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DE60327363D1 - Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen - Google Patents

Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen

Info

Publication number
DE60327363D1
DE60327363D1 DE60327363T DE60327363T DE60327363D1 DE 60327363 D1 DE60327363 D1 DE 60327363D1 DE 60327363 T DE60327363 T DE 60327363T DE 60327363 T DE60327363 T DE 60327363T DE 60327363 D1 DE60327363 D1 DE 60327363D1
Authority
DE
Germany
Prior art keywords
tamoxifes
hydroxy
density
reducing
breast tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327363T
Other languages
German (de)
English (en)
Inventor
Jay Bua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Besins International SAS
Original Assignee
Laboratoires Besins International SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Besins International SAS filed Critical Laboratoires Besins International SAS
Application granted granted Critical
Publication of DE60327363D1 publication Critical patent/DE60327363D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60327363T 2002-12-18 2003-12-15 Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen Expired - Lifetime DE60327363D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43395802P 2002-12-18 2002-12-18
PCT/EP2003/015030 WO2004054558A2 (fr) 2002-12-18 2003-12-15 Reduction de la densite mammaire a l'aide de 4-hydroxy tamoxifene

Publications (1)

Publication Number Publication Date
DE60327363D1 true DE60327363D1 (de) 2009-06-04

Family

ID=32595254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327363T Expired - Lifetime DE60327363D1 (de) 2002-12-18 2003-12-15 Verringerung der dichte des brustgewebes durch 4-hydroxy tamoxifen

Country Status (6)

Country Link
US (1) US7485623B2 (fr)
EP (3) EP1952809B1 (fr)
JP (2) JP4684655B2 (fr)
AU (1) AU2003296757A1 (fr)
DE (1) DE60327363D1 (fr)
WO (1) WO2004054558A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005513080A (ja) * 2001-12-20 2005-05-12 フェムファーマ， インコーポレイテッド 薬物の膣送達
US7786172B2 (en) * 2002-12-18 2010-08-31 Laboratories Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
US9173836B2 (en) 2003-01-02 2015-11-03 FemmeParma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
AU2004203700B2 (en) * 2003-01-02 2007-06-21 Femmepharma Holding Company, Inc. Pharmaceutical preparations for treatments of diseases and disorders of the breast
US7704516B2 (en) * 2003-04-01 2010-04-27 Laboratories Besins International Sa Percutaneous composition comprising 4-hydroxy tamoxifen
JP4682129B2 (ja) 2003-06-09 2011-05-11 アセンド セラピュティクス インコーポレイテッド ４−ヒドロキシタモキシフェンによる過剰瘢痕化の治療及び予防
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US20050208139A1 (en) * 2004-03-22 2005-09-22 Ascend Therapeutics, Inc. Chemically stable compositions of 4-hydroxy tamoxifen
CA2559748C (fr) * 2004-03-22 2013-05-28 Elisabeth Le Nestour Traitement et prevention d'une maladie benine du sein avec 4-hydroxy tamoxifene
US7507769B2 (en) 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
EP1579856A1 (fr) * 2004-03-22 2005-09-28 Laboratoires Besins International 4-Hydroxytamoxifène destiné au traitement des maladies bénignes des seins
EP1647271A1 (fr) * 2004-10-14 2006-04-19 Laboratoires Besins International Formulation sous forme de gel contenant 4-Hydroxy Tamoxifene.
WO2006040196A1 (fr) * 2004-10-14 2006-04-20 Laboratoires Besins International Formulations de gel contenant 4-hydroxy tamoxifene
GB0602739D0 (en) * 2006-02-10 2006-03-22 Ccbr As Breast tissue density measure
US20080153789A1 (en) * 2006-12-26 2008-06-26 Femmepharma Holding Company, Inc. Topical administration of danazol
WO2009065918A1 (fr) * 2007-11-22 2009-05-28 Novo Nordisk Health Care Ag Stabilisation de polypeptides du facteur vii(a) formulés sous forme liquide par des composés contenant des aldéhydes
US20110003000A1 (en) * 2009-07-06 2011-01-06 Femmepharma Holding Company, Inc. Transvaginal Delivery of Drugs
CN110044998B (zh) * 2014-05-12 2021-12-14 奎斯特诊断投资公司 通过质谱法定量他莫昔芬及其代谢物
WO2018034945A1 (fr) 2016-08-19 2018-02-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulateurs sélectifs du récepteur des oestrogènes (serms) conférant une protection contre la dégénérescence des photorécepteurs
EP3681491A4 (fr) 2017-09-11 2021-06-30 Atossa Therapeutics, Inc. Procédés pour la fabrication et l'utilisation d'endoxifène
US12201591B2 (en) 2019-07-03 2025-01-21 Atossa Therapeutics, Inc. Sustained release compositions of endoxifen
WO2023026139A1 (fr) * 2021-08-23 2023-03-02 Singh Divya Dhananjay Composition pharmaceutique comprenant du 4-hydroxytamoxifène pour le traitement de la mastalgie

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
ES2044860T3 (es) * 1987-04-21 1994-01-16 Heumann Pharma Gmbh & Co Estables aductos con disolventes de z-1-(p-beta-di-metil-amino-etoxi-fenil)-1-(p-hidroxi-fenil)-2-fenil-but-1-eno.
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
DE3836862A1 (de) 1988-10-27 1990-05-03 Schering Ag Mittel zur transdermalen applikation von steroidhormonen
TW218849B (fr) 1991-05-17 1994-01-11 Bristol Myers Squibb Co
JPH0679002A (ja) * 1993-12-14 1994-03-22 Hisamitsu Pharmaceut Co Inc 経皮投与用パッチシステム
US5613958A (en) 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5720963A (en) * 1994-08-26 1998-02-24 Mary Kay Inc. Barrier disruption treatments for structurally deteriorated skin
DE4434165A1 (de) * 1994-09-24 1996-03-28 Cassella Ag Haarfärbemittel
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
US6013270A (en) * 1998-04-20 2000-01-11 The Procter & Gamble Company Skin care kit
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
DK1317921T3 (da) * 2001-12-07 2009-12-21 Besins Mfg Belgium Farmaceutisk sammensætning i form af en gel eller oplösning med dihydrotestosteron, fremgangsmåde til fremstilling og anvendelser heraf
US7786172B2 (en) * 2002-12-18 2010-08-31 Laboratories Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
US7704516B2 (en) * 2003-04-01 2010-04-27 Laboratories Besins International Sa Percutaneous composition comprising 4-hydroxy tamoxifen
JP4682129B2 (ja) 2003-06-09 2011-05-11 アセンド セラピュティクス インコーポレイテッド ４−ヒドロキシタモキシフェンによる過剰瘢痕化の治療及び予防
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
US20050208139A1 (en) * 2004-03-22 2005-09-22 Ascend Therapeutics, Inc. Chemically stable compositions of 4-hydroxy tamoxifen
EP1647271A1 (fr) * 2004-10-14 2006-04-19 Laboratoires Besins International Formulation sous forme de gel contenant 4-Hydroxy Tamoxifene.

Also Published As

Publication number Publication date
AU2003296757A1 (en) 2004-07-09
JP2006514645A (ja) 2006-05-11
JP4684655B2 (ja) 2011-05-18
US7485623B2 (en) 2009-02-03
JP2011052020A (ja) 2011-03-17
EP1572171B1 (fr) 2009-04-22
EP2050443A1 (fr) 2009-04-22
EP1952809A3 (fr) 2012-06-20
EP1572171A2 (fr) 2005-09-14
WO2004054558A2 (fr) 2004-07-01
EP2050443B1 (fr) 2017-05-24
EP1952809B1 (fr) 2017-08-02
AU2003296757A8 (en) 2004-07-09
WO2004054558A3 (fr) 2004-10-28
EP1952809A2 (fr) 2008-08-06
US20040138314A1 (en) 2004-07-15

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Legal Events

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