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DE69833784D1 - Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren - Google Patents

Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren

Info

Publication number
DE69833784D1
DE69833784D1 DE69833784T DE69833784T DE69833784D1 DE 69833784 D1 DE69833784 D1 DE 69833784D1 DE 69833784 T DE69833784 T DE 69833784T DE 69833784 T DE69833784 T DE 69833784T DE 69833784 D1 DE69833784 D1 DE 69833784D1
Authority
DE
Germany
Prior art keywords
polypeptides
activity
aminoopeptidase
nucleic acids
encoding nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833784T
Other languages
English (en)
Other versions
DE69833784T2 (de
Inventor
Alexander Blinkovsky
S Byun
V Klotz
Alan Sloma
Kimberly Brown
Maria Tang
Miko Fujii
Chigusa Marumoto
Venke Kofod
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Japan Tobacco Inc
Novozymes Inc
Original Assignee
Novozymes AS
Japan Tobacco Inc
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS, Japan Tobacco Inc, Novozymes Inc filed Critical Novozymes AS
Publication of DE69833784D1 publication Critical patent/DE69833784D1/de
Application granted granted Critical
Publication of DE69833784T2 publication Critical patent/DE69833784T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69833784T 1997-12-16 1998-11-13 Polypeptide mit aminopeptidase-aktivität und für diese codierende nukleinsäuren Expired - Lifetime DE69833784T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6971997P 1997-12-16 1997-12-16
US69719P 1997-12-16
DK146597 1997-12-16
DK146597 1997-12-16
DK67098 1998-05-15
DK67098 1998-05-15
PCT/DK1998/000495 WO1999031226A1 (en) 1997-12-16 1998-11-13 Polypeptides having aminopeptidase activity and nucleic acids encoding same

Publications (2)

Publication Number Publication Date
DE69833784D1 true DE69833784D1 (de) 2006-05-04
DE69833784T2 DE69833784T2 (de) 2006-10-19

Family

ID=27220854

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833784T Expired - Lifetime DE69833784T2 (de) 1997-12-16 1998-11-13 Polypeptide mit aminopeptidase-aktivität und für diese codierende nukleinsäuren

Country Status (12)

Country Link
US (3) US6184020B1 (de)
EP (1) EP1042457B1 (de)
JP (1) JP3979622B2 (de)
KR (2) KR100511655B1 (de)
CN (1) CN1247777C (de)
AT (1) ATE319818T1 (de)
AU (1) AU755387B2 (de)
BR (1) BR9813608B1 (de)
CA (1) CA2315274C (de)
DE (1) DE69833784T2 (de)
NZ (1) NZ505066A (de)
WO (1) WO1999031226A1 (de)

Families Citing this family (36)

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US6171820B1 (en) * 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
EP1176191B1 (de) * 1999-04-12 2004-09-01 ARKRAY, Inc. Alpha-glikolisierte aminosäure freisetzendes enzym
US6261794B1 (en) * 1999-10-14 2001-07-17 Saint Louis University Methods for identifying inhibitors of methionine aminopeptidases
US20020182701A1 (en) * 2001-08-30 2002-12-05 Saint Louis University Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof
US6617209B1 (en) * 2002-02-22 2003-09-09 Intel Corporation Method for making a semiconductor device having a high-k gate dielectric
US20040242566A1 (en) * 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
EP1625122A1 (de) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Dipeptidylpeptidase-hemmer
WO2004105503A1 (ja) * 2003-05-27 2004-12-09 Ajinomoto Co., Inc. 飲食品の呈味および／または風味の改善方法
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CA2535619A1 (en) * 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
EP1697342A2 (de) * 2003-09-08 2006-09-06 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitoren
JP2007505121A (ja) * 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
GEP20094679B (en) * 2004-03-15 2009-05-10 Takeda Pharmaceuticals Co Dipeptidyl peptidase inhibitors
US7687638B2 (en) * 2004-06-04 2010-03-30 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US7888011B2 (en) * 2004-10-18 2011-02-15 U.S. Genomics, Inc. Methods for isolation of nucleic acids from prokaryotic spores
US7872124B2 (en) * 2004-12-21 2011-01-18 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
PE20070622A1 (es) * 2005-09-14 2007-08-22 Takeda Pharmaceutical Administracion de inhibidores de dipeptidil peptidasa
CN101309689B (zh) * 2005-09-14 2012-10-10 武田药品工业株式会社 用于治疗糖尿病的二肽基肽酶抑制剂
ME02005B (me) 2005-09-14 2012-08-31 Takeda Pharmaceuticals Co Inhibitori dipeptidil peptidaze za lečenje dijabetesa
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
CN101360723A (zh) * 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2009531456A (ja) * 2006-03-28 2009-09-03 武田薬品工業株式会社 （ｒ）−３−アミノピペリジン二塩酸塩の調製
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
DK2073810T3 (da) * 2006-09-13 2011-10-31 Takeda Pharmaceutical Anvendelse af 2-6-(3-aminio-piperidin-l-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-l-ylmethyl-4-fluor-benzonitril til behandling af diabetes, cancer, autoimmune sygdomme og HIV infektion
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US20100144140A1 (en) * 2008-12-10 2010-06-10 Novellus Systems, Inc. Methods for depositing tungsten films having low resistivity for gapfill applications
CN102492645A (zh) * 2011-11-22 2012-06-13 江南大学 一种高产氨肽酶的重组枯草芽孢杆菌及其构建方法和应用
CN102492646A (zh) * 2011-11-22 2012-06-13 江南大学 一种高产氨肽酶的重组大肠杆菌及其构建方法
CN102876705B (zh) * 2012-10-29 2013-10-30 江南大学 一种原生质体转化选育高产亮氨酸氨肽酶菌株的方法
KR20250020836A (ko) * 2023-08-04 2025-02-11 소재우 스핑고모나스 야노이쿠야에를 이용한 미생물 균주 및 이를 포함하는 오폐수 정화제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671561B1 (fr) * 1991-01-16 1993-03-26 Bio Merieux Procede et milieu d'identification de bacteries du genre listeria.
US5792931A (en) * 1994-08-12 1998-08-11 Pioneer Hi-Bred International, Inc. Fumonisin detoxification compositions and methods
JP3516318B2 (ja) * 1995-03-07 2004-04-05 雪印乳業株式会社 新規エンドペプチダーゼ
DE69632630T2 (de) * 1995-03-16 2005-05-25 Novozymes A/S Enzym mit aminopeptidaseactivität
DE19526485A1 (de) * 1995-07-20 1997-01-23 Roehm Gmbh Rekombinant hergestellte Leucinaminopeptidase aus Aspergillus sojae
ATE236537T1 (de) * 1997-05-16 2003-04-15 Novozymes Biotech Inc Verfahren zur erzeugung von proteinhydrolysaten

Also Published As

Publication number Publication date
CN1247777C (zh) 2006-03-29
US6184020B1 (en) 2001-02-06
AU1332899A (en) 1999-07-05
BR9813608B1 (pt) 2011-11-01
KR20010033182A (ko) 2001-04-25
JP3979622B2 (ja) 2007-09-19
KR100556071B1 (ko) 2006-03-10
US6673571B2 (en) 2004-01-06
CA2315274C (en) 2009-01-27
KR20050046012A (ko) 2005-05-17
JP2003525573A (ja) 2003-09-02
CN1282369A (zh) 2001-01-31
US20020177210A1 (en) 2002-11-28
WO1999031226A1 (en) 1999-06-24
BR9813608A (pt) 2000-10-17
US6303360B1 (en) 2001-10-16
ATE319818T1 (de) 2006-03-15
EP1042457A1 (de) 2000-10-11
CA2315274A1 (en) 1999-06-24
AU755387B2 (en) 2002-12-12
EP1042457B1 (de) 2006-03-08
NZ505066A (en) 2002-10-25
KR100511655B1 (ko) 2005-08-31
DE69833784T2 (de) 2006-10-19

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