DE69027300D1 - 1,2-dihydro-2-oxoquinoxalinderivate, deren herstellung und verwendung in der therapie - Google Patents
1,2-dihydro-2-oxoquinoxalinderivate, deren herstellung und verwendung in der therapieInfo
- Publication number
- DE69027300D1 DE69027300D1 DE69027300T DE69027300T DE69027300D1 DE 69027300 D1 DE69027300 D1 DE 69027300D1 DE 69027300 T DE69027300 T DE 69027300T DE 69027300 T DE69027300 T DE 69027300T DE 69027300 D1 DE69027300 D1 DE 69027300D1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- group
- alkyl
- branched
- straight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical class C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8913961A FR2653430B1 (fr) | 1989-10-23 | 1989-10-23 | Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique. |
| PCT/FR1990/000752 WO1991005772A1 (fr) | 1989-10-23 | 1990-10-17 | Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69027300D1 true DE69027300D1 (de) | 1996-07-11 |
| DE69027300T2 DE69027300T2 (de) | 1997-01-23 |
Family
ID=9386749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69027300T Expired - Fee Related DE69027300T2 (de) | 1989-10-23 | 1990-10-17 | 1,2-dihydro-2-oxoquinoxalinderivate, deren herstellung und verwendung in der therapie |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5198441A (de) |
| EP (1) | EP0450039B1 (de) |
| JP (1) | JPH04502475A (de) |
| AT (1) | ATE138915T1 (de) |
| DE (1) | DE69027300T2 (de) |
| DK (1) | DK0450039T3 (de) |
| ES (1) | ES2087917T3 (de) |
| FR (1) | FR2653430B1 (de) |
| GR (1) | GR3020392T3 (de) |
| WO (1) | WO1991005772A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2696456B1 (fr) * | 1992-10-07 | 1995-01-06 | Pf Medicament | Dérivés de dihydro-1,2 oxo amino-3 quinoxalines, leur préparation et leur application en thérapeutique. |
| US6690251B2 (en) * | 2001-04-11 | 2004-02-10 | Kyocera Wireless Corporation | Tunable ferro-electric filter |
| KR101637387B1 (ko) * | 2008-03-05 | 2016-07-07 | 메르크 파텐트 게엠베하 | 인슐린 분비 자극제들로서의 퀴녹살리논 유도체들, 이들을 얻기 위한 방법들 및 당뇨병 치료를 위한 이들의 용도 |
| PT3394046T (pt) | 2015-12-24 | 2022-04-05 | Univ California | Reguladores de cftr e seus métodos de uso |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA728649A (en) * | 1966-02-22 | Donau-Pharmazie Gesellschaft M.B.H. | Dihydroquinoxalone-(2) derivatives and process of preparing same | |
| CH624395A5 (de) * | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag | |
| US4181724A (en) * | 1978-09-11 | 1980-01-01 | The Upjohn Company | Quinoxalinone compounds useful for expanding the lumina or air passages in mammals |
| DE3047811A1 (de) * | 1979-12-28 | 1981-10-29 | Medichemie AG, 4107 Ettingen | "pharmazeutische verwendung von caroverin und/oder caroverinsalzen sowie caroverinsalze mit xanthinderivat-saeureresten und nicotinsaeurerest |
| JPS572277A (en) * | 1980-06-07 | 1982-01-07 | Nissan Chem Ind Ltd | Quinoxalinone derivative, its preparation, and fungicide for agricultural and horticultural use |
| JPS62198671A (ja) * | 1986-02-25 | 1987-09-02 | Toyo Jozo Co Ltd | １−置換アルキル１，２−ジヒドロ−２−ピラジノン誘導体 |
| US5034537A (en) * | 1988-09-23 | 1991-07-23 | Smithkline Beecham Corporation | Leukotriene antagonists |
-
1989
- 1989-10-23 FR FR8913961A patent/FR2653430B1/fr not_active Expired - Fee Related
-
1990
- 1990-10-17 US US07/688,536 patent/US5198441A/en not_active Expired - Fee Related
- 1990-10-17 DE DE69027300T patent/DE69027300T2/de not_active Expired - Fee Related
- 1990-10-17 DK DK90916034.3T patent/DK0450039T3/da active
- 1990-10-17 JP JP2514792A patent/JPH04502475A/ja active Pending
- 1990-10-17 AT AT90916034T patent/ATE138915T1/de not_active IP Right Cessation
- 1990-10-17 EP EP90916034A patent/EP0450039B1/de not_active Expired - Lifetime
- 1990-10-17 WO PCT/FR1990/000752 patent/WO1991005772A1/fr not_active Ceased
- 1990-10-17 ES ES90916034T patent/ES2087917T3/es not_active Expired - Lifetime
-
1996
- 1996-06-28 GR GR960401761T patent/GR3020392T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2653430A1 (fr) | 1991-04-26 |
| JPH04502475A (ja) | 1992-05-07 |
| EP0450039B1 (de) | 1996-06-05 |
| US5198441A (en) | 1993-03-30 |
| DE69027300T2 (de) | 1997-01-23 |
| WO1991005772A1 (fr) | 1991-05-02 |
| ES2087917T3 (es) | 1996-08-01 |
| GR3020392T3 (en) | 1996-09-30 |
| EP0450039A1 (de) | 1991-10-09 |
| DK0450039T3 (da) | 1996-10-07 |
| FR2653430B1 (fr) | 1991-12-20 |
| ATE138915T1 (de) | 1996-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |