DE60327936D1 - Modulatoren von ship-1 - Google Patents
Modulatoren von ship-1Info
- Publication number
- DE60327936D1 DE60327936D1 DE60327936T DE60327936T DE60327936D1 DE 60327936 D1 DE60327936 D1 DE 60327936D1 DE 60327936 T DE60327936 T DE 60327936T DE 60327936 T DE60327936 T DE 60327936T DE 60327936 D1 DE60327936 D1 DE 60327936D1
- Authority
- DE
- Germany
- Prior art keywords
- ship
- modulators
- activity
- pelorol
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100021797 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Human genes 0.000 title 1
- 101710174326 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- FFBLMLRQAKGTJN-VQDLLJBESA-N pelorol Chemical compound CC1(C)CCC[C@]2(C)[C@H]3CC(C(O)=C(O)C=C4C(=O)OC)=C4[C@]3(C)CC[C@H]21 FFBLMLRQAKGTJN-VQDLLJBESA-N 0.000 abstract 1
- FFBLMLRQAKGTJN-UHFFFAOYSA-N perolol Natural products CC1(C)CCCC2(C)C3CC(C(O)=C(O)C=C4C(=O)OC)=C4C3(C)CCC21 FFBLMLRQAKGTJN-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- -1 terpene compounds Chemical class 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Amplitude Modulation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2002/001550 WO2003033517A1 (en) | 2001-10-17 | 2002-10-17 | Ship 1 modulators |
| PCT/CA2003/000571 WO2004035601A1 (en) | 2002-10-17 | 2003-04-23 | Ship 1 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60327936D1 true DE60327936D1 (de) | 2009-07-23 |
Family
ID=32097361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60327936T Expired - Lifetime DE60327936D1 (de) | 2002-10-17 | 2003-04-23 | Modulatoren von ship-1 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1554304B1 (de) |
| JP (1) | JP4753581B2 (de) |
| AT (1) | ATE433458T1 (de) |
| CA (1) | CA2502293C (de) |
| DE (1) | DE60327936D1 (de) |
| ES (1) | ES2327829T3 (de) |
| WO (1) | WO2004035601A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007147252A1 (en) * | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator prodrugs |
| EP2507221A1 (de) * | 2009-12-04 | 2012-10-10 | Aquinox Pharmaceuticals Inc. | Ship1-modulatoren und zugehörige verfahren |
| AU2012225268B2 (en) | 2011-03-10 | 2016-10-20 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of peptide drugs |
| US9125805B2 (en) * | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| US9540353B2 (en) | 2013-01-09 | 2017-01-10 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| AU2014228574B2 (en) | 2013-03-14 | 2018-07-26 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| KR102427491B1 (ko) | 2013-03-14 | 2022-08-01 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| WO2016022831A1 (en) | 2014-08-06 | 2016-02-11 | Xeris Pharmaceuticals, Inc. | Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes |
| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| JP2018518494A (ja) | 2015-06-26 | 2018-07-12 | アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド | （１Ｓ，３Ｓ，４Ｒ）−４−（（３ａＳ，４Ｒ，５Ｓ，７ａＳ）−４−（アミノメチル）−７ａ−メチル−１−メチレンオクタヒドロ−１Ｈ−インデン−５−イル）−３−（ヒドロキシメチル）−４−メチルシクロヘキサノールの酢酸塩の結晶固体形態 |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| EP3630061B1 (de) | 2017-06-02 | 2024-04-03 | Xeris Pharmaceuticals, Inc. | Niederschlagsbeständige kleinmolekulare zubereitung |
| EP4143202A4 (de) * | 2020-04-20 | 2024-04-24 | ZebraPeutics Inc. | Verfahren zur behandlung von ship1-vermittelten erkrankungen mit pelorolderivaten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2463136A1 (en) * | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
-
2003
- 2003-04-23 DE DE60327936T patent/DE60327936D1/de not_active Expired - Lifetime
- 2003-04-23 JP JP2004543854A patent/JP4753581B2/ja not_active Expired - Fee Related
- 2003-04-23 WO PCT/CA2003/000571 patent/WO2004035601A1/en not_active Ceased
- 2003-04-23 CA CA2502293A patent/CA2502293C/en not_active Expired - Lifetime
- 2003-04-23 AT AT03714589T patent/ATE433458T1/de not_active IP Right Cessation
- 2003-04-23 ES ES03714589T patent/ES2327829T3/es not_active Expired - Lifetime
- 2003-04-23 EP EP03714589A patent/EP1554304B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004035601A1 (en) | 2004-04-29 |
| JP2006506363A (ja) | 2006-02-23 |
| EP1554304B1 (de) | 2009-06-10 |
| ATE433458T1 (de) | 2009-06-15 |
| EP1554304A1 (de) | 2005-07-20 |
| ES2327829T3 (es) | 2009-11-04 |
| CA2502293A1 (en) | 2004-04-29 |
| CA2502293C (en) | 2011-09-06 |
| JP4753581B2 (ja) | 2011-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE533743T1 (de) | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 | |
| SE0301653D0 (sv) | Novel compounds | |
| DE60327936D1 (de) | Modulatoren von ship-1 | |
| ATE433447T1 (de) | Pyrimiidinverbindungen | |
| CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| BR0307833A (pt) | Sìntese controlada de ziprasidona e suas composições | |
| ATE369755T1 (de) | Verwendung von diphenylmethan-derivaten als tyrosinase-inhibitoren | |
| ATE387435T1 (de) | Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren | |
| MA28985B1 (fr) | Analogues de loxapine et methodes d'utilisation | |
| ATE396993T1 (de) | Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität | |
| ATE335748T1 (de) | Thienopyrimidindione und deren verwendung bei der modulierung von autoimmunerkrankungen | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| PT920410E (pt) | Preparacao de derivados de carboxilato de ciclo-hexeno | |
| AU2003228770A8 (en) | Substituted pyrazolopyrimidines | |
| BG99177A (bg) | Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза | |
| BR0300709A (pt) | Sal de perindopril e as composições farmacêuticas contendo o mesmo | |
| MXPA03010158A (es) | Sulfonamidas. | |
| SE9901077D0 (sv) | Novel use | |
| DE60301339D1 (de) | Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen | |
| PA8586801A1 (es) | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso | |
| AUPR118000A0 (en) | Therapeutic molecules and methods | |
| DE60221537D1 (de) | Pteridinon-derivate als modulatoren der chemokinrezeptor-aktivität | |
| PA8577701A1 (es) | Polipeptido t20 pegilado | |
| SE9801494D0 (sv) | Novel use | |
| DK1383742T3 (da) | Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |