DE60327715D1 - Verfahren zum schutz von thiolgruppen in antikörpern - Google Patents
Verfahren zum schutz von thiolgruppen in antikörpernInfo
- Publication number
- DE60327715D1 DE60327715D1 DE60327715T DE60327715T DE60327715D1 DE 60327715 D1 DE60327715 D1 DE 60327715D1 DE 60327715 T DE60327715 T DE 60327715T DE 60327715 T DE60327715 T DE 60327715T DE 60327715 D1 DE60327715 D1 DE 60327715D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- protection
- thiol groups
- protein
- protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/066—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002370822 | 2002-12-20 | ||
| PCT/JP2003/016362 WO2004056872A1 (ja) | 2002-12-20 | 2003-12-19 | タンパク質のチオール基を保護する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60327715D1 true DE60327715D1 (de) | 2009-07-02 |
Family
ID=32677181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60327715T Expired - Fee Related DE60327715D1 (de) | 2002-12-20 | 2003-12-19 | Verfahren zum schutz von thiolgruppen in antikörpern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060257393A1 (de) |
| EP (1) | EP1574521B1 (de) |
| JP (1) | JPWO2004056872A1 (de) |
| AT (1) | ATE431835T1 (de) |
| AU (1) | AU2003289455A1 (de) |
| CA (1) | CA2511228A1 (de) |
| DE (1) | DE60327715D1 (de) |
| ES (1) | ES2326076T3 (de) |
| WO (1) | WO2004056872A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| AR103172A1 (es) | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
| ES2064336T3 (es) * | 1987-10-13 | 1995-02-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de proteinas. |
| US5130418A (en) * | 1989-05-02 | 1992-07-14 | California Biotechnology Inc. | Method to stabilize basic fibroblast growth factor |
| ATE230024T1 (de) * | 1990-10-25 | 2003-01-15 | Univ Columbia | Entwicklung von dns-sonden und immunologischen reagenzien von menschlichen tumor-assoziierten antigenen |
| US5284830A (en) * | 1991-02-13 | 1994-02-08 | The Board Of Trustees Of The Leland Stanford Junior University | Thyroid-derived chondrocyte-stimulating factor |
| JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
| JP3236667B2 (ja) * | 1991-06-28 | 2001-12-10 | 三菱化学株式会社 | ヒト型モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ並びに抗腫瘍剤 |
| CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
| FI950062L (fi) * | 1992-07-06 | 1995-01-05 | Biomira Research Inc | Proteiinien foroaktivaatio konjugaatiotarkoituksia varten |
| EP0943690B1 (de) * | 1995-12-21 | 2006-11-29 | Ajinomoto Co., Inc. | Verfahren zur rückfaltung von menschlichem activin a |
| CA2257122C (en) * | 1996-06-11 | 2004-04-06 | Boehringer Mannheim Gmbh | Method of activating denatured protein |
| EP1273655A4 (de) * | 2000-03-30 | 2004-08-04 | Takeda Chemical Industries Ltd | Verfahren zur herstellung eines rekombinanten proteins |
| AU2002354363A1 (en) * | 2001-12-04 | 2003-06-17 | Mitsubishi Pharma Corporation | Method of activating protein |
-
2003
- 2003-12-19 WO PCT/JP2003/016362 patent/WO2004056872A1/ja not_active Ceased
- 2003-12-19 AU AU2003289455A patent/AU2003289455A1/en not_active Abandoned
- 2003-12-19 DE DE60327715T patent/DE60327715D1/de not_active Expired - Fee Related
- 2003-12-19 AT AT03780938T patent/ATE431835T1/de not_active IP Right Cessation
- 2003-12-19 JP JP2004562060A patent/JPWO2004056872A1/ja not_active Withdrawn
- 2003-12-19 US US10/539,756 patent/US20060257393A1/en not_active Abandoned
- 2003-12-19 EP EP03780938A patent/EP1574521B1/de not_active Expired - Lifetime
- 2003-12-19 CA CA002511228A patent/CA2511228A1/en not_active Abandoned
- 2003-12-19 ES ES03780938T patent/ES2326076T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060257393A1 (en) | 2006-11-16 |
| ES2326076T3 (es) | 2009-09-30 |
| EP1574521A4 (de) | 2006-04-12 |
| AU2003289455A1 (en) | 2004-07-14 |
| EP1574521A1 (de) | 2005-09-14 |
| EP1574521B1 (de) | 2009-05-20 |
| WO2004056872A1 (ja) | 2004-07-08 |
| ATE431835T1 (de) | 2009-06-15 |
| CA2511228A1 (en) | 2004-07-08 |
| JPWO2004056872A1 (ja) | 2006-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |