[go: up one dir, main page]

DE69717630D1 - 3-phenyl-furan-(5h)-2-on- und dihydrofuran-2-on-derivate als antibakterielle mittel - Google Patents

3-phenyl-furan-(5h)-2-on- und dihydrofuran-2-on-derivate als antibakterielle mittel

Info

Publication number
DE69717630D1
DE69717630D1 DE69717630T DE69717630T DE69717630D1 DE 69717630 D1 DE69717630 D1 DE 69717630D1 DE 69717630 T DE69717630 T DE 69717630T DE 69717630 T DE69717630 T DE 69717630T DE 69717630 D1 DE69717630 D1 DE 69717630D1
Authority
DE
Germany
Prior art keywords
dihydrofuran
furan
phenyl
derivatives
antibacterial agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69717630T
Other languages
English (en)
Other versions
DE69717630T2 (de
Inventor
Barry Gravestock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69717630D1 publication Critical patent/DE69717630D1/de
Publication of DE69717630T2 publication Critical patent/DE69717630T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69717630T 1996-05-11 1997-04-17 3-phenyl-furan-(5h)-2-on- und dihydrofuran-2-on-derivate als antibakterielle mittel Expired - Fee Related DE69717630T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9609919.7A GB9609919D0 (en) 1996-05-11 1996-05-11 Chemical compounds
PCT/GB1997/001061 WO1997043280A1 (en) 1996-05-11 1997-04-17 3-phenyl-furan-(5h)-2-one and dihydrofuran-2-one derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
DE69717630D1 true DE69717630D1 (de) 2003-01-16
DE69717630T2 DE69717630T2 (de) 2003-06-26

Family

ID=10793591

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717630T Expired - Fee Related DE69717630T2 (de) 1996-05-11 1997-04-17 3-phenyl-furan-(5h)-2-on- und dihydrofuran-2-on-derivate als antibakterielle mittel

Country Status (7)

Country Link
US (3) US6110936A (de)
EP (1) EP0912561B1 (de)
JP (1) JP2000510143A (de)
AU (1) AU2572297A (de)
DE (1) DE69717630T2 (de)
GB (1) GB9609919D0 (de)
WO (1) WO1997043280A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
PT1427711E (pt) 2001-09-11 2005-11-30 Astrazeneca Ab Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos
WO2003035073A1 (en) 2001-10-25 2003-05-01 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
BR0308018A (pt) 2002-02-28 2005-01-04 Astrazeneca Ab Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo
MXPA05001558A (es) * 2002-08-12 2005-09-08 Pharmacia & Upjohn Co Llc N-aril-2-oxazolidinonas y sus derivados.
AR042086A1 (es) * 2002-11-21 2005-06-08 Upjohn Co N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos
CA2515269A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
MXPA05007724A (es) * 2003-02-07 2005-09-30 Warner Lambert Co Agentes antibacterianos.
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
WO2004106329A2 (en) * 2003-06-03 2004-12-09 Dr. Reddy's Laboratories Ltd. Novel antiinfective compounds and their pharmaceutical compositions
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2008509125A (ja) * 2004-08-06 2008-03-27 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのオキシンドールオキサゾリジノン
GB0500895D0 (en) * 2005-01-17 2005-02-23 Isis Innovation Biocidal surface functionalisation
GB0616724D0 (en) * 2006-08-23 2006-10-04 Isis Innovation Surface adhesion using arylcarbene reactive intermediates
KR101753917B1 (ko) 2009-03-02 2017-07-04 옥스포드 어드밴스드 서패이시즈 리미티드 공유결합 3차원 네트워크를 형성할 수 있는 화학제

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2458547B2 (fr) * 1978-06-09 1986-05-16 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
CH647772A5 (fr) * 1979-05-07 1985-02-15 Delalande Sa Derives de la 5h-furanone-2 et de la 3h-dihydro-furanone-2, leurs procedes de preparation, et medicament les contenant.
FR2456097A1 (fr) * 1979-05-07 1980-12-05 Delalande Sa Nouveaux derives de la 5 h-furanone-2 et de la 3 h-dihydrofuranone-2, leur procede de preparation et leur application en therapeutique
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
DE3884563T2 (de) * 1987-10-21 1994-02-17 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel.
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
DE68918792T2 (de) * 1988-09-15 1995-03-30 Upjohn Co 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one.
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
WO1993009103A1 (en) * 1991-11-01 1993-05-13 The Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
EP0648119A1 (de) * 1992-07-08 1995-04-19 The Upjohn Company Gegen mycobacterium tuberculosis verwendbare 5'-indolinyloxazolidinone
DK0673370T3 (da) * 1992-12-08 1998-09-07 Upjohn Co Troponsubstituerede phenyloxazolidinoner som antibakterielle midler
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1995014684A1 (en) * 1993-11-22 1995-06-01 The Upjohn Company Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
TW286317B (de) * 1993-12-13 1996-09-21 Hoffmann La Roche
JPH0873455A (ja) * 1994-03-15 1996-03-19 Upjohn Co:The オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
US5668286A (en) * 1994-03-15 1997-09-16 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions containing them
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
EP0788498B1 (de) * 1994-10-26 2001-08-16 PHARMACIA & UPJOHN COMPANY Phenyloxazolidinone mit antimikrobieller wirkung
CN1046520C (zh) * 1994-11-15 1999-11-17 法玛西雅厄普约翰美国公司 二环噁嗪及噻嗪噁唑烷酮抗菌剂
DE69615002T2 (de) * 1995-02-03 2002-06-13 Pharmacia & Upjohn Co., Kalamazoo Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
NZ306310A (en) * 1995-05-11 2001-05-25 Upjohn Co Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
CA2228647A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
WO1997010223A1 (en) * 1995-09-15 1997-03-20 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
ES2185800T3 (es) * 1995-09-15 2003-05-01 Upjohn Co Agentes antibacterianos basados en 5-amidometilo, 3-arilo butirolactona alfa, beta saturada e insaturada.
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
ZA969622B (en) * 1995-12-13 1998-05-15 Upjohn Co Oxazolidinone antibacterial agents having a six-membered heteroaromatic ring.
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9604301D0 (en) 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
US5837870A (en) * 1996-04-11 1998-11-17 Pharmacia & Upjohn Company Process to prepare oxazolidinones
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
ES2186916T3 (es) * 1996-08-21 2003-05-16 Upjohn Co Derivados de isoxazolina como agentes antimicrobianos.
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
JP2001514259A (ja) 1997-08-29 2001-09-11 ゼネカ・リミテッド アミノメチルオキソオキサゾリジニルベンゼン誘導体
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
AU2572297A (en) 1997-12-05
DE69717630T2 (de) 2003-06-26
EP0912561A1 (de) 1999-05-06
WO1997043280A1 (en) 1997-11-20
US6350775B1 (en) 2002-02-26
GB9609919D0 (en) 1996-07-17
JP2000510143A (ja) 2000-08-08
EP0912561B1 (de) 2002-12-04
US20030166684A1 (en) 2003-09-04
US6110936A (en) 2000-08-29

Similar Documents

Publication Publication Date Title
DE69717630D1 (de) 3-phenyl-furan-(5h)-2-on- und dihydrofuran-2-on-derivate als antibakterielle mittel
DE69625515D1 (de) Benzooxazine als antimikrobielle mittel
DE59608798D1 (de) Endoparasitizide mittel
ATE219485T1 (de) N-benzyl-2-phenylindole als östrogene mittel
NO20000125D0 (no) Tiadiazolyl- og oksadiazolylfenyloksazolidinon- antibakterielle midler
DE69509464D1 (de) Antimikrobielles Mittel
DE69720194D1 (de) Piperazinonphenyloxazolidinon derivate und ihre verwendung als antibakterielle mittel
DE69814349D1 (de) Befeuchtendes mittel
DE69904147D1 (de) Juckreizstillende agentien in kosmetische mittel
DE60026540D1 (de) Mutilin-derivate und ihre anwendung als antibakterielle mittel
DE69826704D1 (de) Pleuromutlin-derivate als antimikrobielles wirkungsmittel
DE69510254D1 (de) Antimikrobielles Mittel
ATE219490T1 (de) Indazoleamid-verbindungen als serotoninergene mittel
DE69520235D1 (de) Schweisshemmende mittel
ATE326452T1 (de) Piperidinyloxy- und pyrrolidinyloxyphenyloxazolidinone als antibakterielle mittel
NO985227L (no) Alkylaminobenzothiazol og -benzoksazol - derivater
DE69528445D1 (de) Anti-mikrobielles Mittel
ATE226203T1 (de) Azabicycliache carbamoyloxy mutilin derivate als antibakterielles mittel
DE59610836D1 (de) Mittel gegen parasitäre protozoen
EP0778847A4 (de) Immunstimulierende mittel
BR9612583A (pt) Mancal de rolamento
DE69714145D1 (de) 1,4-Diaryl-2-fluoro-2-butene als insectizide und akarizide Mittel
DE69526203D1 (de) Biologische zielgerichtete mittel
ATE204255T1 (de) Carbostyrilderivate als antithrombotische mittel
DE69627332D1 (de) Verbesserte phenolische vorvernetzungshemmende mittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee