DE69923464D1 - Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems - Google Patents

Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems

Info

Publication number: DE69923464D1
Authority: DE; Germany
Prior art keywords: disorders; treatment; combination; nervous system; beta blockers
Prior art date: 1998-09-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69923464T

Other languages

English (en)

Other versions

DE69923464T2 (de

Inventor

Klaus Wirth

Christian Englert

Helmut Bohn

Heinz Goegelein

Holger Heitsch

Uwe Gerlach

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis Deutschland GmbH

Original Assignee

Aventis Pharma Deutschland GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-10

Filing date

1999-09-02

Publication date

2005-03-03

1998-09-10 Priority claimed from DE1998141534 external-priority patent/DE19841534A1/de

1999-01-14 Priority claimed from DE1999101061 external-priority patent/DE19901061A1/de

1999-09-02 Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH

1999-09-02 Priority to DE69923464T priority Critical patent/DE69923464T2/de

2005-03-03 Application granted granted Critical

2005-03-03 Publication of DE69923464D1 publication Critical patent/DE69923464D1/de

2006-05-11 Publication of DE69923464T2 publication Critical patent/DE69923464T2/de

2019-09-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/54—Silicon-containing compounds
- C08K5/5406—Silicon-containing compounds containing elements other than oxygen or nitrogen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Polymers & Plastics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69923464T 1998-09-10 1999-09-02 Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems Expired - Lifetime DE69923464T2 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE69923464T DE69923464T2 (de)	1998-09-10	1999-09-02	Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DE1998141534 DE19841534A1 (de)	1998-09-10	1998-09-10	Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung und Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern
DE19841534		1998-09-10
DE1999101061 DE19901061A1 (de)	1999-01-14	1999-01-14	Verwendung von Benzolsulfonyl(thio)harnstoffen zur Behandlung von Prophylaxe von Dysfunktionen des autonomen Nervensystems und Verwendung von Benzolsulfonyl(thio)harnstoffen in Kombination mit Betarezeptoren-Blockern
DE19901061		1999-01-14
DE69923464T DE69923464T2 (de)	1998-09-10	1999-09-02	Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems
PCT/EP1999/006450 WO2000015204A2 (en)	1998-09-10	1999-09-02	Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers

Publications (2)

Publication Number	Publication Date
DE69923464D1 true DE69923464D1 (de)	2005-03-03
DE69923464T2 DE69923464T2 (de)	2006-05-11

Family

ID=26048790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69923464T Expired - Lifetime DE69923464T2 (de)	1998-09-10	1999-09-02	Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems

Country Status (27)

Country	Link
US (1)	US6414030B1 (de)
EP (1)	EP1117409B1 (de)
JP (1)	JP4733268B2 (de)
KR (1)	KR100981592B1 (de)
CN (1)	CN1195524C (de)
AR (1)	AR020411A1 (de)
AT (1)	ATE287718T1 (de)
AU (1)	AU762832B2 (de)
BR (1)	BR9913572A (de)
CA (1)	CA2343009C (de)
CZ (1)	CZ301165B6 (de)
DE (1)	DE69923464T2 (de)
DK (1)	DK1117409T3 (de)
ES (1)	ES2235507T3 (de)
HK (1)	HK1040187B (de)
HU (1)	HU228988B1 (de)
ID (1)	ID28854A (de)
IL (2)	IL141414A0 (de)
MY (1)	MY121798A (de)
NO (1)	NO330215B1 (de)
NZ (1)	NZ510424A (de)
PL (1)	PL194986B1 (de)
PT (1)	PT1117409E (de)
RU (1)	RU2247562C2 (de)
TR (1)	TR200100692T2 (de)
TW (1)	TWI238817B (de)
WO (1)	WO2000015204A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19917233A1 (de) *	1999-04-16	2000-10-19	Aventis Pharma Gmbh	Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids
DE19923086A1 (de)	1999-05-20	2000-11-23	Aventis Pharma Gmbh	Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US7620611B1 (en) *	1999-07-20	2009-11-17	Trilithic, Inc.	Neural networks for ingress monitoring
DE10054482A1 (de)	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054481A1 (de)	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10129704A1 (de) *	2001-06-22	2003-01-02	Aventis Pharma Gmbh	Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
CN1330630C (zh) *	2004-03-10	2007-08-08	中国药科大学	新的磺酰(硫)脲衍生物、其制备方法及含有它们的药物组合物
DE102004061017A1 (de)	2004-12-18	2006-06-22	Sanofi-Aventis Deutschland Gmbh	Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
KR101608702B1 (ko) *	2007-06-05	2016-04-04	사노피	디(헤테로)아릴사이클로헥산 유도체, 이들의 제조방법, 이들의 용도 및 이들을 포함하는 약제학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1185180B (de) *	1963-10-19	1965-01-14	Hoechst Ag	Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) *	1964-10-07	1975-03-13	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE3009047A1 (de)	1980-03-08	1981-09-24	C.H. Boehringer Sohn, 6507 Ingelheim	Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung
GB8716972D0 (en) *	1987-07-17	1987-08-26	Pfizer Ltd	Treatment of cardiac arrhythmias
DE59401361D1 (de)	1993-02-23	1997-02-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19505397A1 (de) *	1995-02-17	1996-08-22	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ZA961314B (en) *	1995-02-21	1996-08-27	Hoechst Ag	Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
EP0813530A1 (de)	1995-03-10	1997-12-29	Hoechst Marion Roussel, Inc.	Verfahren zur herstellung von 2,3-dihydrobenzofuranol derivaten
FR2746013B1 (fr)	1996-03-18	1998-05-29	Sanofi Sa	Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus

1999
- 1999-09-02 WO PCT/EP1999/006450 patent/WO2000015204A2/en not_active Ceased
- 1999-09-02 HK HK02101438.6A patent/HK1040187B/zh not_active IP Right Cessation
- 1999-09-02 RU RU2001109434/15A patent/RU2247562C2/ru not_active IP Right Cessation
- 1999-09-02 EP EP99944585A patent/EP1117409B1/de not_active Expired - Lifetime
- 1999-09-02 AU AU57444/99A patent/AU762832B2/en not_active Ceased
- 1999-09-02 TR TR2001/00692T patent/TR200100692T2/xx unknown
- 1999-09-02 ES ES99944585T patent/ES2235507T3/es not_active Expired - Lifetime
- 1999-09-02 CN CNB998107794A patent/CN1195524C/zh not_active Expired - Fee Related
- 1999-09-02 ID IDW20010566A patent/ID28854A/id unknown
- 1999-09-02 CZ CZ20010858A patent/CZ301165B6/cs not_active IP Right Cessation
- 1999-09-02 HU HU0103534A patent/HU228988B1/hu not_active IP Right Cessation
- 1999-09-02 KR KR1020017003067A patent/KR100981592B1/ko not_active Expired - Fee Related
- 1999-09-02 JP JP2000569788A patent/JP4733268B2/ja not_active Expired - Fee Related
- 1999-09-02 CA CA2343009A patent/CA2343009C/en not_active Expired - Fee Related
- 1999-09-02 BR BR9913572-8A patent/BR9913572A/pt not_active Application Discontinuation
- 1999-09-02 DK DK99944585T patent/DK1117409T3/da active
- 1999-09-02 PL PL347215A patent/PL194986B1/pl unknown
- 1999-09-02 NZ NZ510424A patent/NZ510424A/xx not_active IP Right Cessation
- 1999-09-02 PT PT99944585T patent/PT1117409E/pt unknown
- 1999-09-02 AT AT99944585T patent/ATE287718T1/de active
- 1999-09-02 DE DE69923464T patent/DE69923464T2/de not_active Expired - Lifetime
- 1999-09-02 IL IL14141499A patent/IL141414A0/xx active IP Right Grant
- 1999-09-08 AR ARP990104515A patent/AR020411A1/es not_active Application Discontinuation
- 1999-09-09 MY MYPI99003906A patent/MY121798A/en unknown
- 1999-11-25 TW TW088115446A patent/TWI238817B/zh not_active IP Right Cessation
2001
- 2001-02-13 IL IL141414A patent/IL141414A/en not_active IP Right Cessation
- 2001-03-05 NO NO20011117A patent/NO330215B1/no not_active IP Right Cessation
- 2001-11-09 US US09/986,626 patent/US6414030B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL347215A1 (en)	2002-03-25
EP1117409A2 (de)	2001-07-25
JP2002524497A (ja)	2002-08-06
US20020082300A1 (en)	2002-06-27
CN1195524C (zh)	2005-04-06
AU5744499A (en)	2000-04-03
ES2235507T3 (es)	2005-07-01
TR200100692T2 (tr)	2001-07-23
WO2000015204A2 (en)	2000-03-23
US6414030B1 (en)	2002-07-02
DK1117409T3 (da)	2005-05-30
CZ301165B6 (cs)	2009-11-25
IL141414A0 (en)	2002-03-10
NO20011117D0 (no)	2001-03-05
NO20011117L (no)	2001-05-02
HUP0103534A2 (hu)	2002-05-29
CA2343009A1 (en)	2000-03-23
HUP0103534A3 (en)	2003-09-29
RU2247562C2 (ru)	2005-03-10
PT1117409E (pt)	2005-04-29
CN1319014A (zh)	2001-10-24
KR20010086396A (ko)	2001-09-10
DE69923464T2 (de)	2006-05-11
IL141414A (en)	2006-07-05
ATE287718T1 (de)	2005-02-15
HK1040187B (zh)	2005-09-02
PL194986B1 (pl)	2007-07-31
NO330215B1 (no)	2011-03-07
NZ510424A (en)	2003-06-30
CZ2001858A3 (en)	2001-06-13
MY121798A (en)	2006-02-28
CA2343009C (en)	2011-03-15
WO2000015204A3 (en)	2000-07-13
BR9913572A (pt)	2001-05-22
HK1040187A1 (en)	2002-05-31
TWI238817B (en)	2005-09-01
EP1117409B1 (de)	2005-01-26
AR020411A1 (es)	2002-05-08
AU762832B2 (en)	2003-07-03
KR100981592B1 (ko)	2010-09-13
HU228988B1 (hu)	2013-07-29
ID28854A (id)	2001-07-05
JP4733268B2 (ja)	2011-07-27

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IS5113A (is)	1999-07-12	Notkun antagónista CB1-viðtaka til meðhöndlunar löngunartruflana
ATA76995A (de)	2002-04-15	Stabiles präparat zur behandlung von blutgerinnungsstörungen
ATE287718T1 (de)	2005-02-15	Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems
ID27214A (id)	2001-03-08	Triazolopiridina untuk pengobatan gangguan trombosis
EE200000391A (et)	2002-02-15	Triasiiniühendid kesknärvisüsteemihäirete raviks
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IS6098A (is)	2001-09-28	Ósantant til meðhöndlunar á skaptruflunum
NO984189D0 (no)	1998-09-11	Fremgangsmåte for behandling av bipolar forstyrrelse

Legal Events

Date	Code	Title	Description
2005-12-15	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,
2006-04-06	8364	No opposition during term of opposition