DE60318030D1 - Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychose - Google Patents
Piperazine-substituierte aryl-benzodiazepinen und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychoseInfo
- Publication number
- DE60318030D1 DE60318030D1 DE60318030T DE60318030T DE60318030D1 DE 60318030 D1 DE60318030 D1 DE 60318030D1 DE 60318030 T DE60318030 T DE 60318030T DE 60318030 T DE60318030 T DE 60318030T DE 60318030 D1 DE60318030 D1 DE 60318030D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- sub
- alkyl
- optionally substituted
- substituted phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000028017 Psychotic disease Diseases 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 229940121891 Dopamine receptor antagonist Drugs 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000013078 crystal Chemical group 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000012453 solvate Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36867002P | 2002-03-28 | 2002-03-28 | |
| US368670P | 2002-03-28 | ||
| PCT/US2003/006708 WO2003082877A1 (en) | 2002-03-28 | 2003-03-17 | Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60318030D1 true DE60318030D1 (de) | 2008-01-24 |
| DE60318030T2 DE60318030T2 (de) | 2008-04-10 |
Family
ID=28675525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318030T Expired - Fee Related DE60318030T2 (de) | 2002-03-28 | 2003-03-17 | Piperazine-substituierte aryl-benzodiazepine und ihre verwendung als dopaminrezeptor-antagonisten zur behandlung von psychosen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7214673B2 (de) |
| EP (1) | EP1492794B1 (de) |
| JP (1) | JP2005533009A (de) |
| AT (1) | ATE380818T1 (de) |
| AU (1) | AU2003217936A1 (de) |
| CA (1) | CA2479932A1 (de) |
| DE (1) | DE60318030T2 (de) |
| ES (1) | ES2297142T3 (de) |
| WO (1) | WO2003082877A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE361289T1 (de) * | 2002-08-05 | 2007-05-15 | Lilly Co Eli | Piperazinsubstituierte arylbenzodiazepine |
| WO2005026177A1 (en) * | 2003-09-09 | 2005-03-24 | Eli Lilly And Company | Substituted piperazines of azepines, oxazepines, and thiazepines |
| CA2550735A1 (en) | 2003-12-22 | 2005-07-14 | Acadia Pharmaceuticals Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7423149B2 (en) * | 2003-12-23 | 2008-09-09 | Schering Corporation | Substituted n-aryl amidines as selective D1 dopamine receptor antagonists for the treatment of obesity and CNS disorders |
| RU2325154C1 (ru) * | 2007-02-05 | 2008-05-27 | Государственное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарева" | Способ лечения истерической формы подострого реактивного психоза |
| CA2678897C (en) | 2007-03-15 | 2015-10-20 | Aryx Therapeutics, Inc. | Dibenzo[b,f][1,4]oxazapine compounds |
| JP2012502915A (ja) | 2008-09-15 | 2012-02-02 | バイオビスタ インコーポレイテッド | てんかんを治療する組成物及び方法 |
| AU2009303335B2 (en) | 2008-10-09 | 2016-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| EP2395986A1 (de) * | 2009-02-10 | 2011-12-21 | Abbott Laboratories | Verfahren für die herstellung von s1p-rezeptoragonisten und -antagonisten |
| JP2013525438A (ja) | 2010-04-29 | 2013-06-20 | アメリカ合衆国 | ヒトピルビン酸キナーゼ活性剤 |
| PL395468A1 (pl) * | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| WO2013130422A1 (en) | 2012-02-27 | 2013-09-06 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
| CA2882557C (en) | 2012-08-21 | 2020-10-27 | Ortho-Clinical Diagnostics, Inc. | Haptens of quetiapine for use in immunoassays |
| CA2882597C (en) | 2012-08-21 | 2020-04-14 | Ortho-Clinical Diagnostics, Inc. | Antibodies to quetiapine haptens and use thereof |
| JP6389176B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールハプテンに対する抗体及びその使用 |
| CN104736565B (zh) | 2012-08-21 | 2019-03-12 | 詹森药业有限公司 | 利培酮半抗原的抗体及其用途 |
| CN107043424B (zh) | 2012-08-21 | 2021-03-16 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| ES2733963T3 (es) | 2012-08-21 | 2019-12-03 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de olanzapina y uso de los mismos |
| PL3333195T3 (pl) | 2012-08-21 | 2021-02-22 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| JP2015527365A (ja) | 2012-08-21 | 2015-09-17 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンに対する抗体及びその使用 |
| PL3354751T3 (pl) | 2012-08-21 | 2020-03-31 | Janssen Pharmaceutica Nv | Przeciwciała dla arypiprazolu i ich zastosowanie |
| AU2013305938B2 (en) | 2012-08-21 | 2017-08-17 | Saladax Biomedical Inc. | Antibodies to paliperidone haptens and use thereof |
| JP6286429B2 (ja) | 2012-08-21 | 2018-02-28 | ヤンセン ファーマシューティカ エヌ．ベー． | パリペリドンのハプテン |
| EP2888263B1 (de) | 2012-08-21 | 2018-05-09 | Janssen Pharmaceutica NV | Haptene aus risperidon und paliperidon |
| EP2888590B1 (de) | 2012-08-21 | 2020-07-08 | Janssen Pharmaceutica NV | Antikörper gegen olanzapin und verwendung davon |
| ES2701062T3 (es) * | 2012-08-21 | 2019-02-20 | Janssen Pharmaceutica Nv | Haptenos de olanzapina |
| PT2888234T (pt) | 2012-08-21 | 2018-02-22 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| HK1215797A1 (zh) | 2014-06-20 | 2016-09-15 | 三得利控股株式会社 | 尿酸值下降剂 |
| CN104370833A (zh) * | 2014-10-26 | 2015-02-25 | 湖南华腾制药有限公司 | 一种1,4-二取代三唑衍生物的制备方法 |
| CN108368180B (zh) | 2015-12-17 | 2022-07-26 | 詹森药业有限公司 | 喹硫平的抗体及其用途 |
| MA44056A (fr) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica Nv | Anticorps anti-rispéridone et leur utilisation |
| CN110452183B (zh) * | 2019-09-04 | 2023-03-14 | 中国科学院上海有机化学研究所 | 一种手性杂环化合物的制备方法 |
| CN114671829B (zh) * | 2022-04-22 | 2023-07-25 | 合肥工业大学 | 以茚酮和二苯并氮杂卓为母核的杂二联体及其盐酸盐、其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457264A (en) | 1965-07-06 | 1969-07-22 | Farmochimica Cutolo Calosi Spa | N-(5h-dibenzo-(a,d)-cyclohepten - 5 - one-11-yl)-piperazines and method of preparing the same |
| US4087421A (en) | 1976-04-19 | 1978-05-02 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US4431589A (en) | 1980-12-11 | 1984-02-14 | Lilly House | Benzodiazepine compounds and their use as pharmaceuticals |
| US4987421A (en) * | 1988-06-09 | 1991-01-22 | Mitsubishi Denki Kabushiki Kaisha | Microstrip antenna |
| GB8819059D0 (en) | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
-
2003
- 2003-03-17 EP EP03713911A patent/EP1492794B1/de not_active Expired - Lifetime
- 2003-03-17 AU AU2003217936A patent/AU2003217936A1/en not_active Abandoned
- 2003-03-17 US US10/505,805 patent/US7214673B2/en not_active Expired - Fee Related
- 2003-03-17 WO PCT/US2003/006708 patent/WO2003082877A1/en not_active Ceased
- 2003-03-17 DE DE60318030T patent/DE60318030T2/de not_active Expired - Fee Related
- 2003-03-17 JP JP2003580342A patent/JP2005533009A/ja not_active Withdrawn
- 2003-03-17 AT AT03713911T patent/ATE380818T1/de not_active IP Right Cessation
- 2003-03-17 CA CA002479932A patent/CA2479932A1/en not_active Abandoned
- 2003-03-17 ES ES03713911T patent/ES2297142T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60318030T2 (de) | 2008-04-10 |
| CA2479932A1 (en) | 2003-10-09 |
| US7214673B2 (en) | 2007-05-08 |
| EP1492794A1 (de) | 2005-01-05 |
| AU2003217936A1 (en) | 2003-10-13 |
| JP2005533009A (ja) | 2005-11-04 |
| EP1492794B1 (de) | 2007-12-12 |
| ES2297142T3 (es) | 2008-05-01 |
| US20050203296A1 (en) | 2005-09-15 |
| WO2003082877A1 (en) | 2003-10-09 |
| ATE380818T1 (de) | 2007-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |