DE60328202D1 - Diarylharnstoffderivate und deren verwendung als chloridkanalblocker - Google Patents
Diarylharnstoffderivate und deren verwendung als chloridkanalblockerInfo
- Publication number
- DE60328202D1 DE60328202D1 DE60328202T DE60328202T DE60328202D1 DE 60328202 D1 DE60328202 D1 DE 60328202D1 DE 60328202 T DE60328202 T DE 60328202T DE 60328202 T DE60328202 T DE 60328202T DE 60328202 D1 DE60328202 D1 DE 60328202D1
- Authority
- DE
- Germany
- Prior art keywords
- channel blockers
- chloride channel
- diaryl
- harvest
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010062745 Chloride Channels Proteins 0.000 title abstract 2
- 102000011045 Chloride Channels Human genes 0.000 title abstract 2
- 238000003306 harvesting Methods 0.000 title 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical compound C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000003651 basophil Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201306 | 2002-09-05 | ||
| DKPA200201310 | 2002-09-05 | ||
| PCT/DK2003/000575 WO2004022529A2 (en) | 2002-09-05 | 2003-09-04 | Diarylurea derivatives and their use as chloride channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60328202D1 true DE60328202D1 (de) | 2009-08-13 |
Family
ID=31979712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60328202T Expired - Lifetime DE60328202D1 (de) | 2002-09-05 | 2003-09-04 | Diarylharnstoffderivate und deren verwendung als chloridkanalblocker |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060160856A1 (de) |
| EP (1) | EP1537075B1 (de) |
| JP (1) | JP2005538152A (de) |
| CN (1) | CN100497302C (de) |
| AT (1) | ATE435199T1 (de) |
| CA (1) | CA2495284A1 (de) |
| DE (1) | DE60328202D1 (de) |
| MX (1) | MXPA05002493A (de) |
| NZ (1) | NZ538513A (de) |
| WO (1) | WO2004022529A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000041698A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| AU2004247429B2 (en) * | 2003-06-17 | 2010-01-28 | Neurosearch A/S | Diphenylurea derivatives and their use as chloride channel blockers |
| NZ544920A (en) | 2003-07-23 | 2009-11-27 | Bayer Healthcare Llc | 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions |
| WO2005023238A1 (en) * | 2003-09-04 | 2005-03-17 | Poseidon Pharmaceuticals A/S | Erg channel openers for the treatment of hyperexcitability-related neuronal diseases |
| EP1663192B1 (de) | 2003-09-04 | 2008-12-03 | NeuroSearch A/S | hERG1-KANAL-ÖFFNER ZUR BEHANDLUNG VON HERZARRYTHMIEN |
| TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| CA2591616A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
| US7645778B2 (en) | 2005-01-19 | 2010-01-12 | Bristol-Myers Squibb Company | Heteroaryl compounds as P2Y1 receptor inhibitors |
| EP1899299B1 (de) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
| US7816382B2 (en) | 2005-06-27 | 2010-10-19 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition |
| US7728008B2 (en) | 2005-06-27 | 2010-06-01 | Bristol-Myers Squibb Company | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| AT502219B1 (de) * | 2005-08-04 | 2007-04-15 | Sanochemia Pharmazeutika Ag | Verfahren zur reindarstellung von 5-substituierten tetrazolen |
| JP5238506B2 (ja) * | 2005-10-06 | 2013-07-17 | エグゼリクシス, インコーポレイテッド | Pim−1および/またはpim−3のピリドピリミジノンインヒビター |
| CN101421257A (zh) * | 2006-03-21 | 2009-04-29 | 欧洲分子生物学实验室 | 阻断细胞复制的试剂以及它们在抑制病理状态中的用途 |
| US20080076800A1 (en) * | 2006-08-24 | 2008-03-27 | Huang Kenneth H | Benzene, Pyridine, and Pyridazine Derivatives |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2008047067A1 (en) * | 2006-10-20 | 2008-04-24 | University Court Of The University Of Edinburgh | Treatment of inflammatory disease |
| TW201103943A (en) * | 2009-04-27 | 2011-02-01 | Shionogi & Co | Urea derivative having pi3k inhibitory activity |
| BR112012003462A2 (pt) * | 2009-08-24 | 2016-02-23 | Ascepion Pharmaceuticals Inc | "composto, composição farmacêutica, e, método para tratar um paciente tendo uma condição mediada pela proteína quinase." |
| CN104114164B (zh) | 2011-10-26 | 2016-11-16 | 阿勒根公司 | 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物 |
| AU2013202982C1 (en) | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
| DE102012007558A1 (de) * | 2012-04-14 | 2013-10-17 | Alf Hammes | Gabe substituierter bis-aryl-harnstoffderivate zur behandlung von anämien |
| RU2768730C2 (ru) | 2013-03-06 | 2022-03-24 | Аллерган, Инк. | Применение агонистов формилпептидного рецептора 2 для лечения воспалительных заболеваний глаз |
| CN105007908B (zh) * | 2013-03-06 | 2017-10-03 | 阿勒根公司 | 用于治疗皮肤病的甲酰基肽受体2的激动剂的用途 |
| US20160152560A1 (en) * | 2013-05-28 | 2016-06-02 | The Regents Of The University Of California | Compounds for the treatment of hypertension and hypertensive end stage renal disease |
| CN104277060A (zh) * | 2014-09-23 | 2015-01-14 | 河南科技学院 | 一种合成2-氨基-4-烷氧羰基苯硼酸盐酸盐的方法 |
| CA2998647A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| CN105566341B (zh) * | 2014-10-10 | 2017-11-24 | 中国科学院宁波材料技术与工程研究所 | 一种7‑氧杂二环[2.2.1]庚‑5‑烯单体及其制备方法和应用 |
| EP3256461B1 (de) * | 2015-02-13 | 2023-09-13 | Azienda Ospedaliera Universitaria Senese | Harnstoff- und sulfonamidderivate als humane helikase ddx3-hemmer zur behandlung von viruserkrankungen |
| CN105348168B (zh) * | 2015-11-06 | 2018-04-10 | 厦门大学 | 1‑(2‑(金刚烷‑1‑基)‑1h‑吲哚‑5‑基)‑3‑取代脲衍生物及制备和用途 |
| ITUA20161994A1 (it) * | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
| CN106008577A (zh) * | 2016-06-03 | 2016-10-12 | 南开大学 | 一种含有苯硼酸官能团的琥珀酰亚胺酯及其制备方法 |
| EP3476829B1 (de) | 2016-06-22 | 2021-12-15 | Fudan University | Biarylharnstoffderivat oder salz davon sowie herstellung und verwendung davon |
| US11253525B2 (en) | 2018-08-29 | 2022-02-22 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| JP7336133B2 (ja) * | 2019-08-07 | 2023-08-31 | 国立大学法人東北大学 | ジフェニル尿素化合物誘導体 |
| EP4021894A1 (de) * | 2019-08-30 | 2022-07-06 | University of Rochester | Septininhibitoren zur behandlung von krebs |
| CN112076185A (zh) * | 2020-08-17 | 2020-12-15 | 西安交通大学 | 一类卤代二芳基脲类化合物及其在制备抗过敏药物中的应用 |
| EP4211121A1 (de) * | 2020-09-14 | 2023-07-19 | Genzyme Corporation | Carbonsäurehaltige verbindungen als modulatoren der bis-phosphoglyceratmutase zur behandlung von sichelzellanämie |
| WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
| CN117229258B (zh) * | 2022-06-07 | 2024-07-19 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584884A (de) * | 1968-10-03 | 1970-01-02 | ||
| JPS55153763A (en) * | 1979-05-21 | 1980-11-29 | Kyowa Hakko Kogyo Co Ltd | Modifier for citrus fruits |
| DE3242344A1 (de) * | 1982-11-16 | 1984-05-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| FR2646847B1 (fr) * | 1989-05-12 | 1991-07-12 | Rhone Poulenc Sante | N-phenyl amides, leurs procedes de preparation et les medicaments les contenant |
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| JP4073489B2 (ja) * | 1996-05-24 | 2008-04-09 | ニューロサーチ・アクティーゼルスカブ | 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法 |
| JP2000510862A (ja) * | 1996-05-24 | 2000-08-22 | ニューロサーチ・アクティーゼルスカブ | クロライドチャンネル遮断剤として有用なフエニル誘導体 |
| US6696475B2 (en) * | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| IL132107A (en) * | 1997-04-22 | 2004-09-27 | Neurosearch As | Substituted phenyl derivatives, their preparation and use |
| WO1999032111A1 (en) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
| HUP0103673A3 (en) * | 1998-10-22 | 2003-03-28 | Neurosearch As | Substituted phenyl derivatives, their preparation and use |
| GB9823873D0 (en) * | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| JP2003530328A (ja) * | 2000-04-07 | 2003-10-14 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| WO2002039987A2 (en) * | 2000-11-14 | 2002-05-23 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
| US20040077634A1 (en) * | 2001-02-15 | 2004-04-22 | Ulrik Lademann | Treatment of diseases characterized by excessive or insufficient cell death |
| CA2445003A1 (en) * | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| US20050080112A1 (en) * | 2001-06-22 | 2005-04-14 | Madsen Lars Siim | Compounds for use in disorders associated with mast cell or basophil acitvity |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
-
2003
- 2003-09-04 US US10/526,208 patent/US20060160856A1/en not_active Abandoned
- 2003-09-04 EP EP03793605A patent/EP1537075B1/de not_active Expired - Lifetime
- 2003-09-04 WO PCT/DK2003/000575 patent/WO2004022529A2/en not_active Ceased
- 2003-09-04 CN CNB038209853A patent/CN100497302C/zh not_active Expired - Fee Related
- 2003-09-04 DE DE60328202T patent/DE60328202D1/de not_active Expired - Lifetime
- 2003-09-04 JP JP2004533214A patent/JP2005538152A/ja active Pending
- 2003-09-04 CA CA002495284A patent/CA2495284A1/en not_active Abandoned
- 2003-09-04 AT AT03793605T patent/ATE435199T1/de not_active IP Right Cessation
- 2003-09-04 MX MXPA05002493A patent/MXPA05002493A/es active IP Right Grant
- 2003-09-04 NZ NZ538513A patent/NZ538513A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060160856A1 (en) | 2006-07-20 |
| CN100497302C (zh) | 2009-06-10 |
| MXPA05002493A (es) | 2005-05-27 |
| EP1537075A2 (de) | 2005-06-08 |
| AU2003258490A1 (en) | 2004-03-29 |
| WO2004022529A2 (en) | 2004-03-18 |
| CN1678573A (zh) | 2005-10-05 |
| NZ538513A (en) | 2007-02-23 |
| WO2004022529A3 (en) | 2004-05-13 |
| JP2005538152A (ja) | 2005-12-15 |
| CA2495284A1 (en) | 2004-03-18 |
| ATE435199T1 (de) | 2009-07-15 |
| EP1537075B1 (de) | 2009-07-01 |
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