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DE69636904D1 - System und verfahren zur herstellung arzneistoffbeladener mikropartikel - Google Patents

System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Info

Publication number
DE69636904D1
DE69636904D1 DE69636904T DE69636904T DE69636904D1 DE 69636904 D1 DE69636904 D1 DE 69636904D1 DE 69636904 T DE69636904 T DE 69636904T DE 69636904 T DE69636904 T DE 69636904T DE 69636904 D1 DE69636904 D1 DE 69636904D1
Authority
DE
Germany
Prior art keywords
microparticles
emulsion
mixing chamber
drug
linking agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636904T
Other languages
English (en)
Other versions
DE69636904T2 (de
Inventor
C Bomberger
G Catz
I Smedley
C Stearns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of DE69636904D1 publication Critical patent/DE69636904D1/de
Application granted granted Critical
Publication of DE69636904T2 publication Critical patent/DE69636904T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69636904T 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel Expired - Lifetime DE69636904T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US480624 1995-06-07
PCT/US1996/010031 WO1996040069A1 (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Publications (2)

Publication Number Publication Date
DE69636904D1 true DE69636904D1 (de) 2007-03-29
DE69636904T2 DE69636904T2 (de) 2007-11-15

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69636904T Expired - Lifetime DE69636904T2 (de) 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Country Status (8)

Country Link
US (3) US5879712A (de)
EP (1) EP0833614B1 (de)
JP (1) JP4156665B2 (de)
AT (1) ATE353631T1 (de)
CA (1) CA2224074C (de)
DE (1) DE69636904T2 (de)
ES (1) ES2281084T3 (de)
WO (1) WO1996040069A1 (de)

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US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
ATE242001T1 (de) 1996-03-06 2003-06-15 Boehringer Ingelheim Pharma Pulverförmiges arzneimittel enthaltend interzelluläres adhäsionsmolekül
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
IT1291559B1 (it) * 1997-04-14 1999-01-11 Univ Degli Studi Milano Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
CA2308291A1 (en) * 1997-10-31 1999-05-14 Thierry Nivaggioli Controlled release compositions comprising gellan gum gels
AU747099B2 (en) * 1997-10-31 2002-05-09 Pharmacia Corporation Gellan gum tablet coating
JP2001522820A (ja) * 1997-11-10 2001-11-20 クエスト・インターナショナル・ビー・ブイ アルギナートマトリックス中の活性物質の包封体
US6485747B1 (en) * 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
US6927223B1 (en) 2000-05-26 2005-08-09 Washington State University Research Foundation Use of serotonin agents for adjunct therapy in the treatment of cancer
IL153923A0 (en) * 2000-09-08 2003-07-31 Gryphon Therapeutics Inc Synthetic erythropoiesis stimulating proteins
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US7008650B2 (en) * 2001-08-09 2006-03-07 Lam Paul Y S Compositions for the treatment of acquired immunodeficiency disease
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ES2322896T3 (es) * 2002-04-29 2009-07-01 Supernus Pharmaceuticals, Inc. Formulaciones farmaceuticas con biodisponibilidad mejorada.
US20030206957A1 (en) * 2002-05-06 2003-11-06 Scherr George H. Orally administered medicament delivery systems
GB2399084B (en) * 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
DK2891666T3 (en) 2002-10-16 2017-10-02 Purdue Pharma Lp Antibodies that bind cell-associated CA 125 / O722P and methods for its use
US9687449B2 (en) 2002-11-07 2017-06-27 Advanced Bionutrition Corp. Nutraceuticals and method of feeding aquatic animals
US20050053655A1 (en) * 2003-09-05 2005-03-10 Pharmaceutical Industry Technology And Development Center Rapid disintegrating tablets (RDTs) for pharmaceutical use and method for preparing the same
EP2210605B1 (de) * 2003-11-04 2017-03-01 TCD Royalty Sub, LLC Einmal tägliche Dosierungsformen von Trospium
AU2004289222B2 (en) 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
US20050260258A1 (en) 2003-12-18 2005-11-24 The Texas A&M University System Use of vitelline protein B as a microencapsulating additive
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
AR048220A1 (es) * 2005-01-28 2006-04-12 Lkm S A Lab Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
CA2632183A1 (en) 2005-08-25 2007-03-01 Philip R. Houle Treatment systems for delivery of sensitizer solutions
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
US9381477B2 (en) * 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008124639A2 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
AU2008314647B2 (en) * 2007-10-12 2013-03-21 Massachusetts Institute Of Technology Vaccine nanotechnology
US20100015240A1 (en) * 2008-07-16 2010-01-21 Danielle Biggs Process for preparing microparticles containing bioactive peptides
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
BR112012012997B8 (pt) * 2009-12-04 2021-05-25 Magle Ab microesfera biodegradável, material para utilização em conexão com o tratamento de feridas compreendendo microesferas, curativo de ferida e método para cultura de células in vitro
MD20160061A2 (ro) * 2013-11-13 2016-10-31 Tillotts Pharma Ag Sistem de livrare a medicamentului compus din particule multiple
DE112016001911A5 (de) * 2015-05-21 2018-01-11 Arnold Lösler Matrixmembranschicht auf Alginatbasis
US12447200B2 (en) 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
US12447166B2 (en) 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants

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JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
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Also Published As

Publication number Publication date
ATE353631T1 (de) 2007-03-15
EP0833614A1 (de) 1998-04-08
US20030091649A1 (en) 2003-05-15
JP4156665B2 (ja) 2008-09-24
ES2281084T3 (es) 2007-09-16
CA2224074C (en) 2009-09-08
EP0833614B1 (de) 2007-02-14
US5879712A (en) 1999-03-09
EP0833614A4 (de) 2001-07-11
US7087245B2 (en) 2006-08-08
JPH11507382A (ja) 1999-06-29
US6375985B1 (en) 2002-04-23
DE69636904T2 (de) 2007-11-15
CA2224074A1 (en) 1996-12-19
WO1996040069A1 (en) 1996-12-19

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