DE69915693D1 - 2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde - Google Patents

2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde

Info

Publication number: DE69915693D1
Authority: DE; Germany
Prior art keywords: heptide; diazabicyclo; medication; derivatives; preparation
Prior art date: 1998-12-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69915693T

Other languages

English (en)

Inventor

Alistair Lochead

Samir Jegham

Alain Nedelec

Jean Jeunesse

Frederic Galli

Luc Even

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-04

Filing date

1999-12-01

Publication date

2004-04-22

1999-12-01 Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA

2004-04-22 Application granted granted Critical

2004-04-22 Publication of DE69915693D1 publication Critical patent/DE69915693D1/de

2019-12-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE69915693T 1998-12-04 1999-12-01 2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde Expired - Lifetime DE69915693D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9815325A FR2786769B1 (fr)	1998-12-04	1998-12-04	Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
PCT/FR1999/002974 WO2000034284A1 (fr)	1998-12-04	1999-12-01	Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
DE69915693D1 true DE69915693D1 (de)	2004-04-22

Family

ID=9533581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69915693T Expired - Lifetime DE69915693D1 (de)	1998-12-04	1999-12-01	2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde

Country Status (9)

Country	Link
US (1)	US6635645B1 (de)
EP (1)	EP1144413B1 (de)
JP (1)	JP2002531568A (de)
AR (1)	AR021533A1 (de)
AT (1)	ATE261972T1 (de)
AU (1)	AU1392900A (de)
DE (1)	DE69915693D1 (de)
FR (1)	FR2786769B1 (de)
WO (1)	WO2000034284A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7265115B2 (en) *	1999-01-29	2007-09-04	Abbott Laboratories	Diazabicyclic CNS active agents
PT1147112E (pt) *	1999-01-29	2004-03-31	Abbott Lab	Derivados diazabiciclicos como liganos nicotinicos do receptor de acetilcolina
EP1177196B1 (de)	1999-05-04	2004-03-10	Neurosearch A/S	Heteroaryl diazabicycloalkene, deren herstellung und verwendung
FR2804430B1 (fr) *	2000-01-28	2002-03-22	Sanofi Synthelabo	Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
US6809105B2 (en)	2000-04-27	2004-10-26	Abbott Laboratories	Diazabicyclic central nervous system active agents
MY137020A (en) *	2000-04-27	2008-12-31	Abbott Lab	Diazabicyclic central nervous system active agents
CN1195756C (zh)	2000-05-25	2005-04-06	塔加西普特公司	作为烟碱性胆碱能受体配体的杂芳基二氮杂二环烷类
US6552015B2 (en) *	2000-08-03	2003-04-22	Pfizer Inc.	Azabicycloalkane derivatives and therapeutic uses thereof
CN1331864C (zh)	2001-03-02	2007-08-15	神经研究公司	新型2,5－二氮杂二环[2.2.1]庚烷衍生物
FR2834511B1 (fr) *	2002-01-07	2004-02-13	Sanofi Synthelabo	Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
WO2003094831A2 (en) *	2002-05-07	2003-11-20	Neurosearch A/S	Novel diazabicyclic biaryl derivatives
US7238715B2 (en) *	2002-12-06	2007-07-03	The Feinstein Institute For Medical Research	Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
WO2004052365A2 (en) *	2002-12-06	2004-06-24	North Shore-Long Island Jewish Research Institute	Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists
GB0311201D0 (en) *	2003-05-15	2003-06-18	Merck Sharp & Dohme	Therapeutic agents
MXPA06001938A (es) *	2003-08-18	2006-05-17	Lundbeck & Co As H	Trans-1-(6-cloro-3-fenilindan-1-il)-3,3-dimetilpiperazina.
US7399765B2 (en) *	2003-09-19	2008-07-15	Abbott Laboratories	Substituted diazabicycloalkane derivatives
US20050065178A1 (en) *	2003-09-19	2005-03-24	Anwer Basha	Substituted diazabicycloakane derivatives
DK1713487T3 (da)	2004-02-04	2010-04-06	Neurosearch As	Diazabicykliske aryl-derivater som kolinerge receptor-modulatorer
EP1802258A4 (de)	2004-09-13	2015-09-23	Chrono Therapeutics Inc	Biosynchrone transdermale arzneiabgabe
WO2006087305A1 (en)	2005-02-16	2006-08-24	Neurosearch A/S	Novel diazabicyclic aryl derivatives and their medical use
TWI453198B (zh)	2005-02-16	2014-09-21	Lundbeck & Co As H	製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
TWI376373B (en)	2005-02-16	2012-11-11	Lundbeck & Co As H	Crystalline base of a pharmaceutical compound
US7662812B2 (en)	2005-02-16	2010-02-16	Neurosearch A/S	Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors
FR2889847B1 (fr)	2005-08-18	2007-10-05	Sanofi Aventis Sa	Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique.
US8316104B2 (en)	2005-11-15	2012-11-20	California Institute Of Technology	Method and apparatus for collaborative system
ES2521494T3 (es)	2007-04-02	2014-11-12	Parkinson's Institute	Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos
AU2009243813B2 (en) *	2008-05-07	2014-05-29	H. Lundbeck A/S	Method for treating cognitive deficits
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
US10213586B2 (en)	2015-01-28	2019-02-26	Chrono Therapeutics Inc.	Drug delivery methods and systems
WO2018129304A1 (en)	2017-01-06	2018-07-12	Chrono Therapeutics Inc.	Transdermal drug delivery devices and methods
WO2019232077A1 (en)	2018-05-29	2019-12-05	Chrono Therapeutics Inc.	Drug delivery methods and systems
CA3119992A1 (en)	2018-11-16	2020-05-22	Morningside Venture Investments Limited	Thermally regulated transdermal drug delivery system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954502A (en) *	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US4994460A (en) *	1989-06-01	1991-02-19	Bristol-Myers Squibb Co.	Agents for treatment of brain ischemia
US5478939A (en) *	1994-07-20	1995-12-26	American Cyanamid Company	(R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives

1998
- 1998-12-04 FR FR9815325A patent/FR2786769B1/fr not_active Expired - Fee Related
1999
- 1999-12-01 EP EP99973293A patent/EP1144413B1/de not_active Expired - Lifetime
- 1999-12-01 JP JP2000586729A patent/JP2002531568A/ja not_active Withdrawn
- 1999-12-01 AT AT99973293T patent/ATE261972T1/de not_active IP Right Cessation
- 1999-12-01 US US09/856,946 patent/US6635645B1/en not_active Expired - Lifetime
- 1999-12-01 AU AU13929/00A patent/AU1392900A/en not_active Abandoned
- 1999-12-01 WO PCT/FR1999/002974 patent/WO2000034284A1/fr not_active Ceased
- 1999-12-01 DE DE69915693T patent/DE69915693D1/de not_active Expired - Lifetime
- 1999-12-03 AR ARP990106159A patent/AR021533A1/es unknown

Also Published As

Publication number	Publication date
EP1144413A1 (de)	2001-10-17
ATE261972T1 (de)	2004-04-15
AR021533A1 (es)	2002-07-24
FR2786769A1 (fr)	2000-06-09
JP2002531568A (ja)	2002-09-24
WO2000034284A1 (fr)	2000-06-15
AU1392900A (en)	2000-06-26
US6635645B1 (en)	2003-10-21
EP1144413B1 (de)	2004-03-17
FR2786769B1 (fr)	2002-10-25

Publication	Publication Date	Title
DE69915693D1 (de)	2004-04-22	2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde
ATE249460T1 (de)	2003-09-15	1,4-diazabicyclo(3.2.2)nonanderivate, deren herstellung und deren verwendung in heilkunde
DE60023012D1 (de)	2006-02-16	3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel
DE60034683D1 (de)	2007-06-14	3(5)-ureido-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel
DE59911249D1 (de)	2005-01-13	Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung
DE69838829D1 (de)	2008-01-24	N-Phenyl-alkylsulfonamid-Derivate, deren Herstellung und deren Verwendung als alpha1A/1L-Adrenoceptor Agonisten
DE59814449D1 (de)	2010-06-10	Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE69427117D1 (de)	2001-05-23	Organometall-Fluorenylverbindungen deren Herstellung und deren Verwendung
DE69527451D1 (de)	2002-08-29	Organometall-Fluorenylverbindungen, deren Herstellung und deren Verwendung
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DE69907698D1 (de)	2003-06-12	Azetidinderivate, deren herstellung und sie enthaltende arzneimittel
ATE302604T1 (de)	2005-09-15	Thienylazolylalkoxyethanamine, deren herstellung und deren verwendung als medikamente
DE59905572D1 (de)	2003-06-18	Substituierte 4-amino-2-aryl-pyrimidine, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE60127434D1 (de)	2007-05-03	Benzoxazinonderivative, deren herstellung und verwendung
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ATE242197T1 (de)	2003-06-15	3-amino-3-arylpropan-1-ol-derivate, deren herstellung und verwendung
ATE261959T1 (de)	2004-04-15	Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung
ATE202782T1 (de)	2001-07-15	Optisch-aktives benzothiepin-derivate, ihre herstellung und verwendung
DE60005690D1 (de)	2003-11-06	Titanverbindungen, deren herstellung und verwendung
DE69204909D1 (de)	1995-10-26	Amino-Urazilderivate, deren Herstellung und Verwendung.
ATE212346T1 (de)	2002-02-15	3-substituierte tetrahydropyridopyrimidinon- derivate, ihre herstellung und verwendung
EP0672052A1 (de)	1995-09-20	Tachyquinin antagonisten, ihre herstellung und ihre verwendung in pharmazeutischen formulierungen.
DE59712148D1 (de)	2005-02-03	1,3-dimethyl-5-fluor-pyrazol-4-carboxamide derivative, deren herstellung und deren verwendung als mikrobizide
DE69735123D1 (de)	2006-04-06	Trehalose phosphorylase, deren Herstellung und Verwendung

Legal Events

Date	Code	Title	Description
2004-12-23	8332	No legal effect for de