DE69923744D1 - 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten - Google Patents
1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor AgonistenInfo
- Publication number
- DE69923744D1 DE69923744D1 DE69923744T DE69923744T DE69923744D1 DE 69923744 D1 DE69923744 D1 DE 69923744D1 DE 69923744 T DE69923744 T DE 69923744T DE 69923744 T DE69923744 T DE 69923744T DE 69923744 D1 DE69923744 D1 DE 69923744D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- orl1
- compounds
- receptor agonists
- decanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010020615 nociceptin receptor Proteins 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title abstract 2
- 229940044601 receptor agonist Drugs 0.000 title abstract 2
- JDPQWHLMBJZURR-UHFFFAOYSA-N decan-5-one Chemical class CCCCCC(=O)CCCC JDPQWHLMBJZURR-UHFFFAOYSA-N 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/IB98/01702 | 1998-10-23 | ||
| IBPCT/IB98/01702 | 1998-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69923744D1 true DE69923744D1 (de) | 2005-03-24 |
| DE69923744T2 DE69923744T2 (de) | 2006-02-23 |
Family
ID=11004769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69923744T Expired - Fee Related DE69923744T2 (de) | 1998-10-23 | 1999-10-07 | 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6465478B1 (de) |
| EP (1) | EP0997464B1 (de) |
| JP (1) | JP3436509B2 (de) |
| AT (1) | ATE289307T1 (de) |
| BR (1) | BR9904962A (de) |
| CA (1) | CA2287054C (de) |
| DE (1) | DE69923744T2 (de) |
| ES (1) | ES2237047T3 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| EP1537110B1 (de) * | 1999-12-06 | 2007-01-17 | Euro-Celtique, S.A. | Triazospiroverbindungen mit nociceptin-rezeptoraffinität |
| CA2443868C (en) | 2001-04-10 | 2011-01-25 | Ortho-Mcneil Pharmaceutical, Inc. | 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
| DE60226874D1 (de) | 2001-07-23 | 2008-07-10 | Banyu Pharma Co Ltd | 4-oxoimidazolidin-2-spiro piperidin derivat |
| DK1491212T3 (da) | 2002-03-29 | 2012-10-29 | Mitsubishi Tanabe Pharma Corp | Middel til behandling af søvnforstyrrelser |
| EP1601674B1 (de) | 2002-09-09 | 2012-08-08 | Janssen Pharmaceutica NV | Hydroxyalkylsubstituierte 1,3,8-Triazaspiro[4.5]decan-4-on-Derivate zur Verwendung bei der Behandlung von Krankheiten, die mit dem ORL-1-Rezeptor in Zusammenhang stehen |
| JP4500509B2 (ja) * | 2002-09-10 | 2010-07-14 | 富士フイルム株式会社 | アゾ化合物の製造方法 |
| AU2004241134A1 (en) * | 2003-05-23 | 2004-12-02 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| ITMI20031349A1 (it) * | 2003-07-01 | 2005-01-02 | Ufpeptides S R L | Antagonisti del recettore nop e loro usi terapeutici. |
| AR046756A1 (es) * | 2003-12-12 | 2005-12-21 | Solvay Pharm Gmbh | Derivados de hidronopol como agonistas de receptores orl-1 humanos. |
| US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| CN101622254B (zh) | 2006-11-28 | 2013-05-29 | 詹森药业有限公司 | 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐 |
| CN101679430B (zh) * | 2007-04-09 | 2013-12-25 | 詹森药业有限公司 | 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物 |
| BR112023022050A2 (pt) * | 2021-05-03 | 2023-12-26 | Jazz Pharmaceuticals Ireland Ltd | Agonistas do receptor de orexina e usos destes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633914A (de) * | 1962-06-22 | |||
| US4051248A (en) * | 1975-07-14 | 1977-09-27 | E. R. Squibb & Sons, Inc. | 1,3,8-triazaspiro(4.5)decan-4-one derivatives |
| CA2226058C (en) * | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
| DK0921125T3 (da) * | 1997-12-05 | 2002-05-13 | Hoffmann La Roche | 1,3,8-triazaspiro[4.5]decan-4-on-derivater |
| EP0921125B1 (de) * | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on-derivate |
| ATE219772T1 (de) * | 1998-01-19 | 2002-07-15 | Pfizer | 4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste |
| AU3809999A (en) * | 1998-05-18 | 1999-12-06 | Novo Nordisk A/S | Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
| EP0963985B1 (de) * | 1998-06-12 | 2003-03-12 | F. Hoffmann-La Roche Ag | Di- oder Triazaspiro[4,5]decanderivate |
-
1999
- 1999-10-07 ES ES99307892T patent/ES2237047T3/es not_active Expired - Lifetime
- 1999-10-07 EP EP99307892A patent/EP0997464B1/de not_active Expired - Lifetime
- 1999-10-07 AT AT99307892T patent/ATE289307T1/de not_active IP Right Cessation
- 1999-10-07 DE DE69923744T patent/DE69923744T2/de not_active Expired - Fee Related
- 1999-10-19 JP JP29621199A patent/JP3436509B2/ja not_active Expired - Fee Related
- 1999-10-21 CA CA002287054A patent/CA2287054C/en not_active Expired - Fee Related
- 1999-10-22 US US09/426,824 patent/US6465478B1/en not_active Expired - Fee Related
- 1999-10-22 BR BR9904962-7A patent/BR9904962A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2287054A1 (en) | 2000-04-23 |
| CA2287054C (en) | 2003-04-22 |
| JP3436509B2 (ja) | 2003-08-11 |
| EP0997464A1 (de) | 2000-05-03 |
| JP2000128879A (ja) | 2000-05-09 |
| EP0997464B1 (de) | 2005-02-16 |
| DE69923744T2 (de) | 2006-02-23 |
| BR9904962A (pt) | 2000-08-08 |
| ATE289307T1 (de) | 2005-03-15 |
| US6465478B1 (en) | 2002-10-15 |
| ES2237047T3 (es) | 2005-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |