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DE69108402D1 - 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls. - Google Patents

5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.

Info

Publication number
DE69108402D1
DE69108402D1 DE69108402T DE69108402T DE69108402D1 DE 69108402 D1 DE69108402 D1 DE 69108402D1 DE 69108402 T DE69108402 T DE 69108402T DE 69108402 T DE69108402 T DE 69108402T DE 69108402 D1 DE69108402 D1 DE 69108402D1
Authority
DE
Germany
Prior art keywords
pyrimidinthiamine
fluor
derivatives
minoxidil
hair loss
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108402T
Other languages
English (en)
Other versions
DE69108402T2 (de
Inventor
Heinrich Schostarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE69108402D1 publication Critical patent/DE69108402D1/de
Application granted granted Critical
Publication of DE69108402T2 publication Critical patent/DE69108402T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Developing Agents For Electrophotography (AREA)
DE69108402T 1990-11-14 1991-09-20 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls. Expired - Fee Related DE69108402T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61269590A 1990-11-14 1990-11-14
PCT/US1991/006728 WO1992008705A1 (en) 1990-11-14 1991-09-20 5-fluoro-2,4,6-pyrimidinetriamine compounds

Publications (2)

Publication Number Publication Date
DE69108402D1 true DE69108402D1 (de) 1995-04-27
DE69108402T2 DE69108402T2 (de) 1995-10-05

Family

ID=24454264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108402T Expired - Fee Related DE69108402T2 (de) 1990-11-14 1991-09-20 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.

Country Status (10)

Country Link
US (1) US5373012A (de)
EP (1) EP0557301B1 (de)
JP (1) JPH06501947A (de)
AT (1) ATE120190T1 (de)
AU (1) AU651630B2 (de)
CA (1) CA2092811A1 (de)
DE (1) DE69108402T2 (de)
DK (1) DK0557301T3 (de)
ES (1) ES2070513T3 (de)
WO (1) WO1992008705A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US7629384B2 (en) 1997-09-17 2009-12-08 Strategic Science & Technologies, Llc Topical delivery of L-arginine to cause beneficial effects
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
AU2005235309B2 (en) 2004-04-19 2012-07-26 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
EP2445493A1 (de) 2009-06-24 2012-05-02 Strategic Science & Technologies, LLC Topische zusammensetzung mit naproxen
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
NZ597542A (en) 2009-06-24 2014-01-31 Strategic Science & Tech Llc Topical composition containing ibuprofen
US12138268B2 (en) 2009-06-24 2024-11-12 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
US9289495B2 (en) 2010-12-29 2016-03-22 Strategic Science & Technologies, Llc Systems and methods for treatment of allergies and other indications
EP2658551B1 (de) 2010-12-29 2020-07-01 Strategic Science & Technologies, LLC Behandlung von erektionsstörungen und anderen indikationen
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
HU230149B1 (hu) * 2012-11-21 2015-09-28 Richter Gedeon Nyrt. Új eljárás triklór-pirimidin-amin származékok előállítására
SG10202002705YA (en) * 2014-10-29 2020-05-28 Samson Clinical Pty Ltd Detection and treatment of excessive hair shedding
CN109485608B (zh) * 2018-12-24 2020-09-22 大连大学 一种4,6-二氯-5-氟-2-氨基嘧啶工业化生产方法
WO2024262969A1 (ko) * 2023-06-20 2024-12-26 주식회사 아이코어바이오 탈모 치료 성분이 고정화된 신규한 구조를 가지는 화합물 및 이의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3382248A (en) * 1965-11-01 1968-05-07 Upjohn Co 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines
US3464987A (en) * 1966-02-21 1969-09-02 Upjohn Co 1,2-dihydro-1-hydroxy-2-imino-6-(lower alkyl)pyrimidines
US3644364A (en) * 1970-03-31 1972-02-22 Upjohn Co Compounds and process
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4596812A (en) * 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
US4287338A (en) * 1980-03-10 1981-09-01 The Upjohn Company Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
BG94957A (bg) * 1990-08-10 1993-12-24 Ciba - Geigy Ag Пиримидинови производни и средство за борба срещу вредители по растенията

Also Published As

Publication number Publication date
JPH06501947A (ja) 1994-03-03
ES2070513T3 (es) 1995-06-01
ATE120190T1 (de) 1995-04-15
EP0557301A1 (de) 1993-09-01
US5373012A (en) 1994-12-13
AU8720691A (en) 1992-06-11
CA2092811A1 (en) 1992-05-15
WO1992008705A1 (en) 1992-05-29
AU651630B2 (en) 1994-07-28
DK0557301T3 (da) 1995-07-24
EP0557301B1 (de) 1995-03-22
DE69108402T2 (de) 1995-10-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee