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DE60324385D1 - Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren - Google Patents

Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren

Info

Publication number
DE60324385D1
DE60324385D1 DE60324385T DE60324385T DE60324385D1 DE 60324385 D1 DE60324385 D1 DE 60324385D1 DE 60324385 T DE60324385 T DE 60324385T DE 60324385 T DE60324385 T DE 60324385T DE 60324385 D1 DE60324385 D1 DE 60324385D1
Authority
DE
Germany
Prior art keywords
cells
methods
small molecules
functionalities
development
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324385T
Other languages
English (en)
Inventor
Neil Goldsmith
Soeren V Nielsen
Alexandra M Soerensen
Curt Aime Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evolva Holding SA
Original Assignee
Evolva AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2002/000057 external-priority patent/WO2002059290A2/en
Application filed by Evolva AG filed Critical Evolva AG
Application granted granted Critical
Publication of DE60324385D1 publication Critical patent/DE60324385D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5097—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60324385T 2002-01-25 2003-01-24 Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren Expired - Lifetime DE60324385D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/DK2002/000057 WO2002059290A2 (en) 2001-01-25 2002-01-25 A method for evolving a cell having desired phenotype and envolved cells
DKPA200201174 2002-08-01
PCT/DK2003/000044 WO2003062419A1 (en) 2002-01-25 2003-01-24 Methods for multiple parameter screening and evolution of cells to produce small molecules with multiple functionalities

Publications (1)

Publication Number Publication Date
DE60324385D1 true DE60324385D1 (de) 2008-12-11

Family

ID=32992148

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324385T Expired - Lifetime DE60324385D1 (de) 2002-01-25 2003-01-24 Screeningmethoden nach mehreren parametern und entwicklung von zellen, um kleine moleküle mit mehreren funktionalitäten zu produzieren

Country Status (8)

Country Link
US (1) US20050164162A1 (de)
EP (1) EP1472349B1 (de)
JP (1) JP4472345B2 (de)
AT (1) ATE412742T1 (de)
AU (1) AU2003237662B2 (de)
CA (1) CA2511229A1 (de)
DE (1) DE60324385D1 (de)
WO (1) WO2003062419A1 (de)

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US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
EP1356037B1 (de) * 2001-01-25 2011-03-09 Evolva Ltd. Zellbibliothek
WO2004016791A1 (en) * 2002-08-01 2004-02-26 Evolva Ltd Methods of mixing large numbers of heterologous genes
WO2005071112A2 (en) * 2004-01-26 2005-08-04 Isis Innovation Ltd Molecular analysis
EP1866428A2 (de) 2005-03-18 2007-12-19 Microbia, Inc. Produktion von carotenoiden in ölhaltigen hefen und pilzen
WO2008073166A2 (en) * 2006-08-23 2008-06-19 Xcellerex, Inc. Multi-variant cell indication technique
EP2078092A2 (de) 2006-09-28 2009-07-15 Microbia, Inc. Herstellung von carotenoiden in öliger hefe und pilzen
WO2008157358A1 (en) * 2007-06-15 2008-12-24 University Of Medicine And Dentistry Of New Jersey Methods for treating neoplasia and for identifying compositions useful in such therapy
JP5676837B2 (ja) * 2007-11-02 2015-02-25 丸善製薬株式会社 毛乳頭細胞増殖促進剤、線維芽細胞増殖因子−７（ｆｇｆ−７）産生促進剤、血管内皮増殖因子（ｖｅｇｆ）産生促進剤、抗男性ホルモン剤、育毛剤及び頭髪化粧料
US8030095B2 (en) 2008-03-04 2011-10-04 Crystal Bioscience Inc. Gel microdrop composition and method of using the same
JP4918582B2 (ja) * 2009-09-28 2012-04-18 富山県 グルクロン酸転移酵素の製造方法
JP5773447B2 (ja) * 2010-03-26 2015-09-02 国立大学法人三重大学 マラリア原虫人工染色体を用いた薬剤耐性遺伝子の迅速同定法および組換えマラリア原虫作製法
EP2571991A1 (de) 2010-05-20 2013-03-27 Evolva SA Verfahren zur herstellung von isoprenoidverbindungen in hefe
JP7007298B2 (ja) 2016-01-25 2022-02-10 バイオ―ラッド ヨーロッパ ゲーエムベーハー デジタル微生物学
EP3589741A1 (de) * 2017-03-03 2020-01-08 Biomillenia SAS Mikropartikel zur kultivierung und prüfung von zellen
US20210208045A9 (en) * 2017-06-12 2021-07-08 Biomillenia Sas Method Of Measuring Viscosity In A Microfluidic System
CN114868678A (zh) * 2022-04-28 2022-08-09 淮阴师范学院 一种加州鲈鱼水槽养殖方法
WO2024173944A1 (en) * 2023-02-17 2024-08-22 Carnegie Mellon University Prioritizing candidate cell type-specific enhancers through comparative genomics

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US5316922A (en) * 1992-04-15 1994-05-31 The United States Of America As Represented By Department Of Health And Human Services Method for indentifying and expressing proteins that recognize and adhere to specific probes
US6268140B1 (en) * 1994-02-03 2001-07-31 Neugenesis Combinatorial metabolic libraries
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) * 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
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Also Published As

Publication number Publication date
EP1472349A1 (de) 2004-11-03
ATE412742T1 (de) 2008-11-15
JP4472345B2 (ja) 2010-06-02
WO2003062419A1 (en) 2003-07-31
AU2003237662B2 (en) 2008-04-24
CA2511229A1 (en) 2003-07-31
EP1472349B1 (de) 2008-10-29
US20050164162A1 (en) 2005-07-28
JP2005514947A (ja) 2005-05-26

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