DE69820081D1 - 1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmer - Google Patents
1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmerInfo
- Publication number
- DE69820081D1 DE69820081D1 DE69820081T DE69820081T DE69820081D1 DE 69820081 D1 DE69820081 D1 DE 69820081D1 DE 69820081 T DE69820081 T DE 69820081T DE 69820081 T DE69820081 T DE 69820081T DE 69820081 D1 DE69820081 D1 DE 69820081D1
- Authority
- DE
- Germany
- Prior art keywords
- dioxolo
- ampa
- benzodiazepine derivatives
- receptor inhibitors
- kainate receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003678 AMPA Receptors Human genes 0.000 title abstract 2
- 108090000078 AMPA Receptors Proteins 0.000 title abstract 2
- 102000000079 Kainic Acid Receptors Human genes 0.000 title abstract 2
- 108010069902 Kainic Acid Receptors Proteins 0.000 title abstract 2
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9701382A HUP9701382A3 (en) | 1997-08-12 | 1997-08-12 | New 7,8-dihydro-8-methyl-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component and process for producing them |
| HU9701383A HUP9701383A3 (en) | 1997-08-12 | 1997-08-12 | New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them |
| PCT/HU1998/000076 WO1999007708A1 (en) | 1997-08-12 | 1998-08-07 | 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69820081D1 true DE69820081D1 (de) | 2004-01-08 |
Family
ID=89995503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69820081T Expired - Lifetime DE69820081D1 (de) | 1997-08-12 | 1998-08-07 | 1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmer |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1015457B1 (de) |
| JP (1) | JP2001512731A (de) |
| KR (1) | KR20010022856A (de) |
| CN (1) | CN1271360A (de) |
| AT (1) | ATE255112T1 (de) |
| AU (1) | AU748801B2 (de) |
| BR (1) | BR9812119A (de) |
| CA (1) | CA2300142A1 (de) |
| DE (1) | DE69820081D1 (de) |
| NO (1) | NO20000654L (de) |
| NZ (1) | NZ503301A (de) |
| PL (1) | PL338681A1 (de) |
| RU (1) | RU2208014C2 (de) |
| SK (1) | SK1792000A3 (de) |
| WO (1) | WO1999007708A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900354A3 (en) * | 1999-02-15 | 2001-02-28 | Egyt Gyogyszervegyeszeti Gyar | Use of condensed 2,3-benzodiazepine derivatives for the preparation of pharmaceutical compositions treating and preventing diseases related with the inhibition of lipide peroxidation |
| HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
| US6858605B2 (en) | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
| EP2338492A1 (de) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Verfahren und Zusammensetzung zur Behandlung von Alzheimer |
| FR2972454B1 (fr) * | 2011-03-08 | 2013-03-01 | Servier Lab | Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| HU230684B1 (hu) * | 2014-01-21 | 2017-08-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Új dihidro-oxazino-benzodiazepin vegyületek és eljárás ezek elõállítására, illetve az ezeket tartalmazó gyógyászati készítmények |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206719B (en) * | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
| HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
| HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
| DE4428835A1 (de) * | 1994-08-01 | 1996-02-08 | Schering Ag | Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
| TR199501070A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevinin kristalli bicimi. |
| TR199501071A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem. |
-
1998
- 1998-08-07 RU RU2000106061/04A patent/RU2208014C2/ru not_active IP Right Cessation
- 1998-08-07 KR KR1020007001458A patent/KR20010022856A/ko not_active Ceased
- 1998-08-07 AT AT98939782T patent/ATE255112T1/de not_active IP Right Cessation
- 1998-08-07 DE DE69820081T patent/DE69820081D1/de not_active Expired - Lifetime
- 1998-08-07 AU AU88182/98A patent/AU748801B2/en not_active Ceased
- 1998-08-07 SK SK179-2000A patent/SK1792000A3/sk unknown
- 1998-08-07 EP EP98939782A patent/EP1015457B1/de not_active Expired - Lifetime
- 1998-08-07 NZ NZ503301A patent/NZ503301A/xx unknown
- 1998-08-07 CA CA002300142A patent/CA2300142A1/en not_active Abandoned
- 1998-08-07 JP JP2000506211A patent/JP2001512731A/ja active Pending
- 1998-08-07 CN CN98809317A patent/CN1271360A/zh active Pending
- 1998-08-07 BR BR9812119-7A patent/BR9812119A/pt not_active IP Right Cessation
- 1998-08-07 WO PCT/HU1998/000076 patent/WO1999007708A1/en not_active Ceased
- 1998-08-07 PL PL98338681A patent/PL338681A1/xx unknown
-
2000
- 2000-02-09 NO NO20000654A patent/NO20000654L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU748801B2 (en) | 2002-06-13 |
| RU2208014C2 (ru) | 2003-07-10 |
| CN1271360A (zh) | 2000-10-25 |
| JP2001512731A (ja) | 2001-08-28 |
| NO20000654L (no) | 2000-04-10 |
| EP1015457A1 (de) | 2000-07-05 |
| KR20010022856A (ko) | 2001-03-26 |
| WO1999007708A1 (en) | 1999-02-18 |
| CA2300142A1 (en) | 1999-02-18 |
| PL338681A1 (en) | 2000-11-20 |
| NO20000654D0 (no) | 2000-02-09 |
| BR9812119A (pt) | 2004-06-22 |
| AU8818298A (en) | 1999-03-01 |
| EP1015457B1 (de) | 2003-11-26 |
| ATE255112T1 (de) | 2003-12-15 |
| SK1792000A3 (en) | 2000-09-12 |
| NZ503301A (en) | 2002-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |