[go: up one dir, main page]

DE69629474D1 - Antifungale tetrahydrofurane - Google Patents

Antifungale tetrahydrofurane

Info

Publication number
DE69629474D1
DE69629474D1 DE69629474T DE69629474T DE69629474D1 DE 69629474 D1 DE69629474 D1 DE 69629474D1 DE 69629474 T DE69629474 T DE 69629474T DE 69629474 T DE69629474 T DE 69629474T DE 69629474 D1 DE69629474 D1 DE 69629474D1
Authority
DE
Germany
Prior art keywords
ester
group
tetrahydrofurane
antifungal
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69629474T
Other languages
English (en)
Other versions
DE69629474T2 (de
Inventor
G Lovey
M Girijavallabhan
K Saksena
E Pike
Frank Bennet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69629474D1 publication Critical patent/DE69629474D1/de
Application granted granted Critical
Publication of DE69629474T2 publication Critical patent/DE69629474T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69629474T 1995-06-19 1996-06-17 Antifungale tetrahydrofurane Expired - Fee Related DE69629474T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30595P 1995-06-19 1995-06-19
US305P 1995-06-19
US59685296A 1996-02-05 1996-02-05
US596852 1996-02-05
PCT/US1996/009242 WO1997000255A1 (en) 1995-06-19 1996-06-17 Tetrahydrofuran antifungals

Publications (2)

Publication Number Publication Date
DE69629474D1 true DE69629474D1 (de) 2003-09-18
DE69629474T2 DE69629474T2 (de) 2004-06-24

Family

ID=26667465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69629474T Expired - Fee Related DE69629474T2 (de) 1995-06-19 1996-06-17 Antifungale tetrahydrofurane

Country Status (10)

Country Link
EP (1) EP0837859B1 (de)
JP (1) JPH11507668A (de)
AT (1) ATE247108T1 (de)
AU (1) AU6257396A (de)
CA (1) CA2224707A1 (de)
DE (1) DE69629474T2 (de)
ES (1) ES2203707T3 (de)
IL (1) IL118668A0 (de)
MX (1) MX9710270A (de)
WO (1) WO1997000255A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0958289T1 (en) 1997-02-11 2004-12-31 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
EP0957101A1 (de) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus
EP1177192B1 (de) * 1999-05-04 2003-03-19 Janssen Pharmaceutica N.V. Antimykotische ether
EP2343980A4 (de) * 2008-09-08 2012-06-06 Nian Wu Triazolfungizide
CN102892750B (zh) 2010-05-19 2016-03-02 桑多斯股份公司 制备手性酰肼的方法
EP2571871B1 (de) 2010-05-19 2017-06-21 Sandoz AG Verfahren zur Herstellung von chiralen Triazolonen
CA2798010C (en) 2010-05-19 2018-09-25 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9073904B2 (en) 2010-05-19 2015-07-07 Sandoz Ag Preparation of posaconazole intermediates
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
TW377349B (en) * 1993-12-21 1999-12-21 Schering Corp Tetrahydrofuran antifungals
JP3764750B2 (ja) * 1994-01-24 2006-04-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 水溶性アゾール抗真菌剤

Also Published As

Publication number Publication date
EP0837859B1 (de) 2003-08-13
CA2224707A1 (en) 1997-01-03
IL118668A0 (en) 1996-10-16
ATE247108T1 (de) 2003-08-15
WO1997000255A1 (en) 1997-01-03
AU6257396A (en) 1997-01-15
EP0837859A1 (de) 1998-04-29
MX9710270A (es) 1998-08-30
ES2203707T3 (es) 2004-04-16
JPH11507668A (ja) 1999-07-06
DE69629474T2 (de) 2004-06-24

Similar Documents

Publication Publication Date Title
DE69428125D1 (de) Fungizide tetrahydrofurane
ATE306261T1 (de) Antithrombosemittel
IL133623A0 (en) Antithrombotic agents
EA199600104A1 (ru) Повышенная биодоступность биологически активных соединений при связывании с производными полипирролкарбоксамидонафталиновой кислоты
YU164791A (sh) Nezasićene hidroksialkilhinolin kiseline
DE69629474D1 (de) Antifungale tetrahydrofurane
AU3583989A (en) New cephem compounds and processes for preparation thereof
ATE308540T1 (de) Antithrombosemittel
EA200200292A1 (ru) Производные гигромицина
FI905559A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten pradimisiinijohdannaisten valmistamiseksi
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
TR200000753T2 (tr) Mukabil antifungal ajan için prodrog olarak tetrahidrofuran fosfat ve hidroksi esterleri.
AR003437A1 (es) Un compuesto antifungico de tetrahidrofurano, una composicion farmaceutica que los contiene, su uso para preparar un medicamento antifungico y una sal deester aminoacido del mismo
NZ329604A (en) Isoxazole derivatives substituted by an amino, guanidinyl or azacycloalkyl-oxy, -sulphinyl or -sulphenyl group, pharmaceutical compositions comprising them

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee