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DE69606165D1 - Bizyclische isothioharnstoff-derivate mit therapeutischer wirkung - Google Patents

Bizyclische isothioharnstoff-derivate mit therapeutischer wirkung

Info

Publication number
DE69606165D1
DE69606165D1 DE69606165T DE69606165T DE69606165D1 DE 69606165 D1 DE69606165 D1 DE 69606165D1 DE 69606165 T DE69606165 T DE 69606165T DE 69606165 T DE69606165 T DE 69606165T DE 69606165 D1 DE69606165 D1 DE 69606165D1
Authority
DE
Germany
Prior art keywords
isothioune
bizyclic
derivatives
therapeutic effect
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69606165T
Other languages
English (en)
Other versions
DE69606165T2 (de
Inventor
Edwin Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9502669.6A external-priority patent/GB9502669D0/en
Priority claimed from GBGB9502670.4A external-priority patent/GB9502670D0/en
Application filed by Astra AB filed Critical Astra AB
Publication of DE69606165D1 publication Critical patent/DE69606165D1/de
Application granted granted Critical
Publication of DE69606165T2 publication Critical patent/DE69606165T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE69606165T 1995-02-11 1996-02-09 Bizyclische isothioharnstoff-derivate mit therapeutischer wirkung Expired - Fee Related DE69606165T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9502669.6A GB9502669D0 (en) 1995-02-11 1995-02-11 Pharmaceutically active compounds
GBGB9502670.4A GB9502670D0 (en) 1995-02-11 1995-02-11 Pharmaceutically active compounds
PCT/SE1996/000162 WO1996024588A1 (en) 1995-02-11 1996-02-09 Bicyclic isothiourea derivatives useful in therapy

Publications (2)

Publication Number Publication Date
DE69606165D1 true DE69606165D1 (de) 2000-02-17
DE69606165T2 DE69606165T2 (de) 2000-08-24

Family

ID=26306479

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69606165T Expired - Fee Related DE69606165T2 (de) 1995-02-11 1996-02-09 Bizyclische isothioharnstoff-derivate mit therapeutischer wirkung

Country Status (29)

Country Link
US (2) US5786364A (de)
EP (1) EP0808307B1 (de)
JP (1) JPH10513194A (de)
KR (1) KR19980702114A (de)
CN (1) CN1181070A (de)
AR (1) AR002961A1 (de)
AT (1) ATE188689T1 (de)
AU (1) AU699546B2 (de)
BR (1) BR9607264A (de)
CA (1) CA2211299A1 (de)
CZ (1) CZ237597A3 (de)
DE (1) DE69606165T2 (de)
DK (1) DK0808307T3 (de)
EE (1) EE03439B1 (de)
ES (1) ES2143181T3 (de)
FI (1) FI973273A7 (de)
GR (1) GR3033135T3 (de)
HU (1) HUP9801363A3 (de)
IL (1) IL116966A (de)
IS (1) IS4528A (de)
NO (1) NO309036B1 (de)
NZ (1) NZ301831A (de)
PL (1) PL321741A1 (de)
PT (1) PT808307E (de)
RU (1) RU2157802C2 (de)
SK (1) SK281205B6 (de)
TR (1) TR199700769T1 (de)
TW (1) TW397812B (de)
WO (1) WO1996024588A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
TW458978B (en) * 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
US6140322A (en) * 1995-11-07 2000-10-31 Astra Aktiebolag Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase
AU4947197A (en) * 1996-10-16 1998-05-11 Glaxo Group Limited Tetrahydro-6h-pyrazino{1,2-b}isoquinoline 1,4-diones as apoprotein b-100 inhibitors
US5929085A (en) * 1996-11-06 1999-07-27 Astra Aktiebolag Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
GB9719530D0 (en) * 1997-09-12 1997-11-19 Smithkline Beecham Plc Novel compounds
DE19844291A1 (de) * 1998-09-18 2000-03-23 Schering Ag Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln
US6664293B2 (en) * 1999-02-26 2003-12-16 Fujiwawa Pharmaceutical Co., Ltd. Amide compounds for the potentiation of cholinergic activity
GB0016169D0 (en) * 2000-06-30 2000-08-23 Univ London Diagnostic method
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
RU2223952C2 (ru) * 2001-06-04 2004-02-20 Институт физиологически активных веществ РАН Производные n,s-замещенных n'-1-[(гетеро)арил]-n'-[(гетеро)арил]метилизотиомочевин или их солей с фармакологически приемлемыми кислотами нх, способы получения их солей и оснований, фармацевтическая композиция, способ лечения и способ изучения глутаматэргической системы
RU2252936C2 (ru) * 2002-12-05 2005-05-27 Институт физиологически активных веществ РАН S-замещенные n-1-[(гетеро)арил]алкил-n`-[(гетеро)арил]алкилизотиомочевины, способ их получения, фармацевтическая композиция, способ изучения глутаматэргической системы, способы лечения (варианты)
ITTO20040125A1 (it) 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
RU2353614C1 (ru) * 2007-11-06 2009-04-27 Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова Антигипотензивное средство

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1157626B (de) * 1959-06-27 1963-11-21 Hoechst Ag Verfahren zur Herstellung von N-p-Alkoxy-phenyl-N'-chinolylthioharnstoffen mit tuberkulostatischen Eigenschaften
GB1178242A (en) * 1966-02-05 1970-01-21 Wellcome Found Novel Biologically Active Bis-Isothioureas
BE792078A (fr) * 1971-12-01 1973-05-29 Wander Ag Dr A Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
NL7902993A (nl) * 1978-04-24 1979-10-26 Rhone Poulenc Ind Nieuwe isochinolinederivaten, de bereiding ervan en farmaceutische preparaten, die de nieuwe isochinoline- derivaten bevatten.
ES2036213T3 (es) * 1986-10-28 1993-05-16 Smith Kline & French Laboratories Limited Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos.
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
US4988688A (en) * 1989-08-02 1991-01-29 Warner-Lambert Company 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
CN1095710A (zh) * 1992-11-27 1994-11-30 惠尔康基金会集团公司 酶抑制剂
IL110643A (en) * 1993-08-12 1998-07-15 Astra Ab Amidine derivatives their preparation and pharmaceutical compositions containing them
EP0723438A1 (de) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substitutierte harnstoff und isothioharnstoff derivate als no synthase inhibitoren
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
SK104097A3 (en) 1998-10-07
CA2211299A1 (en) 1996-08-15
SK281205B6 (sk) 2001-01-18
AU699546B2 (en) 1998-12-03
TW397812B (en) 2000-07-11
EE9700168A (et) 1998-02-16
PL321741A1 (en) 1997-12-22
WO1996024588A1 (en) 1996-08-15
GR3033135T3 (en) 2000-08-31
HUP9801363A2 (hu) 1998-09-28
NO973614L (no) 1997-09-29
EP0808307B1 (de) 2000-01-12
PT808307E (pt) 2000-04-28
BR9607264A (pt) 1997-12-30
DK0808307T3 (da) 2000-05-08
FI973273A0 (fi) 1997-08-08
MX9705965A (es) 1997-11-29
AU4734796A (en) 1996-08-27
US6040314A (en) 2000-03-21
FI973273L (fi) 1997-08-08
IS4528A (is) 1997-07-21
EE03439B1 (et) 2001-06-15
NO309036B1 (no) 2000-12-04
US5786364A (en) 1998-07-28
ES2143181T3 (es) 2000-05-01
ATE188689T1 (de) 2000-01-15
CZ237597A3 (cs) 1998-05-13
KR19980702114A (ko) 1998-07-15
CN1181070A (zh) 1998-05-06
IL116966A (en) 2000-02-17
NO973614D0 (no) 1997-08-05
AR002961A1 (es) 1998-05-27
RU2157802C2 (ru) 2000-10-20
NZ301831A (en) 1998-05-27
IL116966A0 (en) 1996-05-14
JPH10513194A (ja) 1998-12-15
EP0808307A1 (de) 1997-11-26
FI973273A7 (fi) 1997-08-08
TR199700769T1 (xx) 1998-03-21
HUP9801363A3 (en) 1999-01-28
DE69606165T2 (de) 2000-08-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee