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DE69420974D1 - Separationsverfahren - Google Patents

Separationsverfahren

Info

Publication number
DE69420974D1
DE69420974D1 DE69420974T DE69420974T DE69420974D1 DE 69420974 D1 DE69420974 D1 DE 69420974D1 DE 69420974 T DE69420974 T DE 69420974T DE 69420974 T DE69420974 T DE 69420974T DE 69420974 D1 DE69420974 D1 DE 69420974D1
Authority
DE
Germany
Prior art keywords
separation procedure
separation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69420974T
Other languages
English (en)
Other versions
DE69420974T2 (de
Inventor
Jukka Tuunanen
Matti Korpela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Fisher Scientific Oy
Original Assignee
Labsystems Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labsystems Oy filed Critical Labsystems Oy
Publication of DE69420974D1 publication Critical patent/DE69420974D1/de
Application granted granted Critical
Publication of DE69420974T2 publication Critical patent/DE69420974T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/26Details of magnetic or electrostatic separation for use in medical or biological applications
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1048General features of the devices using the transfer device for another function
    • G01N2035/1055General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE69420974T 1993-06-21 1994-06-20 Separationsverfahren Expired - Lifetime DE69420974T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI932866A FI932866A0 (fi) 1993-06-21 1993-06-21 Separeringsfoerfarande
PCT/FI1994/000275 WO1995000247A1 (en) 1993-06-21 1994-06-20 Separation method

Publications (2)

Publication Number Publication Date
DE69420974D1 true DE69420974D1 (de) 1999-11-04
DE69420974T2 DE69420974T2 (de) 2000-05-31

Family

ID=8538179

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420974T Expired - Lifetime DE69420974T2 (de) 1993-06-21 1994-06-20 Separationsverfahren

Country Status (8)

Country Link
US (1) US5647994A (de)
EP (1) EP0737110B1 (de)
JP (1) JP3254681B2 (de)
AU (1) AU7074394A (de)
DE (1) DE69420974T2 (de)
FI (2) FI932866A0 (de)
NO (1) NO309756B1 (de)
WO (1) WO1995000247A1 (de)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI930440A0 (fi) 1993-02-01 1993-02-01 Labsystems Oy Bestaemningsfoerfarande
DE1130397T1 (de) * 1993-02-01 2002-04-04 Thermo Labsystems Oy, Helsinki Ausrüstung zur Bestimmung eines Analyten in einer Probe
AU738171B2 (en) * 1994-06-15 2001-09-13 Precision System Science Co., Ltd. Magnetic material attracting/releasing control method making use of a pipette device and various types of clinical inspection apparatus using the method
JP3115501B2 (ja) * 1994-06-15 2000-12-11 プレシジョン・システム・サイエンス株式会社 分注機を利用した磁性体の脱着制御方法及びこの方法によって処理される各種装置
US5837144A (en) * 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
DE4423878A1 (de) * 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
FI944939A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerfarande foer separering av partiklar
FI944938A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Foerflyttningsanordning
FI944940A0 (fi) * 1994-10-20 1994-10-20 Labsystems Oy Tvaofasigt separeringsfoerfarande
FI944937A0 (fi) 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning
WO1996029602A1 (en) 1995-03-20 1996-09-26 Precision System Science Co., Ltd. Method and apparatus for liquid treatment utilizing dispenser
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
CA2255658C (en) 1996-05-20 2007-07-17 Precision System Science Co., Ltd. Method and apparatus for controlling magnetic particles by pipetting machine
US5833144A (en) * 1996-06-17 1998-11-10 Patchen, Inc. High speed solenoid valve cartridge for spraying an agricultural liquid in a field
DE19730497C2 (de) * 1997-07-16 2000-02-10 Heermann Klaus Hinrich Verfahren zum Waschen, zur Separierung und Konzentrierung von Biomolekülen unter Verwendung eines Magnetstifts
IL123210A0 (en) * 1998-02-06 1998-09-24 Gombinsky Moshe A device and system for the collection of magnetic particles
FI102906B (fi) * 1998-02-23 1999-03-15 Bio Nobile Oy Menetelmä ja väline aineen siirtämiseksi
ES2279600T3 (es) * 1998-03-12 2007-08-16 Miltenyi Biotec Gmbh Sistema de microcolumna para separacion magnetica.
DE69939622D1 (de) * 1998-03-19 2008-11-06 Prec System Science Co Ltd Apparat zur integration von magnetteilchen - verarbeitung und steuerungsverfahren
DE19823719B4 (de) * 1998-05-27 2011-12-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zum Aufkonzentrieren von Substanzen
US5973138A (en) 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
DE19963032A1 (de) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur Bearbeitung von Proben in einer Mehrkammeranordnung
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
CN1374528A (zh) * 2001-03-13 2002-10-16 清华大学 微电磁分配头及其在微小颗粒分发中的应用
US20040166502A1 (en) * 2001-03-13 2004-08-26 Yaming Lai Microelectromagnetic dispenser heads and uses thereof
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7514270B2 (en) 2002-04-12 2009-04-07 Instrumentation Laboratory Company Immunoassay probe
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
CN101398428B (zh) * 2002-11-07 2012-09-05 三菱化学美迪恩斯株式会社 用于收集磁性颗粒的磁性材料及其应用
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
KR100483684B1 (ko) * 2003-01-29 2005-04-18 (주)바이오넥스 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
KR101089882B1 (ko) 2003-04-15 2011-12-05 유니바사루 바이오 리사치 가부시키가이샤 분주용 실린더, 대용량 분주장치 및 대용량 분주장치의사용방법
EP2407243B1 (de) 2003-07-31 2020-04-22 Handylab, Inc. Mehrschichtige mikrofluidische vorrichtung
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
WO2005059929A2 (en) * 2003-12-12 2005-06-30 Xing-Xiang Li Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA3198754A1 (en) 2004-05-03 2005-11-17 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
FI20045231A0 (fi) * 2004-06-18 2004-06-18 Bio Nobile Oy Menetelmä ja laite näytteen ottamiseksi ja annostelemiseksi
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7906276B2 (en) * 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US20060013926A1 (en) * 2004-07-16 2006-01-19 Lindsey H M Magnetic dispensing funnel
WO2006017427A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
US7219567B2 (en) * 2005-01-05 2007-05-22 Bio-Magnetics Ltd. Combinatorial pipettor device
GB2425498A (en) * 2005-04-25 2006-11-01 Dynal Biotech Asa A magnetic separation device
US7534081B2 (en) * 2005-05-24 2009-05-19 Festo Corporation Apparatus and method for transferring samples from a source to a target
US7597520B2 (en) * 2005-05-24 2009-10-06 Festo Corporation Apparatus and method for transferring samples from a source to a target
FI20051248L (fi) 2005-12-02 2007-06-03 Bio Nobile Oy Biologisten komponenttien rikastusyksikkö ja rikastusmenetelmä
WO2007075891A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Multiplex assays using magnetic and non-magnetic particles
US20070166810A1 (en) * 2005-12-23 2007-07-19 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
GB2436616A (en) 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
JP2010506172A (ja) * 2006-10-06 2010-02-25 プロメガ・コーポレーション 磁性粒子を溶液から分離する装置および方法
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
US7799281B2 (en) 2007-01-16 2010-09-21 Festo Corporation Flux concentrator for biomagnetic particle transfer device
US8163183B2 (en) * 2007-02-07 2012-04-24 Universal Bio Research Co., Ltd. Magnetic particle parallel processing apparatus permitting repeated use of container and method of magnetic particle parallel processing permitting repeated use of container
IL184183A0 (en) * 2007-06-25 2007-10-31 Benjamin Alspector Bi directional transfer of an aliquot of fluid between compartments
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
TWI325337B (en) * 2007-07-26 2010-06-01 Ind Tech Res Inst Magnetic separation device
TWI316874B (en) * 2007-07-26 2009-11-11 Ind Tech Res Inst Magnetic separation device
CN101377456B (zh) * 2007-08-27 2010-12-08 财团法人工业技术研究院 磁性转换分离装置
JP2009066476A (ja) * 2007-09-11 2009-04-02 Tamagawa Seiki Co Ltd 液体中の磁性粒子の集合/分散方法及び装置
WO2009125971A2 (ko) * 2008-04-09 2009-10-15 (주)바이오니아 자동정제장치, 멀티 웰 플레이트 키트 및 생물학적 시료로부터 핵산을 추출하는 방법
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US10407660B2 (en) 2010-08-10 2019-09-10 Greiner Bio-One North America, Inc. Hardware for magnetic 3D culture
KR101423936B1 (ko) 2009-03-11 2014-07-29 (주)바이오니아 실시간 핵산 분석 통합 장치 및 이를 이용한 타겟 핵산의 검출방법
DE102009021201A1 (de) * 2009-05-13 2010-11-25 Stratec Biomedical Systems Ag Stabanordnung und Verfahren zur Extraktion magnetisierbarer Partikel aus Lösungen
US8276762B2 (en) 2009-05-15 2012-10-02 Gen-Probe Incorporated Method and system for performing a magnetic separation procedure
JP5292267B2 (ja) * 2009-12-16 2013-09-18 株式会社日立ハイテクノロジーズ 試料処理装置、試料処理方法及びこれらに使用する反応容器
WO2011136624A2 (ko) 2010-04-30 2011-11-03 (주)바이오니아 자기장 인가부를 구비한 생물학적 시료 자동정제장치, 생물학적 시료로부터 타겟물질을 추출하는 방법, 그리고 단백질 발현 및 정제 방법
JP5846773B2 (ja) * 2010-06-29 2016-01-20 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft サンプルの分配
KR101400675B1 (ko) 2010-11-18 2014-05-29 (주)바이오니아 에어로졸방지를 위한 자동정제장비 및 자동정제방법
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
WO2013009654A1 (en) 2011-07-08 2013-01-17 Life Technologies Corporation Method and apparatus for automated sample manipulation
EP2739717B1 (de) * 2011-08-02 2017-09-20 Nano3d Biosciences, Inc. Hardware für eine magnetische 3d-kultur
US8988684B1 (en) 2011-09-08 2015-03-24 Lawrence Livermore National Security, Llc System and method for measuring fluorescence of a sample
US9372135B1 (en) * 2011-09-08 2016-06-21 Lawrence Livermore National Security, Llc Fluidics platform and method for sample preparation
EP3273253B1 (de) 2011-09-30 2020-08-26 Becton, Dickinson and Company Vereinheitlichter reagenzienstreifen
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
US9315853B2 (en) 2012-01-30 2016-04-19 Exact Sciences Corporation Modification of DNA on magnetic beads
BR112014018995B1 (pt) 2012-02-03 2021-01-19 Becton, Dickson And Company sistemas para executar ensaio automatizado
KR101762295B1 (ko) 2012-02-10 2017-08-04 (주)바이오니아 생체시료의 자동 분석 장치 및 방법
KR101870311B1 (ko) 2012-03-09 2018-06-25 (주)바이오니아 핫스타트 역전사반응 또는 핫스타트 역전사 중합효소 연쇄반응용 조성물
KR101545848B1 (ko) 2012-04-09 2015-08-21 (주)바이오니아 핵산중합효소로 핵산을 검출하는데 사용되는 고민감도 핵산준비방법
CN103084227B (zh) * 2012-12-13 2016-08-03 宁波大学 针对磁性复合微粒悬浊液离析程序的化学实验用装置
US10401373B1 (en) 2013-02-18 2019-09-03 Theranos Ip Company, Llc Systems and methods for analyte testing and laboratory oversight
US11008628B1 (en) * 2013-02-18 2021-05-18 Labrador Diagnostics Llc Systems and methods for analyte testing and laboratory oversight
EP3068902B1 (de) 2013-11-12 2018-08-29 Life Technologies Corporation System und verfahren zur emulsionsspaltung
US10040062B2 (en) * 2014-01-14 2018-08-07 Wisconsin Alumni Research Foundation Device and method for transferring a target between locations
US11360107B1 (en) 2014-02-25 2022-06-14 Labrador Diagnostics Llc Systems and methods for sample handling
WO2015191877A1 (en) 2014-06-11 2015-12-17 Life Technologies Corporation Systems and methods for substrate enrichment
DE102015218010A1 (de) 2015-09-18 2017-03-23 Hamilton Bonaduz Ag Magnetische Trennvorrichtung mit magnetischer Aktivierung und Deaktivierung
CN105543090B (zh) * 2016-01-19 2018-08-10 山西振东基赛生物科技有限公司 一种脱水装置及方法
WO2017158425A1 (en) * 2016-03-18 2017-09-21 Andrew Alliance S.A. Methods and apparatus for bead manipulation in a tip of a liquid handler
DE102016219053A1 (de) 2016-09-30 2018-04-05 Hamilton Bonaduz Ag Magnetische Trennvorrichtung mit unkörperlicher Kopplung zwischen Magnetanordnung und deren Bewegungsantrieb
US11673134B2 (en) * 2017-06-06 2023-06-13 Northwestern University Trans-interfacial magnetic separation
US11278915B1 (en) * 2018-07-20 2022-03-22 NeoGeneStar LLC Device for capturing and releasing magnetic particles
CN110455790B (zh) * 2019-08-19 2022-05-13 中国石油大学(华东) 一种啶虫脒检测装置及检测方法
WO2021198959A1 (en) 2020-04-03 2021-10-07 Andrew Alliance S.A. Bead manipulation in a consumable
US11480565B2 (en) * 2020-06-12 2022-10-25 Bio-Rad Laboratories, Inc. Automated immunoassay
WO2022039904A2 (en) 2020-07-29 2022-02-24 Exact Sciences Corporation Purification of sulfonated dna
FR3120235B1 (fr) * 2021-02-26 2025-05-02 Univ Versailles Saint Quentin En Yvelines Dispositif de verrouillage, outil de pipetage, procédé, accessoire et installation associés
TWI840043B (zh) * 2022-12-22 2024-04-21 緯創資通股份有限公司 多功能移液器及自動化檢測機器

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
DE3200988A1 (de) * 1982-01-14 1983-07-28 Thomas A. Dr. 6900 Heidelberg Reed Verfahren und vorrichtung zur abtrennung von organischen stoffen aus einer suspension oder loesung
FR2554016B1 (fr) * 1983-10-27 1986-08-08 Pasteur Institut Perfectionnements apportes aux moyens magnetiques destines a retirer des billes de gel magnetique d'un fluide de dosage
FR2572178B1 (fr) * 1984-10-23 1988-10-28 Pasteur Institut Nouveau dispositif magnetique destine a retirer des billes de gel magnetique d'un milieu a analyser et a les transferer sur un milieu de dosage immunoenzymatique
FI851702A0 (fi) * 1985-04-29 1985-04-29 Labsystems Oy Foerfarande och anordning foer utfoering immunobestaemningar.
FI865002A7 (fi) * 1985-04-29 1986-12-08 Labsystems Oy Menetelmä ja laitteisto immunomääritysten suorittamiseksi.
SE8601143L (sv) * 1986-03-12 1987-09-13 Carbematrix Ab Sett och anordning for samling och spridning av ferromagnetiska partiklar i ett fluidformigt medium
JP2701891B2 (ja) * 1987-11-16 1998-01-21 ジーン−トラック・システムス 磁気的分離デバイスおよび不均質検定における使用法
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
EP0339980B1 (de) * 1988-04-26 1994-07-20 Nippon Telegraph And Telephone Corporation Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
EP0479448A3 (en) * 1990-10-02 1992-12-23 Beckman Instruments, Inc. Magnetic separation device

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EP0737110B1 (de) 1999-09-29
FI932866A0 (fi) 1993-06-21
JP3254681B2 (ja) 2002-02-12
JPH08511721A (ja) 1996-12-10
FI117470B (fi) 2006-10-31
FI956135A0 (fi) 1995-12-20
WO1995000247A1 (en) 1995-01-05
FI956135L (fi) 1995-12-20
US5647994A (en) 1997-07-15
DE69420974T2 (de) 2000-05-31
NO955200L (no) 1995-12-20
NO955200D0 (no) 1995-12-20
NO309756B1 (no) 2001-03-26
AU7074394A (en) 1995-01-17
EP0737110A1 (de) 1996-10-16

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