DE69828524D1 - Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel - Google Patents

Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel

Info

Publication number: DE69828524D1
Authority: DE; Germany
Prior art keywords: antifungicides; prodrugs; tetrahydrofuran; phosphate; appropriate
Prior art date: 1997-09-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69828524T

Other languages

English (en)

Other versions

DE69828524T2 (de

Inventor

Frank Bennett

M Girijavallabhan

M Patel

K Saksena

Ashit Ganguly

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-25

Filing date

1998-09-22

Publication date

2005-02-10

1998-09-22 Application filed by Schering Corp filed Critical Schering Corp

2005-02-10 Publication of DE69828524D1 publication Critical patent/DE69828524D1/de

2005-12-29 Application granted granted Critical

2005-12-29 Publication of DE69828524T2 publication Critical patent/DE69828524T2/de

2018-09-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE69828524T 1997-09-25 1998-09-22 Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel Expired - Lifetime DE69828524T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US93782797A	1997-09-25	1997-09-25
US937827		1997-09-25
PCT/US1998/018508 WO1999015522A1 (en)	1997-09-25	1998-09-22	Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent

Publications (2)

Publication Number	Publication Date
DE69828524D1 true DE69828524D1 (de)	2005-02-10
DE69828524T2 DE69828524T2 (de)	2005-12-29

Family

ID=25470461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69828524T Expired - Lifetime DE69828524T2 (de)	1997-09-25	1998-09-22	Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel

Country Status (25)

Country	Link
EP (1)	EP1027349B1 (de)
JP (1)	JP3473949B2 (de)
KR (1)	KR20010024297A (de)
CN (1)	CN1125066C (de)
AR (1)	AR015458A1 (de)
AT (1)	ATE286502T1 (de)
AU (1)	AU1698199A (de)
BR (1)	BR9812671A (de)
CA (1)	CA2304624C (de)
CO (1)	CO5011088A1 (de)
DE (1)	DE69828524T2 (de)
ES (1)	ES2232974T3 (de)
HU (1)	HUP0004616A3 (de)
ID (1)	ID28294A (de)
IL (1)	IL134469A0 (de)
MY (1)	MY133775A (de)
NO (1)	NO20001557D0 (de)
NZ (1)	NZ502709A (de)
PE (1)	PE120799A1 (de)
PL (1)	PL339488A1 (de)
PT (1)	PT1027349E (de)
SK (1)	SK3912000A3 (de)
TR (1)	TR200000753T2 (de)
WO (1)	WO1999015522A1 (de)
ZA (1)	ZA988688B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000030655A1 (en)	1998-11-20	2000-06-02	Bristol-Myers Squibb Company	Water soluble prodrugs of azole compounds
RU2585760C2 (ru) *	2010-05-19	2016-06-10	Сандоз Аг	Способ получения хиральных триазолонов
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5693626A (en) *	1993-12-21	1997-12-02	Schering Corporation	Tetrahydrofuran antifungals
TW377349B (en) *	1993-12-21	1999-12-21	Schering Corp	Tetrahydrofuran antifungals

1998
- 1998-09-22 EP EP98961721A patent/EP1027349B1/de not_active Expired - Lifetime
- 1998-09-22 SK SK391-2000A patent/SK3912000A3/sk unknown
- 1998-09-22 NZ NZ502709A patent/NZ502709A/en unknown
- 1998-09-22 CN CN98809550A patent/CN1125066C/zh not_active Expired - Fee Related
- 1998-09-22 ES ES98961721T patent/ES2232974T3/es not_active Expired - Lifetime
- 1998-09-22 CA CA002304624A patent/CA2304624C/en not_active Expired - Fee Related
- 1998-09-22 BR BR9812671-7A patent/BR9812671A/pt not_active IP Right Cessation
- 1998-09-22 AT AT98961721T patent/ATE286502T1/de not_active IP Right Cessation
- 1998-09-22 AU AU16981/99A patent/AU1698199A/en not_active Abandoned
- 1998-09-22 PE PE1998000905A patent/PE120799A1/es not_active Application Discontinuation
- 1998-09-22 TR TR2000/00753T patent/TR200000753T2/xx unknown
- 1998-09-22 HU HU0004616A patent/HUP0004616A3/hu unknown
- 1998-09-22 ID IDW20000551A patent/ID28294A/id unknown
- 1998-09-22 IL IL13446998A patent/IL134469A0/xx unknown
- 1998-09-22 AR ARP980104741A patent/AR015458A1/es unknown
- 1998-09-22 MY MYPI98004343A patent/MY133775A/en unknown
- 1998-09-22 PT PT98961721T patent/PT1027349E/pt unknown
- 1998-09-22 DE DE69828524T patent/DE69828524T2/de not_active Expired - Lifetime
- 1998-09-22 PL PL98339488A patent/PL339488A1/xx unknown
- 1998-09-22 KR KR1020007003196A patent/KR20010024297A/ko not_active Withdrawn
- 1998-09-22 ZA ZA988688A patent/ZA988688B/xx unknown
- 1998-09-22 WO PCT/US1998/018508 patent/WO1999015522A1/en not_active Ceased
- 1998-09-22 JP JP2000512827A patent/JP3473949B2/ja not_active Expired - Fee Related
- 1998-09-23 CO CO98055163A patent/CO5011088A1/es unknown
2000
- 2000-03-24 NO NO20001557A patent/NO20001557D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20001557L (no)	2000-03-24
CA2304624C (en)	2007-06-19
CN1125066C (zh)	2003-10-22
JP2001517665A (ja)	2001-10-09
JP3473949B2 (ja)	2003-12-08
EP1027349B1 (de)	2005-01-05
NO20001557D0 (no)	2000-03-24
PE120799A1 (es)	1999-12-01
CN1271356A (zh)	2000-10-25
AU1698199A (en)	1999-04-12
BR9812671A (pt)	2000-08-22
AR015458A1 (es)	2001-05-02
ZA988688B (en)	1999-03-23
ATE286502T1 (de)	2005-01-15
CA2304624A1 (en)	1999-04-01
PT1027349E (pt)	2005-05-31
TR200000753T2 (tr)	2001-01-22
IL134469A0 (en)	2001-04-30
PL339488A1 (en)	2000-12-18
KR20010024297A (ko)	2001-03-26
HUP0004616A2 (hu)	2002-03-28
HUP0004616A3 (en)	2002-04-29
DE69828524T2 (de)	2005-12-29
HK1025960A1 (en)	2000-12-01
SK3912000A3 (en)	2000-08-14
EP1027349A1 (de)	2000-08-16
NZ502709A (en)	2001-11-30
CO5011088A1 (es)	2001-02-28
ID28294A (id)	2001-05-10
MY133775A (en)	2007-11-30
WO1999015522A1 (en)	1999-04-01
ES2232974T3 (es)	2005-06-01

Publication	Publication Date	Title
FI972865A7 (fi)	1997-09-03	Hydroksimetyyli-imidatsodiatseptiinejä ja niiden esterit
NO972156D0 (no)	1997-05-09	2-cyanacrylsyre-estere
BR9606173A (pt)	1998-08-18	Esteres de rapamicina hidrossolúveis
DE69710191D1 (de)	2002-03-14	Alkyl-4-silyl-phenole und deren ester als antiatherosclerotische mittel
ATE240992T1 (de)	2003-06-15	Wenig gefärbte kolophoniumester und klebstoffzusammensetzungen
DE59813902D1 (de)	2007-03-29	Schmierstoffzusammensetzungen mit Thiophosphorsäureestern und Dithiophosphorsäureestern
DE69700261D1 (de)	1999-07-15	Faradayscher Käfig
DE69729302D1 (de)	2004-07-01	Illudin analoge verwendet als antitumormittel
DE59607236D1 (de)	2001-08-09	Bremskraftverstärker und montageverfahren hierfür
DE69828524D1 (de)	2005-02-10	Tetrahydrofuran-phosphat- und hydroxy-ester als prodrugs der entsprechenden antifungiziden mittel
DE69406153D1 (de)	1997-11-20	Phenylalkansäureester und ihre Anwendung als Antioxydantien
AU8136598A (en)	1999-01-19	Device to facilitate the removal of bile duct stones
DE59809194D1 (de)	2003-09-11	8-Ocimenylester und ihre Verwendung als Riech- und Aromastoffe
FR2754739B1 (fr)	1998-12-18	Compositions anti-mousse et compositions anhydres intermediaires
DE68916634D1 (de)	1994-08-11	Alicyclische Ester und ihre Anwendung als Riechstoffkomponenten.
ID22427A (id)	1999-10-14	Pembuatan ester-ester (met) akrilik
DE69821101D1 (de)	2004-02-19	Ester und verbesserte ölzusammensetzungen
NO974995D0 (no)	1997-10-30	Estere av karbapenemer
DE69609079D1 (de)	2000-08-03	Fahrbare einrichtung zur unterhaltung und ausbesserung von gleisanlagen
DK1027349T3 (da)	2005-03-29	Tetrahydrofuranphosphat- og tetrahydrofuranhydroxyestere som pro-medikamenter for det tilsvarende antisvampemiddel
BR9608313A (pt)	1999-01-26	Esteres de carbapenemas
GB9815203D0 (en)	1998-09-09	Plant sterols and their esters
KR970034574U (ko)	1997-07-26	자동차 잭 수납장치
KR970043749U (ko)	1997-07-31	자동차의 방진구조
DE69612836D1 (de)	2001-06-21	Esterschmiermittel

Legal Events

Date	Code	Title	Description
2006-02-02	8364	No opposition during term of opposition