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DE69842134D1 - Elektronische verfahren und vorrichtung zum nachweis von analyten - Google Patents

Elektronische verfahren und vorrichtung zum nachweis von analyten

Info

Publication number
DE69842134D1
DE69842134D1 DE69842134T DE69842134T DE69842134D1 DE 69842134 D1 DE69842134 D1 DE 69842134D1 DE 69842134 T DE69842134 T DE 69842134T DE 69842134 T DE69842134 T DE 69842134T DE 69842134 D1 DE69842134 D1 DE 69842134D1
Authority
DE
Germany
Prior art keywords
electronic method
detecting analytes
electronic
techniques
analytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69842134T
Other languages
English (en)
Inventor
Stephen D O'connor
Jon F Kayyem
Thomas J Meade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Micro Sensors Inc
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Application granted granted Critical
Publication of DE69842134D1 publication Critical patent/DE69842134D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Inorganic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69842134T 1997-06-12 1998-06-12 Elektronische verfahren und vorrichtung zum nachweis von analyten Expired - Lifetime DE69842134D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4948997P 1997-06-12 1997-06-12
PCT/US1998/012430 WO1998057159A1 (en) 1997-06-12 1998-06-12 Electronic methods for the detection of analytes

Publications (1)

Publication Number Publication Date
DE69842134D1 true DE69842134D1 (de) 2011-03-31

Family

ID=21960096

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69842134T Expired - Lifetime DE69842134D1 (de) 1997-06-12 1998-06-12 Elektronische verfahren und vorrichtung zum nachweis von analyten

Country Status (9)

Country Link
US (7) US7560237B2 (de)
EP (1) EP0988534B1 (de)
JP (1) JP4124830B2 (de)
AT (1) ATE498838T1 (de)
AU (1) AU744503B2 (de)
CA (1) CA2293744A1 (de)
DE (1) DE69842134D1 (de)
DK (1) DK0988534T3 (de)
WO (1) WO1998057159A1 (de)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
ATE498838T1 (de) 1997-06-12 2011-03-15 Clinical Micro Sensors Inc Elektronische verfahren und vorrichtung zum nachweis von analyten
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7407811B2 (en) 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
US7390667B2 (en) 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
US7494816B2 (en) 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
AU764926B2 (en) * 1998-01-27 2003-09-04 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) * 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
JP2002513916A (ja) * 1998-05-06 2002-05-14 クリニカル・マイクロ・センサーズ・インコーポレイテッド 単層を利用する被検体の電子的検出方法
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
WO2000038836A1 (en) * 1998-12-30 2000-07-06 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
AU768210B2 (en) 1999-05-03 2003-12-04 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of actinomycetes
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
AU5267800A (en) 1999-05-03 2000-11-17 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae
ATE335847T1 (de) 1999-05-03 2006-09-15 Gen Probe Inc Poynukleotidsonden zur exklusiven detektion und quantifizierung von staphylococcus
AU6360500A (en) * 1999-07-20 2001-02-05 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
WO2001007665A2 (en) * 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
JP2004530860A (ja) * 2000-01-11 2004-10-07 クリニカル・マイクロ・センサーズ・インコーポレイテッド バイオチップ多重化デバイスおよび方法
US20020034744A1 (en) * 2000-03-27 2002-03-21 Creager Stephen E. Compositions and methods for detecting redox-active molecules in solution
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
US6560471B1 (en) * 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
EP1397068A2 (de) * 2001-04-02 2004-03-17 Therasense, Inc. Gerät und verfahren zur blutzuckerverfolgung
US6861224B2 (en) * 2001-11-02 2005-03-01 Fujitsu Limited Protein detecting device
US7613491B2 (en) * 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
GB0316075D0 (en) * 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7774145B2 (en) * 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20060003382A1 (en) * 2004-05-10 2006-01-05 Amanda Eckermann Compositions and methods for analyte detection
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
US7713574B2 (en) 2004-07-13 2010-05-11 Dexcom, Inc. Transcutaneous analyte sensor
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7935309B2 (en) * 2005-04-15 2011-05-03 Worcester Polytechnic Institute Multi-transduction mechanism based microfluidic analyte sensors
EP1913374B1 (de) 2005-07-20 2019-01-09 Ascensia Diabetes Care Holdings AG Verfahren zur signalisierung des benutzers zum hinzufügen einer zusätzlichen probe zu einem prüfstreifen, verfahren zum messen der temperatur einer probe und verfahren zur bestimmung der konzentration eines analyten auf basis von puls-amperometrie
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4086090B2 (ja) * 2005-09-29 2008-05-14 Ｔｏｔｏ株式会社 光電流を用いた被検物質の特異的検出方法、それに用いられる電極、測定用セルおよび測定装置
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US20080064937A1 (en) * 2006-06-07 2008-03-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
JP4321599B2 (ja) * 2007-02-06 2009-08-26 セイコーエプソン株式会社 検出素子
JP4301316B2 (ja) * 2007-03-30 2009-07-22 ダイキン工業株式会社 スクロール部材及びその製造方法、並びに圧縮機構及びスクロール圧縮機
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8197650B2 (en) * 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
EP2152350A4 (de) 2007-06-08 2013-03-27 Dexcom Inc Integrierte medikamentenfreisetzungsvorrichtung mit kontinuierlichem analytsensor
EP4098177A1 (de) 2007-10-09 2022-12-07 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
AU2008312352A1 (en) 2007-10-17 2009-04-23 Ohmx Corporation Electrochemical assay for the detection of enzymes
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US7820391B2 (en) 2007-11-06 2010-10-26 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
US8290559B2 (en) 2007-12-17 2012-10-16 Dexcom, Inc. Systems and methods for processing sensor data
US9143569B2 (en) 2008-02-21 2015-09-22 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
CA2770071C (en) 2009-08-07 2014-07-15 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
JP2011232328A (ja) * 2010-04-09 2011-11-17 Hitachi Ltd 生体物質検出アレイ、計測装置および計測方法
US20120034638A1 (en) 2010-05-21 2012-02-09 Michael Ahrens Electrochemical assay for the detection of enzymatically active PSA
RU2013102436A (ru) * 2010-06-11 2014-07-20 Закрытое акционерное общество "Научные приборы" Точные интегрированные электродные чипы для микроанализа и способ использования в системах с возбуждением электрохемилюминесценции горячими электронами
GB2500550A (en) 2010-12-16 2013-09-25 Sensor Innovations Inc Electrochemical sensors
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
CA2851632A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
WO2013067349A1 (en) 2011-11-04 2013-05-10 Ohmx Corporation Novel chemistry used in biosensors
CA2860739A1 (en) 2012-01-09 2013-07-18 Ohmx Corporation Enzyme cascade methods for e-trace assay signal amplification
US9048431B2 (en) 2012-05-07 2015-06-02 California Instistute Of Technology Electronic devices employing aligned organic polymers
CA2880101A1 (en) 2012-07-27 2014-01-30 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
JP2015529809A (ja) 2012-07-27 2015-10-08 オームクス コーポレイション 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
CA2889415C (en) 2012-10-24 2020-06-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US9222623B2 (en) 2013-03-15 2015-12-29 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
GB201314402D0 (en) 2013-08-12 2013-09-25 Isis Innovation Capacitance Spectroscopic Method and Electrode
WO2015042493A2 (en) 2013-09-20 2015-03-26 Ohmx Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US9470634B1 (en) * 2013-12-10 2016-10-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Electride mediated surface enhanced Raman scattering (SERS)
US9880121B2 (en) 2014-04-29 2018-01-30 Ohmx Corporation Bioelectronic binding assay using peak profiling
WO2016025539A1 (en) 2014-08-11 2016-02-18 Ohmx Corporation Enzyme triggered redox altering chemical elimination (-trace) assay with multiplexing capabilities
JP2018502309A (ja) 2014-11-11 2018-01-25 ジェンマーク ダイアグノスティクス， インコーポレイテッド 閉止サンプル調製・反応システムにおいて、アッセイを実行するための装置及びカートリッジ
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US10883000B1 (en) * 2016-03-09 2021-01-05 The Regents Of The University Of California Chemically modified surfaces with self-assembled aromatic functionalities
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
ES3030837T3 (en) 2017-08-24 2025-07-02 Roche Diagnostics Gmbh Electrochemical detection of bacterial and/or fungal infections
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
EP3700416B1 (de) 2017-10-24 2024-06-26 Dexcom, Inc. Vorverbundene analytsensoren
CA3193835A1 (en) * 2020-09-24 2022-03-31 Jason Heikenfeld Continuous sensing with adapters and aptamers
AU2021349959A1 (en) * 2020-09-24 2023-05-04 University Of Cincinnati Small volume aptamer sensing without solution impedance or analyte depletion
JP2025505358A (ja) 2022-01-13 2025-02-26 カナリー メディカル スウィッツァーランド アクチェンゲゼルシャフト 分析物及び環境センサー

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5078830A (de) * 1973-11-16 1975-06-26
SE407115B (sv) 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
US4819658A (en) * 1982-02-11 1989-04-11 American Telephone And Telegraph Company, At&T Bell Laboratories Method and apparatus for measuring the temperature profile of a surface
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US4735907A (en) * 1985-03-18 1988-04-05 Eastman Kodak Company Stabilized fluorescent rare earth labels and labeled physiologically reactive species
EP0213825A3 (de) 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
GB2217447A (en) 1988-04-21 1989-10-25 Atomic Energy Authority Uk Bonding to metal surfaces
US4920047A (en) * 1988-05-20 1990-04-24 General Electric Company Electrical detection of the immune reaction
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5874316A (en) * 1989-01-27 1999-02-23 Australian Membrane Biotechnology Research Institute Receptor membranes and ionophore gating
US5089112A (en) * 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US4964972A (en) 1989-03-30 1990-10-23 Yeda Research And Development Company Limited Ionic recognition and selective response in self assembling monolayer membranes on electrodes
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5320725A (en) * 1989-08-02 1994-06-14 E. Heller & Company Electrode and method for the detection of hydrogen peroxide
US5262035A (en) * 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
EP0712139A3 (de) * 1990-01-31 1998-03-25 Fujikura Ltd. Elektrisch isolierter Draht und Kabel, das diesen verwendet
GB2244135B (en) 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
US5108573A (en) 1990-06-05 1992-04-28 The United States Of America As Represented By The United States Department Of Energy Morphology in electrochemically grown conducting polymer films
US5763191A (en) 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
US5180968A (en) * 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
CA2050057A1 (en) * 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5171853A (en) 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
US5187096A (en) 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
IL102930A (en) 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
CA2157503A1 (en) 1993-03-05 1994-09-15 John M. Riviello Pulsed electrochemical detection using polymer electroactive electrodes
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
IL108726A (en) * 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
US5780324A (en) 1994-03-30 1998-07-14 Denso Corporation Method of manufacturing a vertical semiconductor device
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US5506420A (en) * 1994-09-14 1996-04-09 The Regents Of The University Of California Semiconductor bio-electronic devices incorporating biochemical stabilization layers
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
DE4442253A1 (de) * 1994-11-28 1996-05-30 Bayer Corp N D Ges D Staates I Elektrochemischer Enzymbiosensor
KR100449615B1 (ko) * 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법
US5534132A (en) * 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
US5972199A (en) * 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
CA2255952A1 (en) 1996-05-22 1997-11-27 Australian Membrane And Biotechnology Research Institute Nucleic acid sensor
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) * 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6060327A (en) * 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
ATE498838T1 (de) 1997-06-12 2011-03-15 Clinical Micro Sensors Inc Elektronische verfahren und vorrichtung zum nachweis von analyten
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US5922183A (en) * 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors
AU764926B2 (en) 1998-01-27 2003-09-04 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20030087228A1 (en) 1998-05-06 2003-05-08 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
JP2002513916A (ja) 1998-05-06 2002-05-14 クリニカル・マイクロ・センサーズ・インコーポレイテッド 単層を利用する被検体の電子的検出方法
US6269150B1 (en) * 1998-06-11 2001-07-31 Lucent Technologies, Inc. Reliable, unattended, automated testing system and method for complex telecommunication systems
US7087148B1 (en) * 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
JP2005519630A (ja) 2001-04-03 2005-07-07 クリニカル・マイクロ・センサーズ・インコーポレイテッド 異なるレドックス電位を有する標識を用いた核酸反応
US7658700B2 (en) * 2004-08-09 2010-02-09 Tate Maloy Training device for exercising muscle groups of the entire body

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US8383356B2 (en) 2013-02-26
US20020009810A1 (en) 2002-01-24
US7601507B2 (en) 2009-10-13
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US8741585B2 (en) 2014-06-03
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US7560237B2 (en) 2009-07-14
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US20090242430A1 (en) 2009-10-01
US20080237061A1 (en) 2008-10-02
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US20130220832A1 (en) 2013-08-29
US20120199499A1 (en) 2012-08-09

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