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DE69813263T2 - Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte - Google Patents

Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte Download PDF

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Publication number
DE69813263T2
DE69813263T2 DE69813263T DE69813263T DE69813263T2 DE 69813263 T2 DE69813263 T2 DE 69813263T2 DE 69813263 T DE69813263 T DE 69813263T DE 69813263 T DE69813263 T DE 69813263T DE 69813263 T2 DE69813263 T2 DE 69813263T2
Authority
DE
Germany
Prior art keywords
benzazulen
hydrazono
derivatives
pharmaceutical compositions
intermediate products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813263T
Other languages
English (en)
Other versions
DE69813263D1 (de
Inventor
Denis Carniato
R Gadek
Francois Goubet
Jean-Francois Gourvest
Jochen Knolle
Robert Mcdowell
Karl-Heinz Scheunemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Genentech Inc
Original Assignee
Aventis Pharma SA
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA, Genentech Inc filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of DE69813263D1 publication Critical patent/DE69813263D1/de
Publication of DE69813263T2 publication Critical patent/DE69813263T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69813263T 1997-09-24 1998-09-23 Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte Expired - Lifetime DE69813263T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9711859A FR2768734B1 (fr) 1997-09-24 1997-09-24 Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
PCT/FR1998/002039 WO1999015507A1 (fr) 1997-09-24 1998-09-23 Derives d'hydrazono-benzazulene, compositions pharmaceutiques et intermediaires

Publications (2)

Publication Number Publication Date
DE69813263D1 DE69813263D1 (de) 2003-05-15
DE69813263T2 true DE69813263T2 (de) 2004-01-29

Family

ID=9511409

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813263T Expired - Lifetime DE69813263T2 (de) 1997-09-24 1998-09-23 Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte

Country Status (11)

Country Link
US (1) US6277845B1 (de)
EP (1) EP1017681B1 (de)
JP (1) JP4493839B2 (de)
AT (1) ATE236885T1 (de)
AU (1) AU9270598A (de)
DE (1) DE69813263T2 (de)
DK (1) DK1017681T3 (de)
ES (1) ES2192789T3 (de)
FR (1) FR2768734B1 (de)
PT (1) PT1017681E (de)
WO (1) WO1999015507A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
CA2444821C (en) 2001-04-24 2012-07-10 Merck Patent Gesellschaft Mit Beschraenkter Haftung Combination therapy using anti-angiogenic agents and tnfa
EA201200560A1 (ru) 2006-01-18 2012-09-28 Мерк Патент Гмбх Специфическая терапия, использующая интегриновые лиганды для лечения рака
EP2441464B1 (de) 2007-01-18 2014-04-09 Merck Patent GmbH Integrin-liganden zur verwendung in der behandlung von darmkrebs
US8580998B2 (en) 2008-12-11 2013-11-12 University Of Georgia Research Foundation, Inc. Preparation of alkenes by mild thermolysis of sulfoxides
EP2445534A2 (de) 2009-05-25 2012-05-02 Merck Patent GmbH Kontinuierliche verabreichung von cilengitid in der krebstherapie
MX2016015467A (es) 2014-05-30 2017-03-23 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos.
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0777657A1 (de) * 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclische verbindungen
FR2731217B1 (fr) * 1995-03-03 1997-06-13 Roussel Uclaf Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires
CA2249471A1 (fr) * 1996-03-20 1997-09-25 Hoechst Marion Roussel Composes tricycliques ayant une activite vis-a-vis des integrines notamment vis-a-vis de l'integrine alphavbeta3, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

Also Published As

Publication number Publication date
JP4493839B2 (ja) 2010-06-30
EP1017681A1 (de) 2000-07-12
DK1017681T3 (da) 2003-07-14
US6277845B1 (en) 2001-08-21
JP2001517657A (ja) 2001-10-09
FR2768734B1 (fr) 2000-01-28
FR2768734A1 (fr) 1999-03-26
EP1017681B1 (de) 2003-04-09
PT1017681E (pt) 2004-06-30
AU9270598A (en) 1999-04-12
ES2192789T3 (es) 2003-10-16
DE69813263D1 (de) 2003-05-15
ATE236885T1 (de) 2003-04-15
WO1999015507A1 (fr) 1999-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC