[go: up one dir, main page]

DE69530792D1 - Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation - Google Patents

Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation

Info

Publication number
DE69530792D1
DE69530792D1 DE69530792T DE69530792T DE69530792D1 DE 69530792 D1 DE69530792 D1 DE 69530792D1 DE 69530792 T DE69530792 T DE 69530792T DE 69530792 T DE69530792 T DE 69530792T DE 69530792 D1 DE69530792 D1 DE 69530792D1
Authority
DE
Germany
Prior art keywords
inhalation
pharmaceutical composition
composition containing
proliposome powder
proliposome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69530792T
Other languages
English (en)
Other versions
DE69530792T2 (de
Inventor
Katarina Bystroem
Per-Gunnar Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9404466A external-priority patent/SE9404466D0/xx
Priority claimed from SE9502369A external-priority patent/SE9502369D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69530792D1 publication Critical patent/DE69530792D1/de
Publication of DE69530792T2 publication Critical patent/DE69530792T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69530792T 1994-12-22 1995-12-20 Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation Expired - Lifetime DE69530792T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9404466A SE9404466D0 (sv) 1994-12-22 1994-12-22 Process for the preparation of powders for inhalation
SE9404466 1994-12-22
SE9502369A SE9502369D0 (sv) 1995-06-30 1995-06-30 Process for the preparation of compositions for inhalation
SE9502369 1995-06-30
PCT/SE1995/001560 WO1996019199A1 (en) 1994-12-22 1995-12-20 Proliposome powders for inhalation

Publications (2)

Publication Number Publication Date
DE69530792D1 true DE69530792D1 (de) 2003-06-18
DE69530792T2 DE69530792T2 (de) 2004-04-15

Family

ID=26662194

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530792T Expired - Lifetime DE69530792T2 (de) 1994-12-22 1995-12-20 Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation

Country Status (32)

Country Link
US (1) US6045828A (de)
EP (1) EP0800383B1 (de)
JP (1) JPH10510830A (de)
KR (1) KR100432461B1 (de)
CN (1) CN1087932C (de)
AR (1) AR002009A1 (de)
AT (1) ATE240095T1 (de)
AU (1) AU693632B2 (de)
BR (1) BR9510512A (de)
CA (1) CA2208517A1 (de)
CZ (1) CZ286469B6 (de)
DE (1) DE69530792T2 (de)
DK (1) DK0800383T3 (de)
EE (1) EE03592B1 (de)
EG (1) EG23683A (de)
ES (1) ES2194931T3 (de)
FI (1) FI972653L (de)
HU (1) HUT77628A (de)
IL (1) IL116454A (de)
IS (1) IS1978B (de)
MY (1) MY114114A (de)
NO (1) NO320434B1 (de)
NZ (1) NZ298180A (de)
PL (1) PL184393B1 (de)
PT (1) PT800383E (de)
RU (1) RU2162689C2 (de)
SA (1) SA95160463B1 (de)
SK (1) SK284918B6 (de)
TR (1) TR199501633A1 (de)
TW (1) TW508248B (de)
UA (1) UA43886C2 (de)
WO (1) WO1996019199A1 (de)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
TW497974B (en) * 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
EP0927025A4 (de) * 1996-09-18 2001-07-25 Dragoco Inc Trockene pulverzusammensetzung mit in liposomen verkapseltem wirkstoff
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
IL133597A0 (en) * 1997-06-27 2001-04-30 Astra Ab New combination of antiasthma medicaments
EE9900601A (et) * 1997-06-27 2000-08-15 Astra Aktiebolag Tokoferooliga stabiliseeritud inhaleeritavad proliposoomipulbrid
US7052678B2 (en) * 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US7348025B2 (en) 1997-09-23 2008-03-25 Research Development Foundation Small particle liposome aerosols for delivery of anticancer drugs
US6090407A (en) 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
SE9704833D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New formulation
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
EP1128813B1 (de) * 1998-11-12 2007-02-14 Inc. Transave Inhalationssystem
EP1839648A3 (de) * 1998-11-12 2007-11-21 Transave, Inc. Inhalationssystem
GB9912639D0 (en) * 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
EP1133301A1 (de) * 1998-11-26 2001-09-19 Britannia Pharmaceuticals Limited Antiasthmatische kombinationen enthaltend oberflächenaktive phospholipide
SK286981B6 (sk) * 1999-03-05 2009-08-06 Chiesi Farmaceutici S.P.A. Prášok na použitie v inhalátore na suché prášky, nosič na tento prášok a spôsob výroby prášku
EP1043016B1 (de) * 1999-03-30 2014-08-20 Sodic Sa Pflanzenextrakt auf Glycerid-, Phospholipid- und Phytosphingolipidbasis, Verfahren für die Gewinnung dieses Extrakts und ihn enthaltende kosmetische Zusammensetzungen
JP2002540850A (ja) * 1999-04-05 2002-12-03 ファーマシューティカル ディスカバリー コーポレイション 微粉形成のための方法
US7364749B1 (en) 1999-05-27 2008-04-29 Euro-Celtique, S.A. Preparations for the application of anti-infective and/or anti-inflammatory agents
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
JP2003507410A (ja) * 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ，インコーポレイテッド 乾燥粉末製剤からの放出調節
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
GB9928311D0 (en) * 1999-11-30 2000-01-26 Novartis Ag Organic compounds
DE10012151A1 (de) * 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
GB0008660D0 (en) * 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DK1280520T4 (en) 2000-05-10 2018-06-25 Novartis Ag Phospholipid based powders for drug delivery
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
EP2067784A3 (de) 2000-08-05 2012-08-22 Glaxo Group Limited 17.beta.-Carbothioat-17.alpha.-Arylcarbonyloxyloxy-Androstan-Derivate als entzündungshemmende Mittel
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
DK1920763T3 (da) 2000-11-30 2014-07-07 Vectura Ltd Farrmaceutiske præparater til inhalation
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
IL158222A0 (en) 2001-04-30 2004-05-12 Glaxo Group Ltd Anti-inflammatory 17. beta-carbothioate ester derivatives of androstane with a cyclic ester group in position 17. alpha
CA2465675C (en) * 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
AU2003201569B2 (en) * 2002-01-21 2008-09-11 Vasogen Ireland Limited Pharmaceutically acceptable phosphate-glycerol carrying bodies
EP1487413A4 (de) * 2002-03-05 2010-11-10 Transave Inc Inhalationssystem zur prävention und behandlung von intrazellulären infektionen
EP1494732B1 (de) 2002-03-20 2008-01-30 MannKind Corporation Inhalationsgerät
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7879351B2 (en) 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
CA2504317C (en) 2002-10-29 2012-05-22 Transave, Inc. Sustained release of antiinfectives
CN1208052C (zh) 2003-03-20 2005-06-29 上海家化联合股份有限公司 一种辅酶q10前体脂质体及其制备方法
WO2004093848A2 (en) * 2003-04-14 2004-11-04 Vectura Ltd Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
US20060147389A1 (en) * 2004-04-14 2006-07-06 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
CN100427064C (zh) * 2003-04-16 2008-10-22 沈阳药科大学 一种制备脂质体的新方法
EP1699434B1 (de) 2003-09-02 2011-02-16 Norton Healthcare Limited Verfahren zur herstellung eines medikaments
WO2005044226A2 (en) * 2003-11-04 2005-05-19 Nectar Therapeutics Lipid formulations for spontaneous drug encapsulation
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
EP2314298B1 (de) 2004-08-23 2015-05-27 MannKind Corporation Mikropartikel enthaltend Diketopiperazinsalze zur Arzneimitteldarreichung
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
EP1928423B1 (de) 2005-09-14 2015-12-09 Mannkind Corporation Verfahren zur arzneimittelformulierung basierend auf der affinitätssteigerung von aktiven wirkstoffen für kristalline mikropartikel-flächen
US8226975B2 (en) 2005-12-08 2012-07-24 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
DK1986679T3 (da) 2006-02-22 2017-11-20 Mannkind Corp Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof
CN1895223B (zh) * 2006-04-05 2012-06-27 沈阳药科大学 一种新的脂质体制备方法
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
AU2008227852B2 (en) * 2007-03-19 2011-02-24 Fresenius Kabi Oncology Ltd. Proliposomal and liposomal compositions
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
US8485180B2 (en) * 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
CN103751892B (zh) 2008-06-20 2017-03-01 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL3578169T3 (pl) 2009-02-26 2024-09-02 Glaxo Group Limited Preparaty farmaceutyczne zawierające 4-{(1r)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
KR102092361B1 (ko) 2012-05-21 2020-03-23 인스메드 인코포레이티드 폐 감염을 치료하기 위한 시스템
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
EA035868B1 (ru) * 2012-08-17 2020-08-24 Смартек Интернэшнл Эл-Эл-Си Приготовление высушенных липосом для применения в системах выпуска в прессованном виде
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
BR112015012351A8 (pt) 2012-11-29 2019-10-01 Insmed Inc composição de antibiótico de glicopeptídeo à base de lipídeo estabilizado e uso de um componente lipídico, um componente de antibiótico de glicopeptídeo e um aminoácido ou derivado do mesmo
US9603799B2 (en) * 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
KR102321339B1 (ko) 2013-07-18 2021-11-02 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
KR102489036B1 (ko) 2014-05-15 2023-01-13 인스메드 인코포레이티드 폐의 비-결핵성 마이코박테리아 감염을 치료하기 위한 방법
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP7066632B2 (ja) * 2016-05-09 2022-05-13 アストラゼネカ・アクチエボラーグ 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法
EP3773505A4 (de) 2018-03-30 2021-12-22 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514674A (en) * 1894-02-13 Ejector for breakdown guns
EP0026241B1 (de) * 1978-10-12 1984-03-14 Bowater-Scott Limited Halter und Ausgeber für aufgestapelte Rollen
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
DE3585967D1 (de) * 1984-03-08 1992-06-11 Phares Pharma Holland Liposombildende zusammensetzung.
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
RU2014071C1 (ru) * 1991-03-26 1994-06-15 Научно-производственный центр медицинской биотехнологии Способ получения липосом, содержащих водорастворимые низкомолекулярные соединения
CA2087902C (en) * 1992-02-05 2006-10-17 Narendra Raghunathji Desai Liposome compositions of porphyrin photosensitizers
ATE163541T1 (de) * 1993-08-06 1998-03-15 Opperbas Holding Bv Herstellungsverfahren von mit biologischen strukturen, biopolymeren und/oder oligomeren beladenen vesikeln
US5635206A (en) * 1994-01-20 1997-06-03 Hoffmann-La Roche Inc. Process for liposomes or proliposomes
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.

Also Published As

Publication number Publication date
EP0800383B1 (de) 2003-05-14
SA95160463B1 (ar) 2005-10-04
RU2162689C2 (ru) 2001-02-10
DK0800383T3 (da) 2003-07-07
TW508248B (en) 2002-11-01
MY114114A (en) 2002-08-30
NZ298180A (en) 1999-01-28
KR100432461B1 (ko) 2004-07-16
CN1087932C (zh) 2002-07-24
WO1996019199A1 (en) 1996-06-27
FI972653A7 (fi) 1997-08-20
DE69530792T2 (de) 2004-04-15
IS1978B (is) 2005-01-14
EE03592B1 (et) 2002-02-15
CA2208517A1 (en) 1996-06-27
BR9510512A (pt) 1998-07-07
EP0800383A1 (de) 1997-10-15
IS4500A (is) 1997-06-06
AR002009A1 (es) 1998-01-07
PL320825A1 (en) 1997-11-10
FI972653L (fi) 1997-08-20
IL116454A (en) 2002-03-10
CZ286469B6 (en) 2000-04-12
MX9704406A (es) 1997-10-31
ATE240095T1 (de) 2003-05-15
AU693632B2 (en) 1998-07-02
PL184393B1 (pl) 2002-10-31
TR199501633A1 (tr) 1997-03-21
US6045828A (en) 2000-04-04
NO972847L (no) 1997-06-19
CZ194897A3 (en) 1997-10-15
SK284918B6 (sk) 2006-02-02
JPH10510830A (ja) 1998-10-20
SK81497A3 (en) 1997-11-05
EG23683A (en) 2007-05-09
HUT77628A (hu) 1998-06-29
EE9700134A (et) 1997-12-15
AU4360596A (en) 1996-07-10
PT800383E (pt) 2003-07-31
NO972847D0 (no) 1997-06-19
IL116454A0 (en) 1996-03-31
NO320434B1 (no) 2005-12-05
ES2194931T3 (es) 2003-12-01
CN1171047A (zh) 1998-01-21
UA43886C2 (uk) 2002-01-15
FI972653A0 (fi) 1997-06-19

Similar Documents

Publication Publication Date Title
ATE240095T1 (de) Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation
EP0768094A3 (de) Inhalator für Arzneimittel in Pulverform
ZA9810490B (en) 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
HUP9802999A3 (en) Pharmaceutical composition containing n-propargyl-1-aminoindan
IL120246A0 (en) Powdered medication inhaler
HUP0104255A3 (en) An pharmaceutical composition suitable for inhalation
GB9120024D0 (en) Nasal pharmaceutical composition
HUP9701554D0 (en) Pharmaceutical composition containing plazma proteins
NO953388D0 (no) Medikamentbærer for törr-pulver inhalator
IL118369A0 (en) Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IL116211A0 (en) Peptide compounds pharmaceutical compositions containing the same and processes for the preparation thereof
SG52435A1 (en) Pharmaceutical composition containing lipophilic drugs
HUP9903407A3 (en) Oral pharmaceutical preparation containing ibandronat
IL122618A0 (en) Substituted imidazolylacetonitrile compounds their preparation and pharmaceutical compositions containing them
ZA962916B (en) New arylglycineamide derivatives processes for the manufacture thereof and pharmaceutical compositions containing these compounds
AP9701160A0 (en) Compounds and pharmaceutical compositions containing them
IL117620A0 (en) Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same
IL125820A0 (en) Therapeutic agent for diabetes and a pharmaceutical composition containing the same
EP0448091A3 (en) Pharmaceutical composition containing slightly water-soluble drug
IL116771A (en) 9-Substituted 2-(2-n-alkoxyphenyl) purin-6-one compounds their preparation and pharmaceutical compositions containing them
IL133928A0 (en) Pharmaceutical composition containing peptichemio
IL117397A (en) Substituted naphthyl compounds and pharmaceutical compositions comprising them
IL115272A0 (en) Asp-pallidipin pharmaceutical compositions containing the same and processes for the preparation thereof
IL118007A0 (en) Isoxazoline compounds pharmaceutical compositions containing them and their use
IL123424A0 (en) Heterocyclic compounds their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8364 No opposition during term of opposition