DE69840816D1 - Isochinoline und deren Herstellung - Google Patents

Isochinoline und deren Herstellung

Info

Publication number: DE69840816D1
Authority: DE; Germany
Prior art keywords: isoquinolines; preparation
Prior art date: 1997-03-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69840816T

Other languages

English (en)

Inventor

John-Joseph Cornell Rese Savarese

Roy-Archibald Swaringen Jr

Vincente Samano

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cornell Research Foundation Inc

Avera Pharmaceuticals Inc

Original Assignee

Cornell Research Foundation Inc

Avera Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-25

Filing date

1998-03-23

Publication date

2009-06-18

1997-03-25 Priority claimed from GBGB9706117.0A external-priority patent/GB9706117D0/en

1997-11-27 Priority claimed from GBGB9724987.4A external-priority patent/GB9724987D0/en

1998-03-23 Application filed by Cornell Research Foundation Inc, Avera Pharmaceuticals Inc filed Critical Cornell Research Foundation Inc

2009-06-18 Application granted granted Critical

2009-06-18 Publication of DE69840816D1 publication Critical patent/DE69840816D1/de

2018-03-24 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE69840816T 1997-03-25 1998-03-23 Isochinoline und deren Herstellung Expired - Lifetime DE69840816D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9706117.0A GB9706117D0 (en)	1997-03-25	1997-03-25	Ultra-short acting neuromuscular blockers
GBGB9724987.4A GB9724987D0 (en)	1997-11-27	1997-11-27	Ultra-short acting neuromuscular blockers

Publications (1)

Publication Number	Publication Date
DE69840816D1 true DE69840816D1 (de)	2009-06-18

Family

ID=26311255

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE69819703T Expired - Lifetime DE69819703T2 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker
DE69840816T Expired - Lifetime DE69840816D1 (de)	1997-03-25	1998-03-23	Isochinoline und deren Herstellung
DE69830157T Expired - Lifetime DE69830157T2 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultrakurz wirkende neuromuskuläre blocker

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69819703T Expired - Lifetime DE69819703T2 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultra kurz wirkende neuromuskuläre blocker

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69830157T Expired - Lifetime DE69830157T2 (de)	1997-03-25	1998-03-23	Substituierte isochinoline als ultrakurz wirkende neuromuskuläre blocker

Country Status (36)

Country	Link
US (2)	US6177445B1 (de)
EP (4)	EP1526130A1 (de)
JP (3)	JP4112016B2 (de)
KR (2)	KR100578443B1 (de)
CN (1)	CN1203061C (de)
AP (1)	AP1797A (de)
AR (1)	AR012156A1 (de)
AT (3)	ATE430734T1 (de)
AU (2)	AU745382B2 (de)
BR (1)	BR9808422B1 (de)
CA (1)	CA2284802C (de)
CO (1)	CO4940499A1 (de)
CZ (1)	CZ293786B6 (de)
DE (3)	DE69819703T2 (de)
DK (2)	DK0971898T3 (de)
EA (1)	EA002224B1 (de)
EE (1)	EE04113B1 (de)
ES (2)	ES2242275T3 (de)
HR (1)	HRP980157B1 (de)
HU (1)	HU228230B1 (de)
ID (1)	ID22901A (de)
IL (1)	IL131918A (de)
IS (2)	IS2346B (de)
MA (1)	MA26476A1 (de)
MY (1)	MY121316A (de)
NO (1)	NO314726B1 (de)
NZ (1)	NZ337797A (de)
PE (1)	PE68399A1 (de)
PL (1)	PL190860B1 (de)
PT (2)	PT971898E (de)
RS (1)	RS49869B (de)
SI (1)	SI0975599T1 (de)
TR (1)	TR199902330T2 (de)
TW (1)	TW505635B (de)
UY (1)	UY24933A1 (de)
WO (2)	WO1998042674A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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KR100578443B1 (ko) *	1997-03-25	2006-05-11	아베라 파마슈티칼스, 인크.	초단기 작용성 신경근 차단제인 치환된 이소퀴놀린
US6911455B2 (en) *	1999-12-22	2005-06-28	Smithkline Beecham Corporation	Methods for preparing pharmaceutical formulations
US6670140B2 (en) *	2001-03-06	2003-12-30	The Procter & Gamble Company	Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US6844904B2 (en) *	2002-12-07	2005-01-18	Cubic Corporation	Fast PDLC device
EP1684753A2 (de) *	2003-10-28	2006-08-02	Cornell Research Foundation, Inc.	Neuromuskuläre blockiermittel und ihre antagonisten
CA2671904C (en) *	2006-12-06	2012-07-03	Cornell Research Foundation, Inc.	Intermediate duration neuromuscular blocking agents and antagonists thereof
BRPI0808272A2 (pt)	2007-03-08	2014-07-08	Chemagis Ltd	"método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
WO2008117271A1 (en) *	2007-03-26	2008-10-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
BRPI0809892A2 (pt) *	2007-05-01	2014-09-30	Chemagis Ltd	Composto de isoquinolínio, forma cristalina, composto cristalino (vii) e método para preparar cis-atracúrio
AU2008243749B2 (en) *	2007-05-01	2012-05-03	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
CA2687157A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
AU2008320380A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel R,R'-atracurium salts
BRPI0907656A2 (pt) *	2008-05-01	2019-08-27	Chemagis Ltd	composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio
US8592451B2 (en)	2009-03-17	2013-11-26	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en)	2009-08-19	2015-12-29	Cornell University	Cysteine for physiological injection
US9156826B2 (en) *	2012-06-29	2015-10-13	Cornell University	Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) *	2013-06-14	2013-10-30	安徽省先锋制药有限公司	顺式苄基异喹啉类化合物的制备方法及其用途
WO2014210369A2 (en) *	2013-06-28	2014-12-31	Cornell University	Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents
CN108375644B (zh) *	2016-12-07	2021-11-30	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂中间体的分析方法
CN108938573B (zh) *	2017-05-26	2021-08-10	四川科瑞德制药股份有限公司	一种神经肌肉阻滞剂组合物及其制备方法和用途
CN110776481B (zh) *	2018-07-24	2023-06-16	四川大学华西医院	一类双阳离子化合物及其制备方法和用途
CN109776486A (zh) *	2019-02-26	2019-05-21	武汉松石科技股份有限公司	一种硫酸亚丙酯的制备方法
CN111662230A (zh) *	2019-03-06	2020-09-15	四川道珍科技有限公司	一类苄基异喹啉化合物、制备方法和用途
CN110117297A (zh) *	2019-04-10	2019-08-13	珠海市赛纬电子材料股份有限公司	一种2-磷酸盐基硫酸丙烯酯的制备方法
WO2021115413A1 (zh) *	2019-12-11	2021-06-17	江苏恒瑞医药股份有限公司	神经肌肉阻滞剂及其制备方法
CN111471013B (zh) *	2020-05-26	2021-04-30	朗天药业(湖北)有限公司	一种米库氯铵及其注射液的制备方法
CN111909089B (zh) *	2020-08-14	2023-04-14	广东嘉博制药有限公司	一种米库氯铵对照品的制备方法
CN114057642B (zh) *	2021-12-10	2023-03-28	广东嘉博制药有限公司	一种米库氯铵中间体的合成方法
CN115073373A (zh) *	2022-07-08	2022-09-20	广东嘉博制药有限公司	一种不对称合成（r）-5’-甲氧基劳丹素的方法

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US3004031A (en) *	1958-07-03	1961-10-10	Allen & Hauburys Ltd	Diquaternary salts of papaverino esters
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
PL121492B1 (en) *	1977-08-01	1982-05-31	Massachusetts Gen Hospital	Process for preparing novel salts of bis-tetrahydroisoquinolinium-alkyl m-or p-phenylene-dialkanocarboxylatessilanov bis-tetragidroizokhinolino-alkilovykh solejj
US4701460A (en) *	1980-12-17	1987-10-20	Burroughs Wellcome Co.	Long duration neuromuscular blocking agents
JPS5899465A (ja) *	1981-11-23	1983-06-13	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	イソキノリン誘導体
GB8418303D0 (en)	1984-07-18	1984-08-22	Wellcome Found	Compounds
BG41897A1 (en) *	1985-07-19	1987-09-15	Ivanov	Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
GB9015473D0 (en)	1990-07-13	1990-08-29	Wellcome Found	Neuromuscular blocking agents
JPH04112016A (ja) *	1990-09-03	1992-04-14	Fuji Electric Co Ltd	トランスファ成形金型用プランジャ及びトランスファ成形装置
US5240939A (en) *	1991-10-31	1993-08-31	Anaquest, Inc.	Nitrogen bridge tetrahydroisoquinolines
KR100578443B1 (ko) *	1997-03-25	2006-05-11	아베라 파마슈티칼스, 인크.	초단기 작용성 신경근 차단제인 치환된 이소퀴놀린

1998
- 1998-03-23 KR KR1020057019867A patent/KR100578443B1/ko not_active Expired - Fee Related
- 1998-03-23 MY MYPI98001252A patent/MY121316A/en unknown
- 1998-03-23 US US09/381,721 patent/US6177445B1/en not_active Expired - Fee Related
- 1998-03-23 CN CNB988053004A patent/CN1203061C/zh not_active Expired - Fee Related
- 1998-03-23 DE DE69819703T patent/DE69819703T2/de not_active Expired - Lifetime
- 1998-03-23 ES ES98912494T patent/ES2242275T3/es not_active Expired - Lifetime
- 1998-03-23 DK DK98912494T patent/DK0971898T3/da active
- 1998-03-23 DE DE69840816T patent/DE69840816D1/de not_active Expired - Lifetime
- 1998-03-23 ID IDW991103A patent/ID22901A/id unknown
- 1998-03-23 CA CA002284802A patent/CA2284802C/en not_active Expired - Fee Related
- 1998-03-23 ES ES98922626T patent/ES2210757T3/es not_active Expired - Lifetime
- 1998-03-23 PL PL335885A patent/PL190860B1/pl not_active IP Right Cessation
- 1998-03-23 HU HU0001556A patent/HU228230B1/hu not_active IP Right Cessation
- 1998-03-23 RS YUP-483/99A patent/RS49869B/sr unknown
- 1998-03-23 AU AU75210/98A patent/AU745382B2/en not_active Ceased
- 1998-03-23 AU AU67305/98A patent/AU6730598A/en not_active Abandoned
- 1998-03-23 DK DK98922626T patent/DK0975599T3/da active
- 1998-03-23 JP JP54323398A patent/JP4112016B2/ja not_active Expired - Fee Related
- 1998-03-23 AT AT03020565T patent/ATE430734T1/de not_active IP Right Cessation
- 1998-03-23 EE EEP199900424A patent/EE04113B1/xx not_active IP Right Cessation
- 1998-03-23 PT PT98912494T patent/PT971898E/pt unknown
- 1998-03-23 PT PT98922626T patent/PT975599E/pt unknown
- 1998-03-23 WO PCT/EP1998/001651 patent/WO1998042674A1/en not_active Ceased
- 1998-03-23 AP APAP/P/1999/001658A patent/AP1797A/en active
- 1998-03-23 EP EP05001475A patent/EP1526130A1/de not_active Withdrawn
- 1998-03-23 KR KR1019997008687A patent/KR100554601B1/ko not_active Expired - Fee Related
- 1998-03-23 DE DE69830157T patent/DE69830157T2/de not_active Expired - Lifetime
- 1998-03-23 EA EA199900756A patent/EA002224B1/ru not_active IP Right Cessation
- 1998-03-23 EP EP03020565A patent/EP1380573B1/de not_active Expired - Lifetime
- 1998-03-23 WO PCT/EP1998/001652 patent/WO1998042675A1/en not_active Ceased
- 1998-03-23 CZ CZ19993404A patent/CZ293786B6/cs not_active IP Right Cessation
- 1998-03-23 PE PE1998000209A patent/PE68399A1/es not_active Application Discontinuation
- 1998-03-23 NZ NZ337797A patent/NZ337797A/xx not_active IP Right Cessation
- 1998-03-23 EP EP98912494A patent/EP0971898B1/de not_active Expired - Lifetime
- 1998-03-23 EP EP98922626A patent/EP0975599B1/de not_active Expired - Lifetime
- 1998-03-23 MA MA25006A patent/MA26476A1/fr unknown
- 1998-03-23 IL IL13191898A patent/IL131918A/xx not_active IP Right Cessation
- 1998-03-23 JP JP54323298A patent/JP4112015B2/ja not_active Expired - Fee Related
- 1998-03-23 BR BRPI9808422-4A patent/BR9808422B1/pt not_active IP Right Cessation
- 1998-03-23 TR TR1999/02330T patent/TR199902330T2/xx unknown
- 1998-03-23 SI SI9830593T patent/SI0975599T1/xx unknown
- 1998-03-23 AT AT98912494T patent/ATE295351T1/de not_active IP Right Cessation
- 1998-03-23 AT AT98922626T patent/ATE254107T1/de active
- 1998-03-23 US US09/381,719 patent/US6187789B1/en not_active Expired - Lifetime
- 1998-03-24 AR ARP980101340A patent/AR012156A1/es active IP Right Grant
- 1998-03-24 UY UY24933A patent/UY24933A1/es not_active IP Right Cessation
- 1998-03-24 HR HR980157A patent/HRP980157B1/xx not_active IP Right Cessation
- 1998-03-25 CO CO98016617A patent/CO4940499A1/es unknown
- 1998-04-29 TW TW087106631A patent/TW505635B/zh not_active IP Right Cessation
1999
- 1999-09-17 IS IS5185A patent/IS2346B/is unknown
- 1999-09-24 NO NO19994680A patent/NO314726B1/no not_active IP Right Cessation
2007
- 2007-09-25 JP JP2007247928A patent/JP2008019272A/ja active Pending
2008
- 2008-03-03 IS IS8717A patent/IS8717A/is unknown

Also Published As

Publication number	Publication date
EE9900424A (et)	2000-04-17
AR012156A1 (es)	2000-09-27
DE69830157D1 (de)	2005-06-16
JP2008019272A (ja)	2008-01-31
EE04113B1 (et)	2003-08-15
DK0971898T3 (da)	2005-09-05
IS8717A (is)	2008-03-03
HK1023342A1 (en)	2000-09-08
US6187789B1 (en)	2001-02-13
IL131918A (en)	2005-09-25
PL335885A1 (en)	2000-05-22
EP1526130A1 (de)	2005-04-27
IS2346B (is)	2008-03-15
HRP980157B1 (en)	2004-10-31
IS5185A (is)	1999-09-17
DK0975599T3 (da)	2004-03-15
EP0975599A1 (de)	2000-02-02
JP4112015B2 (ja)	2008-07-02
WO1998042674A1 (en)	1998-10-01
AP1797A (en)	2007-11-15
CA2284802C (en)	2009-06-16
JP4112016B2 (ja)	2008-07-02
KR100578443B1 (ko)	2006-05-11
JP2002503220A (ja)	2002-01-29
AU7521098A (en)	1998-10-20
KR20050103984A (ko)	2005-11-01
NZ337797A (en)	2001-03-30
DE69819703T2 (de)	2004-09-30
BR9808422A (pt)	2000-05-23
KR20010005621A (ko)	2001-01-15
HUP0001556A2 (hu)	2001-04-28
EP0971898A1 (de)	2000-01-19
PT971898E (pt)	2005-07-29
MY121316A (en)	2006-01-28
ATE254107T1 (de)	2003-11-15
TW505635B (en)	2002-10-11
AU745382B2 (en)	2002-03-21
EP1380573A2 (de)	2004-01-14
EP1380573B1 (de)	2009-05-06
KR100554601B1 (ko)	2006-03-03
AP9901658A0 (en)	1999-09-30
AU6730598A (en)	1998-10-20
MA26476A1 (fr)	2004-12-20
ES2210757T3 (es)	2004-07-01
HRP980157A2 (en)	1999-02-28
DE69819703D1 (de)	2003-12-18
EA199900756A1 (ru)	2000-08-28
ES2242275T3 (es)	2005-11-01
RS49869B (sr)	2008-08-07
SI0975599T1 (en)	2004-04-30
TR199902330T2 (xx)	2000-02-21
ATE430734T1 (de)	2009-05-15
NO314726B1 (no)	2003-05-12
UY24933A1 (es)	2000-12-29
CN1257483A (zh)	2000-06-21
BR9808422B1 (pt)	2010-08-24
IL131918A0 (en)	2001-03-19
JP2002517168A (ja)	2002-06-11
CO4940499A1 (es)	2000-07-24
CZ340499A3 (cs)	2000-04-12
EP1380573A3 (de)	2004-01-21
ATE295351T1 (de)	2005-05-15
CA2284802A1 (en)	1998-10-01
EP0971898B1 (de)	2005-05-11
PL190860B1 (pl)	2006-02-28
DE69830157T2 (de)	2006-05-11
WO1998042675A1 (en)	1998-10-01
NO994680D0 (no)	1999-09-24
EP0975599B1 (de)	2003-11-12
EA002224B1 (ru)	2002-02-28
PE68399A1 (es)	1999-07-23
CZ293786B6 (cs)	2004-07-14
NO994680L (no)	1999-11-24
ID22901A (id)	1999-12-16
YU48399A (sh)	2002-06-19
HU228230B1 (en)	2013-02-28
US6177445B1 (en)	2001-01-23
HUP0001556A3 (en)	2002-01-28
PT975599E (pt)	2004-03-31
CN1203061C (zh)	2005-05-25

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DE69840816D1 (de)	2009-06-18	Isochinoline und deren Herstellung
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NO965539D0 (no)	1996-12-23	Farmasöytiske tacrinepreparater
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FR2744442B1 (fr)	1998-02-27	Preparation du 1,1,1,3,3-pentachlorobutane et du 1,1,1,3,3,-pentafluorobutane
BR9506832A (pt)	1997-10-14	N-pirazolilanilinas e n-pirazolilaminopiridinas
DE69830119D1 (de)	2005-06-16	Teigzusammensetzung und derer Herstellung
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DE69710924D1 (de)	2002-04-11	Insektizide und akarizide mittel

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