 (en) * 1991-01-15 1991-02-27 Medimech Int Ltd Subcutaneous injector
FR2671729A1 (fr) * 1991-01-17 1992-07-24 Micro Dose Pharma Dispositif de delivrance de doses controlees, en particulier du genre seringue a insuline jetable.
US5176643A (en) * 1991-04-29 1993-01-05 George C. Kramer System and method for rapid vascular drug delivery
CA2102920A1 (en) * 1991-05-13 1992-11-14 John G. Wilmot Automatic injectors
GB9111600D0 (en) * 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
EP0518416A1 (de) * 1991-06-13 1992-12-16 Duphar International Research B.V Injektionsvorrichtung
DE4120267A1 (de) * 1991-06-19 1992-12-24 Bader & Partner Medizintechnik Verfahren zum betrieb einer vorrichtung zur abgabe eines fluessigen medizinischen behandlungsstoffes an einen zu behandelnden koerper und vorrichtung zur durchfuehrung des verfahrens
EP0525525B1 (de) * 1991-07-24 1995-05-03 Medico Development Investment Company Injektor
AU3260993A (en) * 1992-01-07 1993-08-03 Sti International Limited Automatic injectors
DE69302852T2 (de) * 1992-03-27 1996-09-26 Duphar Int Res Automatische Spritze
MX9302834A (es) * 1992-05-15 1993-11-01 Safe T Ltd Aplicador de aguja hueca.
US5334144A (en) * 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector

Also Published As

Publication number Publication date
US5480381A (en) 1996-01-02
EP0599940A1 (de) 1994-06-08
ES2110513T3 (es) 1998-02-16
CA2116341C (en) 1999-12-14
GB9118204D0 (en) 1991-10-09
HK1010993A1 (en) 1999-07-02
BR9206407A (pt) 1994-12-13
EP0599940B1 (de) 1997-12-29
RU2129445C1 (ru) 1999-04-27
CA2116341A1 (en) 1993-03-04
JPH07500417A (ja) 1995-01-12
JPH06509954A (ja) 1994-11-10
RU94028893A (ru) 1996-06-10
DE69223793T2 (de) 1998-04-23
JP3257795B2 (ja) 2002-02-18
NO940606L (no) 1994-04-21
KR100233339B1 (ko) 1999-12-01
WO1993003779A1 (en) 1993-03-04
AU2444592A (en) 1993-03-16
NO940606D0 (no) 1994-02-22
NO307817B1 (no) 2000-06-05
ATE161427T1 (de) 1998-01-15
JP3257794B2 (ja) 2002-02-18

Similar Documents

Publication Publication Date Title
DE69223793D1 (de) Nadelloser injektor
ES8404777A1 (es) Un inyector hipodermico sin aguja.
DE69411113D1 (de) Vorrichtung zum dosieren eines flüssigen präparates
BR9206436A (pt) Aparelho de injeção
DE69506521D1 (de) Automatische medikamenteneinspritzvorrichtung
GR3019275T3 (en) Injection device
DE69218592D1 (de) Spritze
FI934132A0 (fi) Doseringsanordning foer ett laekemedel
PT101030A (pt) Processo e dispositivo para doseamento repetido de preparados liquidos
JPS57139216A (en) Liquid injection equipment
DE69211640D1 (de) Injektionsvorrichtung
PT95341A (pt) Seringa hipodermica para uma unica utilizacaao
GB1513463A (en) Self-contained injection apparatus

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ARADIGM CORP., HAYWARD, CALIF., US

8339 Ceased/non-payment of the annual fee