DE60318101D1 - Verfahren und zwischenverbindungen zur gewinnung von 1-(1h-benzimidazol-2-yl)-4-(pyrimidin-2-ylamino)piperidin-derivaten - Google Patents
Verfahren und zwischenverbindungen zur gewinnung von 1-(1h-benzimidazol-2-yl)-4-(pyrimidin-2-ylamino)piperidin-derivatenInfo
- Publication number
- DE60318101D1 DE60318101D1 DE60318101T DE60318101T DE60318101D1 DE 60318101 D1 DE60318101 D1 DE 60318101D1 DE 60318101 T DE60318101 T DE 60318101T DE 60318101 T DE60318101 T DE 60318101T DE 60318101 D1 DE60318101 D1 DE 60318101D1
- Authority
- DE
- Germany
- Prior art keywords
- benzimidazole
- piperidine
- optionally
- obtaining
- intermediations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- FGFZOQCGHRFBKZ-UHFFFAOYSA-N n-[1-(1h-benzimidazol-2-yl)piperidin-4-yl]pyrimidin-2-amine Chemical class C1CN(C=2NC3=CC=CC=C3N=2)CCC1NC1=NC=CC=N1 FGFZOQCGHRFBKZ-UHFFFAOYSA-N 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical class 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200202251A ES2208098B1 (es) | 2002-10-02 | 2002-10-02 | Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina. |
| PCT/ES2003/000488 WO2004031170A1 (es) | 2002-10-02 | 2003-09-26 | Procedimiento e intermedios para la obtención de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60318101D1 true DE60318101D1 (de) | 2008-01-24 |
Family
ID=32050274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318101T Expired - Lifetime DE60318101D1 (de) | 2002-10-02 | 2003-09-26 | Verfahren und zwischenverbindungen zur gewinnung von 1-(1h-benzimidazol-2-yl)-4-(pyrimidin-2-ylamino)piperidin-derivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050228006A1 (de) |
| EP (1) | EP1564212B1 (de) |
| JP (1) | JP2006505539A (de) |
| AT (1) | ATE380808T1 (de) |
| AU (1) | AU2003271767A1 (de) |
| CA (1) | CA2500815A1 (de) |
| DE (1) | DE60318101D1 (de) |
| ES (1) | ES2208098B1 (de) |
| WO (1) | WO2004031170A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101531628B (zh) * | 2009-04-17 | 2012-01-11 | 大连凯飞精细化工有限公司 | 4-二甲胺基哌啶盐酸盐的合成方法 |
| CN108997308A (zh) * | 2018-07-09 | 2018-12-14 | 西藏大学 | 一种苯并咪唑类衍生物及其制备方法和应用 |
| CN116969922B (zh) * | 2023-07-27 | 2025-08-26 | 沈阳三九药业有限公司 | 一种咪唑斯汀的精制方法 |
| CN119707917B (zh) * | 2024-12-24 | 2025-12-09 | 沈阳三九药业有限公司 | 一种咪唑斯汀中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2587029B1 (fr) * | 1985-09-11 | 1987-10-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| FR2666582B1 (fr) * | 1990-09-07 | 1994-09-02 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique. |
-
2002
- 2002-10-02 ES ES200202251A patent/ES2208098B1/es not_active Expired - Fee Related
-
2003
- 2003-09-26 DE DE60318101T patent/DE60318101D1/de not_active Expired - Lifetime
- 2003-09-26 JP JP2004540823A patent/JP2006505539A/ja active Pending
- 2003-09-26 AT AT03753600T patent/ATE380808T1/de not_active IP Right Cessation
- 2003-09-26 AU AU2003271767A patent/AU2003271767A1/en not_active Abandoned
- 2003-09-26 EP EP03753600A patent/EP1564212B1/de not_active Expired - Lifetime
- 2003-09-26 WO PCT/ES2003/000488 patent/WO2004031170A1/es not_active Ceased
- 2003-09-26 CA CA002500815A patent/CA2500815A1/en not_active Abandoned
-
2005
- 2005-03-31 US US11/095,315 patent/US20050228006A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2208098B1 (es) | 2005-10-16 |
| JP2006505539A (ja) | 2006-02-16 |
| ES2208098A1 (es) | 2004-06-01 |
| EP1564212B1 (de) | 2007-12-12 |
| EP1564212A1 (de) | 2005-08-17 |
| ATE380808T1 (de) | 2007-12-15 |
| CA2500815A1 (en) | 2004-04-15 |
| AU2003271767A1 (en) | 2004-04-23 |
| WO2004031170A1 (es) | 2004-04-15 |
| US20050228006A1 (en) | 2005-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |