[go: up one dir, main page]

DE60336602D1 - Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis - Google Patents

Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis

Info

Publication number
DE60336602D1
DE60336602D1 DE60336602T DE60336602T DE60336602D1 DE 60336602 D1 DE60336602 D1 DE 60336602D1 DE 60336602 T DE60336602 T DE 60336602T DE 60336602 T DE60336602 T DE 60336602T DE 60336602 D1 DE60336602 D1 DE 60336602D1
Authority
DE
Germany
Prior art keywords
metered dose
dose inhaler
container
suspension
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336602T
Other languages
English (en)
Inventor
Saeed Chaudhry
Stefan A Sharpe
Julianne Berry
Joel A Sequeira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60336602D1 publication Critical patent/DE60336602D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/003—Adding propellants in fluid form to aerosol containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE60336602T 2002-08-27 2003-08-26 Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis Expired - Lifetime DE60336602D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40612702P 2002-08-27 2002-08-27
US42243602P 2002-10-30 2002-10-30

Publications (1)

Publication Number Publication Date
DE60336602D1 true DE60336602D1 (de) 2011-05-12

Family

ID=31981380

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60318727T Expired - Lifetime DE60318727T2 (de) 2002-08-27 2003-08-26 Verfahren zur herstellung von dosierinhalatorformulierungen
DE60336602T Expired - Lifetime DE60336602D1 (de) 2002-08-27 2003-08-26 Verfahren zur Herstellung von Formulierungen für Inhaliergeräte mit abgemessener Dosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60318727T Expired - Lifetime DE60318727T2 (de) 2002-08-27 2003-08-26 Verfahren zur herstellung von dosierinhalatorformulierungen

Country Status (14)

Country Link
US (3) US20040042973A1 (de)
EP (2) EP1542904B1 (de)
JP (3) JP4679901B2 (de)
AT (2) ATE384001T1 (de)
AU (1) AU2003265639A1 (de)
CA (1) CA2495875C (de)
CY (1) CY1107376T1 (de)
DE (2) DE60318727T2 (de)
DK (1) DK1542904T3 (de)
ES (1) ES2297262T3 (de)
MX (1) MXPA05002248A (de)
PT (1) PT1542904E (de)
SI (1) SI1542904T1 (de)
WO (1) WO2004020289A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0207906D0 (en) 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
CA2495689A1 (en) * 2002-08-23 2004-03-04 Schering Corporation Pharmaceutical compositions
BRPI0415707A (pt) * 2003-10-20 2006-12-19 Schering Corp composições farmacêuticas
SE0401408D0 (sv) * 2004-06-02 2004-06-02 Astrazeneca Ab Diameter measuring device
EP1811981B1 (de) * 2004-10-12 2008-08-13 Merck Generics (UK) Limited Verfahren zur herstellung von suspensionsaerosolformulierungen, worin die partikel durch präzipition in einem aerosolbehälter gebildet werden
US20070099883A1 (en) * 2005-10-07 2007-05-03 Cheryl Lynn Calis Anhydrous mometasone furoate formulation
US20090325917A1 (en) * 2006-10-19 2009-12-31 Cipla Limited Pharmaceutical Compositions and Nasal Spray Incorporating Anhydrous Mometasone Furoate
US20080253970A1 (en) * 2007-02-09 2008-10-16 Schering Corporation Stable Pharmaceutical Drug Products
CA2677347A1 (en) 2007-02-09 2008-08-14 Jill K. Sherwood Stable pharmaceutical drug aerosols
ES2613733T3 (es) * 2009-05-12 2017-05-25 Galenica Ab Emulsión de aceite en agua de mometasona
EP2962688B1 (de) 2009-05-12 2020-06-24 Galenica AB Öl-in-wasser emulsion enthaltend mometason und propylenglycol
AU2015200276B2 (en) * 2010-02-10 2016-01-21 Astrazeneca Uk Limited A filled canister for an inhaler
EP2534054A1 (de) * 2010-02-10 2012-12-19 AstraZeneca UK Limited Verfahren zur bereitstellung eines gefüllten kanisters für einen inhalator
CN107626019A (zh) * 2016-07-18 2018-01-26 卓效医疗有限公司 手持式喷雾器
CN107951893B (zh) * 2016-10-18 2022-04-26 天津金耀集团有限公司 一种糠酸莫米松粉吸入剂组合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592319A (en) * 1968-10-28 1971-07-13 Roy S Rousseau Article feed control
US3835898A (en) * 1972-11-13 1974-09-17 Kartridg Pak Co Remotely adjustable filling head
US4793461A (en) * 1987-02-26 1988-12-27 The Kartridg Pak Co. Container feed apparatus
US5143260A (en) * 1990-06-05 1992-09-01 Nozone Dispenser Systems, Inc. Aerosol adapter clamp and power system
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
HUT67445A (en) * 1991-06-10 1995-04-28 Schering Corp Aerosol formulations containing 1,1,1,2-tetrafluorethane
ATE134509T1 (de) * 1991-06-10 1996-03-15 Schering Corp Fluorchlorkohlenwasserstoffreie aerosolformulierungen
US5275212A (en) * 1993-02-24 1994-01-04 Minnesota Mining And Manufacturing Company Aerosol filling method
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
US5698161A (en) 1996-08-26 1997-12-16 Michigan Critical Care Consultants, Inc. Hollow, multi-dimensional array membrane
US6068832A (en) * 1996-08-29 2000-05-30 Schering Corporation Chlorofluorocarbon-free mometasone furoate aerosol formulations
ID18137A (id) * 1996-08-29 1998-03-05 Schering Corp Formulasi-formulasi aerosol mometason furoat bebas klorofluorokarbon
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6004537A (en) 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
GB9904919D0 (en) * 1999-03-03 1999-04-28 Novartis Ag Organic compounds
WO2001047493A1 (en) * 1999-12-24 2001-07-05 Glaxo Group Limited Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
AU2001278115A1 (en) * 2000-08-04 2002-02-18 Longwood Pharmaceutical Research, Inc. Formulations of mometasone and a bronchodilator for pulmonary administration
ITMI20010428A1 (it) * 2001-03-02 2002-09-02 Chemo Breath S A Composizioni ad uso inalatorio a base di formoterolo
AR036358A1 (es) * 2001-08-28 2004-09-01 Schering Corp Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma
GB0207906D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
CA2495689A1 (en) * 2002-08-23 2004-03-04 Schering Corporation Pharmaceutical compositions
BRPI0415707A (pt) * 2003-10-20 2006-12-19 Schering Corp composições farmacêuticas
JP2009526062A (ja) * 2006-02-09 2009-07-16 シェーリング コーポレイション 薬学的処方物
US20080253970A1 (en) * 2007-02-09 2008-10-16 Schering Corporation Stable Pharmaceutical Drug Products

Also Published As

Publication number Publication date
EP1878664A1 (de) 2008-01-16
DE60318727T2 (de) 2009-01-08
CA2495875C (en) 2010-06-22
ES2297262T3 (es) 2008-05-01
DK1542904T3 (da) 2008-04-21
ATE503687T1 (de) 2011-04-15
JP2006305390A (ja) 2006-11-09
US20130068218A1 (en) 2013-03-21
WO2004020289A1 (en) 2004-03-11
CA2495875A1 (en) 2004-03-11
EP1542904B1 (de) 2008-01-16
DE60318727D1 (de) 2008-03-06
ATE384001T1 (de) 2008-02-15
JP2011046726A (ja) 2011-03-10
US20080066744A1 (en) 2008-03-20
SI1542904T1 (sl) 2008-06-30
EP1542904A1 (de) 2005-06-22
MXPA05002248A (es) 2005-06-08
AU2003265639A1 (en) 2004-03-19
CY1107376T1 (el) 2012-12-19
PT1542904E (pt) 2008-03-24
EP1878664B1 (de) 2011-03-30
JP2005537095A (ja) 2005-12-08
JP4679901B2 (ja) 2011-05-11
US20040042973A1 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
CY1107376T1 (el) Μεθοδος παρασκευης συνταγοποιησεων για συσκευη εισπνοης μετρημενης δοσης
FI2515855T6 (fi) Yhdistelmähoito keuhkoahtaumatautia (copd) varten
CA2353959A1 (en) A medicinal aerosol formulation
FI109875B (fi) Painekaasupakkauksia, jotka on saatu käyttämällä polyoksietyleeniglyseryylioleaatteja
UA89751C2 (ru) Состав, который содержит сульфат альбутерола и бромид ипратропия, способ его получения и ингалятор
EA200100338A1 (ru) Способ и устройство для введения действующего вещества в виде аэрозоли в легкие пациента
RU94040361A (ru) Аэрозольная фармацевтическая композиция, баллончик для доставки композиции, дозировочный ингалятор, способ лечения респираторных заболеваний, способ получения композиции
RU2016141961A (ru) Несмываемая химическая пена, содержащая пероксид бензоила
JPH07502954A (ja) エアゾールバルブ
BR112015026053A8 (pt) composição farmacêutica, recipiente vedado, inalador dosimetrado, uso de um componente propelente, e, método para fabricação de uma composição farmacêutica
ATE293957T1 (de) Verfahren zur herstellung von inhalationspulvern
WO2002024261A3 (en) Shock wave aerosolization apparatus and method
US20110240504A1 (en) Method and apparatus for packaging and dispensing pharmaceuticals
US20160220465A1 (en) Minoxidil formulations
MXPA05006528A (es) Proceso para preparar formulaciones farmaceuticas en combinacion utilizando fluidos supercriticos.
EP1267796B1 (de) Schäumbare fluoridzubereitungen für zahnärztliche zwecke
CN110547977B (zh) 一种含小苏打的口腔护理组合物及其制备方法和应用
JP6018438B2 (ja) 滴下式エアゾール製品
BRPI0607990A2 (pt) formulação de um aerossol farmacêutico para inaladores dosimetrados pressurizados contendo um agente seqüestrante, uso do agente sequestrante, inalador de dosimetrado pressurizado e método de preenchimento do inalador de aerossol
CN1385165A (zh) 利巴韦林雾化吸入溶液
CN103751814A (zh) 制备长有效期的锝[99mTc]亚甲基二膦酸盐注射液药品的方法
CN105213424A (zh) 一种甘油果糖氯化钠注射液的制备方法
CN110801461A (zh) 一种治疗湿疹的气雾剂
JP2017061395A (ja) 二酸化塩素ガス発生方法
JP2019131414A (ja) 二酸化塩素発生エアゾール