DE69915687D1 - Heterocyclische amide als inhibitoren von faktor xa - Google Patents
Heterocyclische amide als inhibitoren von faktor xaInfo
- Publication number
- DE69915687D1 DE69915687D1 DE69915687T DE69915687T DE69915687D1 DE 69915687 D1 DE69915687 D1 DE 69915687D1 DE 69915687 T DE69915687 T DE 69915687T DE 69915687 T DE69915687 T DE 69915687T DE 69915687 D1 DE69915687 D1 DE 69915687D1
- Authority
- DE
- Germany
- Prior art keywords
- factor
- inhibitors
- heterocyclic amides
- amides
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11359598P | 1998-12-24 | 1998-12-24 | |
| US113595P | 1998-12-24 | ||
| PCT/US1999/029834 WO2000039092A1 (en) | 1998-12-24 | 1999-12-15 | HETEROCYCLIC AMIDES AS INHIBITORS OF FACTOR Xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69915687D1 true DE69915687D1 (de) | 2004-04-22 |
| DE69915687T2 DE69915687T2 (de) | 2005-02-10 |
Family
ID=22350387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69915687T Expired - Fee Related DE69915687T2 (de) | 1998-12-24 | 1999-12-15 | Heterocyclische amide als inhibitoren von faktor xa |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6660739B1 (de) |
| EP (1) | EP1140839B1 (de) |
| JP (1) | JP2002533442A (de) |
| AT (1) | ATE261941T1 (de) |
| AU (1) | AU2364000A (de) |
| CA (1) | CA2356214A1 (de) |
| DE (1) | DE69915687T2 (de) |
| ES (1) | ES2217879T3 (de) |
| WO (1) | WO2000039092A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL133625A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| AU8270898A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| ES2248911T3 (es) | 1997-06-26 | 2006-03-16 | Eli Lilly And Company | Agentes antitromboticos. |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| AU5196399A (en) * | 1998-08-11 | 2000-03-06 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| DE69919212T2 (de) | 1998-12-23 | 2005-07-28 | Eli Lilly And Co., Indianapolis | Aromatische amiden |
| US6689780B1 (en) | 1998-12-23 | 2004-02-10 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor Xa |
| DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
| ATE303988T1 (de) | 1999-06-14 | 2005-09-15 | Lilly Co Eli | Inhibitoren von serin proteasen |
| TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| ES2292607T3 (es) | 2000-07-27 | 2008-03-16 | Eli Lilly And Company | Amidas heterociclicas sustituidas. |
| EP1311501B1 (de) | 2000-08-17 | 2005-11-02 | Eli Lilly And Company | Antithrombosemittel |
| AU2001297648A1 (en) | 2000-11-28 | 2002-08-28 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
| CN1298715C (zh) * | 2001-03-13 | 2007-02-07 | 先灵公司 | 作为组胺h3拮抗剂的非咪唑化合物 |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| AU2002350172A1 (en) | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8203887D0 (sv) * | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6359134B1 (en) | 1997-05-30 | 2002-03-19 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| ES2241151T3 (es) | 1997-06-26 | 2005-10-16 | Eli Lilly And Company | Agentes antitromboticos. |
| AU8270898A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| ES2248911T3 (es) | 1997-06-26 | 2006-03-16 | Eli Lilly And Company | Agentes antitromboticos. |
| IL133625A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| DK1031563T3 (da) | 1997-09-30 | 2006-05-08 | Daiichi Seiyaku Co | Sulfonylderivater |
| DE69919212T2 (de) | 1998-12-23 | 2005-07-28 | Eli Lilly And Co., Indianapolis | Aromatische amiden |
| DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
| ES2196917T3 (es) | 1998-12-23 | 2003-12-16 | Lilly Co Eli | Amidas heteroaromaticas como inhibidores del factor xa`. |
-
1999
- 1999-12-15 ES ES99967344T patent/ES2217879T3/es not_active Expired - Lifetime
- 1999-12-15 US US09/857,748 patent/US6660739B1/en not_active Expired - Fee Related
- 1999-12-15 JP JP2000591004A patent/JP2002533442A/ja not_active Withdrawn
- 1999-12-15 DE DE69915687T patent/DE69915687T2/de not_active Expired - Fee Related
- 1999-12-15 EP EP99967344A patent/EP1140839B1/de not_active Expired - Lifetime
- 1999-12-15 CA CA002356214A patent/CA2356214A1/en not_active Abandoned
- 1999-12-15 AU AU23640/00A patent/AU2364000A/en not_active Abandoned
- 1999-12-15 WO PCT/US1999/029834 patent/WO2000039092A1/en not_active Ceased
- 1999-12-15 AT AT99967344T patent/ATE261941T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6660739B1 (en) | 2003-12-09 |
| DE69915687T2 (de) | 2005-02-10 |
| ES2217879T3 (es) | 2004-11-01 |
| AU2364000A (en) | 2000-07-31 |
| WO2000039092A1 (en) | 2000-07-06 |
| JP2002533442A (ja) | 2002-10-08 |
| ATE261941T1 (de) | 2004-04-15 |
| EP1140839B1 (de) | 2004-03-17 |
| CA2356214A1 (en) | 2000-07-06 |
| EP1140839A1 (de) | 2001-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |