DE69917717D1 - C11-Carbamate von antibakteriellen Makroliden - Google Patents
C11-Carbamate von antibakteriellen MakrolidenInfo
- Publication number
- DE69917717D1 DE69917717D1 DE69917717T DE69917717T DE69917717D1 DE 69917717 D1 DE69917717 D1 DE 69917717D1 DE 69917717 T DE69917717 T DE 69917717T DE 69917717 T DE69917717 T DE 69917717T DE 69917717 D1 DE69917717 D1 DE 69917717D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- formula
- relates
- carbamates
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 229940041033 macrolides Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9707598P | 1998-08-19 | 1998-08-19 | |
| US97075P | 1998-08-19 | ||
| US10478598P | 1998-10-19 | 1998-10-19 | |
| US104785P | 1998-10-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69917717D1 true DE69917717D1 (de) | 2004-07-08 |
| DE69917717T2 DE69917717T2 (de) | 2004-09-23 |
Family
ID=26792507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69917717T Expired - Fee Related DE69917717T2 (de) | 1998-08-19 | 1999-07-29 | C11-Carbamate von antibakteriellen Makroliden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6043227A (de) |
| EP (1) | EP0984019B1 (de) |
| JP (1) | JP2000063397A (de) |
| AT (1) | ATE268337T1 (de) |
| BR (1) | BR9903737A (de) |
| CA (1) | CA2280328C (de) |
| DE (1) | DE69917717T2 (de) |
| DK (1) | DK0984019T3 (de) |
| ES (1) | ES2220008T3 (de) |
| PT (1) | PT984019E (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710033B1 (en) | 1996-08-14 | 2004-03-23 | Vanderbilt University | Methods and treatment of multiple sclerosis |
| US6890526B2 (en) | 1997-05-06 | 2005-05-10 | Vanderbilt University | Methods and reagents for the treatment of multiple sclerosis |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| CA2292359C (en) * | 1999-01-28 | 2004-09-28 | Pfizer Products Inc. | Novel azalides and methods of making same |
| CA2373117C (en) * | 1999-05-24 | 2006-02-28 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
| EP1101769A3 (de) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Stickstoff-enthaltend Erythromycin-Derivate |
| AU2001247629A1 (en) * | 2000-03-22 | 2001-10-03 | Thomas Jefferson University | Use of azithromycin for infections with leishmania |
| EP1483277A4 (de) | 2002-02-15 | 2007-10-03 | Merckle Gmbh | Konjugate biologisch aktiver verbindungen, verfahren zu deren herstellung und anwendung, formulierung und pharmazeutische anwendungen davon |
| NZ535355A (en) * | 2002-02-15 | 2007-09-28 | Merckle Gmbh | Antibiotic conjugates |
| US20040186063A1 (en) * | 2002-02-15 | 2004-09-23 | Hans-Jurgen Gutke | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| WO2003070173A2 (en) * | 2002-02-15 | 2003-08-28 | Sympore Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| BR0312634A (pt) | 2002-07-08 | 2005-05-10 | Pliva Istrazivacki Inst D O O | Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias |
| JP2005536488A (ja) * | 2002-07-08 | 2005-12-02 | プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー | 新規な非ステロイド抗炎症物質、組成物、およびその使用方法 |
| HRP20050002A2 (en) | 2002-07-08 | 2006-03-31 | Pliva-Istra�iva�ki institut d.o.o. | Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
| JP2009502838A (ja) * | 2005-07-26 | 2009-01-29 | メルクレ，ゲーエムベーハー | ピロリジンおよびインドリジン化合物のマクロライド接合体 |
| CN101423539B (zh) * | 2008-12-09 | 2011-04-27 | 山东大学 | 4″,11-二氨基甲酸酯阿奇霉素衍生物、制备方法及其药物组合物 |
| FR2995605B1 (fr) * | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| CN104844671B (zh) * | 2015-05-19 | 2017-07-04 | 山东大学 | 11‑o‑芳烷基氨基甲酸酯克拉霉素衍生物及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
| US4464527A (en) * | 1983-06-30 | 1984-08-07 | Pfizer Inc. | Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore |
| US4921839A (en) * | 1987-02-24 | 1990-05-01 | Beecham Group P.L.C. | Erythromycin a 11,12-carbonate 9-oxime derivatives |
| US5350839A (en) * | 1990-10-15 | 1994-09-27 | Taisho Pharmaceutical Co., Ltd. | 2'-position modified compound of erythromycin or its derivative |
| CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
| HRP930014A2 (en) * | 1993-01-08 | 1994-08-31 | Pliva Pharm & Chem Works | 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates |
| HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
| HN1998000074A (es) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
| HRP970714B1 (en) * | 1997-12-31 | 2003-08-31 | Pliva Pharm & Chem Works | Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
-
1999
- 1999-05-26 US US09/320,352 patent/US6043227A/en not_active Expired - Fee Related
- 1999-07-29 AT AT99306034T patent/ATE268337T1/de not_active IP Right Cessation
- 1999-07-29 ES ES99306034T patent/ES2220008T3/es not_active Expired - Lifetime
- 1999-07-29 DK DK99306034T patent/DK0984019T3/da active
- 1999-07-29 DE DE69917717T patent/DE69917717T2/de not_active Expired - Fee Related
- 1999-07-29 PT PT99306034T patent/PT984019E/pt unknown
- 1999-07-29 EP EP99306034A patent/EP0984019B1/de not_active Expired - Lifetime
- 1999-08-17 CA CA002280328A patent/CA2280328C/en not_active Expired - Fee Related
- 1999-08-18 BR BR9903737-8A patent/BR9903737A/pt not_active IP Right Cessation
- 1999-08-19 JP JP11232449A patent/JP2000063397A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69917717T2 (de) | 2004-09-23 |
| ATE268337T1 (de) | 2004-06-15 |
| PT984019E (pt) | 2004-08-31 |
| CA2280328A1 (en) | 2000-02-19 |
| ES2220008T3 (es) | 2004-12-01 |
| CA2280328C (en) | 2005-07-26 |
| BR9903737A (pt) | 2000-09-19 |
| EP0984019A1 (de) | 2000-03-08 |
| DK0984019T3 (da) | 2004-08-30 |
| JP2000063397A (ja) | 2000-02-29 |
| EP0984019B1 (de) | 2004-06-02 |
| US6043227A (en) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |