DE69917000T2 - Butorphanol enthaltende formulierungen mit verzögerter freisetzung - Google Patents
Butorphanol enthaltende formulierungen mit verzögerter freisetzung Download PDFInfo
- Publication number
- DE69917000T2 DE69917000T2 DE69917000T DE69917000T DE69917000T2 DE 69917000 T2 DE69917000 T2 DE 69917000T2 DE 69917000 T DE69917000 T DE 69917000T DE 69917000 T DE69917000 T DE 69917000T DE 69917000 T2 DE69917000 T2 DE 69917000T2
- Authority
- DE
- Germany
- Prior art keywords
- butorphanol
- delayed release
- containing formulations
- formulations
- freebase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000003111 delayed effect Effects 0.000 title 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 3
- 229960001113 butorphanol Drugs 0.000 abstract 2
- 230000036592 analgesia Effects 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012053 oil suspension Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3021798A | 1998-02-25 | 1998-02-25 | |
| PCT/US1999/004113 WO1999043300A1 (en) | 1998-02-25 | 1999-02-25 | Butorphanol sustained release formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69917000D1 DE69917000D1 (de) | 2004-06-09 |
| DE69917000T2 true DE69917000T2 (de) | 2005-04-21 |
Family
ID=21853121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69917000T Expired - Fee Related DE69917000T2 (de) | 1998-02-25 | 1999-02-25 | Butorphanol enthaltende formulierungen mit verzögerter freisetzung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6197344B1 (de) |
| EP (1) | EP1056443B1 (de) |
| JP (1) | JP2002504505A (de) |
| AT (1) | ATE265846T1 (de) |
| AU (1) | AU753278B2 (de) |
| CA (1) | CA2321924A1 (de) |
| DE (1) | DE69917000T2 (de) |
| WO (1) | WO1999043300A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6680067B2 (en) * | 2001-11-26 | 2004-01-20 | Oliver Yoa-Pu Hu | Controlled-release pharmaceutical preparation containing nalbuphine and a process for preparing the same |
| AU2003225837B2 (en) * | 2002-03-15 | 2008-11-06 | Forest Laboratories Holdings Limited | NE and 5-HT reuptake inhibitors for treating visceral pain syndromes |
| US20050020613A1 (en) * | 2002-09-20 | 2005-01-27 | Alpharma, Inc. | Sustained release opioid formulations and method of use |
| US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| US20040121010A1 (en) * | 2002-10-25 | 2004-06-24 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| EP1592453A1 (de) * | 2003-01-28 | 2005-11-09 | Collegium Pharmaceutical, Inc. | Multiparticulate aufbau von milnacipran für orale einnahme |
| RU2254852C1 (ru) * | 2004-01-23 | 2005-06-27 | Ефим Давыдович Нежинский | Раствор для инъекций, обладающий выраженным анальгетическим действием, и способ его получения |
| US20080227805A1 (en) * | 2007-02-28 | 2008-09-18 | Abbott Laboratories | Sustained release parenteral formulations of buprenorphine |
| US9364430B2 (en) * | 2010-10-29 | 2016-06-14 | Relmada Therapeutics, Inc. | Compositions of (-)-17-(cyclobutylmethyl)morphinan-3,14-diol |
| WO2016020901A1 (en) | 2014-08-07 | 2016-02-11 | Acerta Pharma B.V. | Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate |
| US11234974B2 (en) | 2015-05-28 | 2022-02-01 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
| CA2987378C (en) | 2015-05-28 | 2023-08-01 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
| US10183018B2 (en) | 2015-05-28 | 2019-01-22 | Lumosa Therapeutics Co., Ltd. | Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester |
| CN111904928A (zh) * | 2019-05-07 | 2020-11-10 | 江苏恒瑞医药股份有限公司 | 一种包含布托啡诺的可注射的药物组合物及其制备方法 |
| CN116818928B (zh) * | 2023-04-28 | 2024-04-19 | 杭州沐源生物医药科技有限公司 | 一种酒石酸布托啡诺注射液中杂质的分离检测方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788478A (fr) | 1971-09-08 | 1973-03-06 | Bristol Myers Co | Procede de preparation de composes analgesiques |
| CA1098444A (en) * | 1975-05-26 | 1981-03-31 | Leo Geller | Peptide preparations with prolonged action |
| US4338324A (en) * | 1981-03-17 | 1982-07-06 | Mcneilab, Inc. | Analgesic potentiation |
| US4322427A (en) | 1981-04-16 | 1982-03-30 | Bristol-Myers Company | Analgetic compositions and methods of use |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| DK175572B1 (da) * | 1987-07-24 | 2004-12-13 | Nexstar Pharmaceuticals Inc | Anvendelse af phospholipidkapsler til indkapsling af et opoid-analgetika |
| FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| GB9202464D0 (en) * | 1992-02-05 | 1992-03-18 | Danbiosyst Uk | Composition for nasal administration |
| GB9226905D0 (en) * | 1992-12-24 | 1993-02-17 | Wellcome Found | Pharmaceutical preparation |
| JP2596255Y2 (ja) | 1993-03-23 | 1999-06-07 | ナカミチ株式会社 | ディスク再生装置 |
| JPH10513471A (ja) | 1995-02-10 | 1998-12-22 | メドトロニック、インコーポレイテッド | 鎮痛薬投与のための方法と装置 |
| TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
-
1999
- 1999-02-25 CA CA002321924A patent/CA2321924A1/en not_active Abandoned
- 1999-02-25 WO PCT/US1999/004113 patent/WO1999043300A1/en not_active Ceased
- 1999-02-25 AT AT99936027T patent/ATE265846T1/de not_active IP Right Cessation
- 1999-02-25 JP JP2000533099A patent/JP2002504505A/ja active Pending
- 1999-02-25 DE DE69917000T patent/DE69917000T2/de not_active Expired - Fee Related
- 1999-02-25 EP EP99936027A patent/EP1056443B1/de not_active Expired - Lifetime
- 1999-02-25 AU AU33112/99A patent/AU753278B2/en not_active Ceased
- 1999-10-28 US US09/429,391 patent/US6197344B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1056443A1 (de) | 2000-12-06 |
| EP1056443B1 (de) | 2004-05-06 |
| AU753278B2 (en) | 2002-10-10 |
| WO1999043300A1 (en) | 1999-09-02 |
| AU3311299A (en) | 1999-09-15 |
| JP2002504505A (ja) | 2002-02-12 |
| US6197344B1 (en) | 2001-03-06 |
| DE69917000D1 (de) | 2004-06-09 |
| CA2321924A1 (en) | 1999-09-02 |
| ATE265846T1 (de) | 2004-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |