DE60329729D1 - Implantierbare Vorrichtung zur Arzneimittelverabreichung - Google Patents
Implantierbare Vorrichtung zur ArzneimittelverabreichungInfo
- Publication number
- DE60329729D1 DE60329729D1 DE60329729T DE60329729T DE60329729D1 DE 60329729 D1 DE60329729 D1 DE 60329729D1 DE 60329729 T DE60329729 T DE 60329729T DE 60329729 T DE60329729 T DE 60329729T DE 60329729 D1 DE60329729 D1 DE 60329729D1
- Authority
- DE
- Germany
- Prior art keywords
- drug administration
- implantable device
- implantable
- administration
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001647 drug administration Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0464—Cerebrospinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M25/0075—Valve means
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/092,954 US20030171738A1 (en) | 2002-03-06 | 2002-03-06 | Convection-enhanced drug delivery device and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60329729D1 true DE60329729D1 (de) | 2009-12-03 |
Family
ID=27754038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60329729T Expired - Lifetime DE60329729D1 (de) | 2002-03-06 | 2003-03-05 | Implantierbare Vorrichtung zur Arzneimittelverabreichung |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20030171738A1 (de) |
| EP (1) | EP1342481B1 (de) |
| JP (1) | JP4574120B2 (de) |
| AU (1) | AU2003200925B2 (de) |
| CA (1) | CA2420584C (de) |
| DE (1) | DE60329729D1 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2389791B (en) * | 2002-04-30 | 2006-12-13 | Steven Gill | Implantable drug delivery pump |
| US20050238506A1 (en) * | 2002-06-21 | 2005-10-27 | The Charles Stark Draper Laboratory, Inc. | Electromagnetically-actuated microfluidic flow regulators and related applications |
| US7963956B2 (en) * | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
| WO2005007223A2 (en) * | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
| US7896865B2 (en) * | 2003-09-30 | 2011-03-01 | Codman & Shurtleff, Inc. | Two-compartment reduced volume infusion pump |
| US9138537B2 (en) | 2003-10-02 | 2015-09-22 | Medtronic, Inc. | Determining catheter status |
| US7320676B2 (en) | 2003-10-02 | 2008-01-22 | Medtronic, Inc. | Pressure sensing in implantable medical devices |
| US9033920B2 (en) | 2003-10-02 | 2015-05-19 | Medtronic, Inc. | Determining catheter status |
| US8323244B2 (en) | 2007-03-30 | 2012-12-04 | Medtronic, Inc. | Catheter malfunction determinations using physiologic pressure |
| US7867194B2 (en) | 2004-01-29 | 2011-01-11 | The Charles Stark Draper Laboratory, Inc. | Drug delivery apparatus |
| WO2005072793A1 (en) * | 2004-01-29 | 2005-08-11 | The Charles Stark Draper Laboratory, Inc. | Implantable drug delivery apparatus |
| US8353896B2 (en) | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
| US9011329B2 (en) | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
| US8512219B2 (en) | 2004-04-19 | 2013-08-20 | The Invention Science Fund I, Llc | Bioelectromagnetic interface system |
| US7850676B2 (en) * | 2004-04-19 | 2010-12-14 | The Invention Science Fund I, Llc | System with a reservoir for perfusion management |
| CA2486934C (en) * | 2004-11-22 | 2011-07-19 | Jonathan Tyler | Systems for csf drainage |
| JP2008531726A (ja) * | 2005-03-04 | 2008-08-14 | ニューロシステック コーポレイション | 改良されたガシクリジン製剤 |
| US20110077579A1 (en) * | 2005-03-24 | 2011-03-31 | Harrison William V | Cochlear implant with localized fluid transport |
| US8002730B2 (en) * | 2005-04-29 | 2011-08-23 | Medtronic, Inc. | Anti-thrombogenic venous shunt system and method |
| US20060280655A1 (en) * | 2005-06-08 | 2006-12-14 | California Institute Of Technology | Intravascular diagnostic and therapeutic sampling device |
| US20070055196A1 (en) * | 2005-09-02 | 2007-03-08 | Gormley William B | Implantable shunt system and method |
| US9042974B2 (en) * | 2005-09-12 | 2015-05-26 | New York University | Apparatus and method for monitoring and treatment of brain disorders |
| US8083710B2 (en) * | 2006-03-09 | 2011-12-27 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
| US8936590B2 (en) * | 2005-11-09 | 2015-01-20 | The Invention Science Fund I, Llc | Acoustically controlled reaction device |
| US9067047B2 (en) | 2005-11-09 | 2015-06-30 | The Invention Science Fund I, Llc | Injectable controlled release fluid delivery system |
| US8992511B2 (en) | 2005-11-09 | 2015-03-31 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
| US9028467B2 (en) | 2005-11-09 | 2015-05-12 | The Invention Science Fund I, Llc | Osmotic pump with remotely controlled osmotic pressure generation |
| US9474712B2 (en) | 2005-11-09 | 2016-10-25 | Gearbox, Llc | In situ reaction device |
| US20070106271A1 (en) | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation | Remote control of substance delivery system |
| US8273071B2 (en) | 2006-01-18 | 2012-09-25 | The Invention Science Fund I, Llc | Remote controller for substance delivery system |
| GB0603037D0 (en) * | 2006-02-15 | 2006-03-29 | Renishaw Plc | Implantable fluid distribution device and a method of drug delivery |
| US20080140057A1 (en) | 2006-03-09 | 2008-06-12 | Searete Llc, A Limited Liability Corporation Of State Of The Delaware | Injectable controlled release fluid delivery system |
| WO2007123764A2 (en) | 2006-04-06 | 2007-11-01 | Medtronic, Inc. | Systems and methods of identifying catheter malfunctions using pressure sensing |
| US20080082036A1 (en) * | 2006-04-25 | 2008-04-03 | Medtronic, Inc. | Cerebrospinal fluid shunt having long term anti-occlusion agent delivery |
| US8267905B2 (en) | 2006-05-01 | 2012-09-18 | Neurosystec Corporation | Apparatus and method for delivery of therapeutic and other types of agents |
| US7803148B2 (en) * | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
| EP2037999B1 (de) | 2006-07-07 | 2016-12-28 | Proteus Digital Health, Inc. | Intelligentes parenterales verabreichungssystem |
| JP2009544355A (ja) * | 2006-07-20 | 2009-12-17 | ニューロシステック コーポレイション | 眼科薬物送達のためのデバイス、システム、および方法 |
| US20080145439A1 (en) * | 2006-07-31 | 2008-06-19 | Neurosystec Corporation | Nanoparticle drug formulations |
| US20100280494A1 (en) * | 2006-08-08 | 2010-11-04 | Matsuura James E | Catheter and array for anticancer therapy |
| GB0623395D0 (en) | 2006-11-23 | 2007-01-03 | Renishaw Plc | Port |
| WO2008094672A2 (en) * | 2007-01-31 | 2008-08-07 | Charles Stark Draper Laboratory, Inc. | Membrane-based fluid control in microfluidic devices |
| EP1970001B1 (de) * | 2007-03-16 | 2014-07-23 | Brainlab AG | Katheter mit Drucksensorik |
| US20110135569A1 (en) * | 2007-03-20 | 2011-06-09 | Peak Biosciences Inc. | Method for therapeutic administration of radionucleosides |
| US9044537B2 (en) | 2007-03-30 | 2015-06-02 | Medtronic, Inc. | Devices and methods for detecting catheter complications |
| US8470295B2 (en) * | 2007-05-10 | 2013-06-25 | Peak Biosciences, Inc. | Methods of treatment of androgenic steroidal hormone dependent cancer with auger electron-emitting nucleoside analogs |
| US8485411B2 (en) | 2007-05-16 | 2013-07-16 | The Invention Science Fund I, Llc | Gentle touch surgical stapler |
| US7922064B2 (en) * | 2007-05-16 | 2011-04-12 | The Invention Science Fund, I, LLC | Surgical fastening device with cutter |
| US7832611B2 (en) | 2007-05-16 | 2010-11-16 | The Invention Science Fund I, Llc | Steerable surgical stapler |
| US7823761B2 (en) | 2007-05-16 | 2010-11-02 | The Invention Science Fund I, Llc | Maneuverable surgical stapler |
| US7798385B2 (en) * | 2007-05-16 | 2010-09-21 | The Invention Science Fund I, Llc | Surgical stapling instrument with chemical sealant |
| US8568445B2 (en) | 2007-08-21 | 2013-10-29 | St. Jude Medical Puerto Rico Llc | Extra-vascular sealing device and method |
| US8333787B2 (en) * | 2007-12-31 | 2012-12-18 | St. Jude Medical Puerto Rico Llc | Vascular closure device having a flowable sealing material |
| WO2009055733A1 (en) | 2007-10-25 | 2009-04-30 | Proteus Biomedical, Inc. | Fluid transfer port information system |
| US8419638B2 (en) | 2007-11-19 | 2013-04-16 | Proteus Digital Health, Inc. | Body-associated fluid transport structure evaluation devices |
| US8840640B2 (en) * | 2007-12-31 | 2014-09-23 | St. Jude Medical Puerto Rico Llc | Vascular closure device having an improved plug |
| EP2323587B1 (de) * | 2008-08-13 | 2016-08-03 | SMed - TA/TD LLC | Wirkstofffreisetzungsimplantate |
| US20100042213A1 (en) * | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Drug delivery implants |
| US9700431B2 (en) | 2008-08-13 | 2017-07-11 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
| WO2010019788A1 (en) | 2008-08-13 | 2010-02-18 | Smed-Ta/Td. Llc | Drug delivery implants |
| US10842645B2 (en) | 2008-08-13 | 2020-11-24 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
| US9358056B2 (en) | 2008-08-13 | 2016-06-07 | Smed-Ta/Td, Llc | Orthopaedic implant |
| US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
| CA2760836C (en) | 2009-05-05 | 2018-01-23 | Carefusion 303, Inc. | Model-based infusion site monitor |
| JP5330609B2 (ja) | 2010-02-01 | 2013-10-30 | プロテウス デジタル ヘルス, インコーポレイテッド | 2つの手首におけるデータ収集システム |
| BR112012019212A2 (pt) | 2010-02-01 | 2017-06-13 | Proteus Digital Health Inc | sistema de coleta de dados |
| GB201002370D0 (en) | 2010-02-12 | 2010-03-31 | Renishaw Ireland Ltd | Percutaneous drug delivery apparatus |
| EP2575933B1 (de) * | 2010-05-25 | 2017-09-27 | The General Hospital Corporation | Vorhersage, visualisierung und steuerung einer wirkstoffabgabe durch infusionspumpen |
| EP2670456B1 (de) | 2011-02-02 | 2019-12-18 | The Charles Stark Draper Laboratory, Inc. | Vorrichtung zur wirkstofffreisetzung |
| US20120222979A1 (en) * | 2011-03-04 | 2012-09-06 | Elwha LLC, a limited liability company of the State of Delaware | Glassy compositions |
| US9610398B2 (en) * | 2011-11-22 | 2017-04-04 | Incube Labs, Llc | Implantable solid-liquid drug delivery apparatus, formulations, and methods of use |
| MX2014006250A (es) | 2011-11-23 | 2014-10-17 | Gen Hospital Corp | Prediccion, visualizacion, y control de entrega de medicamentos por medio de bombas de infusion. |
| GB201217606D0 (en) | 2012-10-02 | 2012-11-14 | Renishaw Plc | Neurosurgical device and method |
| US9320851B2 (en) | 2013-02-07 | 2016-04-26 | Medizinische Universitaet Graz | Infusion arrangement and method |
| US20220047811A1 (en) * | 2013-08-27 | 2022-02-17 | David S. Goldsmith | Prosthetic disorder response systems |
| US20220184311A1 (en) * | 2013-08-27 | 2022-06-16 | David S. Goldsmith | Prosthetic disorder response systems |
| US20220111143A1 (en) * | 2013-08-27 | 2022-04-14 | David S. Goldsmith | Prosthetic disorder response systems |
| KR101562865B1 (ko) * | 2014-01-24 | 2015-10-26 | 한국과학기술연구원 | 신경 영양인자를 감지하기 위한 초소형 센서 시스템 |
| WO2015175757A1 (en) * | 2014-05-15 | 2015-11-19 | The General Hospital Corporation | Prediction, visualization, and control of drug delivery by multiple infusion pumps |
| WO2016100411A2 (en) * | 2014-12-15 | 2016-06-23 | Northeastern University | Collagenous tissue repair device |
| US9758786B2 (en) | 2016-02-09 | 2017-09-12 | Autotelic, Llc | Compositions and methods for treating pancreatic cancer |
| KR102651496B1 (ko) | 2018-08-23 | 2024-03-25 | 카스텐 하게만 | 뇌-혈액 장벽 투과성을 향상시키기 위한 교번 전기장의 이용 |
| WO2020072235A1 (en) * | 2018-10-03 | 2020-04-09 | Baxalta GmbH | Infusion pump and infusion pump operations |
| US12329930B2 (en) * | 2020-09-29 | 2025-06-17 | Enclear Therapies, Inc. | Subarachnoid fluid management method and system |
| CN113289198B (zh) * | 2021-04-16 | 2023-05-16 | 杭州未名信科科技有限公司 | 给药导管和给药导管的制备方法 |
| US20230127134A1 (en) * | 2021-09-20 | 2023-04-27 | Droplet Biosciences, Inc. | Methods for cancer treatment |
| US12005227B2 (en) * | 2021-10-06 | 2024-06-11 | Product Realization Specialites, LLC | Direct drug/therapeutic infusion via trans-vascular glymphatic system and method |
| AU2024225575A1 (en) | 2023-02-21 | 2025-08-07 | Osteal Therapeutics, Inc. | Systems and devices for treatment of localized infection in and around articulating joints and methods of use |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4193397A (en) * | 1977-12-01 | 1980-03-18 | Metal Bellows Corporation | Infusion apparatus and method |
| IL69431A (en) * | 1983-08-04 | 1987-12-31 | Omikron Scient Ltd | Liquid delivery system particularly useful as an implantable micro-pump for delivering insulin or other drugs |
| US5362307A (en) * | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US4889407A (en) * | 1988-12-02 | 1989-12-26 | Biomedical Sensors Limited | Optical waveguide sensor and method of making same |
| JPH03178669A (ja) * | 1989-12-08 | 1991-08-02 | Sugino Mach Ltd | 薬剤噴射注入装置 |
| EP0706418A1 (de) * | 1993-06-30 | 1996-04-17 | Diametrics Medical Ltd. | Zweiphasiges material |
| WO1995005864A1 (en) * | 1993-08-27 | 1995-03-02 | Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Convection-enhanced drug delivery |
| US5511547A (en) * | 1994-02-16 | 1996-04-30 | Biomedical Sensors, Ltd. | Solid state sensors |
| US5569186A (en) * | 1994-04-25 | 1996-10-29 | Minimed Inc. | Closed loop infusion pump system with removable glucose sensor |
| US5474552A (en) * | 1994-06-27 | 1995-12-12 | Cb-Carmel Biotechnology Ltd. | Implantable drug delivery pump |
| IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US5697899A (en) * | 1995-02-07 | 1997-12-16 | Gensia | Feedback controlled drug delivery system |
| US5556421A (en) * | 1995-02-22 | 1996-09-17 | Intermedics, Inc. | Implantable medical device with enclosed physiological parameter sensors or telemetry link |
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| US5992769A (en) * | 1995-06-09 | 1999-11-30 | The Regents Of The University Of Michigan | Microchannel system for fluid delivery |
| US5676145A (en) * | 1995-08-21 | 1997-10-14 | University Of Maryland At Baltimore | Cerebral hemodynamic monitoring system |
| JP2000504239A (ja) * | 1995-12-19 | 2000-04-11 | アボツト・ラボラトリーズ | アナライトの検出および治療用物質の管理のための装置 |
| US5711315A (en) * | 1996-02-15 | 1998-01-27 | Jerusalmy; Israel | Sinus lift method |
| US5735814A (en) * | 1996-04-30 | 1998-04-07 | Medtronic, Inc. | Techniques of treating neurodegenerative disorders by brain infusion |
| US5711316A (en) * | 1996-04-30 | 1998-01-27 | Medtronic, Inc. | Method of treating movement disorders by brain infusion |
| US5713923A (en) * | 1996-05-13 | 1998-02-03 | Medtronic, Inc. | Techniques for treating epilepsy by brain stimulation and drug infusion |
| SE9601974L (sv) * | 1996-05-23 | 1997-10-13 | Elekta Ab | Anordning för att injicera en substans i en kropp, speciellt human eller animalisk |
| US5782798A (en) * | 1996-06-26 | 1998-07-21 | Medtronic, Inc. | Techniques for treating eating disorders by brain stimulation and drug infusion |
| US5797898A (en) * | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US6913763B2 (en) * | 1996-11-19 | 2005-07-05 | Intrabrain International Nv | Method and device for enhanced delivery of a biologically active agent through the spinal spaces into the central nervous system of a mammal |
| US5792212A (en) * | 1997-03-07 | 1998-08-11 | Medtronic, Inc. | Nerve evoked potential measurement system using chaotic sequences for noise rejection |
| US6016449A (en) * | 1997-10-27 | 2000-01-18 | Neuropace, Inc. | System for treatment of neurological disorders |
| AU741266B2 (en) * | 1998-02-25 | 2001-11-29 | Impian Technologies Limited | Veterinary delivery device and method |
| US6175752B1 (en) * | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6334859B1 (en) * | 1999-07-26 | 2002-01-01 | Zuli Holdings Ltd. | Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments |
| CA2392006C (en) * | 1999-11-17 | 2011-03-15 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
| US6458118B1 (en) * | 2000-02-23 | 2002-10-01 | Medtronic, Inc. | Drug delivery through microencapsulation |
| US6497666B1 (en) * | 2000-10-25 | 2002-12-24 | Acuson Corporation | Medical ultrasonic contrast agent imaging method and apparatus |
| ES2281457T3 (es) * | 2000-11-09 | 2007-10-01 | Insulet Corporation | Medio de suministro transcutaneo. |
| US6571125B2 (en) * | 2001-02-12 | 2003-05-27 | Medtronic, Inc. | Drug delivery device |
| US6685452B2 (en) * | 2001-04-26 | 2004-02-03 | Chris C. Christiansen | Implantable drug delivery pump with desiccant humidity protection |
-
2002
- 2002-03-06 US US10/092,954 patent/US20030171738A1/en not_active Abandoned
-
2003
- 2003-03-03 CA CA2420584A patent/CA2420584C/en not_active Expired - Lifetime
- 2003-03-04 AU AU2003200925A patent/AU2003200925B2/en not_active Ceased
- 2003-03-05 JP JP2003058903A patent/JP4574120B2/ja not_active Expired - Fee Related
- 2003-03-05 DE DE60329729T patent/DE60329729D1/de not_active Expired - Lifetime
- 2003-03-05 EP EP03251316A patent/EP1342481B1/de not_active Expired - Lifetime
-
2008
- 2008-02-01 US US12/024,402 patent/US20080125759A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080125759A1 (en) | 2008-05-29 |
| EP1342481A1 (de) | 2003-09-10 |
| JP4574120B2 (ja) | 2010-11-04 |
| CA2420584C (en) | 2012-06-26 |
| EP1342481B1 (de) | 2009-10-21 |
| CA2420584A1 (en) | 2003-09-06 |
| AU2003200925B2 (en) | 2009-06-11 |
| US20030171738A1 (en) | 2003-09-11 |
| JP2004000495A (ja) | 2004-01-08 |
| AU2003200925A1 (en) | 2003-10-02 |
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