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DE69717044D1 - Flavone-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen - Google Patents

Flavone-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen

Info

Publication number
DE69717044D1
DE69717044D1 DE69717044T DE69717044T DE69717044D1 DE 69717044 D1 DE69717044 D1 DE 69717044D1 DE 69717044 T DE69717044 T DE 69717044T DE 69717044 T DE69717044 T DE 69717044T DE 69717044 D1 DE69717044 D1 DE 69717044D1
Authority
DE
Germany
Prior art keywords
alkyl
optionally substituted
alkoxy
optionally
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69717044T
Other languages
English (en)
Other versions
DE69717044T2 (de
Inventor
Alain Dhainaut
Guy Lewin
Emmanuel Canet
Michel Lonchampt
Yves Rolland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of DE69717044D1 publication Critical patent/DE69717044D1/de
Application granted granted Critical
Publication of DE69717044T2 publication Critical patent/DE69717044T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69717044T 1996-09-27 1997-09-23 Flavone-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen Expired - Fee Related DE69717044T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9611808A FR2753969B1 (fr) 1996-09-27 1996-09-27 Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69717044D1 true DE69717044D1 (de) 2002-12-19
DE69717044T2 DE69717044T2 (de) 2003-07-24

Family

ID=9496129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717044T Expired - Fee Related DE69717044T2 (de) 1996-09-27 1997-09-23 Flavone-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen

Country Status (18)

Country Link
US (1) US5889003A (de)
EP (1) EP0832886B1 (de)
JP (1) JPH10114766A (de)
CN (1) CN1094936C (de)
AT (1) ATE227712T1 (de)
AU (1) AU728990B2 (de)
BR (1) BR9704900A (de)
CA (1) CA2216617C (de)
DE (1) DE69717044T2 (de)
DK (1) DK0832886T3 (de)
ES (1) ES2187738T3 (de)
FR (1) FR2753969B1 (de)
HU (1) HUP9701588A3 (de)
NO (1) NO974455L (de)
NZ (1) NZ328858A (de)
PL (1) PL322297A1 (de)
PT (1) PT832886E (de)
ZA (1) ZA978652B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850055B1 (de) * 1995-09-11 2005-06-29 Osteoarthritis Sciences, Inc. Proteintyrosine-kinaseinhibitoren zur behandlung der osteoarthritis
JP2002523452A (ja) * 1998-08-26 2002-07-30 スミスクライン・ビーチャム・コーポレイション 肺疾患の治療方法
WO2000017184A1 (en) * 1998-09-24 2000-03-30 Mitsubishi Chemical Corporation Hydroxyflavone derivatives as tau protein kinase 1 inhibitors
AU777012B2 (en) 1999-08-21 2004-09-30 Takeda Gmbh Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
US6806257B1 (en) 1999-10-20 2004-10-19 Board Of Trustees Of Southern Illinois University Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
US6334998B1 (en) * 1999-12-07 2002-01-01 Parker Hughes Institute Estrogens for treating ALS
EP1127572A3 (de) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten
US6472436B1 (en) * 2000-07-17 2002-10-29 The Salk Institute For Biological Studies Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
DE10104350A1 (de) * 2001-02-01 2002-08-14 Merck Patent Gmbh Verfahren zur Herstellung von Flavon Derivaten
DE10232595A1 (de) * 2002-07-18 2004-02-05 Merck Patent Gmbh Lichtschutzmittel
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
JP5058481B2 (ja) * 2005-11-28 2012-10-24 丸善製薬株式会社 角化細胞増殖剤、サイクリックａｍｐホスホジエステラーゼ阻害剤、及び保湿剤
WO2008026687A1 (en) * 2006-09-01 2008-03-06 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor comprising the derivative
CN101148444A (zh) * 2006-09-20 2008-03-26 上海特化医药科技有限公司 黄酮衍生物、制备方法及应用
KR100930467B1 (ko) * 2007-06-07 2009-12-08 동아제약주식회사 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도
JP4559531B1 (ja) * 2009-12-03 2010-10-06 ウシオケミックス株式会社 ノビレチンの製造方法
CN103059005B (zh) * 2012-11-22 2015-04-22 中南民族大学 白杨素酰胺衍生物及其医药用途
CN105906598B (zh) * 2016-05-19 2018-05-08 江苏耐雀生物工程技术有限公司 白杨素衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623808B1 (fr) * 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2689127B1 (fr) * 1992-03-31 1994-05-06 Adir Cie Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
FR2753969B1 (fr) 1998-10-30
PL322297A1 (en) 1998-03-30
NO974455D0 (no) 1997-09-26
FR2753969A1 (fr) 1998-04-03
US5889003A (en) 1999-03-30
NO974455L (no) 1998-03-30
BR9704900A (pt) 1998-10-27
CN1179422A (zh) 1998-04-22
HU9701588D0 (en) 1997-11-28
JPH10114766A (ja) 1998-05-06
HUP9701588A3 (en) 1999-03-01
CA2216617C (fr) 2002-12-03
AU728990B2 (en) 2001-01-25
ZA978652B (en) 1998-03-27
EP0832886B1 (de) 2002-11-13
DK0832886T3 (da) 2003-03-10
PT832886E (pt) 2003-03-31
NZ328858A (en) 1998-01-26
CA2216617A1 (fr) 1998-03-27
DE69717044T2 (de) 2003-07-24
HUP9701588A2 (hu) 1998-12-28
AU3927197A (en) 1998-04-02
EP0832886A1 (de) 1998-04-01
ES2187738T3 (es) 2003-06-16
CN1094936C (zh) 2002-11-27
ATE227712T1 (de) 2002-11-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee