DE69524428D1 - Dihydrobenzofuran und verwandte verbindungen als entzündungshemmende mittel - Google Patents
Dihydrobenzofuran und verwandte verbindungen als entzündungshemmende mittelInfo
- Publication number
- DE69524428D1 DE69524428D1 DE69524428T DE69524428T DE69524428D1 DE 69524428 D1 DE69524428 D1 DE 69524428D1 DE 69524428 T DE69524428 T DE 69524428T DE 69524428 T DE69524428 T DE 69524428T DE 69524428 D1 DE69524428 D1 DE 69524428D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- atoms
- alkanyl
- unsubstituted
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30145694A | 1994-09-07 | 1994-09-07 | |
| PCT/US1995/011309 WO1996007651A1 (en) | 1994-09-07 | 1995-09-06 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69524428D1 true DE69524428D1 (de) | 2002-01-17 |
| DE69524428T2 DE69524428T2 (de) | 2002-05-23 |
Family
ID=23163447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69524428T Expired - Fee Related DE69524428T2 (de) | 1994-09-07 | 1995-09-06 | Dihydrobenzofuran und verwandte verbindungen als entzündungshemmende mittel |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5684002A (de) |
| EP (1) | EP0779886B1 (de) |
| JP (1) | JPH10505089A (de) |
| KR (1) | KR100249542B1 (de) |
| CN (1) | CN1183126C (de) |
| AT (1) | ATE210125T1 (de) |
| AU (1) | AU682281B2 (de) |
| BR (1) | BR9508901A (de) |
| CA (1) | CA2199128C (de) |
| DE (1) | DE69524428T2 (de) |
| DK (1) | DK0779886T3 (de) |
| ES (1) | ES2169150T3 (de) |
| MX (1) | MX9701819A (de) |
| NZ (1) | NZ292782A (de) |
| WO (1) | WO1996007651A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5672620A (en) * | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5821250A (en) * | 1996-02-01 | 1998-10-13 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5618835A (en) * | 1996-02-01 | 1997-04-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5686471A (en) * | 1996-02-01 | 1997-11-11 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5684041A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5985930A (en) | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| HRP20130638T1 (en) * | 2003-06-26 | 2013-08-31 | Takeda Pharmaceutical Company Limited | Cannabinoid receptor modulator |
| JP2008539047A (ja) | 2005-04-28 | 2008-11-13 | プロテウス バイオメディカル インコーポレイテッド | ファーマインフォーマティックスシステム |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| US9394267B2 (en) | 2007-07-13 | 2016-07-19 | The Cleveland Clinic Foundation | Heterocyclic modulators of cannabinoid receptors |
| WO2009012227A1 (en) * | 2007-07-13 | 2009-01-22 | Board Of Regents, The University Of Texas System | Hydrazone modulators of cannabinoid receptors |
| US9079854B2 (en) | 2007-07-13 | 2015-07-14 | The Cleveland Clinic Foundation | Hydrazone modulators of cannabinoid receptors |
| JP5453258B2 (ja) * | 2007-07-13 | 2014-03-26 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | カンナビノイド受容体の複素環式モジュレーター |
| CN102316902B (zh) | 2009-02-20 | 2014-09-24 | to-BBB控股股份有限公司 | 基于谷胱甘肽的药物递送系统 |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| WO2014011949A2 (en) | 2012-07-13 | 2014-01-16 | The Cleveland Clinic Foundation | Neuroprotective cb2 receptor agonists |
| KR101592560B1 (ko) * | 2013-06-21 | 2016-02-05 | 제주대학교 산학협력단 | 신규 플라보노이드 및 그 용도 |
| CN114133948A (zh) * | 2021-12-29 | 2022-03-04 | 江苏三吉利化工股份有限公司 | 一种利用呋喃酚焦油制备橡胶油的方法 |
| CN117624095B (zh) * | 2023-11-28 | 2024-09-13 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种新型手性二氢苯并呋喃酰胺的合成方法及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758838A (fr) * | 1969-11-13 | 1971-05-12 | Geigy Ag J R | Esters d'acides carboxyliques heterocyliques et medicaments renfermant de telles substances |
| JPS6031829B2 (ja) * | 1975-06-26 | 1985-07-24 | ウェルファイド株式会社 | アミノアルコ−ル誘導体の製造法 |
| FR2332010A1 (fr) * | 1975-11-18 | 1977-06-17 | Continental Pharma | Amino-alcool heterocyclique, son sel et son procede de preparation |
| JPS6019305B2 (ja) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | ジヒドロベンゾフラン誘導体 |
| JPS603305B2 (ja) * | 1976-12-27 | 1985-01-26 | エーザイ株式会社 | ２，３―ジハイドロベンゾフラン誘導体 |
| US4130666A (en) * | 1977-05-16 | 1978-12-19 | Riker Laboratories, Inc. | Anti-inflammatory method |
| IT1093805B (it) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione |
| DE3110009A1 (de) * | 1981-03-11 | 1982-09-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue benzofuran-derivate, ihre herstellung und verwendung |
| FI842738L (fi) * | 1983-07-14 | 1985-01-15 | Syntex Inc | Aroylbenzofuran- och benzotiofenaettik- och propionsyror. |
| US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
| JPS61158976A (ja) * | 1984-12-28 | 1986-07-18 | Shionogi & Co Ltd | ベンゾフランおよびベンゾチオフエン誘導体 |
| US4708966A (en) * | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
| US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
| IL88674A0 (en) * | 1987-12-18 | 1989-07-31 | Norwich Eaton Pharma | Preparation of certain substituted aromatic compounds |
| JPH07121933B2 (ja) * | 1988-03-28 | 1995-12-25 | キッセイ薬品工業株式会社 | ジヒドロベンゾフラノン誘導体 |
| GB9322781D0 (en) * | 1993-11-04 | 1993-12-22 | Roussel Lab Ltd | Aromatic amides |
-
1995
- 1995-06-07 US US08/486,876 patent/US5684002A/en not_active Expired - Fee Related
- 1995-09-06 JP JP8509653A patent/JPH10505089A/ja not_active Ceased
- 1995-09-06 DE DE69524428T patent/DE69524428T2/de not_active Expired - Fee Related
- 1995-09-06 CA CA002199128A patent/CA2199128C/en not_active Expired - Fee Related
- 1995-09-06 KR KR1019970701514A patent/KR100249542B1/ko not_active Expired - Fee Related
- 1995-09-06 CN CNB951949691A patent/CN1183126C/zh not_active Expired - Fee Related
- 1995-09-06 ES ES95931734T patent/ES2169150T3/es not_active Expired - Lifetime
- 1995-09-06 MX MX9701819A patent/MX9701819A/es not_active IP Right Cessation
- 1995-09-06 WO PCT/US1995/011309 patent/WO1996007651A1/en not_active Ceased
- 1995-09-06 NZ NZ292782A patent/NZ292782A/xx unknown
- 1995-09-06 AU AU35059/95A patent/AU682281B2/en not_active Ceased
- 1995-09-06 BR BR9508901A patent/BR9508901A/pt not_active IP Right Cessation
- 1995-09-06 EP EP95931734A patent/EP0779886B1/de not_active Expired - Lifetime
- 1995-09-06 DK DK95931734T patent/DK0779886T3/da active
- 1995-09-06 AT AT95931734T patent/ATE210125T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2199128C (en) | 2001-03-20 |
| BR9508901A (pt) | 1998-01-06 |
| JPH10505089A (ja) | 1998-05-19 |
| EP0779886A1 (de) | 1997-06-25 |
| AU3505995A (en) | 1996-03-27 |
| CN1183126C (zh) | 2005-01-05 |
| MX9701819A (es) | 1997-06-28 |
| AU682281B2 (en) | 1997-09-25 |
| DK0779886T3 (da) | 2002-03-11 |
| NZ292782A (en) | 1999-02-25 |
| EP0779886B1 (de) | 2001-12-05 |
| WO1996007651A1 (en) | 1996-03-14 |
| DE69524428T2 (de) | 2002-05-23 |
| CA2199128A1 (en) | 1996-03-14 |
| ATE210125T1 (de) | 2001-12-15 |
| KR100249542B1 (ko) | 2000-04-01 |
| KR970705553A (ko) | 1997-10-09 |
| US5684002A (en) | 1997-11-04 |
| ES2169150T3 (es) | 2002-07-01 |
| CN1157613A (zh) | 1997-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |