DE69817214D1 - Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren - Google Patents
Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatorenInfo
- Publication number
- DE69817214D1 DE69817214D1 DE69817214T DE69817214T DE69817214D1 DE 69817214 D1 DE69817214 D1 DE 69817214D1 DE 69817214 T DE69817214 T DE 69817214T DE 69817214 T DE69817214 T DE 69817214T DE 69817214 D1 DE69817214 D1 DE 69817214D1
- Authority
- DE
- Germany
- Prior art keywords
- azaring
- heterocyclic group
- ach receptor
- nicotinic ach
- receptor modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 108010009685 Cholinergic Receptors Proteins 0.000 abstract 1
- 102000034337 acetylcholine receptors Human genes 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK125997 | 1997-11-05 | ||
| DK125997 | 1997-11-05 | ||
| DK85098 | 1998-06-26 | ||
| DKPA199800850 | 1998-06-26 | ||
| PCT/DK1998/000478 WO1999024422A1 (en) | 1997-11-05 | 1998-11-05 | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69817214D1 true DE69817214D1 (de) | 2003-09-18 |
| DE69817214T2 DE69817214T2 (de) | 2004-06-09 |
Family
ID=26064766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69817214T Expired - Lifetime DE69817214T2 (de) | 1997-11-05 | 1998-11-05 | Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6756386B1 (de) |
| EP (2) | EP1034174B1 (de) |
| JP (1) | JP2001522846A (de) |
| CN (1) | CN1173972C (de) |
| AT (1) | ATE247104T1 (de) |
| AU (1) | AU747419B2 (de) |
| CA (1) | CA2306477A1 (de) |
| DE (1) | DE69817214T2 (de) |
| DK (1) | DK1034174T3 (de) |
| NZ (1) | NZ503626A (de) |
| WO (1) | WO1999024422A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562847B1 (en) | 1998-08-25 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
| US6303638B1 (en) | 1999-08-06 | 2001-10-16 | The Regents Of The University Of California | Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor |
| EP1212319A2 (de) * | 1999-09-14 | 2002-06-12 | Abbott Laboratories | 3-pyrrolidinyloxy-3' -pyridyl ether verbindungen verwendbar zur steuerung von chemischer synaptischer übertragung |
| DE10117686A1 (de) * | 2001-04-09 | 2002-10-24 | Celanese Ventures Gmbh | Protonenleitende Membran und deren Verwendung |
| HRP20040550A2 (en) * | 2001-11-19 | 2006-11-30 | Elan Pharmaceuticals | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines and piperazines |
| US20070021404A1 (en) * | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN1812981A (zh) * | 2003-06-27 | 2006-08-02 | 万有制药株式会社 | 杂芳氧基含氮饱和杂环衍生物 |
| CA2570065A1 (en) * | 2004-06-18 | 2005-12-29 | Neurosearch A/S | Novel alkyl substituted piperidine derivatives as monoamine neurotransmitter re-uptake inhibitors |
| CA2580329C (en) | 2004-09-13 | 2015-01-06 | Chrono Therapeutics Inc. | Biosynchronous transdermal drug delivery |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| KR101122469B1 (ko) | 2007-04-02 | 2012-07-12 | 파킨슨즈 인스티튜트 | 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물 |
| EP3250258A4 (de) | 2015-01-28 | 2018-09-05 | Chrono Therapeutics, Inc. | Verfahren und systeme zur wirkstofffreisetzung |
| JP6654960B2 (ja) * | 2016-01-15 | 2020-02-26 | 日本曹達株式会社 | ルテニウム錯体の製造方法 |
| AU2018205529B2 (en) | 2017-01-06 | 2023-08-10 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| MA54245A (fr) | 2018-11-16 | 2022-02-23 | Morningside Venture Investments Ltd | Système d'administration transdermique de médicaments à régulation thermique |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR829845A (fr) | 1936-12-04 | 1938-07-07 | Delle Atel Const Electr | Coupe-circuit à basse tension à élément fusible rechargeable |
| FR2306697A1 (fr) * | 1975-04-10 | 1976-11-05 | Sogeras | Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants |
| US4379161A (en) * | 1979-06-07 | 1983-04-05 | Michel Thominet | Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics |
| DE3227741A1 (de) * | 1982-07-24 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung |
| US4592866A (en) * | 1982-09-30 | 1986-06-03 | A. H. Robins Company, Inc. | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof |
| ZA848275B (en) | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
| US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
| DE3835291A1 (de) | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
| FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| WO1996004266A2 (de) * | 1994-08-03 | 1996-02-15 | Asta Medica Aktiengesellschaft | Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung |
| GB2295387A (en) * | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| IL118279A (en) * | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
| EP0880501A1 (de) * | 1996-02-02 | 1998-12-02 | Zeneca Limited | Heterocyclische verbindungen verwendbar als pharmazeutische mittel |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| ES2208812T3 (es) | 1997-02-25 | 2004-06-16 | Akzo Nobel N.V. | Derivados de azetidina y de pirrolidina. |
| US6562847B1 (en) * | 1998-08-25 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
| DE19904261A1 (de) | 1999-02-03 | 2000-08-10 | Basf Ag | Verfahren zur Herstellung von Dimethylsulfit |
| RU2145680C1 (ru) | 1999-06-28 | 2000-02-20 | Открытое акционерное общество "Магистральные нефтепроводы Центральной Сибири" | Пеногенератор (варианты) |
| GB0203968D0 (en) | 2002-02-19 | 2002-04-03 | Gavon Res & Dev Ltd | Mixer |
| JP2003297848A (ja) | 2002-04-01 | 2003-10-17 | Matsushita Electric Ind Co Ltd | 半導体装置の製造方法 |
-
1998
- 1998-11-05 AU AU10224/99A patent/AU747419B2/en not_active Ceased
- 1998-11-05 JP JP2000520436A patent/JP2001522846A/ja not_active Withdrawn
- 1998-11-05 CN CNB988106507A patent/CN1173972C/zh not_active Expired - Fee Related
- 1998-11-05 EP EP98952578A patent/EP1034174B1/de not_active Expired - Lifetime
- 1998-11-05 WO PCT/DK1998/000478 patent/WO1999024422A1/en not_active Ceased
- 1998-11-05 DK DK98952578T patent/DK1034174T3/da active
- 1998-11-05 CA CA002306477A patent/CA2306477A1/en not_active Abandoned
- 1998-11-05 DE DE69817214T patent/DE69817214T2/de not_active Expired - Lifetime
- 1998-11-05 EP EP03011485A patent/EP1357121A1/de not_active Withdrawn
- 1998-11-05 NZ NZ503626A patent/NZ503626A/en unknown
- 1998-11-05 AT AT98952578T patent/ATE247104T1/de not_active IP Right Cessation
-
2000
- 2000-04-14 US US09/550,379 patent/US6756386B1/en not_active Expired - Fee Related
-
2004
- 2004-05-19 US US10/848,132 patent/US7202237B2/en not_active Expired - Fee Related
-
2007
- 2007-03-09 US US11/715,872 patent/US20070161614A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1278258A (zh) | 2000-12-27 |
| HK1032234A1 (en) | 2001-07-13 |
| WO1999024422A1 (en) | 1999-05-20 |
| ATE247104T1 (de) | 2003-08-15 |
| EP1034174A1 (de) | 2000-09-13 |
| CA2306477A1 (en) | 1999-05-20 |
| DK1034174T3 (da) | 2003-09-22 |
| US7202237B2 (en) | 2007-04-10 |
| EP1357121A1 (de) | 2003-10-29 |
| US6756386B1 (en) | 2004-06-29 |
| US20070161614A1 (en) | 2007-07-12 |
| CN1173972C (zh) | 2004-11-03 |
| AU747419B2 (en) | 2002-05-16 |
| NZ503626A (en) | 2002-05-31 |
| DE69817214T2 (de) | 2004-06-09 |
| EP1034174B1 (de) | 2003-08-13 |
| AU1022499A (en) | 1999-05-31 |
| JP2001522846A (ja) | 2001-11-20 |
| US20040242558A1 (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |