DE69627381D1 - Vefahren zur herstellung von erythrmycinderivate - Google Patents

Vefahren zur herstellung von erythrmycinderivate

Info

Publication number: DE69627381D1
Authority: DE; Germany
Prior art keywords: sup; hydrogen; hydroxy; polar aprotic; erythrmycine
Prior art date: 1995-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69627381T

Other languages

English (en)

Other versions

DE69627381T2 (de

Inventor

Jih-Hua Liu

A Foster

H Montgomery

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-21

Filing date

1996-10-25

Publication date

2003-05-15

1996-10-25 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2003-05-15 Publication of DE69627381D1 publication Critical patent/DE69627381D1/de

2004-03-25 Application granted granted Critical

2004-03-25 Publication of DE69627381T2 publication Critical patent/DE69627381T2/de

2016-10-26 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DE69627381T 1995-11-21 1996-10-25 Vefahren zur herstellung von erythrmycinderivate Expired - Fee Related DE69627381T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/560,752 US5872229A (en)	1995-11-21	1995-11-21	Process for 6-O-alkylation of erythromycin derivatives
US560752		1995-11-21
PCT/US1996/017017 WO1997019096A2 (en)	1995-11-21	1996-10-25	Process for 6-o-alkylation of erythromycin derivatives

Publications (2)

Publication Number	Publication Date
DE69627381D1 true DE69627381D1 (de)	2003-05-15
DE69627381T2 DE69627381T2 (de)	2004-03-25

Family

ID=24239215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69627381T Expired - Fee Related DE69627381T2 (de)	1995-11-21	1996-10-25	Vefahren zur herstellung von erythrmycinderivate

Country Status (11)

Country	Link
US (2)	US5872229A (de)
EP (1)	EP0874862B1 (de)
JP (2)	JP2000500488A (de)
AT (1)	ATE236919T1 (de)
CA (1)	CA2237470C (de)
DE (1)	DE69627381T2 (de)
DK (1)	DK0874862T3 (de)
ES (1)	ES2196184T3 (de)
MX (1)	MX9804047A (de)
PT (1)	PT874862E (de)
WO (1)	WO1997019096A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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US5858986A (en)	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
DE29724846U1 (de)	1996-07-29	2004-12-16	Abbott Laboratories, Abbott Park	Herstellung von kristalliner Form II von Clarithromycin
US5844105A (en) *	1996-07-29	1998-12-01	Abbott Laboratories	Preparation of crystal form II of clarithromycin
US5945405A (en)	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
US5892008A (en) *	1997-12-16	1999-04-06	Abbott Laboratories	Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100317907B1 (ko) *	1998-11-24	2001-12-24	김 완 주	신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR100336447B1 (ko) *	1999-11-24	2002-05-15	민경윤	클라리스로마이신의 개선된 제조방법
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
HUP0204091A3 (en)	1999-12-16	2003-05-28	Teva Pharma	Processes for preparing clarithromycin polymorphs and novel polymorph iv and pharmaceutical composition containing them and their use
EP1280535B1 (de)	2000-01-11	2005-02-09	Teva Pharmaceutical Industries Ltd.	Verfahren zur herstellung von polymorphen des clarithromycins
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6617436B2 (en)	2000-02-29	2003-09-09	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
ES2242668T3 (es) *	2000-03-15	2005-11-16	Hanmi Pharm. Co., Ltd.	Metodo para obtener claritromicina en cristales de forma ii.
KR20000037126A (ko) *	2000-04-08	2000-07-05	김용규	6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6455680B1 (en)	2000-12-21	2002-09-24	Abbott Laboratories	Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
TWI246515B (en)	2001-05-30	2006-01-01	Abbott Lab	An arylation method for the functionalization of O-allyl erythromycin derivatives
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005009368A2 (en) *	2003-07-21	2005-02-03	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
JP2006528185A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258949B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
WO2005016311A1 (en) *	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
WO2005016278A2 (en)	2003-08-12	2005-02-24	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
JP5686494B2 (ja) *	2003-08-29	2015-03-18	シオノギインコーポレイテッド	抗生物質製剤、その使用法及び作成方法
AU2004273830B2 (en) *	2003-09-15	2011-03-24	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2007517039A (ja) *	2003-12-24	2007-06-28	アドバンシスファーマスーティカルコーポレイション	変性放出製剤の吸収増強
EP1771158A4 (de) *	2004-07-02	2008-03-12	Advancis Pharmaceutical Corp	Tablette für pulsierte abgabe
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) *	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
WO2009023191A2 (en) *	2007-08-09	2009-02-19	Teva Pharmaceutical Industries Ltd.	An improved process for the preparation of clarithromycin

Family Cites Families (25)

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Publication number	Priority date	Publication date	Assignee	Title
US3869444A (en)	1972-10-10	1975-03-04	Abbott Lab	Esters of erythromycin oxime
FR2473525A1 (fr)	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en)	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
US4336368A (en)	1981-04-20	1982-06-22	Pfizer Inc.	4 Deoxy-4-methylene oleandomycin and derivatives thereof
JPS5896095A (ja)	1981-11-30	1983-06-07	Taisho Pharmaceut Co Ltd	１１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja)	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS5896098A (ja)	1981-12-03	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンａ誘導体
US4526889A (en)	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
JPS60120895A (ja) *	1983-12-02	1985-06-28	Taisho Pharmaceut Co Ltd	６−０−メチル−２′−０，ν−ビス（ベンジルオキシカルボニル）−ν−デメチルエリスロマイシンａの製法
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja)	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
NO860901L (no)	1985-03-12	1986-09-15	Beecham Group Plc	Fremgangsmaate for fremstilling av farmasoeytisk aktive erytromycinderivater.
GB8506380D0 (en)	1985-03-12	1985-04-11	Beecham Group Plc	Chemical compounds
US4670549A (en)	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja)	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
US4640910A (en)	1985-11-12	1987-02-03	Abbott Laboratories	Erythromycin A silylated compounds and method of use
JPS63107994A (ja)	1986-05-02	1988-05-12	Taisho Pharmaceut Co Ltd	エリスロマイシン誘導体
US4740502A (en)	1986-06-20	1988-04-26	Abbott Laboratories	Semisynthetic erythromycin antibiotics
DE3782994T2 (de) *	1986-09-18	1993-04-08	Taisho Pharma Co Ltd	Erythromycin-a-derivate und verfahren zu ihrer herstellung.
JPH0764867B2 (ja) *	1986-09-18	1995-07-12	大正製薬株式会社	６−ｏ−メチルエリスロマイシンａ誘導体およびその製造方法
JP2526951B2 (ja) *	1986-12-17	1996-08-21	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja)	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
JP2782793B2 (ja) *	1988-06-15	1998-08-06	大正製薬株式会社	エリスロマイシンａ誘導体およびその製造方法
US5302705A (en)	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives

1995
- 1995-11-21 US US08/560,752 patent/US5872229A/en not_active Ceased
1996
- 1996-10-25 AT AT96936904T patent/ATE236919T1/de not_active IP Right Cessation
- 1996-10-25 JP JP9519720A patent/JP2000500488A/ja not_active Ceased
- 1996-10-25 CA CA002237470A patent/CA2237470C/en not_active Expired - Fee Related
- 1996-10-25 WO PCT/US1996/017017 patent/WO1997019096A2/en not_active Ceased
- 1996-10-25 PT PT96936904T patent/PT874862E/pt unknown
- 1996-10-25 EP EP96936904A patent/EP0874862B1/de not_active Expired - Lifetime
- 1996-10-25 ES ES96936904T patent/ES2196184T3/es not_active Expired - Lifetime
- 1996-10-25 DK DK96936904T patent/DK0874862T3/da active
- 1996-10-25 DE DE69627381T patent/DE69627381T2/de not_active Expired - Fee Related
1998
- 1998-05-21 MX MX9804047A patent/MX9804047A/es not_active IP Right Cessation
2004
- 2004-03-22 US US10/806,089 patent/USRE39383E1/en not_active Expired - Lifetime
2007
- 2007-10-24 JP JP2007275992A patent/JP2008110976A/ja active Pending

Also Published As

Publication number	Publication date
US5872229A (en)	1999-02-16
PT874862E (pt)	2003-08-29
ES2196184T3 (es)	2003-12-16
CA2237470A1 (en)	1997-05-29
CA2237470C (en)	2005-01-18
USRE39383E1 (en)	2006-11-07
JP2008110976A (ja)	2008-05-15
DE69627381T2 (de)	2004-03-25
EP0874862B1 (de)	2003-04-09
JP2000500488A (ja)	2000-01-18
ATE236919T1 (de)	2003-04-15
WO1997019096A2 (en)	1997-05-29
WO1997019096A3 (en)	1997-07-03
MX9804047A (es)	1998-09-30
DK0874862T3 (da)	2003-07-28
EP0874862A2 (de)	1998-11-04

Publication	Publication Date	Title
DE69627381D1 (de)	2003-05-15	Vefahren zur herstellung von erythrmycinderivate
BR9812873B1 (pt)	2009-01-13	processo para preparar derivados de triazolinationa.
KR870003164A (ko)	1987-04-15	수용성 아조화합물의 제조방법
HUT37141A (en)	1985-11-28	Process for production of substituted 5,11-dihydro-6h-dibenz /b,e/ azepin-6-ons
MY109628A (en)	1997-03-31	An improved proces for the preparation of substituted indoline derivatives
MX9304378A (es)	1994-03-31	Metodo de preparacion de derivados de carbamato defisostigmina a partir de eseretoles.
DE69909165D1 (de)	2003-08-07	Verfahren zur Herstellung von N-Glycyltyrosin
KR970074748A (ko)	1997-12-10	3-아미노 치환된 크로토네이트의 제조방법
PT968189E (pt)	2002-04-29	Processo para a preparacao de acidos nicotinicos
MX9304397A (es)	1994-02-28	Metodo de preparacion de derivados de carbamato de disoestigmina a partir de fisoestigmina.
EP1092714A3 (de)	2001-07-04	Verfahren zur Herstellung von Benzo[b]thiophenen
KR840005107A (ko)	1984-11-03	피리미디온 및 그의 산부가염의 제조방법
GR3002989T3 (en)	1993-01-25	Process for the production of n-acylated mercapto-alpha-amino acids
CA2005596A1 (en)	1990-07-10	Preparation of 2-amino-4-fluoropyrimidine derivatives
Dalla Croce et al.	1983	1, 3‐Dipolar cycloaddition of nitrones with α, β‐unsaturated sulfones
ATE245149T1 (de)	2003-08-15	Verfahren zur herstellung von alkoxytriazolinonen
DK1109782T3 (da)	2005-10-17	Fremgangsmåde til fremstilling af N-beskyttede azetidin-2-carboxylsyrer (AzeOH'er)
TW227003B (de)	1994-07-21
ES8107190A1 (es)	1981-10-01	Un procedimiento para la preparacion de w-lactamas que con- tienen 5 a 14 atomos de carbono
GR3021336T3 (en)	1997-01-31	New process for the preparation of 20-oxo, 17-alpha, 21-dihydroxy derivatives of pregnane and new intermediates thereof.
HUP0000144A2 (hu)	2000-06-28	Eljárás hidroxi-heteroaromás vegyületek aril-aminokká való átalakítására
KR940007004A (ko)	1994-04-26	4-메톡시벤질-1, 2, 3, 4, 5, 6, 7, 8- 옥타히드로이소퀴놀린의 제조방법
KR880007437A (ko)	1988-08-27	카르복실산 아미드의 제조 방법
SU1741398A1 (ru)	2000-03-10	Способ получения растворимых полиимидов
DE69303577D1 (de)	1996-08-14	Verfahren zur Halognierung von Aromatischen Verbindungen

Legal Events

Date	Code	Title
2003-10-09	8332	No legal effect for de
2003-10-23	8370	Indication related to discontinuation of the patent is to be deleted
2004-05-06	8364	No opposition during term of opposition
2010-08-19	8339	Ceased/non-payment of the annual fee