DE69609725D1 - Neue polymerträger zur nukleinsäuresynthese - Google Patents

Neue polymerträger zur nukleinsäuresynthese

Info

Publication number: DE69609725D1
Authority: DE; Germany
Prior art keywords: nucleic acid; acid synthesis; polymer carrier; new polymer; processes
Prior art date: 1995-11-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69609725T

Other languages

English (en)

Other versions

DE69609725T2 (de

Inventor

Jin-Yan Tang

Jimmy X Tang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nitto Denko Avecia Inc

Original Assignee

Hybridon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-27

Filing date

1996-11-27

Publication date

2000-09-14

1996-11-27 Application filed by Hybridon Inc filed Critical Hybridon Inc

2000-09-14 Application granted granted Critical

2000-09-14 Publication of DE69609725D1 publication Critical patent/DE69609725D1/de

2001-04-05 Publication of DE69609725T2 publication Critical patent/DE69609725T2/de

2016-11-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000001668 nucleic acid synthesis Methods 0.000 title 1
229920000642 polymer Polymers 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000002515 oligonucleotide synthesis Methods 0.000 abstract 1
229920000620 organic polymer Polymers 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)

DE69609725T 1995-11-27 1996-11-27 Neue polymerträger zur nukleinsäuresynthese Expired - Fee Related DE69609725T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/562,841 US5668268A (en)	1995-11-27	1995-11-27	Passivated polymer supports for nucleic acid synthesis
PCT/US1996/019050 WO1997019951A1 (en)	1995-11-27	1996-11-27	Novel polymer supports for nucleic acid synthesis

Publications (2)

Publication Number	Publication Date
DE69609725D1 true DE69609725D1 (de)	2000-09-14
DE69609725T2 DE69609725T2 (de)	2001-04-05

Family

ID=24248010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69609725T Expired - Fee Related DE69609725T2 (de)	1995-11-27	1996-11-27	Neue polymerträger zur nukleinsäuresynthese

Country Status (11)

Country	Link
US (2)	US5668268A (de)
EP (1)	EP0863912B1 (de)
AT (1)	ATE195320T1 (de)
AU (1)	AU1062997A (de)
CA (1)	CA2238865A1 (de)
DE (1)	DE69609725T2 (de)
DK (1)	DK0863912T3 (de)
ES (1)	ES2150702T3 (de)
GR (1)	GR3034534T3 (de)
PT (1)	PT863912E (de)
WO (1)	WO1997019951A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5668268A (en) *	1995-11-27	1997-09-16	Hybridon, Inc.	Passivated polymer supports for nucleic acid synthesis
DE19943374A1 (de) *	1999-09-10	2001-03-29	Max Planck Gesellschaft	Verfahren zum Anbinden von Nukleinsäuren an eine Festphase
EP1287010A1 (de) *	2000-06-02	2003-03-05	Blue Heron Biotechnology, Inc.	Verfahren zur herstellung von synthetischen doppelsträngigen oligonukleotiden mit höherer sequenzgenauigkeit
DE01975541T9 (de) *	2000-09-29	2006-11-16	Molecular Probes, Inc., Eugene	Modifizierte carbocyaninfarbstoffe und deren konjugate
US6932943B1 (en)	2001-01-26	2005-08-23	Third Wave Technologies	Nucleic acid synthesizers
US7435390B2 (en) *	2001-01-26	2008-10-14	Third Wave Technologies, Inc.	Nucleic acid synthesizers
US20030072689A1 (en) *	2001-08-15	2003-04-17	Third Wave Technologies, Inc.	Polymer synthesizer
US7709544B2 (en) *	2005-10-25	2010-05-04	Massachusetts Institute Of Technology	Microstructure synthesis by flow lithography and polymerization
US7947487B2 (en) *	2006-10-05	2011-05-24	Massachusetts Institute Of Technology	Multifunctional encoded particles for high-throughput analysis
JP2009280544A (ja) *	2008-05-26	2009-12-03	Nitto Denko Corp	核酸固相合成用担体
US8431416B2 (en)	2009-04-01	2013-04-30	Becton, Dickinson And Company	Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
US8309059B2 (en) *	2009-08-31	2012-11-13	Promega Corporation	Reactive cyanine compounds
WO2011156432A2 (en)	2010-06-07	2011-12-15	Firefly Bioworks, Inc.	Scanning multifunctional particles
US8623324B2 (en)	2010-07-21	2014-01-07	Aat Bioquest Inc.	Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
US9051441B2 (en)	2012-03-29	2015-06-09	Xerox Corporation	Process for chemical passivation of polymer surfaces
CN107873054B (zh) *	2014-09-09	2022-07-12	博德研究所	用于复合单细胞核酸分析的基于微滴的方法和设备
US9896538B2 (en)	2016-03-28	2018-02-20	Aat Bioquest, Inc.	Polyfluoreno[4,5-cde]oxepine polymers and conjugates thereof
US11220628B2 (en)	2019-02-20	2022-01-11	Aat Bioquest, Inc.	Condensed polycyclic conjugated polymers and their use for biological detection
CN115280147A (zh)	2020-01-30	2022-11-01	阿特生物探索公司	可紫外激发的基于聚芴的缀合物及其在分析物检测方法中的用途
CN120174630B (zh) *	2025-05-21	2025-09-12	天津中合基因科技有限公司	一种编织型dna合成固定相的制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4458066A (en) *	1980-02-29	1984-07-03	University Patents, Inc.	Process for preparing polynucleotides
US4638032A (en) *	1983-12-12	1987-01-20	Genetics Institute, Inc.	Magnetic particles as supports for organic synthesis
US5049656A (en) *	1988-12-21	1991-09-17	Board Of Regents Of The University Of Nebraska	Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
US5262530A (en) *	1988-12-21	1993-11-16	Applied Biosystems, Inc.	Automated system for polynucleotide synthesis and purification
US5112962A (en) *	1989-04-19	1992-05-12	Northwestern University	Labile anchors for solid phase polynucleotide synthesis
US5204455A (en) *	1989-06-15	1993-04-20	Froehler Brian C	Monomethoxytrityl protected oligonucleotides bound to a solid support
US5470463A (en) *	1992-06-19	1995-11-28	Sepracor Inc.	Passivated porous supports and methods for the preparation and use of same
US5668268A (en) *	1995-11-27	1997-09-16	Hybridon, Inc.	Passivated polymer supports for nucleic acid synthesis

1995
- 1995-11-27 US US08/562,841 patent/US5668268A/en not_active Expired - Fee Related
1996
- 1996-11-27 EP EP96941507A patent/EP0863912B1/de not_active Expired - Lifetime
- 1996-11-27 PT PT96941507T patent/PT863912E/pt unknown
- 1996-11-27 AT AT96941507T patent/ATE195320T1/de not_active IP Right Cessation
- 1996-11-27 AU AU10629/97A patent/AU1062997A/en not_active Abandoned
- 1996-11-27 DE DE69609725T patent/DE69609725T2/de not_active Expired - Fee Related
- 1996-11-27 DK DK96941507T patent/DK0863912T3/da active
- 1996-11-27 ES ES96941507T patent/ES2150702T3/es not_active Expired - Lifetime
- 1996-11-27 WO PCT/US1996/019050 patent/WO1997019951A1/en not_active Ceased
- 1996-11-27 CA CA002238865A patent/CA2238865A1/en not_active Abandoned
1997
- 1997-09-10 US US08/926,755 patent/US6392031B1/en not_active Expired - Fee Related
2000
- 2000-10-02 GR GR20000402224T patent/GR3034534T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0863912A1 (de)	1998-09-16
AU1062997A (en)	1997-06-19
DE69609725T2 (de)	2001-04-05
EP0863912B1 (de)	2000-08-09
ATE195320T1 (de)	2000-08-15
CA2238865A1 (en)	1997-06-05
PT863912E (pt)	2000-12-29
WO1997019951A1 (en)	1997-06-05
US5668268A (en)	1997-09-16
US6392031B1 (en)	2002-05-21
DK0863912T3 (da)	2000-11-06
GR3034534T3 (en)	2001-01-31
ES2150702T3 (es)	2000-12-01

Publication	Publication Date	Title
ATE195320T1 (de)	2000-08-15	Neue polymerträger zur nukleinsäuresynthese
ATE154029T1 (de)	1997-06-15	7-deazapurin modifizierte oligonukleotide
NO991942D0 (no)	1999-04-23	FremgangsmÕte for fremstilling av malonat metyliden nanopartikler, nanopartikler eventuelt inneholdende en eller flere biologisk aktive molekyler
DE69840748D1 (de)	2009-05-28	Verfahren zur zubereitung von antisense oligonukleotiden
DE59902306D1 (de)	2002-09-12	Reaktor zur kontinuierlichen durchführung von gas-flüssig-, flüssig-flüssig- oder gas-flüssig-fest-reaktionen
DE69801973D1 (de)	2001-11-15	Verfahren zur Herstellung von 1,1,1,3,3-Pentafluorpropan
WO2001047944A3 (en)	2003-02-20	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
ES2118593T3 (es)	1998-09-16	Analogos de nucleotidos de pteridina como sondas fluorescentes de adn.
WO1997026270A3 (en)	1997-11-20	Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
DE69813523D1 (de)	2003-05-22	Polyalkoxysiloxanverbindungen,verfahren zur herstellung und diese verbindungen enthaltende beschichtungszusammensetzungen
DE69819998D1 (de)	2004-01-08	Verfahren zur chemischen Synthese von Oligonukleotiden
EP1123414A4 (de)	2003-10-01	Antisense modulation der expression von integrin alpha 4
WO2000029623A3 (en)	2001-04-19	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001032935A3 (en)	2002-05-02	Molecular microarrays and methods for production and use thereof
DK0840802T3 (da)	2002-05-06	Fremgangsmåde til sekvensering gennem oligomerhybridisering
ZA975588B (en)	1998-01-23	Isolated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof.
ATE278702T1 (de)	2004-10-15	Verfahren zur synthese von phosphorothioat- oligonukelotiden
WO2001040521A3 (en)	2002-05-16	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001048245A3 (en)	2002-11-28	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
DE60124489D1 (de)	2006-12-28	Verfahren zur endothermischen Umsetzung von Kohlenwasserstoffen, ihre Anwendung und Vorrichtung zur Anwendung dieses Verfahren
ATE301664T1 (de)	2005-08-15	Boronsäurehaltige reagenzien und oligonukleotide
EP1118659A4 (de)	2002-12-04	Expressionssysteme zur funktionellen expression von nukleinsäuren
DE69802329D1 (de)	2001-12-13	Verfahren zur Herstellung von 3,4 disubstituirten Dinitroanilinen
WO2000029622A3 (en)	2002-04-25	Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
DE69814097D1 (de)	2003-06-05	Universale Polymere Träger zur Synthese von Oligonukleotiden

Legal Events

Date	Code	Title	Description
2001-08-30	8364	No opposition during term of opposition
2004-04-22	8327	Change in the person/name/address of the patent owner	Owner name: AVECIA BIOTECHNOLOGY, INC., MILFORD, MASS., US
2007-09-13	8339	Ceased/non-payment of the annual fee