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DE68911616D1 - Piperazin-Derivate und Verfahren zu deren Herstellung. - Google Patents

Piperazin-Derivate und Verfahren zu deren Herstellung.

Info

Publication number
DE68911616D1
DE68911616D1 DE89402101T DE68911616T DE68911616D1 DE 68911616 D1 DE68911616 D1 DE 68911616D1 DE 89402101 T DE89402101 T DE 89402101T DE 68911616 T DE68911616 T DE 68911616T DE 68911616 D1 DE68911616 D1 DE 68911616D1
Authority
DE
Germany
Prior art keywords
preparation
methoxy
piperazine derivatives
naphthalenyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89402101T
Other languages
English (en)
Other versions
DE68911616T2 (de
Inventor
Philippe Manoury
Jean Binet
Daniel Obitz
Gerard Defosse
Elisabeth Dewitte
Corinne Veronique
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of DE68911616D1 publication Critical patent/DE68911616D1/de
Application granted granted Critical
Publication of DE68911616T2 publication Critical patent/DE68911616T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE68911616T 1988-08-03 1989-07-25 Piperazin-Derivate und Verfahren zu deren Herstellung. Expired - Fee Related DE68911616T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8810481A FR2635105B1 (fr) 1988-08-03 1988-08-03 Derives de piperazine et leur procede de preparation

Publications (2)

Publication Number Publication Date
DE68911616D1 true DE68911616D1 (de) 1994-02-03
DE68911616T2 DE68911616T2 (de) 1994-05-19

Family

ID=9369067

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68911616T Expired - Fee Related DE68911616T2 (de) 1988-08-03 1989-07-25 Piperazin-Derivate und Verfahren zu deren Herstellung.

Country Status (7)

Country Link
US (1) US4963680A (de)
EP (1) EP0354093B1 (de)
JP (1) JPH0273075A (de)
AT (1) ATE98958T1 (de)
DE (1) DE68911616T2 (de)
ES (1) ES2062066T3 (de)
FR (1) FR2635105B1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687401B1 (fr) * 1992-02-18 1994-05-20 Meram Laboratoires Derives de la 1,4-dialkylpiperazine, procedes d'obtention et compositions pharmaceutiques les contenant.
DE69427289T2 (de) * 1993-03-16 2001-09-06 Pfizer Inc., New York Naphtalinderivate
FR2725984B1 (fr) * 1994-10-25 1997-01-10 Pf Medicament Nouveaux ethers aromatiques derives de naphtylpiperazine utiles comme medicaments
CA2175395A1 (en) * 1995-06-02 1996-12-03 Ronald J. Mattson Melatonergic indanyl piperazines or homopiperazines
US5780470A (en) * 1995-06-02 1998-07-14 Bristol-Myers Squibb Company Melatonergic indanyl piperazines
US5703239A (en) * 1995-06-02 1997-12-30 Bristol-Myers Squibb Company Indanylpiperidines as melatonergic agents
FR2737723B1 (fr) * 1995-08-09 1997-09-05 Synthelabo Derives de 1-(2-(1h-inden-3-yl)ethyl)-4-(naphtalen-1-yl)- piperazine, leur preparation et leur application en therapeutique
US7175866B2 (en) * 2003-09-12 2007-02-13 Tropicana Products, Inc. Tocopherols as flavor antioxidant in citrus juice

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812127A (en) * 1966-10-31 1974-05-21 Pfizer 4-(quinolin-4-yl)piperazine-1-carboxylic acid esters
US4518712A (en) * 1980-06-30 1985-05-21 Taiho Pharmaceutical Company Limited Piperazine derivative and analgesic composition containing the same
IT1200928B (it) * 1983-07-11 1989-01-27 Malesci Sas Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti
US4686220A (en) * 1985-12-19 1987-08-11 American Cyanamid Company Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals
US4845221A (en) * 1988-04-15 1989-07-04 American Home Products Corporation Serotonergic substituted piperazinyl tetralins
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JPH0273075A (ja) 1990-03-13
EP0354093A1 (de) 1990-02-07
EP0354093B1 (de) 1993-12-22
US4963680A (en) 1990-10-16
DE68911616T2 (de) 1994-05-19
FR2635105A1 (fr) 1990-02-09
ES2062066T3 (es) 1994-12-16
FR2635105B1 (fr) 1991-01-25
ATE98958T1 (de) 1994-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee