DE69833791D1 - Hemmer der "gap junction communication" - Google Patents
Hemmer der "gap junction communication"Info
- Publication number
- DE69833791D1 DE69833791D1 DE69833791T DE69833791T DE69833791D1 DE 69833791 D1 DE69833791 D1 DE 69833791D1 DE 69833791 T DE69833791 T DE 69833791T DE 69833791 T DE69833791 T DE 69833791T DE 69833791 D1 DE69833791 D1 DE 69833791D1
- Authority
- DE
- Germany
- Prior art keywords
- oleamide
- fatty acid
- gap junction
- inhibition
- carbons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000010970 Connexin Human genes 0.000 title abstract 4
- 108050001175 Connexin Proteins 0.000 title abstract 4
- 210000003976 gap junction Anatomy 0.000 title abstract 4
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 abstract 6
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 abstract 6
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- -1 fatty acid primary amide Chemical class 0.000 abstract 2
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- BNBSCAZCQDLUDU-DOFZRALJSA-N arachidonoyl amine Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(N)=O BNBSCAZCQDLUDU-DOFZRALJSA-N 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 210000004498 neuroglial cell Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Junction Field-Effect Transistors (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97749397A | 1997-11-24 | 1997-11-24 | |
| PCT/US1998/024913 WO1999026584A2 (en) | 1997-11-24 | 1998-11-24 | Inhibitors of gap junction communication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69833791D1 true DE69833791D1 (de) | 2006-05-04 |
Family
ID=25525195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69833791T Expired - Lifetime DE69833791D1 (de) | 1997-11-24 | 1998-11-24 | Hemmer der "gap junction communication" |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1039902B1 (de) |
| JP (1) | JP2001523695A (de) |
| AT (1) | ATE319445T1 (de) |
| AU (1) | AU740588B2 (de) |
| CA (1) | CA2308850C (de) |
| DE (1) | DE69833791D1 (de) |
| WO (1) | WO1999026584A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119438D0 (en) * | 2001-02-16 | 2001-10-03 | Aventis Pharm Prod Inc | Gap junction permeability assay |
| SE0102289D0 (sv) * | 2001-06-27 | 2001-06-27 | Anders Hamberger | New use of compound |
| EP1419237A4 (de) * | 2001-07-31 | 2005-12-21 | Scripps Research Inst | Tiermodell für neuroverhalten in verbindung mit fettsäureamiden |
| AU2002951216A0 (en) * | 2002-09-05 | 2002-09-19 | Dbl Australia Pty Ltd | Surfactants and lyotropic phases formed therefrom |
| US20060058379A1 (en) * | 2002-11-29 | 2006-03-16 | Yasuyuki Kita | Connexin 26 inhibitor and cancer metastasis inhibitors |
| FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| GB0403629D0 (en) * | 2004-02-19 | 2004-03-24 | Imp College Innovations Ltd | Methods |
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
| FR2866885B1 (fr) | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique |
| US7846972B2 (en) | 2004-11-02 | 2010-12-07 | The New Industrial Research Organization | Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc |
| AR055831A1 (es) | 2004-12-30 | 2007-09-12 | Janssen Pharmaceutica Nv | Pepirazinilureas y piperidinilureas como moduladores de hidrolasa de amida de acidos grasos |
| EP1954137A4 (de) | 2005-11-18 | 2008-12-17 | Janssen Pharmaceutica Nv | 2-keto-oxazole als modulatoren der fettsäureamidhydrolase |
| WO2007098142A2 (en) | 2006-02-17 | 2007-08-30 | The Scripps Research Institute | Oxazole ketones as modulators of fatty acid amide hydrolase |
| WO2008016139A1 (en) * | 2006-08-04 | 2008-02-07 | Osaka University | Fluorescent oleamide derivative and use thereof |
| ES2342997B1 (es) * | 2008-12-09 | 2011-06-06 | Universitat De Les Illes Balears | Alpha derivados de acidos grasos cis-monoinsaturados para ser usados como medicamento. |
| US20120225097A1 (en) | 2009-11-12 | 2012-09-06 | Hawryluk Natalie A | Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah) |
| UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| AU2015317330B2 (en) | 2014-09-19 | 2021-01-14 | Memorial Sloan-Kettering Cancer Center | Methods for treating brain metastasis |
| US11202743B2 (en) | 2016-07-27 | 2021-12-21 | Conopco, Inc. | Personal care compositions comprising fatty acid amide derivatives |
| EP3980169B1 (de) * | 2019-06-10 | 2024-05-01 | Prodotti Gianni S.r.l. | Durch ein bionachhaltiges verfahren erhaltene emulsionen |
| CN111820448B (zh) * | 2020-06-11 | 2022-10-18 | 内蒙古昆明卷烟有限责任公司 | 一种烟草生物酶灭活装置及方法 |
| IT202000030185A1 (it) * | 2020-12-09 | 2022-06-09 | Prod Gianni S R L | Alchilesteri di lipoamminoacidi quali spf boosters |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851431A (en) * | 1986-11-26 | 1989-07-25 | Bar Ilan University | Physiologically active and nutritional composition |
| US5612380A (en) * | 1994-09-27 | 1997-03-18 | The Scripps Research Institute | Method for sleep induction |
| EP0833899B1 (de) * | 1995-06-12 | 2005-01-19 | The Scripps Research Institute | Cis-9,10-octadecenoamidase |
| US5856537A (en) * | 1996-06-26 | 1999-01-05 | The Scripps Research Institute | Inhibitors of oleamide hydrolase |
| US6858649B1 (en) * | 1998-04-30 | 2005-02-22 | The Scripps Research Institute | Selective potentiation of serotonin receptor subtypes |
-
1998
- 1998-11-24 DE DE69833791T patent/DE69833791D1/de not_active Expired - Lifetime
- 1998-11-24 EP EP98960363A patent/EP1039902B1/de not_active Expired - Lifetime
- 1998-11-24 AT AT98960363T patent/ATE319445T1/de not_active IP Right Cessation
- 1998-11-24 WO PCT/US1998/024913 patent/WO1999026584A2/en not_active Ceased
- 1998-11-24 CA CA002308850A patent/CA2308850C/en not_active Expired - Fee Related
- 1998-11-24 JP JP2000521789A patent/JP2001523695A/ja active Pending
- 1998-11-24 AU AU15973/99A patent/AU740588B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1039902A2 (de) | 2000-10-04 |
| AU1597399A (en) | 1999-06-15 |
| WO1999026584A2 (en) | 1999-06-03 |
| CA2308850C (en) | 2007-07-10 |
| ATE319445T1 (de) | 2006-03-15 |
| EP1039902B1 (de) | 2006-03-08 |
| EP1039902A4 (de) | 2002-07-17 |
| WO1999026584A3 (en) | 1999-07-15 |
| JP2001523695A (ja) | 2001-11-27 |
| AU740588B2 (en) | 2001-11-08 |
| CA2308850A1 (en) | 1999-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |