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DE69942124D1 - Tandemflugzeitmassenspektrometer - Google Patents

Tandemflugzeitmassenspektrometer

Info

Publication number
DE69942124D1
DE69942124D1 DE69942124T DE69942124T DE69942124D1 DE 69942124 D1 DE69942124 D1 DE 69942124D1 DE 69942124 T DE69942124 T DE 69942124T DE 69942124 T DE69942124 T DE 69942124T DE 69942124 D1 DE69942124 D1 DE 69942124D1
Authority
DE
Germany
Prior art keywords
ions
ion
deflector
subset
downstream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69942124T
Other languages
English (en)
Inventor
Douglas E Barofsky
Per Hakansson
Daniel L Katz
C K Piyadasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oregon
Oregon State
Original Assignee
University of Oregon
Oregon State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oregon, Oregon State filed Critical University of Oregon
Application granted granted Critical
Publication of DE69942124D1 publication Critical patent/DE69942124D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/06Electron- or ion-optical arrangements
    • H01J49/061Ion deflecting means, e.g. ion gates
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/40Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE69942124T 1998-09-25 1999-09-24 Tandemflugzeitmassenspektrometer Expired - Lifetime DE69942124D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10185298P 1998-09-25 1998-09-25
PCT/US1999/022275 WO2000018496A1 (en) 1998-09-25 1999-09-24 Tandem time-of-flight mass spectrometer

Publications (1)

Publication Number Publication Date
DE69942124D1 true DE69942124D1 (de) 2010-04-22

Family

ID=22286767

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69942124T Expired - Lifetime DE69942124D1 (de) 1998-09-25 1999-09-24 Tandemflugzeitmassenspektrometer

Country Status (7)

Country Link
US (1) US6489610B1 (de)
EP (1) EP1124624B1 (de)
JP (1) JP4540230B2 (de)
AT (1) ATE460744T1 (de)
AU (1) AU6265799A (de)
DE (1) DE69942124D1 (de)
WO (1) WO2000018496A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2361806B (en) * 2000-03-13 2005-06-08 Univ Warwick Time of flight mass spectrometry apparatus
GB0006046D0 (en) * 2000-03-13 2000-05-03 Univ Warwick Time of flight mass spectrometry apparatus
GB2406436B (en) * 2000-03-13 2005-06-08 Univ Warwick Time of flight mass spectrometry apparatus
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6717133B2 (en) * 2001-06-13 2004-04-06 Agilent Technologies, Inc. Grating pattern and arrangement for mass spectrometers
CA2391140C (en) * 2001-06-25 2008-10-07 Micromass Limited Mass spectrometer
US6762404B2 (en) * 2001-06-25 2004-07-13 Micromass Uk Limited Mass spectrometer
US6717135B2 (en) * 2001-10-12 2004-04-06 Agilent Technologies, Inc. Ion mirror for time-of-flight mass spectrometer
DE10150559C2 (de) * 2001-10-15 2003-10-30 Bruker Daltonik Gmbh Verfahren zur Aufnahme von untergrundfreien Fragmentionen-Flugzeitspektren und Flugzeitmassenspektrometer
WO2003079116A1 (en) * 2002-03-19 2003-09-25 Mapper Lithography Ip B.V. Direct write lithography system
US6794641B2 (en) 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
US7095013B2 (en) * 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
US6800846B2 (en) 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6884995B2 (en) * 2002-07-03 2005-04-26 Micromass Uk Limited Mass spectrometer
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7071467B2 (en) * 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
US20040128081A1 (en) * 2002-12-18 2004-07-01 Herschel Rabitz Quantum dynamic discriminator for molecular agents
US7041968B2 (en) * 2003-03-20 2006-05-09 Science & Technology Corporation @ Unm Distance of flight spectrometer for MS and simultaneous scanless MS/MS
US7462821B2 (en) * 2003-04-25 2008-12-09 Griffin Analytical Technologies, L.L.C. Instrumentation, articles of manufacture, and analysis methods
GB0312940D0 (en) * 2003-06-05 2003-07-09 Shimadzu Res Lab Europe Ltd A method for obtaining high accuracy mass spectra using an ion trap mass analyser and a method for determining and/or reducing chemical shift in mass analysis
US7048154B2 (en) * 2004-03-20 2006-05-23 Phillips Edward W Breathable rupturable closure for a flexible container
GB0408235D0 (en) * 2004-04-13 2004-05-19 Kratos Analytical Ltd Ion selector
US20070258861A1 (en) 2004-06-15 2007-11-08 Barket Dennis Jr Analytical Instruments, Assemblies, and Methods
JP4688504B2 (ja) * 2005-01-11 2011-05-25 日本電子株式会社 タンデム飛行時間型質量分析装置
US7439520B2 (en) * 2005-01-24 2008-10-21 Applied Biosystems Inc. Ion optics systems
US7351958B2 (en) * 2005-01-24 2008-04-01 Applera Corporation Ion optics systems
US20060271305A1 (en) * 2005-02-25 2006-11-30 The Trustees Of Princeton University Optimal dynamic discrimination of similar molecular scale systems using functional data
GB2439261B (en) * 2005-04-25 2011-02-23 Griffin Analytical Technologies Llc Analytical apparatuses and methods
US7265368B2 (en) * 2005-05-13 2007-09-04 Applera Corporation Ion optical mounting assemblies
JP4864501B2 (ja) * 2005-06-28 2012-02-01 富士通株式会社 3次元アトムレベル構造観察装置
JP4982087B2 (ja) * 2006-02-08 2012-07-25 株式会社日立製作所 質量分析装置及び質量分析方法
JP4627744B2 (ja) * 2006-05-29 2011-02-09 株式会社日立ハイテクノロジーズ 飛行時間型質量分析計
GB0612503D0 (en) * 2006-06-23 2006-08-02 Micromass Ltd Mass spectrometer
US8233569B2 (en) * 2006-09-28 2012-07-31 Tektronix, Inc. Realtime spectrum trigger system on realtime oscilloscope
DE102007049640B3 (de) * 2007-10-17 2009-04-02 Bruker Daltonik Gmbh Messung von Tochterionenspektren aus einer MALDI-Ionisierung
TWI479570B (zh) * 2007-12-26 2015-04-01 奈華科技有限公司 從樣本移除材料之方法及系統
GB2454962B (en) * 2008-07-25 2009-10-28 Kratos Analytical Ltd Method and apparatus for ion axial spatial distribution focusing
US8026475B2 (en) * 2008-08-19 2011-09-27 Thermo Finnigan Llc Method and apparatus for a dual gate for a mass spectrometer
US8674292B2 (en) 2010-12-14 2014-03-18 Virgin Instruments Corporation Reflector time-of-flight mass spectrometry with simultaneous space and velocity focusing
US8847155B2 (en) * 2009-08-27 2014-09-30 Virgin Instruments Corporation Tandem time-of-flight mass spectrometry with simultaneous space and velocity focusing
US8461521B2 (en) 2010-12-14 2013-06-11 Virgin Instruments Corporation Linear time-of-flight mass spectrometry with simultaneous space and velocity focusing
US20110049350A1 (en) * 2009-08-27 2011-03-03 Virgin Instruments Corporation Tandem TOF Mass Spectrometer With Pulsed Accelerator To Reduce Velocity Spread
FR2953931B1 (fr) * 2009-12-15 2012-02-17 Univ Claude Bernard Lyon Procede d'analyse a temps de vol en tandem et appareil d'analyse en faisant application
US8399828B2 (en) * 2009-12-31 2013-03-19 Virgin Instruments Corporation Merged ion beam tandem TOF-TOF mass spectrometer
WO2011123477A1 (en) * 2010-03-29 2011-10-06 Glenn Lane Spatial segregation of plasma components
WO2011127091A1 (en) 2010-04-05 2011-10-13 Indiana University Research And Technology Corporation Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry
DE102011017084B4 (de) * 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US8642951B2 (en) 2011-05-04 2014-02-04 Agilent Technologies, Inc. Device, system, and method for reflecting ions
CN103858205B (zh) * 2011-10-03 2016-10-12 株式会社岛津制作所 飞行时间型质量分析装置
WO2013106759A1 (en) * 2012-01-12 2013-07-18 Old Dominion University Research Foundation Processing device using multicharged ions
US9236231B2 (en) * 2012-05-18 2016-01-12 Dh Technologies Development Pte. Ltd. Modulation of instrument resolution dependant upon the complexity of a previous scan
US8735810B1 (en) 2013-03-15 2014-05-27 Virgin Instruments Corporation Time-of-flight mass spectrometer with ion source and ion detector electrically connected
EP2973663B1 (de) 2013-03-15 2018-04-18 Glenn Lane Family Limited Liability Limited Partnership Einstellbare massenauflösungsapertur
US9310335B2 (en) * 2013-06-27 2016-04-12 Implant Sciences Corporation Dual polarity spark ion source
US9543138B2 (en) 2013-08-19 2017-01-10 Virgin Instruments Corporation Ion optical system for MALDI-TOF mass spectrometer
US9029763B2 (en) 2013-08-30 2015-05-12 Agilent Technologies, Inc. Ion deflection in time-of-flight mass spectrometry
CA2932378A1 (en) * 2013-12-24 2015-07-02 Dh Technologies Development Pte. Ltd. High speed polarity switch time-of-flight spectrometer
WO2016042578A2 (en) * 2014-09-19 2016-03-24 Indian Institute Of Technology Delhi A system and method for detecting or identifying the substances and their composition
GB201507363D0 (en) 2015-04-30 2015-06-17 Micromass Uk Ltd And Leco Corp Multi-reflecting TOF mass spectrometer
GB201520130D0 (en) 2015-11-16 2015-12-30 Micromass Uk Ltd And Leco Corp Imaging mass spectrometer
GB201520134D0 (en) 2015-11-16 2015-12-30 Micromass Uk Ltd And Leco Corp Imaging mass spectrometer
GB201520540D0 (en) 2015-11-23 2016-01-06 Micromass Uk Ltd And Leco Corp Improved ion mirror and ion-optical lens for imaging
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
CN107768217A (zh) * 2016-08-18 2018-03-06 孙保胜 自分离离子源
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
US11295944B2 (en) 2017-08-06 2022-04-05 Micromass Uk Limited Printed circuit ion mirror with compensation
US11239067B2 (en) 2017-08-06 2022-02-01 Micromass Uk Limited Ion mirror for multi-reflecting mass spectrometers
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
WO2019030477A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov ACCELERATOR FOR MASS SPECTROMETERS WITH MULTIPASSES
WO2019030475A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov MASS SPECTROMETER WITH MULTIPASSAGE
CN111164731B (zh) 2017-08-06 2022-11-18 英国质谱公司 进入多通道质谱分析仪的离子注入
CN109884261A (zh) * 2017-12-06 2019-06-14 中国科学院大连化学物理研究所 一种基于挥发物成分判别绿茶香型判别的装置和方法
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
KR102088824B1 (ko) * 2018-08-21 2020-03-17 한국기초과학지원연구원 비행시간 질량분석기 및 그의 구동 방법
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
GB201903779D0 (en) 2019-03-20 2019-05-01 Micromass Ltd Multiplexed time of flight mass spectrometer
CN113130289B (zh) * 2019-12-30 2024-07-05 昆山禾信质谱技术有限公司 电压悬浮控制装置、控制方法及飞行时间质谱仪
JP7352755B2 (ja) * 2020-11-12 2023-09-28 シャープ株式会社 分析装置
TWI797747B (zh) * 2021-09-10 2023-04-01 研能科技股份有限公司 微型氣體偵測系統

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737637A (en) * 1986-10-15 1988-04-12 Hughes Aircraft Company Mass separator for ionized cluster beam
JPH03503815A (ja) * 1987-12-24 1991-08-22 ユニサーチ リミテッド 質量分析計
DE3920566A1 (de) * 1989-06-23 1991-01-10 Bruker Franzen Analytik Gmbh Ms-ms-flugzeit-massenspektrometer
US5073713A (en) * 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
US5160840A (en) * 1991-10-25 1992-11-03 Vestal Marvin L Time-of-flight analyzer and method
US5464985A (en) 1993-10-01 1995-11-07 The Johns Hopkins University Non-linear field reflectron
US5614711A (en) * 1995-05-04 1997-03-25 Indiana University Foundation Time-of-flight mass spectrometer
US5654545A (en) 1995-09-19 1997-08-05 Bruker-Franzen Analytik Gmbh Mass resolution in time-of-flight mass spectrometers with reflectors
US5986258A (en) 1995-10-25 1999-11-16 Bruker Daltonics, Inc. Extended Bradbury-Nielson gate
US5753909A (en) 1995-11-17 1998-05-19 Bruker Analytical Systems, Inc. High resolution postselector for time-of-flight mass spectrometery
US5696375A (en) * 1995-11-17 1997-12-09 Bruker Analytical Instruments, Inc. Multideflector
US5821534A (en) * 1995-11-22 1998-10-13 Bruker Analytical Instruments, Inc. Deflection based daughter ion selector
US5869829A (en) * 1996-07-03 1999-02-09 Analytica Of Branford, Inc. Time-of-flight mass spectrometer with first and second order longitudinal focusing
DE19635643C2 (de) * 1996-09-03 2001-03-15 Bruker Daltonik Gmbh Verfahren zur Spektrenaufnahme und lineares Flugzeitmassenspektrometer dafür
US6080985A (en) * 1997-09-30 2000-06-27 The Perkin-Elmer Corporation Ion source and accelerator for improved dynamic range and mass selection in a time of flight mass spectrometer

Also Published As

Publication number Publication date
JP4540230B2 (ja) 2010-09-08
JP2002529887A (ja) 2002-09-10
EP1124624A4 (de) 2005-12-28
EP1124624A1 (de) 2001-08-22
AU6265799A (en) 2000-04-17
ATE460744T1 (de) 2010-03-15
EP1124624B1 (de) 2010-03-10
US6489610B1 (en) 2002-12-03
WO2000018496A1 (en) 2000-04-06

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