DE69638314D1 - Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie - Google Patents

Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie

Info

Publication number: DE69638314D1
Authority: DE; Germany
Prior art keywords: replication; gene therapy; dna molecule; circular dna; production methods
Prior art date: 1995-09-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69638314T

Other languages

English (en)

Inventor

Joel Crouzet

Fabienne Soubrier

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-15

Filing date

1996-09-13

Publication date

2011-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9482580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69638314(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-09-13 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2011-02-03 Application granted granted Critical

2011-02-03 Publication of DE69638314D1 publication Critical patent/DE69638314D1/de

2016-09-14 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Neurology (AREA)
Microbiology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Toxicology (AREA)
Hematology (AREA)
Diabetes (AREA)

DE69638314T 1995-09-15 1996-09-13 Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie Expired - Lifetime DE69638314D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9510825A FR2738842B1 (fr)	1995-09-15	1995-09-15	Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique

Publications (1)

Publication Number	Publication Date
DE69638314D1 true DE69638314D1 (de)	2011-02-03

Family

ID=9482580

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE69636878T Expired - Lifetime DE69636878T2 (de)	1995-09-15	1996-09-13	Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie
DE69638314T Expired - Lifetime DE69638314D1 (de)	1995-09-15	1996-09-13	Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie
DE69634043T Expired - Lifetime DE69634043T2 (de)	1995-09-15	1996-09-13	Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69636878T Expired - Lifetime DE69636878T2 (de)	1995-09-15	1996-09-13	Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69634043T Expired - Lifetime DE69634043T2 (de)	1995-09-15	1996-09-13	Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

Country Status (20)

Country	Link
US (3)	US6977174B2 (de)
EP (3)	EP1508620B1 (de)
JP (3)	JP3818665B2 (de)
KR (1)	KR100522369B1 (de)
AT (3)	ATE284966T1 (de)
BR (1)	BRPI9610511B8 (de)
CA (1)	CA2229307C (de)
CZ (1)	CZ294525B6 (de)
DE (3)	DE69636878T2 (de)
DK (3)	DK1724354T3 (de)
ES (3)	ES2357098T3 (de)
FR (1)	FR2738842B1 (de)
HU (1)	HU224400B1 (de)
IL (4)	IL123641A0 (de)
NO (1)	NO323975B1 (de)
PT (3)	PT1508620E (de)
SK (1)	SK285317B6 (de)
TW (1)	TWI231826B (de)
WO (1)	WO1997010343A1 (de)
ZA (1)	ZA967640B (de)

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US6156574A (en)	1997-06-23	2000-12-05	The Rockefeller University	Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof
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AU2002325346A1 (en)	2001-07-05	2003-01-21	Aventis Pharma S.A.	Method of administration of a gene of interest to the heart and vasculature
US7049121B2 (en)	2001-12-20	2006-05-23	Applied Molecular Evolution	Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US6989261B2 (en) *	2001-12-20	2006-01-24	Eli Lilly And Company	Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
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US8716021B2 (en) *	2005-09-07	2014-05-06	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Use of replicators to prevent gene silencing
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US9080170B2 (en)	2010-03-17	2015-07-14	Association Institut De Myologie	Modified U7 snRNAs for treatment of neuromuscular diseases
WO2012069657A1 (en)	2010-11-26	2012-05-31	Institut Pasteur	Identification of a human gyrovirus and applications.
EP2788477A2 (de)	2011-12-07	2014-10-15	Institut Pasteur	Identifizierung des porcinen parecho-like virus und anwendungen
CA2883227A1 (en)	2012-08-29	2014-03-06	Nature Technology Corporation	Dna plasmids with improved expression
WO2014077863A1 (en)	2012-11-19	2014-05-22	Nature Technology Corporation	Replicative minicircle vectors with improved expression
AU2014236208B2 (en) *	2013-03-14	2018-07-19	Genvivo, Inc.	Thymidine kinase diagnostic assay for gene therapy applications
EP3456821B2 (de)	2017-09-19	2024-01-24	Deutsches Krebsforschungszentrum	Nicht integrierende dna-vektoren zur genetischen modifikation von zellen
WO2019057774A1 (en)	2017-09-19	2019-03-28	Deutsches Krebsforschungszentrum	NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS
ES2950736T3 (es)	2018-03-21	2023-10-13	Aldevron L L C	Vectores de nanoplásmidos virales y no virales con una producción mejorada
CA3132338A1 (en)	2019-04-05	2020-10-08	David Suhy	Improved methods and compositions for synthetic biomarkers
EP4538378A4 (de) *	2022-06-13	2025-11-05	Nanjing Genscript Biotech Co Ltd	Wildtyp-mutante ? expressionssystem, das in der lage ist, die effizienz der herstellung eines plasmids ohne screening-tag zu erhöhen
CN119866375A (zh) *	2022-07-19	2025-04-22	朗帕特生物科学公司	非免疫原性环状非病毒dna载体
WO2025042847A1 (en) *	2023-08-18	2025-02-27	Dna Twopointo, Inc.	Plasmid-host systems
WO2025160245A1 (en)	2024-01-25	2025-07-31	Aldevron, L.L.C.	Viral and non-viral nanoplasmid vectors with improved production
TR2024004346A2 (tr) *	2024-04-05	2024-05-21	Yildiz Teknik Ueniversitesi Doener Sermaye Isletme Mued	Fotodönüştürülebilir floresan gen ihtiva eden antimikrobiyal aktivite tayin kiti.
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US7364894B2 (en) *	1995-09-15	2008-04-29	Centelion	Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
US7279313B2 (en) *	1995-09-15	2007-10-09	Centelion	Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
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1995
- 1995-09-15 FR FR9510825A patent/FR2738842B1/fr not_active Expired - Lifetime
1996
- 1996-09-10 ZA ZA967640A patent/ZA967640B/xx unknown
- 1996-09-13 DK DK06017245.9T patent/DK1724354T3/da active
- 1996-09-13 JP JP51171697A patent/JP3818665B2/ja not_active Expired - Fee Related
- 1996-09-13 EP EP04016978A patent/EP1508620B1/de not_active Expired - Lifetime
- 1996-09-13 DE DE69636878T patent/DE69636878T2/de not_active Expired - Lifetime
- 1996-09-13 PT PT04016978T patent/PT1508620E/pt unknown
- 1996-09-13 DK DK04016978T patent/DK1508620T3/da active
- 1996-09-13 DE DE69638314T patent/DE69638314D1/de not_active Expired - Lifetime
- 1996-09-13 DK DK96931124T patent/DK0850310T3/da active
- 1996-09-13 WO PCT/FR1996/001414 patent/WO1997010343A1/fr not_active Ceased
- 1996-09-13 AT AT96931124T patent/ATE284966T1/de active
- 1996-09-13 ES ES06017245T patent/ES2357098T3/es not_active Expired - Lifetime
- 1996-09-13 ES ES96931124T patent/ES2233975T3/es not_active Expired - Lifetime
- 1996-09-13 HU HU9900018A patent/HU224400B1/hu not_active IP Right Cessation
- 1996-09-13 PT PT06017245T patent/PT1724354E/pt unknown
- 1996-09-13 EP EP96931124A patent/EP0850310B1/de not_active Expired - Lifetime
- 1996-09-13 CZ CZ1998788A patent/CZ294525B6/cs not_active IP Right Cessation
- 1996-09-13 DE DE69634043T patent/DE69634043T2/de not_active Expired - Lifetime
- 1996-09-13 US US09/043,193 patent/US6977174B2/en not_active Expired - Lifetime
- 1996-09-13 AT AT06017245T patent/ATE492642T1/de active
- 1996-09-13 IL IL12364196A patent/IL123641A0/xx active IP Right Grant
- 1996-09-13 SK SK347-98A patent/SK285317B6/sk not_active IP Right Cessation
- 1996-09-13 EP EP06017245A patent/EP1724354B1/de not_active Expired - Lifetime
- 1996-09-13 PT PT96931124T patent/PT850310E/pt unknown
- 1996-09-13 BR BRPI9610511A patent/BRPI9610511B8/pt not_active IP Right Cessation
- 1996-09-13 KR KR1019980701938A patent/KR100522369B1/ko not_active Expired - Fee Related
- 1996-09-13 ES ES04016978T patent/ES2281721T3/es not_active Expired - Lifetime
- 1996-09-13 AT AT04016978T patent/ATE352630T1/de active
- 1996-09-13 CA CA2229307A patent/CA2229307C/fr not_active Expired - Fee Related
- 1996-09-14 TW TW090120803A patent/TWI231826B/zh not_active IP Right Cessation
1998
- 1998-03-10 NO NO19981044A patent/NO323975B1/no not_active IP Right Cessation
- 1998-03-11 IL IL123641A patent/IL123641A/en not_active IP Right Cessation
2005
- 2005-12-02 JP JP2005348779A patent/JP4585435B2/ja not_active Expired - Fee Related
2006
- 2006-01-26 IL IL173399A patent/IL173399A/en not_active IP Right Cessation
2007
- 2007-08-07 JP JP2007205143A patent/JP4756014B2/ja not_active Expired - Fee Related
- 2007-10-30 US US11/978,614 patent/US20090130674A1/en not_active Abandoned
2008
- 2008-05-27 US US12/153,881 patent/US20090149406A1/en not_active Abandoned
2010
- 2010-08-02 IL IL207348A patent/IL207348A0/en unknown

Also Published As

Publication number	Publication date
ES2233975T3 (es)	2005-06-16
BR9610511B1 (pt)	2010-10-19
JP3818665B2 (ja)	2006-09-06
FR2738842A1 (fr)	1997-03-21
JP4585435B2 (ja)	2010-11-24
CA2229307C (fr)	2013-06-11
DK0850310T3 (da)	2005-04-25
AU728231B2 (en)	2001-01-04
EP1724354A3 (de)	2008-10-29
DK1508620T3 (da)	2007-05-29
NO981044D0 (no)	1998-03-10
JP4756014B2 (ja)	2011-08-24
BRPI9610511B8 (pt)	2016-11-08
BR9610511A (pt)	1999-01-26
IL123641A0 (en)	1998-10-30
US20090130674A1 (en)	2009-05-21
SK285317B6 (sk)	2006-10-05
HUP9900018A1 (hu)	1999-04-28
US6977174B2 (en)	2005-12-20
MX9802005A (es)	1998-08-30
EP1508620B1 (de)	2007-01-24
EP1724354A2 (de)	2006-11-22
EP0850310A1 (de)	1998-07-01
EP1508620A1 (de)	2005-02-23
ES2281721T3 (es)	2007-10-01
EP0850310B1 (de)	2004-12-15
NO323975B1 (no)	2007-07-30
PT1508620E (pt)	2007-05-31
FR2738842B1 (fr)	1997-10-31
JP2007325603A (ja)	2007-12-20
IL207348A0 (en)	2010-12-30
PT1724354E (pt)	2011-03-09
ATE352630T1 (de)	2007-02-15
DE69636878D1 (de)	2007-03-15
DK1724354T3 (da)	2011-04-04
US20090149406A1 (en)	2009-06-11
ATE284966T1 (de)	2005-01-15
CA2229307A1 (fr)	1997-03-20
ES2357098T3 (es)	2011-04-18
HUP9900018A3 (en)	2001-10-29
AU6992496A (en)	1997-04-01
EP1724354B1 (de)	2010-12-22
CZ78898A3 (cs)	1998-06-17
HU224400B1 (hu)	2005-08-29
IL173399A0 (en)	2006-06-11
IL173399A (en)	2010-11-30
KR100522369B1 (ko)	2006-10-24
ZA967640B (en)	1997-03-25
SK34798A3 (en)	1998-11-04
ATE492642T1 (de)	2011-01-15
TWI231826B (en)	2005-05-01
NO981044L (no)	1998-03-10
CZ294525B6 (cs)	2005-01-12
DE69636878T2 (de)	2007-11-08
JP2000501281A (ja)	2000-02-08
US20010014476A1 (en)	2001-08-16
KR19990044683A (ko)	1999-06-25
WO1997010343A1 (fr)	1997-03-20
PT850310E (pt)	2005-05-31
IL123641A (en)	2006-06-11
DE69634043T2 (de)	2005-08-18
DE69634043D1 (de)	2005-01-20
JP2006136328A (ja)	2006-06-01

Publication	Publication Date	Title
DE69636878D1 (de)	2007-03-15	Zirkuläres DNA Molekül mit einem abhängigen Replikationsursprung, seine Herstellungsverfahren und seine Verwendung in der Gentherapie
WO1996021007A3 (en)	1996-09-06	Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells
IL118201A0 (en)	1996-09-12	Erythropoietin free of animal proteins processes for production and use thereof
DE69836092D1 (de)	2006-11-16	Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
AU560340B2 (en)	1987-04-02	Rennin from recombinant dna
ATE188740T1 (de)	2000-01-15	Viruspartikel mit veraendertem wirtspektrum
ATE298789T1 (de)	2005-07-15	Negativstrand rna virus mit selbständiger replikationsaktivität
ATE159297T1 (de)	1997-11-15	Expression von menschlichen serumalbumin in methylotrophischen hefen
ATE177472T1 (de)	1999-03-15	Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen
DE69331216D1 (de)	2002-01-10	Planze resistent gegen mindestens zwei viren und dessen preparation
ES8405842A1 (es)	1984-07-01	Procedimiento de producir razas estables de celulas de mamiferos
RU94043698A (ru)	1996-10-20	СПОСОБ ПОЛУЧЕНИЯ ФЕРМЕНТА ДЕСТАБИЛАЗЫ, ОБЛАДАЮЩЕГО ФИБРИНОЛИТИЧЕСКОЙ, ТРОМБОЛИТИЧЕСКОЙ, ЭНДО- И ЭКЗО- Е( -glu)-Lys-ИЗОПЕПТИДАЗНОЙ И АМИДОЛИТИЧЕСКОЙ АКТИВНОСТЬЮ
ES2152976T3 (es)	2001-02-16	Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion.
ATE288476T1 (de)	2005-02-15	Herstellung von proteinen
ATE93893T1 (de)	1993-09-15	Expressionssysteme zur ueberproduktion gewuenschter proteine.
MX9700255A (es)	1998-01-31	Metodo para identificar acidos nucleicos que codifican las proteinas activadoras del promotor c-fos.