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DE69621180D1 - 2,2-Difluor-3-Carbamoylribosesulfonat-Verbindungen und Verfahren zur Herstellung von Beta-Nukleosiden - Google Patents

2,2-Difluor-3-Carbamoylribosesulfonat-Verbindungen und Verfahren zur Herstellung von Beta-Nukleosiden

Info

Publication number
DE69621180D1
DE69621180D1 DE69621180T DE69621180T DE69621180D1 DE 69621180 D1 DE69621180 D1 DE 69621180D1 DE 69621180 T DE69621180 T DE 69621180T DE 69621180 T DE69621180 T DE 69621180T DE 69621180 D1 DE69621180 D1 DE 69621180D1
Authority
DE
Germany
Prior art keywords
ribose
nucleosides
difluoro
carbamoyl
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621180T
Other languages
English (en)
Other versions
DE69621180T2 (de
Inventor
Marvin Emanuel Wildfeuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69621180D1 publication Critical patent/DE69621180D1/de
Application granted granted Critical
Publication of DE69621180T2 publication Critical patent/DE69621180T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
DE69621180T 1995-01-18 1996-01-09 2,2-Difluor-3-Carbamoylribosesulfonat-Verbindungen und Verfahren zur Herstellung von Beta-Nukleosiden Expired - Lifetime DE69621180T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,998 US5521294A (en) 1995-01-18 1995-01-18 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides

Publications (2)

Publication Number Publication Date
DE69621180D1 true DE69621180D1 (de) 2002-06-20
DE69621180T2 DE69621180T2 (de) 2002-10-31

Family

ID=23474799

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621180T Expired - Lifetime DE69621180T2 (de) 1995-01-18 1996-01-09 2,2-Difluor-3-Carbamoylribosesulfonat-Verbindungen und Verfahren zur Herstellung von Beta-Nukleosiden

Country Status (9)

Country Link
US (1) US5521294A (de)
EP (1) EP0732338B1 (de)
JP (1) JP3830999B2 (de)
AT (1) ATE217634T1 (de)
CA (1) CA2167361C (de)
DE (1) DE69621180T2 (de)
DK (1) DK0732338T3 (de)
ES (1) ES2176402T3 (de)
PT (1) PT732338E (de)

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US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
EP1270008B1 (de) * 2001-05-31 2006-07-12 Yung Shin Pharmaceutical Ind. Co., Ltd. Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren
AU2003235676A1 (en) * 2002-01-15 2003-07-30 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
AU2003291726A1 (en) * 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101076536A (zh) * 2004-07-30 2007-11-21 药华医药股份有限公司 β－核苷的立体选择性合成
CN101203524B (zh) * 2005-03-04 2011-06-15 费森尤斯卡比肿瘤学有限公司 用于制备β-异头物富集的21-脱氧，21，21-二氟-D-呋喃核糖核苷的中间体和方法
US7485716B2 (en) * 2005-05-02 2009-02-03 Pharmaessentia Corp. Stereoselective synthesis of β-nucleosides
KR20080094890A (ko) * 2005-12-13 2008-10-27 케마지스 리미티드 젬시타빈 및 관련 중간체의 제조 방법
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP2094651A1 (de) * 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthese und biologische wirkungen neuer tricyclischer bis-enone (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
WO2009023845A2 (en) * 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
EP2217247A4 (de) * 2007-11-06 2011-12-28 Pharmaessentia Corp Neue synthese von beta-nucleosiden
MX356760B (es) 2008-01-11 2018-06-12 Dartmouth College Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad.
WO2009146218A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
NZ588709A (en) 2008-04-18 2012-11-30 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: triterpenoid oleanolic acid derivatives with saturation in the c-ring
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
PT2271658T (pt) 2008-04-18 2017-02-13 Reata Pharmaceuticals Inc Moduladores de inflamação antioxidantes: derivados de ácido oleanólico c-17 homologados
AU2009274037B2 (en) 2008-07-22 2015-07-09 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
ES2628580T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de decitabina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer el tratamiento de cáncer
WO2010118013A1 (en) * 2009-04-06 2010-10-14 Eisai Inc. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8324180B2 (en) * 2009-04-06 2012-12-04 Eisai Inc. Compositions and methods for treating cancer
KR101626703B1 (ko) 2012-04-04 2016-06-02 할로자임, 아이엔씨 항-히알루로난 제제 및 종양-표적 탁산을 이용한 병용 치료
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
BR112016008855B1 (pt) 2013-10-29 2023-01-17 Otsuka Pharmaceutical Co., Ltd 2-desóxi-2,2-difluourotetra-hidrouridinas, e seus métodos de produção
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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US2949449A (en) * 1959-01-14 1960-08-16 Hoffmann La Roche Synthesis of 3, 5-diaroyl-2-deoxy-d-ribofuranosyl ureas
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3658786A (en) * 1969-06-27 1972-04-25 Syntex Corp Branched chain ribofuranosyl nucleosides and intermediates
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US4656260A (en) * 1984-12-27 1987-04-07 Kanto Ishi Pharmaceutical Co., Ltd. Cyclic pyrazolo C-nucleoside compound and process for preparing the same
JPH0692392B2 (ja) * 1986-04-04 1994-11-16 信彦 勝沼 新規プソイドウリジン誘導体
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
DE3812681A1 (de) * 1988-04-16 1989-11-02 Bayer Ag Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4954623A (en) * 1989-03-20 1990-09-04 Eli Lilly And Company Recovery of difluoro sugar
US5216145A (en) * 1991-05-10 1993-06-01 American Cyanamid Company Asymmetric synthesis of 3-substituted furanoside compounds
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides

Also Published As

Publication number Publication date
ES2176402T3 (es) 2002-12-01
DK0732338T3 (da) 2002-06-17
ATE217634T1 (de) 2002-06-15
JP3830999B2 (ja) 2006-10-11
EP0732338A1 (de) 1996-09-18
CA2167361A1 (en) 1996-07-19
US5521294A (en) 1996-05-28
EP0732338B1 (de) 2002-05-15
PT732338E (pt) 2002-09-30
DE69621180T2 (de) 2002-10-31
JPH08239374A (ja) 1996-09-17
CA2167361C (en) 2007-09-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN